{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:59:23Z","timestamp":1786996763257,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["202003N4112"],"award-info":[{"award-number":["202003N4112"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H260001"],"award-info":[{"award-number":["LY20H260001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.semarthrit.2022.152095","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T05:28:20Z","timestamp":1662701300000},"page":"152095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Assessing the causal associations of obstructive sleep apnea with serum uric acid levels and gout: a bidirectional two-sample Mendelian randomization study"],"prefix":"10.1016","volume":"57","author":[{"given":"Zhen","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhai","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3S","key":"10.1016\/j.semarthrit.2022.152095_bib0001","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.semarthrit.2020.04.007","article-title":"The biology of urate","volume":"50","author":"Keenan","year":"2020","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.semarthrit.2022.152095_bib0002","first-page":"550","article-title":"Pathophysiology of Gout. Semin","volume":"40","author":"Narang","year":"2020","journal-title":"Nephrol"},{"issue":"7","key":"10.1016\/j.semarthrit.2022.152095_bib0003","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2020.07.006","article-title":"Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease","volume":"80","author":"Borghi","year":"2020","journal-title":"Eur J Intern Med"},{"issue":"15","key":"10.1016\/j.semarthrit.2022.152095_bib0005","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1056\/NEJMcp1816152","article-title":"Obstructive sleep apnea in adults","volume":"380","author":"Veasey","year":"2019","journal-title":"N Engl J Med"},{"issue":"32","key":"10.1016\/j.semarthrit.2022.152095_bib0006","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2174\/138161205774913255","article-title":"Uric acid and oxidative stress","volume":"11","author":"Glantzounis","year":"2005","journal-title":"Curr Pharm Des"},{"issue":"1","key":"10.1016\/j.semarthrit.2022.152095_bib0007","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13075-016-1012-3","article-title":"Monosodium urate crystals induce oxidative stress in human synoviocytes","volume":"18","author":"Zamudio-Cuevas","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.semarthrit.2022.152095_bib0008","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/annrheumdis-2014-206564","article-title":"Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra","volume":"75","author":"Crisan","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"17","key":"10.1016\/j.semarthrit.2022.152095_bib0009","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1161\/CIRCULATIONAHA.105.556746","article-title":"Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome","volume":"112","author":"Ryan","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.semarthrit.2022.152095_bib0010","doi-asserted-by":"crossref","first-page":"e66891","DOI":"10.1371\/journal.pone.0066891","article-title":"Association between uric acid levels and obstructive sleep apnea syndrome in a large epidemiological sample","volume":"8","author":"Hirotsu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0011","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4573756","article-title":"Evaluation of inflammatory markers in a large sample of obstructive sleep apnea patients without comorbidities","volume":"2017","author":"Bouloukaki","year":"2017","journal-title":"Mediators Inflamm"},{"issue":"3","key":"10.1016\/j.semarthrit.2022.152095_bib0012","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/1479972315586197","article-title":"Serum urate and obstructive sleep apnoea in severe obesity","volume":"12","author":"Seetho","year":"2015","journal-title":"Chron Respir Dis"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4578327","article-title":"Serum uric acid is independently associated with risk of obstructive sleep apnea-hypopnea syndrome in chinese patients with type 2 diabetes","volume":"2019","author":"Zheng","year":"2019","journal-title":"Dis Markers"},{"issue":"12","key":"10.1016\/j.semarthrit.2022.152095_bib0014","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1002\/art.39330","article-title":"Sleep apnea and the risk of incident gout: a population-based, body mass index-matched cohort study","volume":"67","author":"Zhang","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.semarthrit.2022.152095_bib0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/art.40662","article-title":"The risk of gout among patients with sleep apnea: a matched cohort study","volume":"71","author":"Blagojevic-Bucknall","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.semarthrit.2022.152095_bib0016","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s41927-021-00199-y","article-title":"Sleep disorders and gout in Australian adults","volume":"5","author":"New-Tolley","year":"2021","journal-title":"BMC Rheumatol"},{"issue":"9","key":"10.1016\/j.semarthrit.2022.152095_bib0017","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.5664\/jcsm.7328","article-title":"Gout and the risk of incident obstructive sleep apnea in adults 65 years or older: an observational study","volume":"14","author":"Singh","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"10","key":"10.1016\/j.semarthrit.2022.152095_bib0018","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S1579-2129(06)60575-2","article-title":"Blood uric acid levels in patients with sleep-disordered breathing","volume":"42","author":"Ruiz Garcia","year":"2006","journal-title":"Arch Bronconeumol"},{"issue":"3","key":"10.1016\/j.semarthrit.2022.152095_bib0019","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/crj.12626","article-title":"Red cell distribution width and uric acid in patients with obstructive sleep apnea","volume":"12","author":"Sunnetcioglu","year":"2018","journal-title":"Clin Respir J"},{"issue":"12","key":"10.1016\/j.semarthrit.2022.152095_bib0020","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1590\/0004-282x20200069","article-title":"Uric acid as a marker of severity of obstructive sleep apnoea syndrome in older patients","volume":"78","author":"SN","year":"2020","journal-title":"Arq Neuropsiquiatr"},{"issue":"1","key":"10.1016\/j.semarthrit.2022.152095_bib0021","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13075-020-02176-1","article-title":"Obstructive sleep apnea and the risk of gout: a population-based case-control study","volume":"22","author":"van Durme","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2474-14-119","article-title":"The association of gout with sleep disorders: a cross-sectional study in primary care","volume":"14","author":"Roddy","year":"2013","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0023","doi-asserted-by":"crossref","first-page":"k601","DOI":"10.1136\/bmj.k601","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.semarthrit.2022.152095_bib0024","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03091-2020","article-title":"Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health","volume":"57","author":"Strausz","year":"2021","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.semarthrit.2022.152095_bib0025","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","article-title":"Genome-wide association analyses identify 18 new loci associated with serum urate concentrations","volume":"45","author":"Kottgen","year":"2013","journal-title":"Nat Genet"},{"issue":"20","key":"10.1016\/j.semarthrit.2022.152095_bib0026","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.semarthrit.2022.152095_sbref0027","series-title":"UK biobank GWAS results","year":"2018"},{"issue":"1","key":"10.1016\/j.semarthrit.2022.152095_bib0028","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1038\/s41467-018-04951-w","article-title":"Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes","volume":"9","author":"Xue","year":"2018","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.semarthrit.2022.152095_bib0029","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/CIRCRESAHA.117.312086","article-title":"Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease","volume":"122","author":"van der Harst","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0030","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1038\/ncomms10023","article-title":"Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function","volume":"7","author":"Pattaro","year":"2016","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.semarthrit.2022.152095_bib0031","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"issue":"3","key":"10.1016\/j.semarthrit.2022.152095_bib0032","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"issue":"8","key":"10.1016\/j.semarthrit.2022.152095_bib0033","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat Med"},{"issue":"4","key":"10.1016\/j.semarthrit.2022.152095_bib0034","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"6","key":"10.1016\/j.semarthrit.2022.152095_bib0035","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.semarthrit.2022.152095_bib0036","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.semarthrit.2022.152095_bib0037","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.semarthrit.2022.152095_bib0038","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.semarthrit.2022.152095_bib0039","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/ije\/dyu005","article-title":"Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome","volume":"43","author":"Burgess","year":"2014","journal-title":"Int J Epidemiol"},{"issue":"4","key":"10.1016\/j.semarthrit.2022.152095_bib0040","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11325-019-01827-1","article-title":"A meta-analysis of the association between gout, serum uric acid level, and obstructive sleep apnea","volume":"23","author":"Shi","year":"2019","journal-title":"Sleep Breath"},{"issue":"5","key":"10.1016\/j.semarthrit.2022.152095_bib0041","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ejim.2014.04.005","article-title":"Uric acid as a potential mediator of cardiovascular morbidity in obstructive sleep apnea syndrome","volume":"25","author":"Kanbay","year":"2014","journal-title":"Eur J Intern Med"},{"issue":"1","key":"10.1016\/j.semarthrit.2022.152095_bib0042","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13075-019-1821-2","article-title":"Self-reported sleep quality and sleep disorders in people with physician-diagnosed gout: an Internet cross-sectional survey","volume":"21","author":"Singh","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2022.152095_bib0043","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4584936","article-title":"Does continuous positive airway pressure therapy in patients with obstructive sleep apnea improves uric acid? A meta-analysis","volume":"2019","author":"Chen","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"10.1016\/j.semarthrit.2022.152095_bib0044","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1080\/00325481.2020.1866891","article-title":"Serum uric acid and arterial lactate levels in patients with obstructive sleep apnea syndrome: the effect of CPAP treatment","volume":"133","author":"Bartziokas","year":"2021","journal-title":"Postgrad Med"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017222001469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017222001469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:08:37Z","timestamp":1758733717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017222001469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":44,"alternative-id":["S0049017222001469"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2022.152095","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the causal associations of obstructive sleep apnea with serum uric acid levels and gout: a bidirectional two-sample Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2022.152095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152095"}}