{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:54:24Z","timestamp":1793944464044,"version":"4.8.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.semarthrit.2023.152197","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T11:18:59Z","timestamp":1680088739000},"page":"152197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Juvenile and adult-onset scleroderma: Different clinical phenotypes"],"prefix":"10.1016","volume":"60","author":[{"given":"A.","family":"Adrovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Karatemiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Esatoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Barut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ugurlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Kasapcopur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-2918","authenticated-orcid":false,"given":"E.","family":"Seyahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10103","key":"10.1016\/j.semarthrit.2023.152197_bib0001","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.semarthrit.2023.152197_bib0002","first-page":"1004","article-title":"Childhood onset systemic sclerosis: classification, clinical and serologic features, and survival in comparison with adult onset disease","volume":"33","author":"Scalapino","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152197_bib0003","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mvr.2015.07.007","article-title":"A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: a EUSTAR exploratory study","volume":"102","author":"Ingegnoli","year":"2015","journal-title":"Microvasc Res"},{"key":"10.1016\/j.semarthrit.2023.152197_bib0004","first-page":"2143","article-title":"Incidence of systemic connective tissue diseases in children: a nationwide prospective study in Finland","volume":"21","author":"Pelkonen","year":"1994","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152197_bib0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/acr.20070","article-title":"Incidence of childhood linear scleroderma and systemic sclerosis in the UK and Ireland","volume":"62","author":"Herrick","year":"2010","journal-title":"Arthritis Care Res"},{"issue":"6","key":"10.1016\/j.semarthrit.2023.152197_bib0006","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1093\/rheumatology\/keab738","article-title":"Systemic sclerosis sine scleroderma in children","volume":"61","author":"Zulian","year":"2022","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.semarthrit.2023.152197_bib0007","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2174\/1573397114666180423105056","article-title":"Juvenile scleroderma-what has changed in the meantime?","volume":"14","author":"Adrovic","year":"2018","journal-title":"Curr Rheumatol Rev"},{"issue":"10","key":"10.1016\/j.semarthrit.2023.152197_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163894","article-title":"Incidences and risk factors of organ manifestations in the early course of systemic sclerosis: a longitudinal EUSTAR study","volume":"11","author":"Jaeger","year":"2016","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.semarthrit.2023.152197_bib0009","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5606\/ArchRheumatol.2018.6578","article-title":"Juvenile scleroderma: a referral center experience","volume":"33","author":"Adrovic","year":"2018","journal-title":"Arch Rheumatol"},{"issue":"10","key":"10.1016\/j.semarthrit.2023.152197_bib0010","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/acr.24609","article-title":"Differences sustained between diffuse and limited forms of juvenile systemic sclerosis in expanded international cohort","volume":"74","author":"Foeldvari","year":"2022","journal-title":"Arthri Care Res (Hoboken)"},{"issue":"5","key":"10.1016\/j.semarthrit.2023.152197_bib0011","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s11926-022-01067-5","article-title":"Detection and monitoring of interstitial lung disease in patients with systemic sclerosis","volume":"24","author":"Khanna","year":"2022","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"10.1016\/j.semarthrit.2023.152197_bib0012","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/acr.24499","article-title":"Underdetection of interstitial lung disease in juvenile systemic sclerosis","volume":"74","author":"Foeldvari","year":"2022","journal-title":"Arthrit Care Res (Hoboken)"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152197_bib0013","first-page":"576","article-title":"Scleroderma in children. Best practice and research","volume":"31","author":"Zulian","year":"2017","journal-title":"Clin Rheumatol"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152197_bib0014","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/art.21264","article-title":"Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES). Localized scleroderma in childhood is not just a skin disease","volume":"52","author":"Zulian","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.semarthrit.2023.152197_bib0015","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthrit Rheum"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152197_bib0016","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/art.22551","article-title":"The Pediatric Rheumatology European Society\/American College of Rheumatology\/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis","volume":"57","author":"Zulian","year":"2007","journal-title":"Arthrit Rheum"},{"issue":"11","key":"10.1016\/j.semarthrit.2023.152197_bib0017","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.3899\/jrheum.100001","article-title":"Characteristics of patients with juvenile onset systemic sclerosis in an adult single-center cohort","volume":"37","author":"Foeldvari","year":"2010","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.semarthrit.2023.152197_bib0018","doi-asserted-by":"crossref","first-page":"47","DOI":"10.33590\/emjrheumatol\/22-00107","article-title":"Paediatric scleroderma: kids are not just little adults","volume":"9","author":"Li","year":"2022","journal-title":"EMJ Rheumatol"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152197_bib0019","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/14397595.2013.854073","article-title":"The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients","volume":"24","author":"Hatta","year":"2014","journal-title":"Mod Rheumatol"},{"issue":"6","key":"10.1016\/j.semarthrit.2023.152197_bib0020","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.bor.0000245727.40630.c3","article-title":"Localized scleroderma","volume":"18","author":"Laxer","year":"2006","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152197_bib0021","first-page":"30","article-title":"The frequency of pulmonary hypertension in patients with juvenile scleroderma","volume":"15","author":"Adrovic","year":"2015","journal-title":"Bosnian J Bas Med Sci"},{"issue":"21","key":"10.1016\/j.semarthrit.2023.152197_bib0022","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1161\/CIRCULATIONAHA.104.507996","article-title":"Accelerated atherosclerosis in autoimmune rheumatic diseases","volume":"112","author":"Shoenfeld","year":"2005","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.semarthrit.2023.152197_bib0023","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1093\/rheumatology\/kel120","article-title":"Angiographically proven coronary artery disease in scleroderma","volume":"45","author":"Akram","year":"2006","journal-title":"Rheumatol (Oxf)"},{"issue":"10","key":"10.1016\/j.semarthrit.2023.152197_bib0024","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","author":"Tyndall","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"10.1016\/j.semarthrit.2023.152197_bib0025","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1002\/art.22207","article-title":"Systemic sclerosis in childhood: clinical and immunologic features of 153 patients in an international database","volume":"54","author":"Martini","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.semarthrit.2023.152197_bib0026","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/rheumatology\/kes144","article-title":"Juvenile and young adult-onset systemic sclerosis share the same organ involvement in adulthood: data from the EUSTAR database","volume":"51","author":"Foeldvari","year":"2012","journal-title":"Rheumatol (Oxf)"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152197_bib0027","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/rheumatology\/ken388","article-title":"Factors affecting survival in juvenile systemic sclerosis","volume":"48","author":"Martini","year":"2009","journal-title":"Rheumatol (Oxf)"},{"issue":"8","key":"10.1016\/j.semarthrit.2023.152197_bib0028","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1002\/art.22747","article-title":"Clinical subsets, skin thickness progression rate, and serum antibody levels in systemic sclerosis patients with anti-topoisomerase I antibody","volume":"56","author":"Perera","year":"2007","journal-title":"Arthrit Rheum"},{"issue":"5","key":"10.1016\/j.semarthrit.2023.152197_bib0029","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/rheumatology\/39.5.556","article-title":"Favourable outcome in 135 children with juvenile systemic sclerosis: results of a multi-national survey","volume":"39","author":"Foeldvari","year":"2000","journal-title":"Rheumatol (Oxf)"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152197_bib0030","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/rheumatology\/keaa547","article-title":"Disease frequency, patient characteristics, comorbidity outcomes and immunosuppressive therapy in systemic sclerosis and systemic sclerosis-associated interstitial lung disease: a US cohort study","volume":"60","author":"Li","year":"2021","journal-title":"Rheumatol (Oxf)"},{"issue":"25","key":"10.1016\/j.semarthrit.2023.152197_bib0031","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1056\/NEJMoa055120","article-title":"Cyclophosphamide versus placebo in scleroderma lung disease","volume":"354","author":"Tashkin","year":"2006","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152197_bib0032","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/rheumatology\/keaa584","article-title":"Consensus-based recommendations for the management of juvenile systemic sclerosis","volume":"60","author":"Foeldvari","year":"2021","journal-title":"Rheumatol (Oxf)"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152197_bib0033","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/rheumatology\/keaa550","article-title":"Rituximab in the treatment of systemic sclerosisrelated interstitial lung disease: a systematic review and metaanalysis","volume":"60","author":"Goswami","year":"2020","journal-title":"Rheumatol (Oxf)"},{"issue":"1","key":"10.1016\/j.semarthrit.2023.152197_bib0034","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2213-2600(22)00359-9","article-title":"Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial","volume":"11","author":"Maher","year":"2023","journal-title":"Lancet Respirat Med"},{"issue":"5","key":"10.1016\/j.semarthrit.2023.152197_bib0035","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/ard.2008.096677","article-title":"EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)","volume":"68","author":"Kowal-Bielecka","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"10.1016\/j.semarthrit.2023.152197_bib0036","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/annrheumdis-2016-209909","article-title":"Update of EULAR recommendations for the treatment of systemic sclerosis","volume":"76","author":"Kowal-Bielecka","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152197_bib0037","first-page":"1407","article-title":"Intravenous iloprost treatment of Raynaud's phenomenon and ischemic ulcers secondary to systemic sclerosis","volume":"19","author":"Wigley","year":"1992","journal-title":"J Rheumatol"},{"issue":"3","key":"10.1016\/j.semarthrit.2023.152197_bib0038","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-120-3-199402010-00004","article-title":"Intravenous iloprost infusion in patients with Raynaud phenomenon secondary to systemic sclerosis. A multicenter, placebo-controlled, double-blind study","volume":"120","author":"Wigley","year":"1994","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.semarthrit.2023.152197_bib0039","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00002281-199711000-00012","article-title":"Epidemiology of systemic sclerosis and related diseases","volume":"9","author":"Mayes","year":"1997","journal-title":"Curr Opin Rheumatol"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017223000392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017223000392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:11:22Z","timestamp":1758733882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017223000392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":39,"alternative-id":["S0049017223000392"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152197","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Juvenile and adult-onset scleroderma: Different clinical phenotypes","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152197"}}