{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:49:18Z","timestamp":1772560158795,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100015077","name":"Jagiellonian University Medical College Faculty of Medicine","doi-asserted-by":"publisher","award":["N41\/DBS\/000687"],"award-info":[{"award-number":["N41\/DBS\/000687"]}],"id":[{"id":"10.13039\/100015077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.semarthrit.2023.152228","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T21:57:10Z","timestamp":1686261430000},"page":"152228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Increased oxidative stress response in circulating blood of systemic sclerosis patients \u2013 relation to disease characteristics and inflammatory blood biomarkers"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-3557","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Dziedzic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"W\u00f3jcik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Olchawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Sarna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Pi\u0119ta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Jakie\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Padjas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Korona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lech","family":"Zar\u0119ba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Potaczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Kosa\u0142ka-W\u0119giel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Jurczyszyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142awa","family":"Bazan-Socha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10103","key":"10.1016\/j.semarthrit.2023.152228_bib0001","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152228_bib0002","doi-asserted-by":"crossref","first-page":"530","DOI":"10.12968\/hmed.2019.80.9.530","article-title":"Systemic sclerosis","volume":"80","author":"Hughes","year":"2019","journal-title":"Br J Hosp Med"},{"issue":"7","key":"10.1016\/j.semarthrit.2023.152228_bib0003","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","article-title":"Pathophysiology of systemic sclerosis: current understanding and new insights","volume":"15","author":"Cutolo","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152228_bib0004","doi-asserted-by":"crossref","first-page":"495","DOI":"10.5114\/ada.2019.83501","article-title":"Endothelial dysfunction in patients with systemic sclerosis","volume":"37","author":"Pacholczak-Madej","year":"2020","journal-title":"Adv Dermatol Allergol"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152228_bib0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.55563\/clinexprheumatol\/d03dnc","article-title":"Thrombin generation potential is enhanced in systemic sclerosis: impact of selected endothelial biomarkers","volume":"39","author":"Kuszmiersz","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.788250","article-title":"Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies","volume":"8","author":"Zanin-Silva","year":"2021","journal-title":"Front Med"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152228_bib0007","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.3390\/jcm9092687","article-title":"The Pathogenesis of Systemic Sclerosis: An Understanding Based on a Common Pathologic Cascade across Multiple Organs and Additional Organ-Specific Pathologies","volume":"9","author":"Asano","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101122","article-title":"Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis","volume":"25","author":"Doridot","year":"2019","journal-title":"Redox Biol"},{"issue":"5","key":"10.1016\/j.semarthrit.2023.152228_bib0009","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1172\/JCI131700","article-title":"Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis","volume":"130","author":"Maehara","year":"2020","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.semarthrit.2023.152228_bib0010","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1093\/rheumatology\/keab022","article-title":"Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis","volume":"60","author":"Andreucci","year":"2021","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.semarthrit.2023.152228_bib0011","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13510002.2022.2046423","article-title":"Role of mitochondrial reactive oxygen species in homeostasis regulation","volume":"27","author":"Zhang","year":"2022","journal-title":"Redox Rep"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152228_bib0012","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152228_bib0013","first-page":"328","article-title":"Quantification of hydroxyl radical-derived oxidation products in peptides containing glycine, alanine, valine, and proline, Free Radic","volume":"52","author":"Morgan","year":"2012","journal-title":"Biol Med"},{"issue":"7","key":"10.1016\/j.semarthrit.2023.152228_bib0014","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1111\/jcmm.13630","article-title":"Oxidative stress in the pathogenesis of systemic scleroderma: An overview","volume":"22","author":"Vona","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/389582","article-title":"Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis","volume":"2014","author":"Grygiel-G\u00f3rniak","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.semarthrit.2023.152228_bib0016","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0190-9622(93)70014-K","article-title":"A radical proposal for the pathogenesis of scleroderma","volume":"28","author":"Murrell","year":"1993","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152228_bib0017","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/14397595.2016.1206510","article-title":"Oxidative stress markers in blood in systemic sclerosis: A meta-analysis","volume":"27","author":"Luo","year":"2017","journal-title":"Mod Rheumatol"},{"issue":"7","key":"10.1016\/j.semarthrit.2023.152228_bib0018","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1096\/fj.00-0498fje","article-title":"The isoprostane 8-iso-PGF 2\u03b1 stimulates endothelial cells to bind monocytes: difference to thromboxane-mediated endothelial activation","volume":"15","author":"Leitinger","year":"2001","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152228_bib0019","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00403-016-1682-3","article-title":"Oxidative stress parameters in localized scleroderma patients","volume":"308","author":"Kilinc","year":"2016","journal-title":"Arch Dermatol Res"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152228_bib0020","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00296-013-2701-8","article-title":"Oxidative stress in Mexicans with diffuse cutaneous systemic sclerosis","volume":"33","author":"Cruz-Dom\u00ednguez","year":"2013","journal-title":"Rheumatol Int"},{"issue":"3","key":"10.1016\/j.semarthrit.2023.152228_bib0021","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/0019-5154.110840","article-title":"Serum antioxidant status in patients with systemic sclerosis","volume":"58","author":"Hassan","year":"2013","journal-title":"Indian J Dermatol"},{"issue":"32","key":"10.1016\/j.semarthrit.2023.152228_bib0022","doi-asserted-by":"crossref","first-page":"22536","DOI":"10.1074\/jbc.M114.553727","article-title":"Real-time Measurements of Amino Acid and Protein Hydroperoxides Using Coumarin Boronic Acid","volume":"289","author":"Michalski","year":"2014","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.semarthrit.2023.152228_bib0023","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152228_bib0024","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/rheumatology\/keh067","article-title":"Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis","volume":"43","author":"Mukerjee","year":"2004","journal-title":"Rheumatology"},{"issue":"7","key":"10.1016\/j.semarthrit.2023.152228_bib0025","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3390\/biomedicines10071499","article-title":"Increased Oxidative Stress in Asthma\u2014Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices","volume":"10","author":"Bazan-Socha","year":"2022","journal-title":"Biomedicines"},{"issue":"9","key":"10.1016\/j.semarthrit.2023.152228_bib0026","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/ard.2006.067504","article-title":"Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis","volume":"66","author":"Servettaz","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0027","first-page":"90","article-title":"NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis,\u201d Free Radic","volume":"125","author":"Svegliati","year":"2018","journal-title":"Biol Med"},{"issue":"8","key":"10.1016\/j.semarthrit.2023.152228_bib0028","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155761","article-title":"Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex","volume":"7","author":"Zhang","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0029","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vph.2015.03.005","article-title":"The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review","volume":"71","author":"Siti","year":"2015","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2017.04.002","article-title":"Association between cigarette smoking and impaired clinical symptoms in systemic sclerosis: A review","volume":"318","author":"Zhang","year":"2017","journal-title":"Cell Immunol"},{"issue":"12","key":"10.1016\/j.semarthrit.2023.152228_bib0031","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ncprheum0655","article-title":"Tobacco smoking and autoimmune rheumatic diseases","volume":"3","author":"Harel-Meir","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"1","key":"10.1016\/j.semarthrit.2023.152228_bib0032","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1874312901206010087","article-title":"New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis","volume":"6","author":"Gabrielli","year":"2012","journal-title":"Open Rheumatol J"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01177","article-title":"The Role of Oxidative Stress in the Development of Systemic Sclerosis Related Vasculopathy","volume":"9","author":"Abdulle","year":"2018","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.semarthrit.2023.152228_bib0034","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.amjms.2021.10.031","article-title":"Prevalence of peripheral eosinophilia and clinical associations in systemic sclerosis patients","volume":"363","author":"Foocharoen","year":"2022","journal-title":"Am J Med Sci"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152228_bib0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/1346-8138.14774","article-title":"Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis","volume":"46","author":"Hara","year":"2019","journal-title":"J Dermatol"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152228_bib0036","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jaci.2020.08.007","article-title":"Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease","volume":"147","author":"Jakiela","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.semarthrit.2023.152228_bib0037","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1160\/TH14-11-0958","article-title":"Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity","volume":"114","author":"Maurer","year":"2015","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.semarthrit.2023.152228_bib0038","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/iwj.12109","article-title":"Role of fibronectin in normal wound healing","volume":"12","author":"Lenselink","year":"2015","journal-title":"Int Wound J"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00084","article-title":"Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging","volume":"5","author":"Mohanty","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/908539","article-title":"Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View","volume":"2014","author":"Lay","year":"2014","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.semarthrit.2023.152228_bib0041","doi-asserted-by":"crossref","first-page":"713","DOI":"10.5603\/KP.a2018.0071","article-title":"Oxidative stress and cardiovascular disease: new insights","volume":"76","author":"Pignatelli","year":"2018","journal-title":"Kardiol Pol"},{"key":"10.1016\/j.semarthrit.2023.152228_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101088","article-title":"Statin treatment, oxidative stress and inflammation in a Danish population","volume":"21","author":"S\u00f8rensen","year":"2019","journal-title":"Redox Biol"},{"issue":"2","key":"10.1016\/j.semarthrit.2023.152228_bib0043","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/092986707779313381","article-title":"Endothelial Dysfunction, Oxidative Stress and Inflammation in Atherosclerosis: Beneficial Effects of Statins","volume":"14","author":"Lahera","year":"2007","journal-title":"Curr Med Chem"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017223000707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017223000707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:10:25Z","timestamp":1758733825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017223000707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":43,"alternative-id":["S0049017223000707"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152228","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased oxidative stress response in circulating blood of systemic sclerosis patients \u2013 relation to disease characteristics and inflammatory blood biomarkers","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152228"}}