{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:16:34Z","timestamp":1790691394998,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.semarthrit.2023.152303","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T19:26:27Z","timestamp":1698953187000},"page":"152303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The statistical challenge of analysing changes in dual energy computed tomography (DECT) urate volumes in people with gout"],"prefix":"10.1016","volume":"63","author":[{"given":"Sarah","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Nam","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opetaia","family":"Aati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Latto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K","family":"Stamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2023.152303_bib0001","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1136\/ard.2008.094201","article-title":"Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography","volume":"68","author":"Dalbeth","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0002","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/art.27356","article-title":"Cellular characterization of the gouty tophus: a quantitative analysis","volume":"62","author":"Dalbeth","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0003","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0140-6736(62)90501-9","article-title":"Acute arthritis in man and dog after intrasynovial injection of sodium urate crystals","volume":"280","author":"Faires","year":"1962","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0004","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1136\/ard.2008.099713","article-title":"Dual energy computed tomography in tophaceous gout","volume":"68","author":"Choi","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0005","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/ar4343","article-title":"Lack of change in urate deposition by dual-energy computed tomography among clinically stable patients with long-standing tophaceous gout: a prospective longitudinal study","volume":"15","author":"Rajan","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0006","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/art.40929","article-title":"Effects of allopurinol dose escalation on bone erosion and urate volume in gout: a dual-energy computed tomography imaging study within a randomized, controlled trial","volume":"71","author":"Dalbeth","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0007","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2015-000075","article-title":"Tophus resolution with pegloticase: a prospective dual-energy CT study","volume":"1","author":"Araujo","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0008","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13075-018-1714-9","article-title":"Monosodium urate burden assessed with dual-energy computed tomography predicts the risk of flares in gout: a 12-month observational study : MSU burden and risk of gout flare","volume":"20","author":"Pascart","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0009","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/acr.22754","article-title":"Development of a dual-energy computed tomography scoring system for measurement of urate deposition in gout","volume":"68","author":"Bayat","year":"2016","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0010","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1093\/rheumatology\/keac173","article-title":"Dual-energy CT assessment of rapid monosodium urate depletion and bone erosion remodelling during pegloticase plus methotrexate co-therapy","volume":"61","author":"Dalbeth","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0011","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keab533","article-title":"Two-year reduction of dual-energy CT urate depositions during a treat-to-target strategy in gout in the NOR-Gout longitudinal study","volume":"61","author":"Uhlig","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0012","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1080\/14397595.2020.1825053","article-title":"Volumetric reduction and dissolution prediction of monosodium urate crystal during urate-lowering therapy - a study using dual-energy computed tomography","volume":"31","author":"Chui","year":"2021","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0013","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/art.41063","article-title":"Effects of conventional uric acid-lowering therapy on monosodium urate crystal deposits","volume":"72","author":"Ellmann","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0014","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00296-017-3724-3","article-title":"New urate depositions on dual-energy computed tomography in gouty arthritis during urate-lowering therapy","volume":"37","author":"Zhang","year":"2017","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0015","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/1756-185X.12634","article-title":"Dual-energy computed tomography for monitoring the effect of urate-lowering therapy in gouty arthritis","volume":"18","author":"Sun","year":"2015","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0016","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/art.42055","article-title":"Intensive serum urate lowering with oral urate-lowering therapy for erosive gout: a randomized double-blind controlled trial","volume":"74","author":"Dalbeth","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0017","doi-asserted-by":"crossref","first-page":"W103","DOI":"10.2214\/AJR.13.11396","article-title":"Artifacts in dual-energy CT gout protocol: a review of 50 suspected cases with an artifact identification guide","volume":"203","author":"Mallinson","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0018","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box","year":"1964","journal-title":"R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0019","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/acr.24180","article-title":"2020 American College of Rheumatology guideline for the management of gout","volume":"72","author":"FitzGerald","year":"2020","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0020","series-title":"Information criteria and statistical modeling","author":"Konishi","year":"2008"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0021","series-title":"Statistical power analysis for the behavioral sciences and eii","author":"Cohen","year":"1988"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0022","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.publhealth.23.100901.140546","article-title":"The importance of the normality assumption in large public health data sets","volume":"23","author":"Lumley","year":"2002","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0023","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1136\/bmj.312.7039.1153","article-title":"Statistics Notes: The use of transformation when comparing two means","volume":"312","author":"Bland","year":"1996","journal-title":"Br Med J"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0024","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1136\/bmj.312.7038.1079","article-title":"Statistics notes: Transformations, means, and confidence intervals","volume":"312","author":"Bland","year":"1996","journal-title":"Br Med J"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0025","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/bmj.312.7032.700","article-title":"Statistics Notes: Logarithms","volume":"312","author":"Bland","year":"1996","journal-title":"Br Med J"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0026","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/annrheumdis-2017-212046","article-title":"Presence of monosodium urate crystal deposition by dual-energy CT in patients with gout treated with allopurinol","volume":"77","author":"Dalbeth","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0027","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10067-017-3753-z","article-title":"Dual-energy computed tomography has limited diagnostic sensitivity for short-term gout","volume":"37","author":"Jia","year":"2018","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0028","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/1756-185X.14249","article-title":"Characteristics of monosodium urate crystal deposition in the foot in the different stages of gout by dual-energy computed tomography","volume":"25","author":"Zhang","year":"2022","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0029","article-title":"Burden and distribution of MSU deposition in patients with hyperuricemia and gout: a large cohort Chinese population based DECT study","author":"Zhang","year":"2022","journal-title":"Res Square;"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0030","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/annrheumdis-2012-202452","article-title":"DECT urate deposits: now you see them, now you don't","volume":"72","author":"McQueen","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0031","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/acm2.13471","article-title":"Characterization of size-specific effects during dual-energy CT material decomposition of non-iodine materials","volume":"22","author":"Miller","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0032","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1038\/s41598-020-72505-6","article-title":"Urate in fingernail represents the deposition of urate burden in gout patients","volume":"10","author":"Chen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0033","doi-asserted-by":"crossref","first-page":"87","DOI":"10.12809\/hkjr2117173","article-title":"Distribution of urate crystal deposition in the hands and wrists of patients with chronic gout","volume":"24","author":"Leng","year":"2021","journal-title":"Hong Kong J Radiol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0034","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2214\/AJR.11.7015","article-title":"Epithelial malignant pleural mesothelioma after extrapleural pneumonectomy: Stratification of survival with CT-derived tumor volume","volume":"198","author":"Gill","year":"2012","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0035","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0090-4295(02)01728-4","article-title":"Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens","volume":"60","author":"Wise","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0036","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1148\/radiol.2021203964","article-title":"A detailed analysis of infarct patterns and volumes at 24-hour noncontrast CT and diffusion-weighted MRI in acute ischemic stroke due to large vessel occlusion: results from the ESCAPE-NA1 trial","volume":"300","author":"Ospel","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0037","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.nic.2007.09.002","article-title":"Statistical approaches to functional neuroimaging data","volume":"17","author":"Bowman","year":"2007","journal-title":"Neuroimaging Clin N Am"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0038","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1038\/bjc.2014.512","article-title":"Just N: improving tumour heterogeneity MRI assessment with histograms","volume":"111","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0039","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1136\/annrheumdis-2014-206397","article-title":"Urate crystal deposition in asymptomatic hyperuricaemia and symptomatic gout: a dual energy CT study","volume":"74","author":"Dalbeth","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2288-1-6","article-title":"The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study","volume":"1","author":"Vickers","year":"2001","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.semarthrit.2023.152303_bib0041","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1002\/sim.2682","article-title":"Change from baseline and analysis of covariance revisited","volume":"25","author":"Senn","year":"2006","journal-title":"Stat Med"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017223001452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017223001452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:13:17Z","timestamp":1758733997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017223001452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":41,"alternative-id":["S0049017223001452"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152303","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The statistical challenge of analysing changes in dual energy computed tomography (DECT) urate volumes in people with gout","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152303"}}