{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:24:31Z","timestamp":1794014671145,"version":"4.8.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.semarthrit.2023.152324","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T19:22:05Z","timestamp":1700940125000},"page":"152324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["Are there causal mucosal drivers in the preclinical development of rheumatoid arthritis?"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-7746","authenticated-orcid":false,"given":"V. Michael","family":"Holers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2023.152324_bib0001","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/annrheumdis-2019-216243","article-title":"Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era","volume":"79","author":"Hsieh","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0002","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nri.2016.124","article-title":"The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting","volume":"17","author":"Malmstr\u00f6m","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0003","article-title":"Timing of elevations of autoantibody isotypes in rheumatoid arthritis prior to disease diagnosis","author":"Kelmenson","year":"2019","journal-title":"Arth Rheum"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0004","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41584-018-0070-0","article-title":"Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction","volume":"14","author":"Holers","year":"2018","journal-title":"Nature Rev Rheum"},{"issue":"10","key":"10.1016\/j.semarthrit.2023.152324_bib0005","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1002\/art.39771","article-title":"Elevated IgA plasmablast levels in subjects at risk of developing rheumatoid arthritis","volume":"68","author":"Kinslow","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"12","key":"10.1016\/j.semarthrit.2023.152324_bib0006","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/art.40587","article-title":"Affinity maturation drives epitope spreading and generation of proinflammatory anti-citrullinated protein antibodies in rheumatoid arthritis","volume":"70","author":"Elliott","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0007","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.smim.2011.01.014","article-title":"Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis","volume":"23","author":"Klareskog","year":"2011","journal-title":"Semin Immunol"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0008","first-page":"38","article-title":"Association of sputum neutrophil extracellular trap subsets with IgA anti\u2013citrullinated protein antibodies in subjects at risk for rheumatoid arthritis","volume":"74","author":"Okamoto","year":"2022","journal-title":"Arth Rheum"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0009","article-title":"Rheumatoid arthritis specific autoimmunity in the lung before and at the onset of disease","author":"Joshua","year":"2023","journal-title":"Arth Rheum"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155956","article-title":"Prevalence of periodontitis in patients with established rheumatoid arthritis: a Swedish population based case-control study","author":"Eriksson","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0011","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.rdc.2012.04.002","article-title":"Environmental and gene-environment interactions and risk of rheumatoid arthritis","volume":"38","author":"Karlson","year":"2012","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"10.1016\/j.semarthrit.2023.152324_bib0012","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12891-018-2381-3","article-title":"Association of fish intake and smoking with risk of rheumatoid arthritis and age of onset: a prospective cohort study","volume":"20","author":"Sparks","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0013","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13075-016-1100-4","article-title":"Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis","volume":"18","author":"Johansson","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0014","first-page":"8","article-title":"Rheumatoid arthritis-associated mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans","author":"G\u00f3mez-Ba\u00f1uelos","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0015","article-title":"Prevalence of periodontal disease and periodontopathic bacteria in anti-cyclic citrullinated protein antibody-positive at-risk adults without arthritis","volume":"5","author":"Mankia","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0016","article-title":"Oral mucosal breaks trigger unique systemic immune responses that mediate rheumatoid arthritis","author":"Brewer","year":"2022","journal-title":"Sci Trans Med."},{"key":"10.1016\/j.semarthrit.2023.152324_bib0017","doi-asserted-by":"crossref","DOI":"10.1136\/ard-2022-222881","article-title":"Genomic repertoires linked with pathogenic potency of arthritogenic Prevotella copri isolated from the gut of patients with rheumatoid arthritis","author":"Nii","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0018","article-title":"Association of antibodies to Prevotella copri in anti\u2013cyclic citrullinated peptide-positive individuals at risk of developing rheumatoid arthritis and in patients with early or established rheumatoid arthritis","author":"Seifert","year":"2023","journal-title":"Arth Rheum"},{"key":"10.1016\/j.semarthrit.2023.152324_bib0019","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn5166","article-title":"Dual IgA\/IgG family autoantibodies from individuals at-risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum","author":"Chriswell","year":"2022","journal-title":"Sci Trans Med"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004901722300166X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004901722300166X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:12:21Z","timestamp":1758733941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004901722300166X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":19,"alternative-id":["S004901722300166X"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152324","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are there causal mucosal drivers in the preclinical development of rheumatoid arthritis?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152324"}}