{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:01Z","timestamp":1793900161357,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.semarthrit.2025.152744","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:12:03Z","timestamp":1746724323000},"page":"152744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Variability in phenotype clusters of Beh\u00e7et\u2019s syndrome: A systematic review"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-5207","authenticated-orcid":false,"given":"Betul","family":"Macit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-7305","authenticated-orcid":false,"given":"Sinem Nihal","family":"Esatoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevser","family":"Akyuz-Yesilyurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulen","family":"Hatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2025.152744_bib0001","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrrheum.2017.208","article-title":"Behcet syndrome: a contemporary view","volume":"14","author":"Yazici","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0002","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/rheumatology\/keu247","article-title":"Gender-specific differences in Adamantiades-Behcet's disease manifestations: an analysis of the German registry and meta-analysis of data from the literature","volume":"54","author":"Bonitsis","year":"2015","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0003","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3904\/kjim.2016.202","article-title":"Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset, and HLA-B51","volume":"33","author":"Ryu","year":"2018","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0004","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/1744666X.2016.1205486","article-title":"Behcet's disease: epidemiology, clinical manifestations, and diagnosis","volume":"13","author":"Davatchi","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0005","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10067-010-1430-6","article-title":"Behcet's disease: from East to West","volume":"29","author":"Davatchi","year":"2010","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0006","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3346\/jkms.2003.18.2.231","article-title":"Influence of sex on patients with Behcet's disease in Korea","volume":"18","author":"Bang","year":"2003","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0007","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/rheumatology\/ket130","article-title":"Lack of efficacy of tocilizumab in mucocutaneous Behcet's syndrome: report of two cases","volume":"52","author":"Diamantopoulos","year":"2013","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0008","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1093\/rheumatology\/keab944","article-title":"Emergence of new manifestations during infliximab treatment in Behcet's syndrome","volume":"61","author":"Tukek","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0009","article-title":"De novo manifestations during adalimumab treatment in Behcet's syndrome","author":"Esatoglu","year":"2024","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1053\/S0049-0172(03)00133-1","article-title":"Clusters of clinical and immunologic features in systemic lupus erythematosus: analysis of 600 patients from a single center","volume":"33","author":"Font","year":"2004","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0011","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/art.38682","article-title":"Subgrouping of patients with rheumatoid arthritis based on pain, fatigue, inflammation, and psychosocial factors","volume":"66","author":"Lee","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0012","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s10067-020-05536-z","article-title":"Characteristics and phenotype heterogeneity in late-onset Behcet's syndrome: a cohort from a referral center in China","volume":"40","author":"Zou","year":"2021","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0013","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/rheumatology\/ker423","article-title":"The papulopustular lesion\/arthritis cluster of Behcet's syndrome also clusters in families","volume":"51","author":"Karaca","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0014","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13075-020-02406-6","article-title":"Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behcet's disease in Japan","volume":"23","author":"Soejima","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0015","first-page":"2393","article-title":"Target organ associations in Turkish patients with Behcet's disease: a cross sectional study by exploratory factor analysis","volume":"29","author":"Tunc","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0016","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s11739-019-02248-4","article-title":"Behcet's syndrome in Italy: a detailed retrospective analysis of 396 cases seen in 3 tertiary referral clinics","volume":"15","author":"Sota","year":"2020","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0017","unstructured":"Kurosawa M., Takeno M., Soejima Y. Mizuki N. Subgroup classification of Beh\u00e7et\u2019s disease using clinical information: analysis of a clinical database of patients receiving financial aid for treatment. ISBD Conference, Rotterdam, 2018."},{"key":"10.1016\/j.semarthrit.2025.152744_bib0018","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0019","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease. International study group for Behcet's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"The international criteria for Behcet's disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria","volume":"28","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0021","article-title":"Behcet's disease phenotypes and clinical outcomes: a cohort study in Egyptian patients","author":"Attia","year":"2020","journal-title":"Reumatol Clin (Engl Ed)"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0022","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2021-eular.1373","article-title":"AB0765\u2005Phenotypes of behcet\u2019S disease in different ethnic groups","volume":"80","author":"Goloeva","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0023","first-page":"534","article-title":"[Behcet's syndrome. Subtypes and familial form]","volume":"83","author":"Gonzalez","year":"1984","journal-title":"Med Clin"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0024","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4274\/balkanmedj.galenos.2018.2018.1723","article-title":"No family clustering in Behcet's syndrome","volume":"36","author":"Tezcan","year":"2019","journal-title":"Balkan Med J"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0025","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/1346-8138.16250","article-title":"Skin manifestation as an explaining factor of heterogeneity in Behcet's disease: a focused analysis in full-blown conditions","volume":"49","author":"Chung","year":"2022","journal-title":"J Dermatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0026","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s11739-020-02319-x","article-title":"The geographic and clinical clusters of Behcet's syndrome","volume":"15","author":"Marvisi","year":"2020","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0027","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MD.0b013e318211bf28","article-title":"Behcet disease: evolution of clinical manifestations","volume":"90","author":"Ideguchi","year":"2011","journal-title":"Medicine"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0028","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1365-2133.2007.08116.x","article-title":"Clinical features and natural course of Behcet's disease in 661 cases: a multicentre study","volume":"157","author":"Alpsoy","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0029","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s12026-024-09498-1","article-title":"Gender disparities in Behcet's syndrome: identifying distinct phenotypes through cluster analysis","volume":"72","author":"Kilic","year":"2024","journal-title":"Immunol Res"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0030","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s12519-023-00785-9","article-title":"Clinical heterogeneity and five phenotypes identified in pediatric Behcet's syndrome: a cohort study from Shanghai Behcet's syndrome database","volume":"20","author":"Hu","year":"2024","journal-title":"World J Pediatr"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0031","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s10067-024-06995-4","article-title":"Clinical phenotypes of adult-onset Behcet's syndrome: a comprehensive cross-sectional study in China","volume":"43","author":"She","year":"2024","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0032","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/RHU.0000000000001996","article-title":"Characteristics of patients with behcet disease from the Van Province, Eastern Turkey: definition of disease clusters in a tertiary referral center","volume":"29","author":"Oguz","year":"2023","journal-title":"J Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0033","first-page":"S48","article-title":"Are clusters of patients with distinct clinical expression present in Behcet's disease?","volume":"27","author":"Arida","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0034","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/mr\/roac044","article-title":"Cluster analysis of paediatric Behcet's disease: data from the pediatric rheumatology academy-research group","volume":"33","author":"Demir","year":"2023","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0035","first-page":"347","article-title":"Disease patterns of patients with Behcet's disease demonstrated by factor analysis","volume":"17","author":"Krause","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0036","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13075-021-02429-7","article-title":"Cluster analysis of phenotypes of patients with Behcet's syndrome: a large cohort study from a referral center in China","volume":"23","author":"Zou","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2025.152744_bib0037","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1080\/14397595.2021.1891670","article-title":"Distinct clinical characteristics of pediatric Behcet's syndrome: a study from a referral center in China","volume":"31","author":"Zou","year":"2021","journal-title":"Mod Rheumatol"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017225001155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017225001155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:00:47Z","timestamp":1751580047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017225001155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"alternative-id":["S0049017225001155"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2025.152744","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variability in phenotype clusters of Beh\u00e7et\u2019s syndrome: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2025.152744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152744"}}