{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:11:29Z","timestamp":1788754289974,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.semarthrit.2026.153041","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:05:06Z","timestamp":1782849906000},"page":"153041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Interobserver variability in synovial tissue biopsy markers in Rheumatoid Arthritis: Results from OMERACT special interest group on synovial tissue biopsy"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1074-0861","authenticated-orcid":false,"given":"Mario","family":"Ferraioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Small","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Alivernini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Eurico","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Andreas","family":"Just","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maksymowych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fraser","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Nicorescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Perniola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco C.","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen G.H.","family":"van de Sande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander W.","family":"Tas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Veale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir D","family":"Wechalekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Najm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.semarthrit.2026.153041_bib0001","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0002","article-title":"Comparison of remission criteria in patients with rheumatoid arthritis treated with biologic or targeted synthetic disease-modifying anti-rheumatic drugs: results from a nationwide registry","volume":"14","author":"Koh","year":"2022","journal-title":"Ther Adv Musculoskelet"},{"issue":"5","key":"10.1016\/j.semarthrit.2026.153041_bib0003","first-page":"1067","article-title":"Biologics initiation in moderate versus severe rheumatoid arthritis: real-world experience from a Canadian registry","volume":"42","author":"Guo","year":"2024","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"10.1016\/j.semarthrit.2026.153041_bib0004","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3899\/jrheum.181062","article-title":"The 2018 OMERACT synovial tissue biopsy special interest group report on standardization of synovial biopsy analysis","volume":"46","author":"Wechalekar","year":"2019","journal-title":"J Rheumatol"},{"issue":"6","key":"10.1016\/j.semarthrit.2026.153041_bib0005","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41591-022-01789-0","article-title":"Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial","volume":"28","author":"Rivellese","year":"2022","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.semarthrit.2026.153041_bib0006","doi-asserted-by":"crossref","first-page":"e648","DOI":"10.1016\/S2665-9913(23)00241-2","article-title":"Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials","volume":"5","author":"Rivellese","year":"2023","journal-title":"Lancet Rheumatol"},{"issue":"2","key":"10.1016\/j.semarthrit.2026.153041_bib0007","doi-asserted-by":"crossref","DOI":"10.1186\/ar4555","article-title":"Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics","volume":"16","author":"Dennis","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.semarthrit.2026.153041_bib0008","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.41726","article-title":"Inclusion of synovial tissue\u2013derived characteristics in a nomogram for the prediction of treatment response in treatment-naive rheumatoid arthritis patients","volume":"16","author":"Alivernini","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0009","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3389\/fimmu.2020.00845","article-title":"A Pauci-immune synovial pathotype predicts inadequate response to tnf\u03b1-blockade in rheumatoid arthritis patients","volume":"16","author":"Nerviani","year":"2020","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.semarthrit.2026.153041_bib0010","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1136\/annrheumdis-2021-221875","article-title":"EULAR points to consider for minimal reporting requirements in synovial tissue research in rheumatology","volume":"81","author":"Najm","year":"2022","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"10.1016\/j.semarthrit.2026.153041_bib0011","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/ard.2006.061143","article-title":"Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis","volume":"66","author":"Rooney","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0012","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3899\/jrheum.141199","article-title":"Evaluation of minimally invasive, ultrasound-guided synovial biopsy techniques by the OMERACT filter \u2014 determining validation requirements","volume":"43","author":"Humby","year":"2016","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0013","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s13075-018-1795-5","article-title":"Correction to: standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR synovitis and OMERACT synovial tissue biopsy groups","volume":"20","author":"Najm","year":"2018","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.semarthrit.2026.153041_bib0014","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/art.1780400206","article-title":"Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity","volume":"40","author":"Tak","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.semarthrit.2026.153041_bib0015","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.1780390702","article-title":"Decrease in cellularity and expression of adhesion molecules by anti\u2013tumor necrosis factor \u03b1 monoclonal antibody treatment in patients with rheumatoid arthritis","volume":"39","author":"Tak","year":"1996","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.semarthrit.2026.153041_bib0016","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/clin.1995.1149","article-title":"Expression of adhesion molecules in early rheumatoid synovial tissue","volume":"77","author":"Tak","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"issue":"10","key":"10.1016\/j.semarthrit.2026.153041_bib0017","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/art.1780381012","article-title":"Reduction of synovial inflammation after anti-cd4 monoclonal antibody treatment in early rheumatoid arthritis","volume":"38","author":"Tak","year":"1995","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.semarthrit.2026.153041_bib0018","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/art.27287","article-title":"Angiogenesis and blood vessel stability in inflammatory arthritis","volume":"62","author":"Kennedy","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0019","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000616","article-title":"Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology","volume":"4","author":"Najm","year":"2018","journal-title":"RMD Open"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jbspin.2018.04.004","article-title":"IMSYC immunologic synovitis score: a new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis","volume":"86","author":"Najm","year":"2019","journal-title":"Jt Bone Spine"},{"issue":"5","key":"10.1016\/j.semarthrit.2026.153041_bib0021","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1078\/0344-0338-5710261","article-title":"Grading of chronic synovitis \u2014 a histopathological grading system for molecular and diagnostic pathology","volume":"198","author":"Krenn","year":"2002","journal-title":"Pathol Res Pr"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0022","series-title":"Ecological diversity","author":"Kohn","year":"1977"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0023","series-title":"Practical statistics for medical research","first-page":"611.","author":"Altman","year":"1991"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0024","unstructured":"R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria. 2024. Available at: https:\/\/www.R-project.org\/."},{"key":"10.1016\/j.semarthrit.2026.153041_bib0025","author":"Gamer"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0026","author":"Ogle"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0027","author":"Moon"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0028","author":"Cai"},{"issue":"11","key":"10.1016\/j.semarthrit.2026.153041_bib0029","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1007\/s00402-021-03889-x","article-title":"The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis","volume":"142","author":"Mussawy","year":"2021","journal-title":"Arch Orthop Trauma Surg"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0030","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-002116","article-title":"Impact of synovial biopsy procedures and disease-specific aspects on synovial tissue outcome: a systematic literature review informing the EULAR points to consider for the minimal reporting requirements in synovial tissue research in rheumatology","volume":"8","author":"Najm","year":"2022","journal-title":"RMD Open"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0031","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13000-021-01136-w","article-title":"Interobserver variability between experienced and inexperienced observers in the histopathological analysis of Wilms tumors: a pilot study for future algorithmic approach","volume":"16","author":"Rutgers","year":"2021","journal-title":"Diagn Pathol"},{"issue":"3","key":"10.1016\/j.semarthrit.2026.153041_bib0032","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1148\/radiol.2020200478","article-title":"MRI-based Bosniak classification of cystic renal masses, version 2019: interobserver agreement, impact of readers\u2019 Experience, and diagnostic performance","volume":"297","author":"Bai","year":"2020","journal-title":"Radiology"},{"issue":"6","key":"10.1016\/j.semarthrit.2026.153041_bib0033","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00428-020-02998-z","article-title":"Interobserver agreement and the impact of mentorship on the diagnosis of inflammatory bowel disease\u2013associated dysplasia among subspecialist gastrointestinal pathologists","volume":"478","author":"Alpert","year":"2021","journal-title":"Virchows Arch"},{"issue":"1","key":"10.1016\/j.semarthrit.2026.153041_bib0034","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/rheumatology\/39.1.43","article-title":"Quantification of the cell infiltrate in synovial tissue by digital image analysis","volume":"39","author":"Kraan","year":"2000","journal-title":"Rheumatol (Oxf)"},{"key":"10.1016\/j.semarthrit.2026.153041_bib0035","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.1038\/s41467-024-51012-6","article-title":"Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue","volume":"15","author":"Bell","year":"2024","journal-title":"Nat Commun"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017226001319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017226001319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:01:04Z","timestamp":1788753664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017226001319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S0049017226001319"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2026.153041","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interobserver variability in synovial tissue biopsy markers in Rheumatoid Arthritis: Results from OMERACT special interest group on synovial tissue biopsy","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2026.153041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"153041"}}