{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:17:14Z","timestamp":1791173834514,"version":"4.1.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"6","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.semcancer.2013.07.006","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T15:16:37Z","timestamp":1375974997000},"page":"399-409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"PA","title":["Antigen selection in B-cell lymphomas\u2014Tracing the evidence"],"prefix":"10.1016","volume":"23","author":[{"given":"Lesley-Ann","family":"Sutton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Agathangelidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysoula","family":"Belessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Darzentas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Davi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Rosenquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2013.07.006_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(07)95001-4","article-title":"Fate decisions regulating bone marrow and peripheral B lymphocyte development","volume":"95","author":"Monroe","year":"2007","journal-title":"Advances in Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ni.1794","article-title":"Checkpoints in lymphocyte development and autoimmune disease","volume":"11","author":"von Boehmer","year":"2010","journal-title":"Nature Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0015","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-3083.2012.02751.x","article-title":"The pre-B cell receptor; selecting for or against autoreactivity","volume":"76","author":"Almqvist","year":"2012","journal-title":"Scandinavian Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.immunol.19.1.595","article-title":"B cell development pathways","volume":"19","author":"Hardy","year":"2001","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0025","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.4049\/jimmunol.177.5.2749","article-title":"B-1 B cell development","volume":"177","author":"Hardy","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0030","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.coi.2008.09.001","article-title":"B-cell tolerance checkpoints in health and autoimmunity","volume":"20","author":"Meffre","year":"2008","journal-title":"Current Opinion in Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nri2019","article-title":"Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential","volume":"7","author":"Dorshkind","year":"2007","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0040","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri3383","article-title":"Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes","volume":"13","author":"Cerutti","year":"2013","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0045","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/eji.200939575","article-title":"Central tolerance: essential for preventing autoimmune disease","volume":"39","author":"von Boehmer","year":"2009","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2011.06347.x","article-title":"The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases","volume":"1246","author":"Meffre","year":"2011","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/978-0-387-09789-3_2","article-title":"B-cell receptor","volume":"640","author":"Brezski","year":"2008","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri2941","article-title":"Recombination centres and the orchestration of V(D)J recombination","volume":"11","author":"Schatz","year":"2011","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev-genet-110410-132552","article-title":"V(D)J recombination: mechanisms of initiation","volume":"45","author":"Schatz","year":"2011","journal-title":"Annual Review of Genetics"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cell.2013.01.007","article-title":"Mechanisms of programmed DNA lesions and genomic instability in the immune system","volume":"152","author":"Alt","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12026-009-8142-5","article-title":"Controlling somatic hypermutation in immunoglobulin variable and switch regions","volume":"47","author":"Maul","year":"2010","journal-title":"Immunology Research"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387663-8.00005-3","article-title":"AID targeting in antibody diversity","volume":"110","author":"Pavri","year":"2011","journal-title":"Advances in Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/B978-0-12-394280-7.00005-1","article-title":"Activation-induced cytidine deaminase in antibody diversification and chromosome translocation","volume":"113","author":"Gazumyan","year":"2012","journal-title":"Advances in Cancer Research"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0090","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nri3216","article-title":"Immunoglobulin class-switch DNA recombination: induction, targeting and beyond","volume":"12","author":"Xu","year":"2012","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0095","series-title":"The Immunoglobulin FactsBook","author":"Lefranc","year":"2001"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-230X(01)83004-9","article-title":"The occurrence and significance of V gene mutations in B cell-derived human malignancy","volume":"83","author":"Stevenson","year":"2001","journal-title":"Advances in Cancer Research"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1098\/rstb.2000.0751","article-title":"Somatic hypermutation and B-cell lymphoma","volume":"356","author":"Dunn-Walters","year":"2001","journal-title":"Philosophical Transactions of the Royal Society of London Series B. Biological Sciences"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0115","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1182\/blood-2007-07-099564","article-title":"Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis","volume":"111","author":"Murray","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0120","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood-2010-07-155663","article-title":"Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities","volume":"117","author":"Chiorazzi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0125","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1182\/blood-2009-05-221309","article-title":"Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen","volume":"114","author":"Sutton","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0130","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1182\/blood-2012-05-423194","article-title":"Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia","volume":"120","author":"Wiestner","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0135","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1182\/blood-2011-06-338855","article-title":"B-cell receptor signaling in chronic lymphocytic leukemia","volume":"118","author":"Stevenson","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0140","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1182\/blood-2012-02-362624","article-title":"The B-cell receptor signaling pathway as a therapeutic target in CLL","volume":"120","author":"Woyach","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature10113","article-title":"Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia","volume":"475","author":"Puente","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0150","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1084\/jem.20110921","article-title":"Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation","volume":"208","author":"Fabbri","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0155","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1109016","article-title":"SF3B1 and other novel cancer genes in chronic lymphocytic leukemia","volume":"365","author":"Wang","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.1032","article-title":"Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia","volume":"44","author":"Quesada","year":"2012","journal-title":"Nature Genetics"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0165","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1182\/blood-2011-12-395673","article-title":"Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia","volume":"119","author":"Rossi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0170","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood-2011-09-379966","article-title":"Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia","volume":"119","author":"Rossi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0175","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20120904","article-title":"The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development","volume":"209","author":"Rossi","year":"2012","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2013.04.002","article-title":"Genetic aberrations of signaling pathways in lymphomagenesis: Revelations from next generation sequencing studies","author":"Rossi","year":"2013","journal-title":"Seminars in Cancer Biology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0185","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMra0807082","article-title":"Aggressive lymphomas","volume":"362","author":"Lenz","year":"2010","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0190","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.critrevonc.2010.06.006","article-title":"Enteropathy-associated T-cell lymphoma","volume":"79","author":"Ferreri","year":"2011","journal-title":"Critical Reviews in Oncology\/Hematology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0195","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2559.2010.03699.x","article-title":"MALT lymphoma: many roads lead to nuclear factor-kappab activation","volume":"58","author":"Du","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0200","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2217\/fon.12.75","article-title":"Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets","volume":"8","author":"Leblanc","year":"2012","journal-title":"Future Oncology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0205","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev-immunol-020711-075027","article-title":"Pathogenesis of human B cell lymphomas","volume":"30","author":"Shaffer","year":"2012","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0210","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0167-5699(94)90009-4","article-title":"The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire","volume":"15","author":"Schroeder","year":"1994","journal-title":"Immunology Today"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0215","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.181.4.1507","article-title":"Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells","volume":"181","author":"Hashimoto","year":"1995","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0220","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1182\/blood.V87.9.3869.bloodjournal8793869","article-title":"Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia","volume":"87","author":"Efremov","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0225","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4049\/jimmunol.158.1.235","article-title":"Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features","volume":"158","author":"Johnson","year":"1997","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0230","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1172\/JCI3009","article-title":"Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors","volume":"102","author":"Fais","year":"1998","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0235","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0240","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0245","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1182\/blood.V99.6.2262","article-title":"Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia","volume":"99","author":"Tobin","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0250","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/1042819031000147018","article-title":"V(H)3-21 gene usage in chronic lymphocytic leukemia\u2014characterization of a new subgroup with distinct molecular features and poor survival","volume":"45","author":"Tobin","year":"2004","journal-title":"Leukemia & Lymphoma"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0255","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1182\/blood-2004-07-2606","article-title":"Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene","volume":"105","author":"Ghia","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0260","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1182\/blood-2005-06-2227","article-title":"Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status","volume":"107","author":"Thorselius","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0265","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1182\/blood-2006-10-051110","article-title":"Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study","volume":"109","author":"Bomben","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0270","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1182\/blood-2007-12-130229","article-title":"Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection","volume":"111","author":"Ghia","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0275","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1182\/blood-2002-11-3485","article-title":"Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope","volume":"101","author":"Tobin","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0280","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20040544","article-title":"Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia","volume":"200","author":"Messmer","year":"2004","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0285","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1182\/blood-2004-03-0818","article-title":"Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins","volume":"104","author":"Widhopf","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0290","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/blood-2004-01-0132","article-title":"Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia","volume":"104","author":"Tobin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0295","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2006-03-012948","article-title":"Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations","volume":"109","author":"Stamatopoulos","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0300","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1182\/blood-2008-07-166868","article-title":"Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia","volume":"113","author":"Hadzidimitriou","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0305","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/leu.2009.186","article-title":"A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence","volume":"24","author":"Darzentas","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0310","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1182\/blood-2011-11-393694","article-title":"Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies","volume":"119","author":"Agathangelidis","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0315","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.immunol.26.021607.090236","article-title":"The biochemistry of somatic hypermutation","volume":"26","author":"Peled","year":"2008","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0320","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.immunol.26.021607.090248","article-title":"Mechanism and regulation of class switch recombination","volume":"26","author":"Stavnezer","year":"2008","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0325","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1182\/blood-2002-10-3175","article-title":"Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation","volume":"101","author":"Oppezzo","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0330","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1182\/blood-2002-09-2906","article-title":"High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia","volume":"101","author":"McCarthy","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0335","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1182\/blood-2012-08-449744","article-title":"IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions","volume":"120","author":"Patten","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0340","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1172\/JCI24387","article-title":"Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity","volume":"115","author":"Herve","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0345","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2119\/2008-00102.Catera","article-title":"Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation","volume":"14","author":"Catera","year":"2008","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0350","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood-2007-11-125450","article-title":"A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies","volume":"111","author":"Lanemo Myhrinder","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0355","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1182\/blood-2008-06-162024","article-title":"Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA","volume":"112","author":"Chu","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0360","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1182\/blood-2009-01-197822","article-title":"Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells","volume":"114","author":"Seiler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0365","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1182\/blood-2009-09-244251","article-title":"Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin","volume":"115","author":"Chu","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0370","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1182\/blood-2012-08-447904","article-title":"Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells","volume":"121","author":"Zwick","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0375","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood.V88.4.1365.bloodjournal8841365","article-title":"CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis","volume":"88","author":"Zupo","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0380","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1182\/blood-2002-06-1822","article-title":"Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia","volume":"101","author":"Lanham","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0385","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1084\/jem.191.5.883","article-title":"CD5 maintains tolerance in anergic B cells","volume":"191","author":"Hippen","year":"2000","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0390","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/leu.2012.238","article-title":"A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient","volume":"27","author":"Hoogeboom","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0395","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/leu.2008.379","article-title":"Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors","volume":"23","author":"Kostareli","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0400","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1182\/blood-2011-08-374058","article-title":"Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen","volume":"119","author":"Steininger","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0405","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/leu.2011.311","article-title":"Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59\/IGKV3-20 receptors with rheumatoid factor activity","volume":"26","author":"Kostareli","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0410","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.1300321","article-title":"Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability","volume":"190","author":"Marcatili","year":"2013","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0415","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/clim.2001.5143","article-title":"A model B-cell superantigen and the immunobiology of B lymphocytes","volume":"102","author":"Silverman","year":"2002","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0420","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.4049\/jimmunol.142.8.2778","article-title":"Human IgM molecules that bind staphylococcal protein A contain VHIII H chains","volume":"142","author":"Sasso","year":"1989","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0425","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.4049\/jimmunol.151.9.5011","article-title":"Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells","volume":"151","author":"Bhat","year":"1993","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0430","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/bcmd.1996.0020","article-title":"The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells","volume":"22","author":"Silberstein","year":"1996","journal-title":"Blood Cells, Molecules and Diseases"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0435","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1084\/jem.194.11.1639","article-title":"Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia","volume":"194","author":"Rosenwald","year":"2001","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0440","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.194.11.1625","article-title":"Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells","volume":"194","author":"Klein","year":"2001","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0445","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/leu.2010.90","article-title":"Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution","volume":"24","author":"Kostareli","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0450","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1600-0609.2002.01662.x","article-title":"Somatic hypermutation and V(H) gene usage in mantle cell lymphoma","volume":"68","author":"Thorselius","year":"2002","journal-title":"European Journal of Haematology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0455","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1182\/blood-2002-11-3479","article-title":"Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma","volume":"101","author":"Walsh","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0460","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1182\/blood-2002-11-3456","article-title":"Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations","volume":"101","author":"Camacho","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0465","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1182\/blood-2003-05-1383","article-title":"VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome","volume":"102","author":"Kienle","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0470","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1182\/blood-2002-06-1864","article-title":"A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease","volume":"101","author":"Orchard","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0475","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/modpathol.2008.199","article-title":"Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity","volume":"22","author":"Schraders","year":"2009","journal-title":"Modern Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0480","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/blood-2011-03-343434","article-title":"Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases","volume":"118","author":"Hadzidimitriou","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0485","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.semcancer.2011.09.009","article-title":"Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma: implications for the origin and selection of the malignant cells","volume":"21","author":"Agathangelidis","year":"2011","journal-title":"Seminars in Cancer Biology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0490","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1158\/0008-5472.CAN-12-1615","article-title":"Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features","volume":"72","author":"Navarro","year":"2012","journal-title":"Cancer Research"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0495","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1182\/blood-2003-05-1632","article-title":"Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events","volume":"103","author":"Babbage","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0500","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/path.1961","article-title":"Immunoglobulin class-switch recombination occurs in mantle cell lymphomas","volume":"209","author":"Klapper","year":"2006","journal-title":"The Journal of Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0505","series-title":"ASH conference","article-title":"High expression of activation-induced cytidine deaminase and in vivo class switch recombination in mantle cell lymphoma: further support for antigen involvement in lymphomagenesis","author":"Xocheli","year":"2012"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0510","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2012-02-412791","article-title":"IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas","volume":"120","author":"Greisman","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0515","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0520","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1182\/blood-2006-07-037150","article-title":"A novel human B cell subpopulation representing the initial germinal center population to express AID","volume":"109","author":"Kolar","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0525","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nri799","article-title":"Marginal-zone B cells","volume":"2","author":"Martin","year":"2002","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0530","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.immunol.23.021704.115728","article-title":"Marginal zone B cells","volume":"23","author":"Pillai","year":"2005","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0535","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0540","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.immunol.021908.132607","article-title":"Human marginal zone B cells","volume":"27","author":"Weill","year":"2009","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0545","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00281-004-0182-2","article-title":"Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion","volume":"26","author":"Baumgarth","year":"2005","journal-title":"Springer Seminars in Immunopathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0550","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00281-004-0188-9","article-title":"Human innate B cells: a link between host defense and autoimmunity","volume":"26","author":"Milner","year":"2005","journal-title":"Springer Seminars in Immunopathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0555","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3324\/haematol.2009.005983","article-title":"Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas","volume":"94","author":"Bende","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0560","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/sj.leu.2405068","article-title":"Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria","volume":"22","author":"Matutes","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0565","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00000478-199205000-00004","article-title":"Splenic marginal zone cell lymphoma","volume":"16","author":"Schmid","year":"1992","journal-title":"American Journal of Surgical Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0570","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1182\/blood-2011-01-293050","article-title":"The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications","volume":"117","author":"Campo","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0575","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V99.4.1299","article-title":"Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course","volume":"99","author":"Algara","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0580","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bcmd.2009.01.004","article-title":"Splenic marginal zone lymphoma: clinical clustering of immunoglobulin heavy chain repertoires","volume":"42","author":"Arcaini","year":"2009","journal-title":"Blood Cells, Molecules and Diseases"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0585","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0002-9440(10)64159-4","article-title":"Splenic marginal zone lymphomas appear to originate from different B cell types","volume":"161","author":"Bahler","year":"2002","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0590","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0046-8177(98)80007-5","article-title":"Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation","volume":"29","author":"Dunn-Walters","year":"1998","journal-title":"Human Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0595","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1365-2141.2009.07962.x","article-title":"Insight into the molecular pathogenesis of hairy cell leukaemia, hairy cell leukaemia variant and splenic marginal zone lymphoma, provided by the analysis of their IGH rearrangements and somatic hypermutation patterns","volume":"148","author":"Hockley","year":"2009","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0600","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/01.pas.0000213419.08009.b0","article-title":"Splenic marginal-zone lymphoma: one or more entities? A histologic, immunohistochemical, and molecular study of 42 cases","volume":"31","author":"Papadaki","year":"2007","journal-title":"American Journal of Surgical Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0605","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2119\/2005-00001.Stamatopoulos","article-title":"Immunoglobulin heavy- and light-chain repertoire in splenic marginal zone lymphoma","volume":"10","author":"Stamatopoulos","year":"2004","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0610","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0002-9440(10)63862-X","article-title":"Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations","volume":"162","author":"Tierens","year":"2003","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0615","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1182\/blood-2007-07-098848","article-title":"Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity","volume":"111","author":"Traverse-Glehen","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0620","first-page":"470","article-title":"Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection","volume":"90","author":"Traverse-Glehen","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0625","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1182\/blood-2002-01-0169","article-title":"V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo","volume":"100","author":"Zhu","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0630","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1182\/blood.V85.6.1603.bloodjournal8561603","article-title":"Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes","volume":"85","author":"Zhu","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0635","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.3324\/haematol.2010.025437","article-title":"Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma","volume":"95","author":"Zibellini","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0640","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/leu.2012.3","article-title":"Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications","volume":"26","author":"Bikos","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0645","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1038\/leu.2012.207","article-title":"Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire","volume":"26","author":"Bikos","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0650","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1182\/blood-2011-03-341651","article-title":"Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity","volume":"118","author":"Warsame","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0655","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.20022020","article-title":"Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen","volume":"197","author":"Kruetzmann","year":"2003","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0660","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1084\/jem.20091087","article-title":"Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation","volume":"206","author":"Seifert","year":"2009","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.semcancer.2013.07.006_bib0665","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood-2010-03-275859","article-title":"High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations","volume":"116","author":"Wu","year":"2010","journal-title":"Blood"}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X1300076X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X1300076X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T15:40:53Z","timestamp":1688398853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X1300076X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":133,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1044579X1300076X"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.07.006","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antigen selection in B-cell lymphomas\u2014Tracing the evidence","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}