{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:15:17Z","timestamp":1789017317062,"version":"build-2803163510"},"reference-count":103,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.semcancer.2013.08.003","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T17:26:27Z","timestamp":1377883587000},"page":"3-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Monoclonal B cell lymphocytosis and \u201cin situ\u201d lymphoma"],"prefix":"10.1016","volume":"24","author":[{"given":"Kennosuke","family":"Karube","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Scarf\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2013.08.003_bib0005","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0010","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2141.2005.05550.x","article-title":"Diagnostic criteria for monoclonal B-cell lymphocytosis","volume":"130","author":"Marti","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0015","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"Hallek","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0020","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","article-title":"National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment","volume":"87","author":"Cheson","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0025","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/leu.2009.287","article-title":"Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management","volume":"24","author":"Shanafelt","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0030","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1158\/0008-5472.CAN-09-3419","article-title":"Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma","volume":"70","author":"Fernandez","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0035","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1158\/0008-5472.CAN-12-1615","article-title":"Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features","volume":"72","author":"Navarro","year":"2012","journal-title":"Cancer Res"},{"issue":"Suppl. 1","key":"10.1016\/j.semcancer.2013.08.003_bib0040","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1002\/cyto.b.20522","article-title":"Long-term follow-up of monoclonal B-cell lymphocytosis detected in environmental health studies","volume":"78","author":"Marti","year":"2010","journal-title":"Cytometry B: Clin Cytom"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0045","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/j.1365-2141.2007.06870.x","article-title":"Monoclonal B-cell lymphocytosis in blood donors","volume":"139","author":"Rachel","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0050","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1182\/blood.V100.2.635","article-title":"Monoclonal B lymphocytes with the characteristics of \u201cindolent\u201d chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts","volume":"100","author":"Rawstron","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0055","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1182\/blood-2003-09-3277","article-title":"Monoclonal CD5+ and CD5\u2212 B-lymphocyte expansions are frequent in the peripheral blood of the elderly","volume":"103","author":"Ghia","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/blood-2008-09-176933","article-title":"The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring","volume":"114","author":"Dagklis","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0065","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1182\/blood-2011-05-357251","article-title":"General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL","volume":"118","author":"Fazi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1182\/blood-2009-01-197368","article-title":"Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach","volume":"114","author":"Nieto","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0075","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.semcancer.2010.08.005","article-title":"CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it","volume":"20","author":"Scarfo","year":"2010","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0080","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/leu.2010.305","article-title":"CLL-like B-lymphocytes are systematically present at very low numbers in peripheral blood of healthy adults","volume":"25","author":"Almeida","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0085","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1182\/blood-2002-03-0892","article-title":"Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion","volume":"100","author":"Rawstron","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0090","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.leu.2404116","article-title":"Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults","volume":"20","author":"de Tute","year":"2006","journal-title":"Leukemia"},{"issue":"Suppl. 1","key":"10.1016\/j.semcancer.2013.08.003_bib0095","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1002\/cyto.b.20533","article-title":"Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL)","volume":"78","author":"Rawstron","year":"2010","journal-title":"Cytometry B: Clin Cytom"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1056\/NEJMoa075290","article-title":"Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia","volume":"359","author":"Rawstron","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0105","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1200\/JCO.2008.21.2704","article-title":"Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia","volume":"27","author":"Shanafelt","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0110","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1182\/blood-2008-09-176149","article-title":"B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome","volume":"113","author":"Shanafelt","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0115","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/10428190701321277","article-title":"Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis","volume":"48","author":"Fung","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0120","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1056\/NEJMc086211","article-title":"Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia","volume":"359","author":"Mulligan","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0125","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/leu.2012.20","article-title":"Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines","volume":"26","author":"Scarfo","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0130","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJMoa0806122","article-title":"B-cell clones as early markers for chronic lymphocytic leukemia","volume":"360","author":"Landgren","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0167-5699(94)90009-4","article-title":"The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire","volume":"15","author":"Schroeder","year":"1994","journal-title":"Immunol Today"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0140","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1172\/JCI3009","article-title":"Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors","volume":"102","author":"Fais","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0145","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0150","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0155","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2006-03-012948","article-title":"Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations","volume":"109","author":"Stamatopoulos","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0160","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1182\/blood-2011-11-393694","article-title":"Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies","volume":"119","author":"Agathangelidis","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0165","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1182\/blood-2012-12-471698","article-title":"Immunogenetics shows that not all MBL are equal: the larger the clone the more similar to CLL","volume":"121","author":"Vardi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/clin.1998.4580","article-title":"Age-related persistent clonal expansions of CD28(\u2212) cells: phenotypic and molecular TCR analysis reveals both CD4(+) and CD4(+)CD8(+) cells with identical CDR3 sequences","volume":"89","author":"Colombatti","year":"1998","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0175","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1365-2141.2007.06867.x","article-title":"Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly","volume":"139","author":"Ghia","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0180","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.4049\/jimmunol.169.4.1984","article-title":"Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals","volume":"169","author":"Khan","year":"2002","journal-title":"J Immunol"},{"issue":"Suppl. 1","key":"10.1016\/j.semcancer.2013.08.003_bib0185","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1002\/cyto.b.20545","article-title":"Monoclonal B cell lymphocytosis in hepatitis C virus infected individuals","volume":"78","author":"Fazi","year":"2010","journal-title":"Cytometry B: Clin Cytom"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0190","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","article-title":"Genomic aberrations and survival in chronic lymphocytic leukemia","volume":"343","author":"Dohner","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0195","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ccr.2009.11.019","article-title":"The DLEU2\/miR-15a\/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia","volume":"17","author":"Klein","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature10113","article-title":"Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia","volume":"475","author":"Puente","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0205","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood-2011-09-379966","article-title":"Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia","volume":"119","author":"Rossi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0210","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1109016","article-title":"SF3B1 and other novel cancer genes in chronic lymphocytic leukemia","volume":"365","author":"Wang","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.1032","article-title":"Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia","volume":"44","author":"Quesada","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0220","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1182\/blood-2011-12-395673","article-title":"Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia","volume":"119","author":"Rossi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0225","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3324\/haematol.2011.053090","article-title":"Analysis of NOTCH1 mutations in monoclonal B-cell lymphocytosis","volume":"97","author":"Rasi","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0230","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/hon.2013","article-title":"Analysis of SF3B1 mutations in monoclonal B-cell lymphocytosis","volume":"31","author":"Greco","year":"2013","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0235","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1200\/JCO.2006.09.4508","article-title":"Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center","volume":"25","author":"Tsimberidou","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0240","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1200\/JCO.1998.16.8.2780","article-title":"New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project","volume":"16","author":"Armitage","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0245","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1200\/JCO.2007.15.4393","article-title":"Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease","volume":"26","author":"Caligaris-Cappio","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0250","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood.V97.9.2777","article-title":"Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia","volume":"97","author":"Granziero","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0255","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1182\/blood-2009-05-219634","article-title":"In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia","volume":"114","author":"Calissano","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0260","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0265","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3324\/haematol.2011.042333","article-title":"Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis","volume":"96","author":"Gibson","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0270","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3324\/haematol.2011.047712","article-title":"Another piece of the puzzle: is there a \u201cnodal\u201d monoclonal B-cell lymphocytosis","volume":"96","author":"Ghia","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0275","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2141.2009.07711.x","article-title":"The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors","volume":"146","author":"Rossi","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0280","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3324\/haematol.2010.030189","article-title":"Differentiating chronic lymphocytic leukemia from monoclonal B-lymphocytosis according to clinical outcome: on behalf of the GIMEMA chronic lymphoproliferative diseases working group","volume":"96","author":"Molica","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0285","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/leu.2011.211","article-title":"Survival of patients with clinically identified monoclonal B-cell lymphocytosis (MBL) relative to the age- and sex-matched general population","volume":"26","author":"Shanafelt","year":"2012","journal-title":"Leukemia"},{"issue":"Suppl. 1","key":"10.1016\/j.semcancer.2013.08.003_bib0290","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1002\/cyto.b.20543","article-title":"Non-CLL-like monoclonal B-cell lymphocytosis in the general population: prevalence and phenotypic\/genetic characteristics","volume":"78","author":"Nieto","year":"2010","journal-title":"Cytometry B: Clin Cytom"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0295","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1309\/WB56ET6AGM44TM5T","article-title":"Cytogenetic aberrations and immunoglobulin VH gene mutations in clinically benign CD5\u2212 monoclonal B-cell lymphocytosis","volume":"128","author":"Amato","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0300","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.1365-2141.1997.2163033.x","article-title":"Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma","volume":"98","author":"Sole","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0305","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.1587.1587","article-title":"Monoclonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with marginal zone origin: what is this entity?","volume":"120","author":"Xochelli","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0310","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/leu.2012.3","article-title":"Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications","volume":"26","author":"Bikos","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0315","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3324\/haematol.2011.052621","article-title":"In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior","volume":"97","author":"Carvajal-Cuenca","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0320","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1182\/blood.V99.9.3376","article-title":"In situ localization of follicular lymphoma: description and analysis by laser capture microdissection","volume":"99","author":"Cong","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0325","series-title":"World Health Organization Classification of Tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2009"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0330","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2008.10.035","article-title":"Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity","volume":"135","author":"Tsai","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0335","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jncimonographs\/lgn002","article-title":"t(14;18) translocations and risk of follicular lymphoma","volume":"2008","author":"Rabkin","year":"2008","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0340","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/sj.leu.2404035","article-title":"Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individuals","volume":"20","author":"Roulland","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0345","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1158\/0008-5472.CAN-03-3604","article-title":"Characterization of the t(14;18) BCL2-IGH translocation in farmers occupationally exposed to pesticides","volume":"64","author":"Roulland","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0350","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1044-579X(03)00016-6","article-title":"Chromosomal translocation t(14;18) in healthy individuals","volume":"13","author":"Schuler","year":"2003","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0355","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1200\/JCO.1996.14.4.1333","article-title":"BCL-2\/JH rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseases","volume":"14","author":"Dolken","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0360","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1182\/blood.V85.9.2528.bloodjournal8592528","article-title":"Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals","volume":"85","author":"Limpens","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0365","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1084\/jem.20061292","article-title":"Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis","volume":"203","author":"Roulland","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0370","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2559.2011.03897.x","article-title":"Prevalence of follicular lymphoma in situ in consecutively analysed reactive lymph nodes","volume":"59","author":"Henopp","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0375","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1073\/pnas.88.19.8661","article-title":"Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease","volume":"88","author":"Strasser","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0380","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(89)90174-8","article-title":"bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation","volume":"57","author":"McDonnell","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0385","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1111\/j.1349-7006.2009.01344.x","article-title":"Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center type","volume":"100","author":"Sakai","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0390","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1182\/blood-2011-05-355255","article-title":"Follicular lymphoma in situ: clinical implications and comparisons with partial involvement by follicular lymphoma","volume":"118","author":"Jegalian","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0395","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2559.2010.03529.x","article-title":"Intrafollicular neoplasia\/in situ follicular lymphoma: review of a series of 13 cases","volume":"56","author":"Montes-Moreno","year":"2010","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0400","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1182\/blood-2011-07-368944","article-title":"A unique case of follicular lymphoma provides insights to the clonal evolution from follicular lymphoma in situ to manifest follicular lymphoma","volume":"118","author":"Bonzheim","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0405","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1182\/blood-2010-10-299628","article-title":"How I treat: diagnosing and managing \u201cin situ\u201d lymphoma","volume":"117","author":"Carbone","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0410","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/1066896909350174","article-title":"In situ follicular lymphoma associated with progressive transformation of germinal centers","volume":"19","author":"Handa","year":"2011","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0415","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.humpath.2011.01.035","article-title":"In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18)","volume":"43","author":"Li","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0420","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1097\/01.pas.0000173233.29741.38","article-title":"Presence of preserved reactive germinal centers in follicular lymphoma is a strong histopathologic indicator of limited disease stage","volume":"29","author":"Adam","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0425","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/j.semdp.2012.08.008","article-title":"Early neoplastic lymphoid lesions","volume":"30","author":"Carvajal-Cuenca","year":"2013","journal-title":"Sem Diag Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0430","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4103\/0377-4929.97878","article-title":"In situ follicular neoplasia\/lymphoma: three illustrative cases exemplifying unique disease presentations","volume":"55","author":"Sakhadeo","year":"2012","journal-title":"Indian J Pathol Microbiol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0435","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12308-012-0148-6","article-title":"Early lesions in lymphoid neoplasia","volume":"5","author":"Fend","year":"2012","journal-title":"J Hematopathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0440","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1309\/AJCPDSG2J5IBEYFB","article-title":"Coexisting follicular and mantle cell lymphoma with each having an in situ component","volume":"136","author":"Carbone","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0445","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1002\/ajh.22169","article-title":"In situ follicular lymphoma associated with overt B- or T-cell lymphomas in the same lymph node","volume":"86","author":"Carbone","year":"2011","journal-title":"Am J Hematol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0450","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/10428194.2011.624229","article-title":"In situ follicular lymphoma associated with nonlymphoid malignancies","volume":"53","author":"Carbone","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0455","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2012-02-412791","article-title":"IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas","volume":"120","author":"Greisman","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0460","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/S0046-8177(03)00410-6","article-title":"Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes","volume":"34","author":"Nodit","year":"2003","journal-title":"Hum Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0465","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.humpath.2005.08.021","article-title":"Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma","volume":"36","author":"Espinet","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0470","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/leu.2009.31","article-title":"t(11;14)-Positive clones can persist over a long period of time in the peripheral blood of healthy individuals","volume":"23","author":"Lecluse","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0475","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/modpathol.2012.117","article-title":"Incidence of preclinical manifestations of mantle cell lymphoma and mantle cell lymphoma in situ in reactive lymphoid tissues","volume":"25","author":"Adam","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0480","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1200\/JCO.2010.29.8992","article-title":"Mantle cell lymphoma 12 years after allogeneic bone marrow transplantation occurring simultaneously in recipient and donor","volume":"28","author":"Christian","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0485","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/j.1460-2075.1994.tb06488.x","article-title":"Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene","volume":"13","author":"Bodrug","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0490","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1182\/blood.V116.21.323.323","article-title":"Evidence of long latency periods prior to development of mantle cell lymphoma","volume":"116","author":"Racke","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0495","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1309\/AJCP6KFFGTC8PLVR","article-title":"Early lymph node involvement by mantle cell lymphoma limited to the germinal center: report of a case with a novel \u201cfollicular in situ\u201d growth pattern","volume":"136","author":"Edlefsen","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0500","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2559.2007.02906.x","article-title":"In-situ mantle cell lymphoma \u2013 a report of two cases","volume":"52","author":"Aqel","year":"2008","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0505","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1182\/blood-2012-06-438937","article-title":"SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma","volume":"121","author":"Vegliante","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0510","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/leu.2012.72","article-title":"Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease","volume":"26","author":"Royo","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.08.003_bib0515","doi-asserted-by":"crossref","DOI":"10.1002\/hed.23206","article-title":"In situ mantle cell lymphoma in the nasopharynx","author":"Koletsa","year":"2013","journal-title":"Head Neck"}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X13000795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X13000795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T19:14:20Z","timestamp":1596395660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X13000795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":103,"alternative-id":["S1044579X13000795"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.08.003","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monoclonal B cell lymphocytosis and \u201cin situ\u201d lymphoma","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}