{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:44:47Z","timestamp":1791305087983,"version":"4.3.1"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.semcancer.2013.11.003","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T13:01:02Z","timestamp":1386334862000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection"],"prefix":"10.1016","volume":"26","author":[{"given":"Charles R.M.","family":"Bangham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy B.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Melamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2013.11.003_bib0005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological aspects and world distribution of HTLV-1 infection","volume":"3","author":"Gessain","year":"2012","journal-title":"Front Microbiol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0010","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/v3071074","article-title":"HTLV-3\/STLV-3 and HTLV-4 viruses: discovery, epidemiology, serology and molecular aspects","volume":"3","author":"Mahieux","year":"2011","journal-title":"Viruses"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/13550289509111010","article-title":"HTLV-I-associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings","volume":"1","author":"Nakagawa","year":"1995","journal-title":"J Neurovirol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0020","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama","year":"1977","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0025","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1038\/sj.onc.1208980","article-title":"History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2","volume":"24","author":"Gallo","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0030","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1038\/sj.onc.1208981","article-title":"Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis","volume":"24","author":"Yoshida","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0035","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","article-title":"Global epidemiology of HTLV-I infection and associated diseases","volume":"24","author":"Proietti","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0040","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1473-3099(07)70081-6","article-title":"Human T-lymphotropic virus 1: recent knowledge about an ancient infection","volume":"7","author":"Verdonck","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0045","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/jcp.2007.052456","article-title":"Adult T-cell leukaemia\/lymphoma","volume":"60","author":"Matutes","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0050","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0145-2126(92)90168-7","article-title":"Phenotypic diversity and prognosis of adult T-cell leukemia","volume":"16","author":"Kamihira","year":"1992","journal-title":"Leuk Res"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0055","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/ijc.24664","article-title":"FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia","volume":"125","author":"Toulza","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0060","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984\u201387)","volume":"79","author":"Shimoyama","year":"1991","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02983215","article-title":"Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109)","volume":"77","author":"Tsukasaki","year":"2003","journal-title":"Int J Hematol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0070","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1200\/JCO.2007.11.9958","article-title":"VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801","volume":"25","author":"Tsukasaki","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0075","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2141.2001.02737.x","article-title":"A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303","volume":"113","author":"Yamada","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0080","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1182\/blood-2009-09-242347","article-title":"Long-term study of indolent adult T-cell leukemia-lymphoma","volume":"115","author":"Takasaki","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0085","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1200\/JCO.2010.28.0669","article-title":"Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia\/lymphoma showing improved survival in the leukemic subtypes","volume":"28","author":"Bazarbachi","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0090","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1200\/JCO.2011.35.5578","article-title":"Use of zidovudine and interferon alfa with chemotherapy improves survival in both acute and lymphoma subtypes of adult T-cell leukemia\/lymphoma","volume":"29","author":"Hodson","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0095","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1038\/sj.onc.1208973","article-title":"Transcriptional and post-transcriptional gene regulation of HTLV-1","volume":"24","author":"Kashanchi","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0100","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/onc.2010.537","article-title":"Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy","volume":"30","author":"Matsuoka","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0105","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0110","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/sj.bjc.6605345","article-title":"Mechanisms of HTLV-1 persistence and transformation","volume":"101","author":"Boxus","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0115","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.1073\/pnas.0608832104","article-title":"In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection","volume":"104","author":"Asquith","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0120","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1080115","article-title":"Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton","volume":"299","author":"Igakura","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0125","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3390\/v2071427","article-title":"The HTLV-1 virological synapse","volume":"2","author":"Nejmeddine","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0130","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.92.4.1057","article-title":"Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I","volume":"92","author":"Grossman","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0135","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1128\/JVI.77.5.2956-2963.2003","article-title":"Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: inverse correlation with HTLV-1-specific cellular immune response","volume":"77","author":"Hasegawa","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0140","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nm0507-527","article-title":"The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells","volume":"13","author":"Ohsugi","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0145","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/22780","article-title":"Creation of human tumour cells with defined genetic elements","volume":"400","author":"Hahn","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0150","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/eji.200939451","article-title":"CTL quality and the control of human retroviral infections","volume":"39","author":"Bangham","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0155","doi-asserted-by":"crossref","first-page":"12813","DOI":"10.1128\/JVI.76.24.12813-12822.2002","article-title":"The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription","volume":"76","author":"Gaudray","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0160","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells","volume":"103","author":"Satou","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0165","doi-asserted-by":"crossref","first-page":"43620","DOI":"10.1074\/jbc.M307275200","article-title":"factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity","volume":"278","author":"Basbous","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0170","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1182\/blood-2008-06-161729","article-title":"Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB","volume":"113","author":"Zhao","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0175","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/infdis\/jiq078","article-title":"In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome","volume":"203","author":"Hilburn","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0180","doi-asserted-by":"crossref","first-page":"e1001117","DOI":"10.1371\/journal.ppat.1001117","article-title":"HLA class I binding of HBZ determines outcome in HTLV-1 infection","volume":"6","author":"MacNamara","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0185","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2005-11-4551","article-title":"Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1","volume":"107","author":"Arnold","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-4690-4-92","article-title":"HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)","volume":"4","author":"Kuhlmann","year":"2007","journal-title":"Retrovirol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0195","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1126\/science.3201246","article-title":"Human T cell leukemia viruses use a receptor determined by human chromosome 17","volume":"242","author":"Sommerfelt","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0200","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/jvi.64.11.5682-5687.1990","article-title":"In vivo cellular tropism of human T-cell leukemia virus type 1","volume":"64","author":"Richardson","year":"1990","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0205","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm1745","article-title":"Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells","volume":"14","author":"Jones","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0210","first-page":"1699","article-title":"Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation","volume":"8","author":"Macatonia","year":"1992","journal-title":"ARHR"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0215","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/jvi.64.3.1278-1282.1990","article-title":"Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates","volume":"64","author":"Daenke","year":"1990","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0220","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ijc.2910470403","article-title":"Sequence variations in LTR and env regions of HTLV-I do not discriminate between the virus from patients with HTLV-I-associated myelopathy and adult T-cell leukemia","volume":"47","author":"Kinoshita","year":"1991","journal-title":"Int J Cancer"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0225","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/jvi.65.7.3770-3778.1991","article-title":"In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies","volume":"65","author":"Komurian","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0230","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1086\/315897","article-title":"Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy\/tropical spastic paraparesis","volume":"182","author":"Furukawa","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0235","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1182\/blood.V98.6.1858","article-title":"CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I","volume":"98","author":"Nagai","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0240","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.20144","article-title":"Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia\/lymphoma in asymptomatic carriers","volume":"110","author":"Okayama","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0245","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/13550280152403272","article-title":"HTLV-I proviral load correlates with progression of motor disability in HAM\/TSP: analysis of 239 HAM\/TSP patients including 64 patients followed up for 10 years","volume":"7","author":"Matsuzaki","year":"2001","journal-title":"J Neurovirol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0250","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.1059128","article-title":"Selection forces and constraints on retroviral sequence variation","volume":"292","author":"Overbaugh","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0255","first-page":"2419","article-title":"Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP\/HAM","volume":"12","author":"Cavrois","year":"1996","journal-title":"Oncogene"},{"issue":"Suppl. 1","key":"10.1016\/j.semcancer.2013.11.003_bib0260","first-page":"S92","article-title":"Clonal expansion of infected cells: a way of life for HTLV-I","volume":"13","author":"Wattel","year":"1996","journal-title":"J AIDS Hum Retrovirol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0265","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1128\/jvi.69.5.2863-2868.1995","article-title":"Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy","volume":"69","author":"Wattel","year":"1995","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0270","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood.V80.4.1012.1012","article-title":"Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP)","volume":"80","author":"Furukawa","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0275","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.onc.1201906","article-title":"Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis\/HTLV-1 associated myelopathy","volume":"17","author":"Cavrois","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0280","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF02102076","article-title":"Molecular evolution of human T-cell leukemia virus","volume":"31","author":"Ina","year":"1990","journal-title":"J Mol Evol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0285","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.4049\/jimmunol.178.9.5966","article-title":"Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs","volume":"178","author":"Kubota","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0290","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1128\/JVI.74.20.9525-9531.2000","article-title":"In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy","volume":"74","author":"Mansky","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0295","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/sj.icb.7100050","article-title":"Quantifying HTLV-I dynamics","volume":"85","author":"Asquith","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0300","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1086\/428625","article-title":"The clonal expansion of human T lymphotropic virus type 1-infected T cells: a comparison between seroconverters and long-term carriers","volume":"191","author":"Tanaka","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0305","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","article-title":"Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting","volume":"27","author":"Tsukasaki","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0310","series-title":"Genetic susceptibility to infectious diseases","first-page":"303","article-title":"Human T-lymphotropic virus type 1 (HTLV-1)-associated diseases","author":"Bangham","year":"2008"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0315","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.4049\/jimmunol.165.12.7278","article-title":"The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection","volume":"165","author":"Jeffery","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0320","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1073\/pnas.96.7.3848","article-title":"HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy","volume":"96","author":"Jeffery","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0325","doi-asserted-by":"crossref","first-page":"6778","DOI":"10.1128\/jvi.68.10.6778-6781.1994","article-title":"The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis","volume":"68","author":"Niewiesk","year":"1994","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0330","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.4049\/jimmunol.173.8.5121","article-title":"The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1","volume":"173","author":"Vine","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0335","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1099\/vir.0.80766-0","article-title":"A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load","volume":"86","author":"Asquith","year":"2005","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0340","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.4049\/jimmunol.0900069","article-title":"The avidity and lytic efficiency of the CTL response to HTLV-1","volume":"182","author":"Kattan","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0345","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.272.5258.74","article-title":"Population dynamics of immune responses to persistent viruses","volume":"272","author":"Nowak","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0350","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/intimm\/3.8.761","article-title":"Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells","volume":"3","author":"Kannagi","year":"1991","journal-title":"Int Immunol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0355","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1086\/420832","article-title":"Human T cell lymphotropic virus (HTLV) type-1-specific CD8+ T cells: frequency and immunodominance hierarchy","volume":"189","author":"Goon","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0360","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1182\/blood-2010-10-312926","article-title":"The host genomic environment of the provirus determines the abundance of HTLV-1-infected T cell clones","volume":"117","author":"Gillet","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0365","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bioinformatics\/bts004","article-title":"Estimating abundances of retroviral insertion sites from DNA fragment length data","volume":"28","author":"Berry","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0370","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1182\/blood-2012-07-445593","article-title":"HTLV-1-infected T cells contain a single integrated provirus in natural infection","volume":"120","author":"Cook","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0375","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2257.2005.00698.x","article-title":"Proviral status of HTLV-1 integrated into the host genomic DNA of adult T-cell leukemia cells","volume":"27","author":"Kamihira","year":"2005","journal-title":"Clin Lab Haematol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0380","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065","article-title":"Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia","volume":"88","author":"Tamiya","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0385","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood.V89.3.948","article-title":"Integration patterns of HTLV-I provirus in relation to the clinical course of ATL: frequent clonal change at crisis from indolent disease","volume":"89","author":"Tsukasaki","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0390","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1073\/pnas.1107729108","article-title":"Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule","volume":"108","author":"Josefsson","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0395","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-4690-2-52","article-title":"Retroviral superinfection resistance","volume":"2","author":"Nethe","year":"2005","journal-title":"Retrovirology"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0400","doi-asserted-by":"crossref","first-page":"e1003271","DOI":"10.1371\/journal.ppat.1003271","article-title":"Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection","volume":"9","author":"Melamed","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0405","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0092-8674(92)90289-O","article-title":"Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection","volume":"69","author":"Pryciak","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0410","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nrmicro1263","article-title":"Genome-wide analysis of retroviral DNA integration","volume":"3","author":"Bushman","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0415","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1128\/JVI.02752-06","article-title":"Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses","volume":"81","author":"Derse","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0420","doi-asserted-by":"crossref","first-page":"e1000027","DOI":"10.1371\/journal.ppat.1000027","article-title":"HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM\/TSP","volume":"4","author":"Meekings","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0425","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature08784","article-title":"Retroviral intasome assembly and inhibition of DNA strand transfer","volume":"464","author":"Hare","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0430","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature09517","article-title":"The mechanism of retroviral integration from X-ray structures of its key intermediates","volume":"468","author":"Maertens","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0435","doi-asserted-by":"crossref","first-page":"e1000046","DOI":"10.1371\/journal.ppat.1000046","article-title":"The lentiviral integrase binding protein LEDGF\/p75 and HIV-1 replication","volume":"4","author":"Engelman","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0440","doi-asserted-by":"crossref","first-page":"e1002558","DOI":"10.1371\/journal.ppat.1002558","article-title":"LEDGF\/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs","volume":"8","author":"Schrijvers","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0445","doi-asserted-by":"crossref","first-page":"e1001313","DOI":"10.1371\/journal.ppat.1001313","article-title":"HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2","volume":"7","author":"Ocwieja","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0450","doi-asserted-by":"crossref","first-page":"8250","DOI":"10.1128\/JVI.02681-09","article-title":"Transcription factor YY1 interacts with retroviral integrases and facilitates integration of moloney murine leukemia virus cDNA into the host chromosomes","volume":"84","author":"Inayoshi","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0455","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1182\/blood.V95.4.1386.004k22_1386_1392","article-title":"Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes","volume":"95","author":"Hanon","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0460","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1128\/JVI.02536-10","article-title":"Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model","volume":"85","author":"Shan","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0465","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1954.1","article-title":"The age distribution of cancer and a multi-stage theory of carcinogenesis","volume":"8","author":"Armitage","year":"1954","journal-title":"Br J Cancer"},{"key":"10.1016\/j.semcancer.2013.11.003_bib0475","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1182\/blood-2010-11-316463","article-title":"Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs","volume":"117","author":"Rende","year":"2011","journal-title":"Blood"}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X13001247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X13001247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T23:29:20Z","timestamp":1760916560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X13001247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":95,"alternative-id":["S1044579X13001247"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.11.003","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}