{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:23:06Z","timestamp":1791397386262,"version":"4.3.3"},"reference-count":118,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.semcancer.2013.11.004","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T13:01:43Z","timestamp":1386334903000},"page":"49-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["The microenvironment in T-cell lymphomas: Emerging themes"],"prefix":"10.1016","volume":"24","author":[{"given":"Philippe","family":"Gaulard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2013.11.004_bib0005","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","article-title":"International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes","volume":"26","author":"Armitage","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0010","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0015","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1182\/blood-2006-10-055145","article-title":"The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells","volume":"109","author":"de Leval","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0020","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1182\/blood-2011-12-396150","article-title":"Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets","volume":"119","author":"Travert","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0025","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/PAS.0b013e31822067d1","article-title":"Nonhepatosplenic gammadelta T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation","volume":"35","author":"Garcia-Herrera","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0030","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1182\/blood-2009-05-221275","article-title":"Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK\/T-cell lymphoma, nasal type","volume":"115","author":"Huang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0035","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0140-6736(74)90553-4","article-title":"Angio-immunoblastic lymphadenopathy with dysproteinemia","volume":"i","author":"Frizzera","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197501022920101","article-title":"Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease","volume":"292","author":"Lukes","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0045","first-page":"1246","article-title":"Nature, prognosis and nomenclature of angioimmunoblastic (lymphadenopathy (lymphogranulomatosis X or T-zone lymphoma)","volume":"104","author":"Lennert","year":"1979","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0050","first-page":"1056","article-title":"Clinical, cytological and immunological analysis of T-cell type lymphoid malignancies: a classification of T-cell type lymphoid malignancy (author's transl)","volume":"20","author":"Shimoyama","year":"1979","journal-title":"Rinsho Ketsueki"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0055","first-page":"392","article-title":"Clonal T-cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma","volume":"122","author":"Weiss","year":"1986","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0060","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/blood.V72.2.413.413","article-title":"Characteristic karyotypic pattern in T-cell lymphoproliferative disorders with reactive angioimmunoblastic lymphadenopathy with dysproteinemia-type features","volume":"72","author":"Kaneko","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0065","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1182\/blood.V72.3.1000.bloodjournal7231000","article-title":"Clinicopathologic, immunophenotypic, and immunogenotypic analyses of immunoblastic lymphadenopathy-like T-cell lymphoma","volume":"72","author":"Tobinai","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0070","first-page":"549","article-title":"Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy","volume":"133","author":"Feller","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0075","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0080","series-title":"Pathology and genetics. Tumours of haematopoietic and lymphoid tissues","author":"Jaffe","year":"2001"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/annonc\/mdf033","article-title":"Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project","volume":"13","author":"Rudiger","year":"2002","journal-title":"Ann Oncol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0090","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood.V120.21.1607.1607","article-title":"Angioimmunoblastic T-Cell lymphoma (AITL) is the most prevalent T-cell lymphoma entity in Western Europe","volume":"120","author":"Parrens","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0095","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1182\/blood-2007-08-105759","article-title":"Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d\u2019Etude des Lymphomes de l\u2019Adulte (GELA) trials","volume":"111","author":"Mourad","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0100","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1200\/JCO.2011.37.3647","article-title":"Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: analysis of the international peripheral T-cell lymphoma project","volume":"31","author":"Federico","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0105","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.leu.2404013","article-title":"Identification of circulating CD10 positive T cells in angioimmunoblastic T-cell lymphoma","volume":"20","author":"Baseggio","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0110","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/modpathol.2011.53","article-title":"CD10 and ICOS expression by multiparametric flow cytometry in angioimmunoblastic T-cell lymphoma","volume":"24","author":"Baseggio","year":"2011","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0115","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/00000478-199806000-00001","article-title":"Angioimmunoblastic lymphoma (AILD-type T-cell lymphoma) with hyperplastic germinal centers","volume":"22","author":"Ree","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0120","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1182\/blood.V99.2.627","article-title":"Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10","volume":"99","author":"Attygalle","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0125","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1182\/blood-2005-03-1083","article-title":"Angioimmunoblastic T-cell lymphoma: a neoplasm of germinal-center T-helper cells?","volume":"106","author":"Grogg","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0130","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/00000478-200604000-00009","article-title":"Expression of CXCL13 by neoplastic cells in angioimmunoblastic T-cell lymphoma (AITL): a new diagnostic marker providing evidence that AITL derives from follicular helper T cells","volume":"30","author":"Dupuis","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0135","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/modpathol.3800625","article-title":"Expression of CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified","volume":"19","author":"Grogg","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0140","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/PAS.0b013e31802df4ef","article-title":"Characterization of CXCL13+ neoplastic t cells in cutaneous lesions of angioimmunoblastic T-cell lymphoma (AITL)","volume":"31","author":"Ortonne","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0145","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1158\/0008-5472.CAN-07-1708","article-title":"Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation","volume":"67","author":"Piccaluga","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.coi.2009.05.010","article-title":"Follicular helper T cells as cognate regulators of B cell immunity","volume":"21","author":"McHeyzer-Williams","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0155","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nri1714","article-title":"Follicular B helper T cells in antibody responses and autoimmunity","volume":"5","author":"Vinuesa","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0160","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2009.03.003","article-title":"Follicular helper T cells: lineage and location","volume":"30","author":"Fazilleau","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/j.semdp.2011.03.003","article-title":"Follicular helper T cells: implications in neoplastic hematopathology","volume":"28","author":"Gaulard","year":"2011","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0170","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2559.2011.04022.x","article-title":"c-Maf expression in angioimmunoblastic T-cell lymphoma reflects follicular helper T-cell derivation rather than oncogenesis","volume":"60","author":"Bisig","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0175","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2559.2007.02632.x","article-title":"Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified, using morphology, immunophenotype and molecular genetics","volume":"50","author":"Attygalle","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1440-1827.2007.02195.x","article-title":"Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases","volume":"58","author":"Karube","year":"2008","journal-title":"Pathol Int"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0185","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<432::AID-PATH942>3.0.CO;2-4","article-title":"Cytotoxic protein expression in natural killer cell lymphomas and in alpha beta and gamma delta peripheral T-cell lymphomas","volume":"183","author":"Boulland","year":"1997","journal-title":"J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0190","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2141.2009.08003.x","article-title":"Advances in the understanding and management of angioimmunoblastic T-cell lymphoma","volume":"148","author":"de Leval","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0195","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12185-013-1411-z","article-title":"Clinical manifestation of angioimmunoblastic T-cell lymphoma with exuberant plasmacytosis","volume":"98","author":"Nagoshi","year":"2013","journal-title":"Int J Hematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0200","first-page":"416","article-title":"Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: report of 3 cases and review of the literature","volume":"4","author":"Ahsanuddin","year":"2011","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0205","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1200\/JCO.2012.43.3797","article-title":"Angioimmunoblastic T-cell lymphoma partially obscured by an Epstein\u2013Barr virus-negative clonal plasma cell proliferation","volume":"31","author":"Huppmann","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0210","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00428-012-1280-5","article-title":"Atypical angioimmunoblastic T-cell lymphomas masquerading as systemic polyclonal B-immunoblastic proliferation","volume":"461","author":"Papadi","year":"2012","journal-title":"Virchows Arch"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.leukres.2012.09.009","article-title":"Angioimmunoblastic T-cell lymphoma mice model","volume":"37","author":"Sato","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0220","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1182\/blood.V85.10.2862.bloodjournal85102862","article-title":"Patterns of cytokine gene expression in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type","volume":"85","author":"Foss","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0225","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/labinvest.3700145","article-title":"Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-cell lymphoma and related to lymphoma progression","volume":"84","author":"Zhao","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0230","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3109\/10428190109099333","article-title":"Angiogenesis and mast cells in non-Hodgkin's lymphoma: a strong correlation in angioimmunoblastic T-cell lymphoma","volume":"42","author":"Fukushima","year":"2001","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0235","doi-asserted-by":"crossref","first-page":"792","DOI":"10.2353\/ajpath.2010.091286","article-title":"Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma","volume":"177","author":"Tripodo","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0240","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1365-2141.2008.07534.x","article-title":"Angiogenic mediators of the angiopoietin system are highly expressed by CD10-positive lymphoma cells in angioimmunoblastic T-cell lymphoma","volume":"144","author":"Konstantinou","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0245","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.leukres.2008.02.016","article-title":"TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas","volume":"32","author":"Thielen","year":"2008","journal-title":"Leuk Res"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0250","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3109\/10428190009059273","article-title":"Cytoplasmic cytokines in lymphoproliferative disorders: multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia","volume":"38","author":"Ohshima","year":"2000","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0255","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00000478-198904000-00002","article-title":"Angioimmunoblastic lymphadenopathy-type of T-cell lymphoma with a high content of epithelioid cells. Histopathology and comparison with lymphoepithelioid cell lymphoma","volume":"13","author":"Patsouris","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0260","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1440-1827.2010.02514.x","article-title":"Ratio of M2 macrophage expression is closely associated with poor prognosis for angioimmunoblastic T-cell lymphoma (AITL)","volume":"60","author":"Niino","year":"2010","journal-title":"Pathol Int"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0265","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/1097-0142(19871115)60:10<2412::AID-CNCR2820601010>3.0.CO;2-F","article-title":"Immunologic abnormalities in angioimmunoblastic lymphadenopathy","volume":"60","author":"Pizzolo","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0270","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3324\/haematol.2011.061507","article-title":"Targeting intratumoral B cells with rituximab in addition to CHOP in angioimmunoblastic T-cell lymphoma. A clinicobiological study of the GELA","volume":"97","author":"Delfau-Larue","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0275","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2353\/ajpath.2010.100150","article-title":"Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma","volume":"177","author":"Bruneau","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0280","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/his.12251","article-title":"Peripheral T- and NK-cell lymphomas and their mimics: taking a step forward \u2013 report on the Lymphoma Workshop of the XVI meeting of the European Association for Haematopathology in Lisbon 2012","volume":"64","author":"Attygalle","year":"2014","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0285","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/PAS.0b013e3182785610","article-title":"Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin\/Reed\u2013Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist","volume":"37","author":"Nicolae","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0290","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/PAS.0b013e31802d68e9","article-title":"Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression","volume":"31","author":"Attygalle","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0295","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU","article-title":"Epstein\u2013Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified","volume":"117","author":"Zettl","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0300","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2141.2007.06725.x","article-title":"Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein\u2013Barr virus-infected cells in early cases","volume":"138","author":"Willenbrock","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0305","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1084\/jem.194.7.927","article-title":"Survival and clonal expansion of mutating forbidden (immunoglobulin receptor-deficient) Epstein\u2013Barr virus-infected B cells in angioimmunoblastic T-cell lymphoma","volume":"194","author":"Brauninger","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0310","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1038\/sj.leu.2402642","article-title":"Angio-immunoblastic T cell lymphoma (AILD-TL) rich in large B cells and associated with Epstein\u2013Barr virus infection. A different subtype of AILD-TL?","volume":"16","author":"Lome-Maldonado","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0315","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2353\/jmoldx.2006.060016","article-title":"The frequency of B- and T-cell gene rearrangements and Epstein\u2013Barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations","volume":"8","author":"Tan","year":"2006","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2009.01.002","article-title":"Molecular classification of T-cell lymphomas","author":"de Leval","year":"2009","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0325","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1046\/j.1365-2141.2003.04335.x","article-title":"Angioimmunoblastic T-cell lymphoma","volume":"121","author":"Dogan","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0330","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/PAS.0b013e318054dbcf","article-title":"c-Maf expression in angioimmunoblastic T-cell lymphoma","volume":"31","author":"Murakami","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0335","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1182\/blood-2012-02-408542","article-title":"Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters","volume":"120","author":"Lemonnier","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0340","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1182\/blood-2011-11-391748","article-title":"IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma","volume":"119","author":"Cairns","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0345","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJMc1111708","article-title":"TET2 and DNMT3A mutations in human T-cell lymphoma","volume":"366","author":"Couronne","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0350","first-page":"330A","article-title":"Novel fusion transcripts identified in angioimmunoblastic T cell lymphoma","volume":"26","author":"Guo s","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0355","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2011-07-365130","article-title":"Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice","volume":"120","author":"Ellyard","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0360","doi-asserted-by":"crossref","first-page":"e64536","DOI":"10.1371\/journal.pone.0064536","article-title":"ROQUIN\/RC3H1 alterations are not found in angioimmunoblastic T-cell lymphoma","volume":"8","author":"Auguste","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0365","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1182\/blood-2012-01-401760","article-title":"Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma","volume":"120","author":"Beachy","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0370","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1182\/blood-2009-06-227579","article-title":"Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma","volume":"115","author":"Iqbal","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0375","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1182\/blood-2011-08-374371","article-title":"Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan","volume":"119","author":"Tokunaga","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0380","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.immuni.2008.11.008","article-title":"A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts","volume":"30","author":"Dullaers","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0385","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1365-2141.2009.07651.x","article-title":"The Germinal centre-derived lymphomas seen through their cellular microenvironment","volume":"145","author":"Carbone","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0390","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri2217","article-title":"Germinal centres: role in B-cell physiology and malignancy","volume":"8","author":"Klein","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0395","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00000478-200103000-00015","article-title":"Peripheral T-cell lymphoma with follicular involvement and a CD4+\/bcl-6+ phenotype","volume":"25","author":"de Leval","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0400","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/PAS.0b013e3181971591","article-title":"Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas","volume":"33","author":"Huang","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0405","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1097\/PAS.0b013e318268d9ff","article-title":"Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics","volume":"36","author":"Moroch","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0410","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.leu.2404045","article-title":"Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma","volume":"20","author":"Streubel","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0415","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1084\/jem.20092042","article-title":"The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma","volume":"207","author":"Pechloff","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0420","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/PAS.0b013e31818e52fe","article-title":"Primary cutaneous CD4+ small\/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers","volume":"33","author":"Rodriguez Pinilla","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0425","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1309\/AJCP83AOQTMLOJTM","article-title":"Non-mycosis fungoides cutaneous T-cell lymphomas: report of the 2011 Society for Hematopathology\/European Association for Haematopathology workshop","volume":"139","author":"Quintanilla-Martinez","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0430","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1200\/JCO.2011.36.5411","article-title":"Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study","volume":"29","author":"Lamant","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0435","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00428-004-1077-2","article-title":"Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert's) variant are often derived from CD8(+) cytotoxic T-cells","volume":"445","author":"Geissinger","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0440","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1365-2141.1993.tb03079.x","article-title":"Lymphoepithelioid cell lymphoma (Lennert's lymphoma): clinical features derived from analysis of 108 cases","volume":"84","author":"Patsouris","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0445","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/sj.onc.1209178","article-title":"Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas","volume":"25","author":"Ballester","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0450","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1200\/JCO.2006.09.4474","article-title":"Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas","volume":"25","author":"Cuadros","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0455","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/10428194.2010.529204","article-title":"Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified","volume":"52","author":"Zhang","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0460","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1182\/blood-2011-10-381921","article-title":"EBV-associated T\/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases","volume":"119","author":"Kimura","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0465","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/00000478-200107000-00004","article-title":"Bone marrow involvement in lymphomas with hemophagocytic syndrome at presentation: a clinicopathologic study of 11 patients in a Western institution","volume":"25","author":"Allory","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0470","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1172\/JCI119728","article-title":"Upregulation of tumor necrosis factor-alpha gene by Epstein\u2013Barr virus and activation of macrophages in Epstein\u2013Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome","volume":"100","author":"Lay","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0475","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.2353\/ajpath.2007.061026","volume":"170","author":"Chuang","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0480","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0002-9440(10)64104-1","article-title":"An animal model for human EBV-associated hemophagocytic syndrome: herpesvirus papio frequently induces fatal lymphoproliferative disorders with hemophagocytic syndrome in rabbits","volume":"158","author":"Hayashi","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0485","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1182\/blood-2004-04-1477","article-title":"A proportion of patients with lymphoma may harbor mutations of the PERFORIN gene","volume":"105","author":"Clementi","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0490","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5858\/2010-0507-RAR.1","article-title":"Anaplastic large cell lymphoma: twenty-five years of discovery","volume":"135","author":"Kinney","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0495","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1182\/blood.V90.10.4099","article-title":"The role of Mig, the monokine induced by interferon-gamma, and IP-10, the interferon-gamma-inducible protein-10, in tissue necrosis and vascular damage associated with Epstein\u2013Barr virus-positive lymphoproliferative disease","volume":"90","author":"Teruya-Feldstein","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0500","doi-asserted-by":"crossref","first-page":"943089","DOI":"10.5402\/2012\/943089","article-title":"Angiogenesis in non-Hodgkin's lymphoma: an intercategory comparison of microvessel density","volume":"2012","author":"Aggarwal","year":"2012","journal-title":"ISRN Hematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0505","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1182\/blood-2012-03-415638","article-title":"Mast cells play a protumorigenic role in primary cutaneous lymphoma","volume":"120","author":"Rabenhorst","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0510","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrc925","article-title":"Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?","volume":"2","author":"Rafii","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0515","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/MOH.0b013e3283623c07","article-title":"Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma","volume":"20","author":"Tabbo","year":"2013","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0520","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1182\/blood.V96.12.3712","article-title":"Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients","volume":"96","author":"Salven","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0525","doi-asserted-by":"crossref","DOI":"10.3109\/10428194.2013.816700","article-title":"Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: an Eastern Cooperative Oncology Group study (E2404)","author":"Ganjoo","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0530","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.seminhematol.2012.01.003","article-title":"Lymphoproliferative disorders associated with hypereosinophilia","volume":"49","author":"Roufosse","year":"2012","journal-title":"Semin Hematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0535","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1038\/jid.2010.128","article-title":"Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma","volume":"130","author":"Miyagaki","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0540","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2559.2009.03359.x","article-title":"Neutrophil\/eosinophil-rich type of primary cutaneous anaplastic large cell lymphoma: a clinicopathological, immunophenotypic and molecular study of nine cases","volume":"55","author":"Kong","year":"2009","journal-title":"Histopathology"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0545","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1182\/blood-2002-02-0475","article-title":"Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma","volume":"101","author":"Kleinhans","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0550","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jaad.2004.03.003","article-title":"In situ eosinophil activation in 26 primary cutaneous T-cell lymphomas with blood eosinophilia","volume":"52","author":"Ionescu","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0555","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.leukres.2006.10.017","article-title":"Clinical significance of a blood eosinophilia in adult T-cell leukemia\/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor","volume":"31","author":"Utsunomiya","year":"2007","journal-title":"Leuk Res"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0560","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.iac.2007.07.002","article-title":"Lymphocytic variant hypereosinophilic syndromes","volume":"27","author":"Roufosse","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0565","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000058782","article-title":"Eosinophil cytokines","volume":"76","author":"Lacy","year":"2000","journal-title":"Chem Immunol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0570","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1182\/blood-2005-04-1492","article-title":"Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26\/dipeptidylpeptidase IV","volume":"107","author":"Narducci","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0575","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.gcb.2010.09.008","article-title":"Enteropathy-associated T-cell lymphoma: a review on clinical presentation, diagnosis, therapeutic strategies and perspectives","volume":"34","author":"Chandesris","year":"2010","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0580","first-page":"1583","article-title":"MIP-1alpha expression in tissues from patients with hemophagocytic syndrome","volume":"79","author":"Teruya-Feldstein","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0585","doi-asserted-by":"crossref","DOI":"10.1007\/s00277-013-1878-y","article-title":"IP-10\/CXCL10 and MIG\/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome","author":"Maruoka","year":"2013","journal-title":"Ann Hematol"},{"key":"10.1016\/j.semcancer.2013.11.004_bib0590","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1182\/blood-2005-05-1980","article-title":"Severe imbalance of IL-18\/IL-18BP in patients with secondary hemophagocytic syndrome","volume":"106","author":"Mazodier","year":"2005","journal-title":"Blood"}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X13001259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X13001259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T23:18:02Z","timestamp":1647645482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X13001259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":118,"alternative-id":["S1044579X13001259"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.11.004","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The microenvironment in T-cell lymphomas: Emerging themes","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2013.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}