{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:18:19Z","timestamp":1790835499845,"version":"4.1.0"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"ERC CoG ImmunoFIT Methusalem","award":["G066515N"],"award-info":[{"award-number":["G066515N"]}]},{"name":"Flamish government FWO","award":["G0A0818N"],"award-info":[{"award-number":["G0A0818N"]}]},{"name":"Belgian Association Against Cancer"},{"name":"National Institute of Health NIH\/NCI"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.semcancer.2018.06.002","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T23:20:14Z","timestamp":1529536814000},"page":"107-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"P2","title":["The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer"],"prefix":"10.1016","volume":"52","author":[{"given":"Rindert","family":"Missiaen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3545-5171","authenticated-orcid":false,"given":"Gabriele","family":"Bergers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2018.06.002_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc1093","article-title":"Tumorigenesis and the angiogenic switch","volume":"3","author":"Bergers","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpedsurg.2006.09.048","article-title":"Is angiogenesis an organizing principle in biology and medicine?","volume":"42","author":"Folkman","year":"2007","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccr.2006.11.020","article-title":"A perivascular niche for brain tumor stem cells","volume":"11","author":"Calabrese","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0020","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.trecan.2015.10.009","article-title":"Glioblastoma: defining tumor niches","volume":"1","author":"Hambardzumyan","year":"2015","journal-title":"Trends Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0025","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0030","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrm2183","article-title":"Molecular regulation of angiogenesis and lymphangiogenesis","volume":"8","author":"Adams","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4614-5915-6_4","article-title":"Escape mechanisms from antiangiogenic therapy: an immune cell\u2019s perspective","volume":"772","author":"Rivera","year":"2014","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/768758","article-title":"CXC and CC chemokines as angiogenic modulators in nonhaematological tumors","volume":"2014","author":"Santoni","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0045","unstructured":"Folkman, J. (2000) Tumor angiogenesis in Cancer Medicine (al., H. e., ed), B C Decker, Hamilton, Ontario."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0060","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1200\/JCO.2012.46.3653","article-title":"Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers","volume":"31","author":"Jain","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0065","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.gde.2004.12.005","article-title":"Cellular abnormalities of blood vessels as targets in cancer","volume":"15","author":"Baluk","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0070","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1158\/0008-5472.CAN-06-2701","article-title":"Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression","volume":"67","author":"Liao","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0075","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","article-title":"HIF transcription factors, inflammation, and immunity","volume":"41","author":"Palazon","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0080","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc3183","article-title":"HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression","volume":"12","author":"Keith","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0090","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/35091000","article-title":"Identification of an angiogenic mitogen selective for endocrine gland endothelium","volume":"412","author":"LeCouter","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0095","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/jcp.21558","article-title":"The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and ets-1","volume":"217","author":"Simon","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0100","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0105","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1161\/01.RES.0000102937.50486.1B","article-title":"Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1","volume":"93","author":"Kelly","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0110","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)00139-2","article-title":"MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis","volume":"103","author":"Coussens","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0115","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1172\/JCI200422087","article-title":"An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis","volume":"114","author":"Giraudo","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0120","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1158\/0008-5472.CAN-06-1278","article-title":"Macrophages regulate the angiogenic switch in a mouse model of breast cancer","volume":"66","author":"Lin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.bjc.6602901","article-title":"Macrophages promote angiogenesis in human breast tumour spheroids in vivo","volume":"94","author":"Bingle","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0130","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nbt1323","article-title":"Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells","volume":"25","author":"Shojaei","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ccr.2008.01.034","article-title":"HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion","volume":"13","author":"Du","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0140","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrc2444","article-title":"The role of myeloid cells in the promotion of tumour angiogenesis","volume":"8","author":"Murdoch","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jdermsci.2014.11.001","article-title":"Attempts to accelerate wound healing","volume":"76","author":"Kasuya","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/2326-6066.CIR-14-0209","article-title":"Tumors: wounds that do not heal-redux","volume":"3","author":"Dvorak","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0160","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nri3064","article-title":"The parallel lives of angiogenesis and immunosuppression: cancer and other tales","volume":"11","author":"Motz","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0165","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.it.2015.02.005","article-title":"Intertwined regulation of angiogenesis and immunity by myeloid cells","volume":"36","author":"Rivera","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0175","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molmed.2011.01.015","article-title":"VEGF and angiopoietin signaling in tumor angiogenesis and metastasis","volume":"17","author":"Saharinen","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0180","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc.2017.51","article-title":"Microenvironmental regulation of tumour angiogenesis","volume":"17","author":"De Palma","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0185","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.it.2007.09.004","article-title":"Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications","volume":"28","author":"De Palma","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0190","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9679","article-title":"Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation","volume":"9","author":"Allen","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0195","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.4049\/jimmunol.178.3.1505","article-title":"Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy","volume":"178","author":"Bouzin","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0200","first-page":"1111","article-title":"Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors","volume":"56","author":"Griffioen","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0205","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9670","article-title":"Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade","volume":"9","author":"Schmittnaegel","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.immuni.2013.07.005","article-title":"Deciphering and reversing tumor immune suppression","volume":"39","author":"Motz","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0215","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41419-017-0061-0","article-title":"Defining the role of the tumor vasculature in antitumor immunity and immunotherapy","volume":"9","author":"Schaaf","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0220","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1096-1096","article-title":"Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells","volume":"2","author":"Gabrilovich","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0225","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1084\/jem.20111497","article-title":"Neuropilin 1 deficiency on CD4+Foxp3+ regulatory t cells impairs mouse melanoma growth","volume":"209","author":"Hansen","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0230","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.20140559","article-title":"VEGF-A modulates expression of inhibitory checkpoints on CD8++ T cells in tumors","volume":"212","author":"Voron","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0235","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/156652410791316968","article-title":"Molecular pathways linking inflammation and cancer","volume":"10","author":"Mantovani","year":"2010","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0240","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \"N1\" versus \"N2\" TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0245","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrc3581","article-title":"History of myeloid-derived suppressor cells","volume":"13","author":"Talmadge","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0250","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0255","series-title":"Immune Cells and Inflammatory Mediators as Regulators of Tumor Angiogenesis in Angiogenesis: An Integrative Approach from Science to Medicine","author":"de Palma","year":"2008"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0260","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0265","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccr.2010.11.009","article-title":"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PIGF","volume":"19","author":"Rolny","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cytogfr.2004.03.005","article-title":"Insight into the physiological functions of PDGF through genetic studies in mice","volume":"15","author":"Betsholtz","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0275","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4161\/cc.3.12.1289","article-title":"Multiple roles for cysteine cathepsins in cancer","volume":"3","author":"Joyce","year":"2004","journal-title":"ABBV Cell Cycle"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0280","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0285","first-page":"7163","article-title":"Fibroblast growth factors are required for efficient tumor angiogenesis","volume":"60","author":"Compagni","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0290","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood-2003-12-4423","article-title":"SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells","volume":"104","author":"De Falco","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0295","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/35036374","article-title":"Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis","volume":"2","author":"Bergers","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0300","first-page":"1085","article-title":"Potent and selective inhibitors of the Met [hepatocyte growth factor\/scatter factor (HGF\/SF) receptor] tyrosine kinase block HGF\/SF-induced tumor cell growth and invasion","volume":"2","author":"Wang","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0305","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.193.6.727","article-title":"Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy","volume":"193","author":"Lin","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0310","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/sj.bjc.6603240","article-title":"Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach","volume":"95","author":"Zeisberger","year":"2006","journal-title":"Br. J. Cancer."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0315","first-page":"4625","article-title":"Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma","volume":"56","author":"Leek","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0320","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nature07445","article-title":"Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis","volume":"456","author":"Stockmann","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0325","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood-2009-08-237412","article-title":"Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy","volume":"115","author":"Priceman","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0330","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","article-title":"Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors","volume":"8","author":"De Palma","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0335","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ccr.2011.02.005","article-title":"Targeting the ANG2\/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells","volume":"19","author":"Mazzieri","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0340","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1158\/0008-5472.CAN-14-3587","article-title":"Perivascular M2 macrophages stimulate tumor relapse after chemotherapy","volume":"75","author":"Hughes","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0345","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1158\/0008-5472.CAN-09-4446","article-title":"Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation","volume":"70","author":"Kozin","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0350","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1158\/0008-5472.CAN-16-1114","article-title":"Tie2 expression on macrophages Is required for blood vessel reconstruction and tumor relapse after chemotherapy","volume":"76","author":"Chen","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0355","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ccell.2016.05.017","article-title":"The multifaceted role of perivascular macrophages in tumors","volume":"30","author":"Lewis","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0360","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.devcel.2011.07.017","article-title":"Semaphorin signals on the Road of endothelial tip cells","volume":"21","author":"Tamagnone","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0365","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ccr.2012.06.031","article-title":"Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer","volume":"22","author":"Tamagnone","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0370","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ccr.2013.11.007","article-title":"Impeding macrophage entry into hypoxic tumor areas by Sema3A\/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity","volume":"24","author":"Casazza","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0375","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1158\/0008-5472.CAN-17-1435","article-title":"Deletion of neuropilin 1 from microglia or bone marrow-derived macrophages slows glioma progression","volume":"78","author":"Miyauchi","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0380","first-page":"213","article-title":"Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors","volume":"79","author":"Papapetropoulos","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0385","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nri.2016.17","article-title":"Tumour immunology: neutrophils help tumours spread","volume":"16","author":"Bird","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0390","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1158\/2326-6066.CIR-15-0313","article-title":"The complex role of neutrophils in tumor angiogenesis and metastasis","volume":"4","author":"Liang","year":"2016","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0395","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.it.2015.02.006","article-title":"Immune-mediated mechanisms influencing the efficacy of anticancer therapies","volume":"36","author":"Coffelt","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0400","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1182\/blood.V90.10.4153","article-title":"Intracellular pool of vascular endothelial growth factor in human neutrophils","volume":"90","author":"Gaudry","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0405","doi-asserted-by":"crossref","first-page":"12493","DOI":"10.1073\/pnas.0601807103","article-title":"Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis","volume":"103","author":"Nozawa","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0410","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nature06348","article-title":"Bv8 regulates myeloid-cell-dependent tumour angiogenesis","volume":"450","author":"Shojaei","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0415","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0420","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1182\/blood-2007-07-099226","article-title":"Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity","volume":"111","author":"Movahedi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0425","first-page":"2322","article-title":"Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression","volume":"63","author":"Dirkx","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0430","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrclinonc.2018.9","article-title":"Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa","volume":"15","author":"Khan","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0435","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/imm.12380","article-title":"Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment","volume":"143","author":"Kumar","year":"2014","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.semcancer.2018.06.002_bib0440","article-title":"Molecular mechanisms and therapeutic reversal of immune suppression in cancer","volume":"7","author":"Gabrilovich","year":"2007","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0445","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.celrep.2015.03.055","article-title":"Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy","volume":"11","author":"Rivera","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0450","article-title":"B cells promote tumor progression via STAT3 regulated-angiogenesis","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0455","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ccr.2009.12.019","article-title":"FcRgamma activation regulates inflammation-associated squamous carcinogenesis","volume":"17","author":"Andreu","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0460","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2009.06.018","article-title":"CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages","volume":"16","author":"DeNardo","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0465","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature10169","article-title":"Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells","volume":"475","author":"Facciabene","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0470","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature21724","article-title":"Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming","volume":"544","author":"Tian","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0475","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nri2607","article-title":"Interdependence of hypoxic and innate immune responses","volume":"9","author":"Nizet","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0480","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2017.03.001","article-title":"Cancer acidity: an ultimate frontier of tumor immune escape and a novel target of immunomodulation","volume":"43","author":"Huber","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0485","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: Warburg and beyond","volume":"134","author":"Hsu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0490","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1014774","article-title":"Lactic acid polarizes macrophages to a tumor-promoting state","volume":"5","author":"Colegio","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0495","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2013.08.001","article-title":"Role of endothelial cell metabolism in vessel sprouting","volume":"18","author":"De Bock","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0500","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.1257071","article-title":"Angiogenesis. Targeting vascular sprouts","volume":"344","author":"Rivera","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0505","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cmet.2016.09.008","article-title":"Macrophage metabolism controls tumor blood vessel morphogenesis and metastasis","volume":"24","author":"Wenes","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0510","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41467-018-03050-0","article-title":"Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2alpha","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0515","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.1881410","article-title":"Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis","volume":"24","author":"Takeda","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0520","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/cncr.20057","article-title":"Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation","volume":"100","author":"Dillon","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0525","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.it.2015.02.007","article-title":"T cell metabolic fitness in antitumor immunity","volume":"36","author":"Siska","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0530","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1006288526311","article-title":"Expression of inducible nitric oxide synthase in human breast cancer depends on tumor grade","volume":"56","author":"Tschugguel","year":"1999","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0535","first-page":"1352","article-title":"Nitric oxide synthase activity in human gynecological cancer","volume":"54","author":"Thomsen","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0540","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-0463.2009.02569.x","article-title":"Inducible nitric oxide synthase expression and its prognostic significance in colorectal cancer","volume":"118","author":"Zafirellis","year":"2010","journal-title":"APMIS"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0545","first-page":"357","article-title":"Expression of arginase II in prostate cancer","volume":"32","author":"Mumenthaler","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0550","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1158\/0008-5472.CAN-04-0465","article-title":"Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses","volume":"64","author":"Rodriguez","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0555","first-page":"1100","article-title":"Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity","volume":"61","author":"Chang","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0560","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/onc.2013.121","article-title":"Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment","volume":"33","author":"Casazza","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0565","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1158\/0008-5472.CAN-10-1439","article-title":"Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression","volume":"70","author":"Doedens","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0570","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","article-title":"Low-dose irradiation programs macrophage differentiation to an iNOS(+)\/M1 phenotype that orchestrates effective T cell immunotherapy","volume":"24","author":"Klug","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0575","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ccr.2013.11.014","article-title":"Location, location, location: macrophage positioning within tumors determines pro- or antitumor activity","volume":"24","author":"Rivera","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0580","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrclinonc.2018.29","article-title":"Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges","volume":"15","author":"Fukumura","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0585","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrclinonc.2009.63","article-title":"Biomarkers of response and resistance to antiangiogenic therapy","volume":"6","author":"Jain","year":"2009","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0590","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrclinonc.2011.21","article-title":"Antiangiogenic therapy: impact on invasion, disease progression, and metastasis","volume":"8","author":"Ebos","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0595","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nm0901-987","article-title":"Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy","volume":"7","author":"Jain","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0600","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ccell.2014.10.006","article-title":"Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia","volume":"26","author":"Jain","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0605","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrc2442","article-title":"Modes of resistance to anti-angiogenic therapy","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0610","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.celrep.2014.06.059","article-title":"Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade","volume":"8","author":"Rigamonti","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0615","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","article-title":"Anti-PIGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels","volume":"131","author":"Fischer","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0620","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ccr.2005.09.005","article-title":"Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors","volume":"8","author":"Casanovas","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0625","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.tcb.2008.06.003","article-title":"Role of myeloid cells in tumor angiogenesis and growth","volume":"18","author":"Shojaei","year":"2008","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0630","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nm.3291","article-title":"An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy","volume":"19","author":"Chung","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0635","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1172\/JCI93182","article-title":"Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy","volume":"127","author":"Jung","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0640","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1172\/JCI44562","article-title":"TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice","volume":"121","author":"Welford","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0645","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1200\/JCO.2005.07.093","article-title":"A multitargeted, metronomic, and maximum-tolerated dose \"chemo-switch\" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer","volume":"23","author":"Pietras","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0650","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1158\/1078-0432.CCR-10-2847","article-title":"Brivanib, a dual FGF\/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive\/evasive resistance to VEGF inhibition","volume":"17","author":"Allen","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0655","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature19834","article-title":"PI3Kgamma is a molecular switch that controls immune suppression","volume":"539","author":"Kaneda","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0660","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with ipilimumab in patients with metastatic melanoma","volume":"363","author":"Hodi","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0665","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1200\/JCO.2014.56.2736","article-title":"Pooled analysis of Long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma","volume":"33","author":"Schadendorf","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0670","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of anti-PD-L1 antibody in patients with advanced cancer","volume":"366","author":"Brahmer","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0675","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0680","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccell.2015.03.001","article-title":"Immune checkpoint blockade: a common denominator approach to cancer therapy","volume":"27","author":"Topalian","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0685","first-page":"2514","article-title":"Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs","volume":"6","author":"Du Four","year":"2016","journal-title":"Am J. Cancer Res."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0690","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1008791","article-title":"Understanding high endothelial venules: lessons for cancer immunology","volume":"4","author":"Ager","year":"2015","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0695","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3298","article-title":"HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes","volume":"12","author":"Girard","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0700","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/ni.3836","article-title":"De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors","volume":"18","author":"Johansson-Percival","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0705","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/path.5080","article-title":"Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules","volume":"245","author":"He","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0710","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.devcel.2017.04.005","article-title":"It\u2019s T time for Normal blood vessels","volume":"41","author":"Thienpont","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcancer.2018.06.002_bib0715","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJMoa1712126","article-title":"Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma","volume":"378","author":"Motzer","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2018.06.002_bib0720","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1200\/JCO.2014.58.1041","article-title":"Survival, durable response, and Long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab","volume":"33","author":"McDermott","year":"2015","journal-title":"J. Clin. Oncol."}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X18300750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X18300750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T15:57:14Z","timestamp":1571500634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X18300750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":144,"alternative-id":["S1044579X18300750"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2018.06.002","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2018.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}