{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:22:29Z","timestamp":1790140949186,"version":"4.0.1"},"reference-count":235,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.semcancer.2020.06.006","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T10:28:08Z","timestamp":1592735288000},"page":"11-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Gut microbiota contributes towards immunomodulation against cancer: New frontiers in precision cancer therapeutics"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-3861","authenticated-orcid":false,"given":"Kentaro","family":"Inamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9356","key":"10.1016\/j.semcancer.2020.06.006_bib0005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(03)12489-0","article-title":"Gut flora in health and disease","volume":"361","author":"Guarner","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0010","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0015","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0020","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat. Rev. Genet."},{"issue":"7610","key":"10.1016\/j.semcancer.2020.06.006_bib0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/535047a","article-title":"Intestinal microbiota in health and disease","volume":"535","author":"Kahrstrom","year":"2016","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.semcancer.2020.06.006_bib0030","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"6416","key":"10.1016\/j.semcancer.2020.06.006_bib0035","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.aau5812","article-title":"The gut microbiota at the intersection of diet and human health","volume":"362","author":"Gentile","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41591-019-0377-7","article-title":"The microbiome, cancer, and cancer therapy","volume":"25","author":"Helmink","year":"2019","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nm.4517","article-title":"Current understanding of the human microbiome","volume":"24","author":"Gilbert","year":"2018","journal-title":"Nat. Med."},{"issue":"7758","key":"10.1016\/j.semcancer.2020.06.006_bib0050","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41586-019-1238-8","article-title":"The integrative human microbiome project","volume":"569","author":"Proctor","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0055","doi-asserted-by":"crossref","first-page":"e9302","DOI":"10.15252\/emmm.201809302","article-title":"The role of the microbiome in NAFLD and NASH","volume":"11","author":"Kolodziejczyk","year":"2019","journal-title":"EMBO Mol. Med."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0060","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2015.11.001","article-title":"Personalized nutrition by prediction of glycemic responses","volume":"163","author":"Zeevi","year":"2015","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0065","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"issue":"7770","key":"10.1016\/j.semcancer.2020.06.006_bib0075","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-019-1443-5","article-title":"Potential roles of gut microbiome and metabolites in modulating ALS in mice","volume":"572","author":"Blacher","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0080","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ijnp\/pyy067","article-title":"Making sense of \u2026 the microbiome in psychiatry","volume":"22","author":"Bastiaanssen","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0085","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1210\/er.2018-00280","article-title":"The gut microbiome influences host endocrine functions","volume":"40","author":"Rastelli","year":"2019","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41569-018-0108-7","article-title":"Dietary metabolism, the gut microbiome, and heart failure","volume":"16","author":"Tang","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","article-title":"An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system","volume":"122","author":"Mazmanian","year":"2005","journal-title":"Cell"},{"issue":"6086","key":"10.1016\/j.semcancer.2020.06.006_bib0100","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0105","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri2850","article-title":"The immune system and the gut microbiota: friends or foes?","volume":"10","author":"Cerf-Bensussan","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.semcancer.2020.06.006_bib0115","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nrc3610","article-title":"The microbiome and cancer","volume":"13","author":"Schwabe","year":"2013","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrc.2017.13","article-title":"Microbiota: a key orchestrator of cancer therapy","volume":"17","author":"Roy","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.semcancer.2020.06.006_bib0125","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41568-019-0155-3","article-title":"The cancer microbiome","volume":"19","author":"Elinav","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"477","key":"10.1016\/j.semcancer.2020.06.006_bib0130","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw1815","article-title":"Transforming medicine with the microbiome","volume":"11","author":"Zmora","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2019.12.026","article-title":"Roles of microbiota in response to cancer immunotherapy","author":"Inamura","year":"2020","journal-title":"Semin. Cancer Biol."},{"issue":"6382","key":"10.1016\/j.semcancer.2020.06.006_bib0140","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1126\/science.aar6918","article-title":"The microbiome in cancer immunotherapy: diagnostic tools and therapeutic strategies","volume":"359","author":"Zitvogel","year":"2018","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0145","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","article-title":"The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy","volume":"33","author":"Gopalakrishnan","year":"2018","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0150","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/S1470-2045(18)30952-5","article-title":"Modulating the microbiome to improve therapeutic response in cancer","volume":"20","author":"McQuade","year":"2019","journal-title":"Lancet Oncol."},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib0155","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41565-019-0589-5","article-title":"Nanotechnology intervention of the microbiome for cancer therapy","volume":"14","author":"Song","year":"2019","journal-title":"Nat. Nanotechnol."},{"issue":"6371","key":"10.1016\/j.semcancer.2020.06.006_bib0160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1126\/science.aar2946","article-title":"Precision medicine using microbiota","volume":"359","author":"Jobin","year":"2018","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"McGuckin","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0170","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.smim.2013.09.004","article-title":"Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes","volume":"25","author":"Macpherson","year":"2013","journal-title":"Semin. Immunol."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0175","doi-asserted-by":"crossref","first-page":"1131s","DOI":"10.1093\/ajcn\/73.6.1131S","article-title":"Microbial modulation of innate defense: goblet cells and the intestinal mucus layer","volume":"73","author":"Deplancke","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0180","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-pathol-011110-130318","article-title":"The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin","volume":"8","author":"Weaver","year":"2013","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0185","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrmicro2546","article-title":"Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis","volume":"9","author":"Bevins","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0190","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat. Immunol."},{"issue":"7368","key":"10.1016\/j.semcancer.2020.06.006_bib0200","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature10434","article-title":"Peripheral education of the immune system by colonic commensal microbiota","volume":"478","author":"Lathrop","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0205","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/imm.12036","article-title":"The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells","volume":"138","author":"Lindau","year":"2013","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0210","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.semcancer.2020.06.006_bib0215","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41575-018-0025-6","article-title":"Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer","volume":"15","author":"Cani","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib0225","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrmicro.2017.44","article-title":"Anticancer effects of the microbiome and its products","volume":"15","author":"Zitvogel","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0230","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"issue":"9","key":"10.1016\/j.semcancer.2020.06.006_bib0235","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0006-2952(96)00904-5","article-title":"Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors","volume":"53","author":"McBain","year":"1997","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.cdd.4400935","article-title":"Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria","volume":"9","author":"Jan","year":"2002","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0245","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.3109\/10428194.2016.1144879","article-title":"Butyrate production from high-fiber diet protects against lymphoma tumor","volume":"57","author":"Wei","year":"2016","journal-title":"Leuk. Lymphoma"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0250","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis","volume":"8","author":"de Martel","year":"2020","journal-title":"Lancet Glob. Health"},{"issue":"9","key":"10.1016\/j.semcancer.2020.06.006_bib0255","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrc1433","article-title":"Oncogenic mechanisms of the Helicobacter pylori CagA protein","volume":"4","author":"Hatakeyama","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"8390","key":"10.1016\/j.semcancer.2020.06.006_bib0260","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall","year":"1984","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0265","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"Peek","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcancer.2020.06.006_bib0270","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev-immunol-051116-052133","article-title":"Microbes and Cancer","volume":"35","author":"Dzutsev","year":"2017","journal-title":"Annu. Rev. Immunol."},{"issue":"111","key":"10.1016\/j.semcancer.2020.06.006_bib0275","first-page":"285","article-title":"Role of Helicobacter pylori in gastric cancer: advances and controversies","volume":"20","author":"Meng","year":"2015","journal-title":"Discov. Med."},{"issue":"16","key":"10.1016\/j.semcancer.2020.06.006_bib0280","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1056\/NEJM199110173251611","article-title":"Is gastric carcinoma an infectious disease?","volume":"325","author":"Correa","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"8964","key":"10.1016\/j.semcancer.2020.06.006_bib0285","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(95)91084-0","article-title":"Long-term sequelae of Helicobacter pylori gastritis","volume":"345","author":"Kuipers","year":"1995","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0290","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI30111","article-title":"Inflammation, atrophy, and gastric cancer","volume":"117","author":"Fox","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0295","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2017-314281","article-title":"Mucosal microbiome dysbiosis in gastric carcinogenesis","volume":"67","author":"Coker","year":"2018","journal-title":"Gut"},{"issue":"7792","key":"10.1016\/j.semcancer.2020.06.006_bib0300","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1038\/d41586-020-00199-x","article-title":"Fighting cancer with microbes","volume":"577","author":"Dolgin","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0305","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of Fusobacterium with colorectal carcinoma","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0310","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gr.126516.111","article-title":"Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"22","author":"Castellarin","year":"2012","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0315","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0320","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/beta-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0325","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41579-018-0129-6","article-title":"Fusobacterium nucleatum - symbiont, opportunist and oncobacterium","volume":"17","author":"Brennan","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0330","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3748\/wjg.v22.i2.557","article-title":"Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer","volume":"22","author":"Nosho","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0335","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1001\/jamaoncol.2015.1377","article-title":"Fusobacterium nucleatum and T cells in colorectal carcinoma","volume":"1","author":"Mima","year":"2015","journal-title":"JAMA Oncol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0340","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0345","doi-asserted-by":"crossref","first-page":"e1581531","DOI":"10.1080\/2162402X.2019.1581531","article-title":"Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1","volume":"8","author":"Gur","year":"2019","journal-title":"Oncoimmunology"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0350","doi-asserted-by":"crossref","first-page":"e47638","DOI":"10.15252\/embr.201847638","article-title":"Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt\/\u03b2-catenin modulator Annexin A1","volume":"20","author":"Rubinstein","year":"2019","journal-title":"EMBO Rep."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0355","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/ijc.29488","article-title":"Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway","volume":"137","author":"Ito","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib0360","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1136\/gutjnl-2015-310101","article-title":"Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis","volume":"65","author":"Mima","year":"2016","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0365","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1158\/0008-5472.CAN-13-1865","article-title":"Fusobacterium in colonic flora and molecular features of colorectal carcinoma","volume":"74","author":"Tahara","year":"2014","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0370","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1158\/1940-6207.CAPR-16-0264","article-title":"Sessile serrated polyps and colon cancer prevention","volume":"10","author":"Rashtak","year":"2017","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0375","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.gastro.2019.06.048","article-title":"Influence of the gut microbiome, diet, and environment on risk of colorectal cancer","volume":"158","author":"Song","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0380","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1038\/s41598-017-11237-6","article-title":"Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer","volume":"7","author":"Purcell","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.semcancer.2020.06.006_bib0385","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"issue":"6369","key":"10.1016\/j.semcancer.2020.06.006_bib0390","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"Bullman","year":"2017","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.semcancer.2020.06.006_bib0395","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/jamaoncol.2016.6374","article-title":"Association of dietary patterns with risk of colorectal cancer subtypes classified by Fusobacterium nucleatum in tumor tissue","volume":"3","author":"Mehta","year":"2017","journal-title":"JAMA Oncol."},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0400","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.cgh.2018.04.030","article-title":"Diets that promote colon inflammation associate with risk of colorectal carcinomas that contain Fusobacterium nucleatum","volume":"16","author":"Liu","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"6427","key":"10.1016\/j.semcancer.2020.06.006_bib0405","doi-asserted-by":"crossref","first-page":"eaat9931","DOI":"10.1126\/science.aat9931","article-title":"Separating host and microbiome contributions to drug pharmacokinetics and toxicity","volume":"363","author":"Zimmermann","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2020.06.006_bib0410","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-pharmtox-010919-023612","article-title":"The role of the microbiome in drug response","volume":"60","author":"Pryor","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0415","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrgastro.2017.20","article-title":"Gut microbiota modulation of chemotherapy efficacy and toxicity","volume":"14","author":"Alexander","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6161","key":"10.1016\/j.semcancer.2020.06.006_bib0420","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1240537","article-title":"The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide","volume":"342","author":"Viaud","year":"2013","journal-title":"Science"},{"issue":"7762","key":"10.1016\/j.semcancer.2020.06.006_bib0425","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-019-1291-3","article-title":"Mapping human microbiome drug metabolism by gut bacteria and their genes","volume":"570","author":"Zimmermann","year":"2019","journal-title":"Nature"},{"issue":"6356","key":"10.1016\/j.semcancer.2020.06.006_bib0430","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aah5043","article-title":"Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine","volume":"357","author":"Geller","year":"2017","journal-title":"Science"},{"issue":"6161","key":"10.1016\/j.semcancer.2020.06.006_bib0435","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1240527","article-title":"Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment","volume":"342","author":"Iida","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0440","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.semcancer.2020.06.006_bib0445","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nn.4606","article-title":"Gut microbiota is critical for the induction of chemotherapy-induced pain","volume":"20","author":"Shen","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0450","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/JLB.5HI1117-446RR","article-title":"Frontline Science: microbiota reconstitution restores intestinal integrity after cisplatin therapy","volume":"103","author":"Perales-Puchalt","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0455","doi-asserted-by":"crossref","DOI":"10.1177\/1758835918821021","article-title":"D-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation","volume":"11","author":"Wu","year":"2019","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0460","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/imm.12913","article-title":"T-cell modulation by cyclophosphamide for tumour therapy","volume":"154","author":"Hughes","year":"2018","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0465","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.immuni.2016.09.009","article-title":"Enterococcus hirae and Barnesiella intestinihominis facilitate cyclophosphamide-induced therapeutic immunomodulatory effects","volume":"45","author":"Daillere","year":"2016","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0470","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1039\/C4FO00408F","article-title":"Dietary squid ink polysaccharides ameliorated the intestinal microflora dysfunction in mice undergoing chemotherapy","volume":"5","author":"Tang","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103470","article-title":"Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression","volume":"61","author":"Chen","year":"2019","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0480","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00280-006-0350-2","article-title":"Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells","volume":"60","author":"Wang","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0485","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00280-009-0966-0","article-title":"Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells","volume":"64","author":"Li","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0490","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3390\/nu7020799","article-title":"Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer","volume":"7","author":"Wang","year":"2015","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0495","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/03602532.2020.1714645","article-title":"Insights into gastrointestinal microbiota-generated ginsenoside metabolites and their bioactivities","volume":"52","author":"Yang","year":"2020","journal-title":"Drug Metab. Rev."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0500","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1039\/C5FO00120J","article-title":"The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells","volume":"6","author":"Gonzalez-Sarrias","year":"2015","journal-title":"Food Funct."},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib0505","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4014\/jmb.1605.05024","article-title":"Combination therapy of Lactobacillus plantarum supernatant and 5-Fluouracil increases chemosensitivity in colorectal cancer cells","volume":"26","author":"An","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0510","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01635580802192841","article-title":"Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats","volume":"60","author":"Smith","year":"2008","journal-title":"Nutr. Cancer"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0515","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/ijms21020386","article-title":"Fecal microbiota transplantation prevents intestinal injury, upregulation of toll-like receptors, and 5-fluorouracil\/oxaliplatin-induced toxicity in colorectal cancer","volume":"21","author":"Chang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6005","key":"10.1016\/j.semcancer.2020.06.006_bib0520","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1126\/science.1191175","article-title":"Alleviating cancer drug toxicity by inhibiting a bacterial enzyme","volume":"330","author":"Wallace","year":"2010","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib0525","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.4161\/cbt.7.12.6940","article-title":"Faecal microflora and beta-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats","volume":"7","author":"Stringer","year":"2008","journal-title":"Cancer Biol. Ther."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0530","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2020.06.006_bib0535","doi-asserted-by":"crossref","first-page":"116529","DOI":"10.1016\/j.lfs.2019.06.004","article-title":"The administration of Escherichia coli Nissle 1917 ameliorates irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in mice","volume":"231","author":"Wang","year":"2019","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0540","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0545","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1158\/1078-0432.CCR-14-1860","article-title":"Immune escape mechanisms as a guide for cancer immunotherapy","volume":"21","author":"Beatty","year":"2015","journal-title":"Clin. Cancer Res."},{"issue":"6382","key":"10.1016\/j.semcancer.2020.06.006_bib0550","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0555","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc.2016.36","article-title":"Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy","volume":"16","author":"Topalian","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib0560","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.1016\/S1470-2045(16)30406-5","article-title":"Predictive biomarkers for checkpoint inhibitor-based immunotherapy","volume":"17","author":"Gibney","year":"2016","journal-title":"Lancet Oncol."},{"issue":"11","key":"10.1016\/j.semcancer.2020.06.006_bib0565","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrclinonc.2017.88","article-title":"Monitoring immune-checkpoint blockade: response evaluation and biomarker development","volume":"14","author":"Nishino","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"6230","key":"10.1016\/j.semcancer.2020.06.006_bib0570","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.aaa8172","article-title":"The future of immune checkpoint therapy","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0575","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41568-019-0116-x","article-title":"The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy","volume":"19","author":"Havel","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib0580","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI32205","article-title":"Microbial translocation augments the function of adoptively transferred self\/tumor-specific CD8+ T cells via TLR4 signaling","volume":"117","author":"Paulos","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"147","key":"10.1016\/j.semcancer.2020.06.006_bib0585","first-page":"93","article-title":"Modulation of cancer immunotherapy efficacy by gut microbiota","volume":"27","author":"Huo","year":"2019","journal-title":"Discov. Med."},{"issue":"18 Pt 1","key":"10.1016\/j.semcancer.2020.06.006_bib0590","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1158\/1078-0432.CCR-07-1378","article-title":"Toll-like receptors in tumor immunotherapy","volume":"13","author":"Paulos","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0595","doi-asserted-by":"crossref","first-page":"e94952","DOI":"10.1172\/jci.insight.94952","article-title":"Gut microbiota modulates adoptive cell therapy via CD8\u03b1 dendritic cells and IL-12","volume":"3","author":"Uribe-Herranz","year":"2018","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0600","doi-asserted-by":"crossref","first-page":"479","DOI":"10.21037\/hbsn.2018.10.02","article-title":"Gut microbiome: a key player in cancer immunotherapy","volume":"7","author":"Shigematsu","year":"2018","journal-title":"Hepatobiliary Surg. Nutr."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0605","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13045-018-0592-6","article-title":"Gut microbiome modulates efficacy of immune checkpoint inhibitors","volume":"11","author":"Yi","year":"2018","journal-title":"J. Hematol. Oncol."},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0610","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/stem.3051","article-title":"Concise Review: metabolism and gut microbiota in cancer immunoediting, CD8\/Treg ratios, immune cell homeostasis and implications for cancer (immuno)therapy","volume":"37","author":"Kareva","year":"2019","journal-title":"Stem Cells"},{"issue":"6371","key":"10.1016\/j.semcancer.2020.06.006_bib0615","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","article-title":"Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors","volume":"359","author":"Routy","year":"2018","journal-title":"Science"},{"issue":"6371","key":"10.1016\/j.semcancer.2020.06.006_bib0620","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.aan4236","article-title":"Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients","volume":"359","author":"Gopalakrishnan","year":"2018","journal-title":"Science"},{"issue":"6264","key":"10.1016\/j.semcancer.2020.06.006_bib0625","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"Vetizou","year":"2015","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0630","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","article-title":"The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression","volume":"8","author":"Pushalkar","year":"2018","journal-title":"Cancer Discov."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0635","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdy103","article-title":"Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer","volume":"29","author":"Derosa","year":"2018","journal-title":"Ann. Oncol."},{"issue":"6391","key":"10.1016\/j.semcancer.2020.06.006_bib0640","doi-asserted-by":"crossref","first-page":"eaan5931","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"issue":"6264","key":"10.1016\/j.semcancer.2020.06.006_bib0645","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0650","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/annonc\/mdx108","article-title":"Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab","volume":"28","author":"Chaput","year":"2017","journal-title":"Ann. Oncol."},{"issue":"6371","key":"10.1016\/j.semcancer.2020.06.006_bib0655","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.aao3290","article-title":"The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients","volume":"359","author":"Matson","year":"2018","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0660","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-related adverse events associated with immune checkpoint blockade","volume":"378","author":"Postow","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"26","key":"10.1016\/j.semcancer.2020.06.006_bib0665","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0670","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.critrevonc.2019.09.003","article-title":"Gut microbiota and cancer: how gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy","volume":"143","author":"Gori","year":"2019","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0675","doi-asserted-by":"crossref","DOI":"10.1177\/1756284819870911","article-title":"Impact of the gut microbiota on immune checkpoint inhibitor-associated toxicities","volume":"12","author":"Pezo","year":"2019","journal-title":"Therap. Adv. Gastroenterol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0680","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.3389\/fimmu.2019.02254","article-title":"Immunopathogenesis of immune checkpoint inhibitor-related adverse events: roles of the intestinal microbiome and Th17 cells","volume":"10","author":"Anderson","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0685","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1038\/ncomms10391","article-title":"Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis","volume":"7","author":"Dubin","year":"2016","journal-title":"Nat. Commun."},{"issue":"27","key":"10.1016\/j.semcancer.2020.06.006_bib0690","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"220","key":"10.1016\/j.semcancer.2020.06.006_bib0695","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008051","article-title":"Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice","volume":"6","author":"Faith","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib0700","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/s41591-018-0238-9","article-title":"Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis","volume":"24","author":"Wang","year":"2018","journal-title":"Nat. Med."},{"issue":"7791","key":"10.1016\/j.semcancer.2020.06.006_bib0705","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41586-019-1914-8","article-title":"Tertiary lymphoid structures improve immunotherapy and survival in melanoma","volume":"577","author":"Cabrita","year":"2020","journal-title":"Nature"},{"issue":"7791","key":"10.1016\/j.semcancer.2020.06.006_bib0710","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41586-019-1906-8","article-title":"B cells are associated with survival and immunotherapy response in sarcoma","volume":"577","author":"Petitprez","year":"2020","journal-title":"Nature"},{"issue":"7791","key":"10.1016\/j.semcancer.2020.06.006_bib0715","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","article-title":"B cells and tertiary lymphoid structures promote immunotherapy response","volume":"577","author":"Helmink","year":"2020","journal-title":"Nature"},{"issue":"7791","key":"10.1016\/j.semcancer.2020.06.006_bib0720","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/d41586-019-03943-0","article-title":"New predictors for immunotherapy responses sharpen our view of the tumour microenvironment","volume":"577","author":"Bruno","year":"2020","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0725","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41571-020-0338-6","article-title":"B cells and TLSs facilitate a response to ICI","volume":"17","author":"Romero","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"5717","key":"10.1016\/j.semcancer.2020.06.006_bib0730","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"issue":"7484","key":"10.1016\/j.semcancer.2020.06.006_bib0735","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"issue":"1-2","key":"10.1016\/j.semcancer.2020.06.006_bib0740","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"issue":"7122","key":"10.1016\/j.semcancer.2020.06.006_bib0745","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"issue":"7164","key":"10.1016\/j.semcancer.2020.06.006_bib0750","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"issue":"6380","key":"10.1016\/j.semcancer.2020.06.006_bib0755","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0760","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2018.04.022","article-title":"Dietary Fiber Confers protection against flu by shaping Ly6c(-) patrolling monocyte hematopoiesis and CD8(+) T cell metabolism","volume":"48","author":"Trompette","year":"2018","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0765","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.chom.2019.05.005","article-title":"Daily sampling reveals personalized diet-microbiome associations in humans","volume":"25","author":"Johnson","year":"2019","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0770","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chom.2017.11.004","article-title":"Bifidobacteria or Fiber Protects against diet-induced microbiota-mediated colonic mucus deterioration","volume":"23","author":"Schroeder","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0775","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","article-title":"You are what you eat: diet, health and the gut microbiota","volume":"16","author":"Zmora","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0780","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1038\/ncomms7342","article-title":"Fat, fibre and cancer risk in African Americans and rural Africans","volume":"6","author":"O\u2019Keefe","year":"2015","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0785","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3945\/ajcn.112.046607","article-title":"Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma","volume":"97","author":"Chen","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0790","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/ajcn\/nqy041","article-title":"Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis","volume":"107","author":"So","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0795","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The impact of dietary fiber on gut microbiota in host health and disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0800","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41591-019-0405-7","article-title":"Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation","volume":"25","author":"Thomas","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcancer.2020.06.006_bib0805","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1038\/ncomms7528","article-title":"Gut microbiome development along the colorectal adenoma-carcinoma sequence","volume":"6","author":"Feng","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib0810","doi-asserted-by":"crossref","first-page":"e70803","DOI":"10.1371\/journal.pone.0070803","article-title":"Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults","volume":"8","author":"Weir","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0815","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3945\/ajcn.114.088120","article-title":"Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber","volume":"101","author":"Vitaglione","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0820","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/gutjnl-2017-314786","article-title":"Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial","volume":"68","author":"Roager","year":"2019","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib0825","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1039\/C4FO00092G","article-title":"Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species","volume":"5","author":"Selma","year":"2014","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0830","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00394-013-0589-4","article-title":"Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells","volume":"53","author":"Gonzalez-Sarrias","year":"2014","journal-title":"Eur. J. Nutr."},{"issue":"7","key":"10.1016\/j.semcancer.2020.06.006_bib0835","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/tox.22747","article-title":"Ellagic acid ameliorates cisplatin induced hepatotoxicity in colon carcinogenesis","volume":"34","author":"Goyal","year":"2019","journal-title":"Environ. Toxicol."},{"issue":"9","key":"10.1016\/j.semcancer.2020.06.006_bib0840","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3390\/nu9091021","article-title":"Effects of probiotics, prebiotics, and synbiotics on human health","volume":"9","author":"Markowiak","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0845","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s40168-018-0483-7","article-title":"Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies","volume":"6","author":"Panebianco","year":"2018","journal-title":"Microbiome"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0850","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/nu9040331","article-title":"Engineered resistant-starch (ERS) diet shapes colon microbiota profile in parallel with the retardation of tumor growth in in vitro and in vivo pancreatic cancer models","volume":"9","author":"Panebianco","year":"2017","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib0855","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/jn\/121.10.1673","article-title":"Effect of fiber, protein source and time of feeding on methotrexate toxicity in rats","volume":"121","author":"Funk","year":"1991","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0860","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1053\/gast.1996.v111.pm8690198","article-title":"The effects of Lactobacillus strains and oat fiber on methotrexate-induced enterocolitis in rats","volume":"111","author":"Mao","year":"1996","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0865","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3109\/00365529609009128","article-title":"Pectin-supplemented enteral diet reduces the severity of methotrexate induced enterocolitis in rats","volume":"31","author":"Mao","year":"1996","journal-title":"Scand. J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0870","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","article-title":"Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features","volume":"174","author":"Zmora","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0875","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2672.1989.tb05105.x","article-title":"Probiotics in man and animals","volume":"66","author":"Fuller","year":"1989","journal-title":"J. Appl. Bacteriol."},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0880","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0168-1656(00)00375-8","article-title":"Probiotic bacteria: safety, functional and technological properties","volume":"84","author":"Saarela","year":"2000","journal-title":"J. Biotechnol."},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib0885","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0168-1605(97)00136-0","article-title":"Probiotics","volume":"39","author":"Guarner","year":"1998","journal-title":"Int. J. Food Microbiol."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0890","doi-asserted-by":"crossref","first-page":"e000145","DOI":"10.1136\/bmjgast-2017-000145","article-title":"Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention","volume":"4","author":"Hibberd","year":"2017","journal-title":"BMJ Open Gastroenterol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0895","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000475138","article-title":"Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP Study Group","volume":"27","author":"Aso","year":"1995","journal-title":"Eur. Urol."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0900","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.juro.2007.09.031","article-title":"Prevention of recurrence with epirubicin and lactobacillus casei after transurethral resection of bladder cancer","volume":"179","author":"Naito","year":"2008","journal-title":"J. Urol."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0905","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000058450","article-title":"Habitual intake of lactic acid bacteria and risk reduction of bladder cancer","volume":"68","author":"Ohashi","year":"2002","journal-title":"Urol. Int."},{"issue":"7","key":"10.1016\/j.semcancer.2020.06.006_bib0910","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/jgh.14516","article-title":"Single probiotic supplement suppresses colitis-associated colorectal tumorigenesis by modulating inflammatory development and microbial homeostasis","volume":"34","author":"Rong","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0915","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10875-012-9708-x","article-title":"Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model","volume":"32","author":"Maroof","year":"2012","journal-title":"J. Clin. Immunol."},{"issue":"13","key":"10.1016\/j.semcancer.2020.06.006_bib0920","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1016\/j.celrep.2018.08.090","article-title":"Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: a strategy to promote immunosurveillance against lung metastases","volume":"24","author":"Le Noci","year":"2018","journal-title":"Cell Rep."},{"issue":"Suppl. 45","key":"10.1016\/j.semcancer.2020.06.006_bib0925","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/MCG.0b013e318227414a","article-title":"Impact of probiotics on colonizing microbiota of the gut","author":"Sanders","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0930","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.chom.2016.09.001","article-title":"Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome","volume":"20","author":"Maldonado-Gomez","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0935","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cell.2018.08.047","article-title":"Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT","volume":"174","author":"Suez","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2020.06.006_bib0940","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2019.06.004","article-title":"The microbiome and cancer for clinicians","volume":"141","author":"Picardo","year":"2019","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib0945","first-page":"557","article-title":"Prevention of postoperative microbial infection by synbiotics","volume":"46","author":"Nomoto","year":"2008","journal-title":"Indian J. Exp. Biol."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0950","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clnu.2015.11.008","article-title":"Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients","volume":"36","author":"Motoori","year":"2017","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib0955","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/nu12010103","article-title":"Synbiotic combination of djulis (Chenopodium formosanum) and Lactobacillus acidophilus inhibits colon carcinogenesis in rats","volume":"12","author":"Lee","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0960","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.4238\/2015.May.25.16","article-title":"Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model","volume":"14","author":"Gui","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0965","doi-asserted-by":"crossref","first-page":"e1150399","DOI":"10.1080\/2162402X.2016.1150399","article-title":"Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota","volume":"5","author":"Pflug","year":"2016","journal-title":"Oncoimmunology"},{"issue":"7","key":"10.1016\/j.semcancer.2020.06.006_bib0970","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1053\/j.gastro.2018.12.045","article-title":"The role of the microbiome in immunologic development and its implication for pancreatic cancer immunotherapy","volume":"156","author":"Sethi","year":"2019","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib0975","first-page":"391","article-title":"A bacteriophage cocktail targeting Escherichia coli reduces E. coli in simulated gut conditions, while preserving a non-targeted representative commensal normal microbiota","volume":"9","author":"Cieplak","year":"2018","journal-title":"Gut Microbes"},{"key":"10.1016\/j.semcancer.2020.06.006_bib0980","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13099-017-0196-7","article-title":"Bacteriophages in the gastrointestinal tract and their implications","volume":"9","author":"Lusiak-Szelachowska","year":"2017","journal-title":"Gut Pathog."},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib0985","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2019.01.017","article-title":"Bacteriophages of the human gut: the \u201cknown unknown\u201d of the microbiome","volume":"25","author":"Shkoporov","year":"2019","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib0990","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/gutjnl-2017-313952","article-title":"Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome","volume":"67","author":"Zuo","year":"2018","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib0995","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1007\/s00253-018-8811-1","article-title":"Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?","volume":"102","author":"Maciejewska","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib1000","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/cid\/cir632","article-title":"Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection","volume":"53","author":"Gough","year":"2011","journal-title":"Clin. Infect. Dis."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib1005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJMoa1205037","article-title":"Duodenal infusion of donor feces for recurrent Clostridium difficile","volume":"368","author":"van Nood","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"26","key":"10.1016\/j.semcancer.2020.06.006_bib1010","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1056\/NEJMc1803103","article-title":"Fecal microbiota transplantation for primary Clostridium difficile infection","volume":"378","author":"Juul","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib1015","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib1020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.gastro.2015.04.001","article-title":"Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial","volume":"149","author":"Moayyedi","year":"2015","journal-title":"Gastroenterology"},{"issue":"21","key":"10.1016\/j.semcancer.2020.06.006_bib1025","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1056\/NEJMoa1910437","article-title":"Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant","volume":"381","author":"DeFilipp","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.semcancer.2020.06.006_bib1030","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1053\/j.gastro.2017.08.022","article-title":"Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice","volume":"153","author":"Wong","year":"2017","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib1035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40259-018-0328-8","article-title":"The impact of the fecal microbiome on cancer immunotherapy","volume":"33","author":"Osman","year":"2019","journal-title":"BioDrugs"},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib1040","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ijc.32003","article-title":"Fecal microbiota transplantation in cancer management: current status and perspectives","volume":"145","author":"Chen","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"19","key":"10.1016\/j.semcancer.2020.06.006_bib1045","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.7150\/jca.35648","article-title":"Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis","volume":"10","author":"Wang","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.semcancer.2020.06.006_bib1050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canlet.2019.01.037","article-title":"Genetically engineered Salmonella typhimurium: recent advances in cancer therapy","volume":"448","author":"Liang","year":"2019","journal-title":"Cancer Lett."},{"issue":"376","key":"10.1016\/j.semcancer.2020.06.006_bib1055","doi-asserted-by":"crossref","first-page":"eaak9537","DOI":"10.1126\/scitranslmed.aak9537","article-title":"Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin","volume":"9","author":"Zheng","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"31","key":"10.1016\/j.semcancer.2020.06.006_bib1060","doi-asserted-by":"crossref","first-page":"12879","DOI":"10.1073\/pnas.0701959104","article-title":"Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth","volume":"104","author":"Loeffler","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib1065","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1200\/JCO.2002.20.1.142","article-title":"Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma","volume":"20","author":"Toso","year":"2002","journal-title":"J. Clin. Oncol."},{"issue":"12 Pt 1","key":"10.1016\/j.semcancer.2020.06.006_bib1070","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2020.06.006_bib1075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-60761-609-2_3","article-title":"Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting","volume":"624","author":"Greish","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib1080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/bcr432","article-title":"Liposome-based drug delivery in breast cancer treatment","volume":"4","author":"Park","year":"2002","journal-title":"Breast Cancer Res."},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib1085","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"issue":"52","key":"10.1016\/j.semcancer.2020.06.006_bib1090","doi-asserted-by":"crossref","first-page":"e1805007","DOI":"10.1002\/adma.201805007","article-title":"Trapping of lipopolysaccharide to promote immunotherapy against colorectal cancer and attenuate liver metastasis","volume":"30","author":"Song","year":"2018","journal-title":"Adv Mater"},{"issue":"3","key":"10.1016\/j.semcancer.2020.06.006_bib1095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc1566","article-title":"Cancer nanotechnology: opportunities and challenges","volume":"5","author":"Ferrari","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"5625","key":"10.1016\/j.semcancer.2020.06.006_bib1100","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.semcancer.2020.06.006_bib1105","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib1110","first-page":"1800016","article-title":"Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection","volume":"1","author":"Angsantikul","year":"2018","journal-title":"Adv. Ther. (Weinh.)"},{"issue":"9","key":"10.1016\/j.semcancer.2020.06.006_bib1115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41551-019-0423-2","article-title":"Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy","volume":"3","author":"Zheng","year":"2019","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.semcancer.2020.06.006_bib1120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.semcancer.2020.06.006_bib1125","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41568-019-0203-z","article-title":"Phage warriors","volume":"19","author":"Dart","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"530","key":"10.1016\/j.semcancer.2020.06.006_bib1130","doi-asserted-by":"crossref","first-page":"eaax0876","DOI":"10.1126\/scitranslmed.aax0876","article-title":"Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies","volume":"12","author":"Gurbatri","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"6298","key":"10.1016\/j.semcancer.2020.06.006_bib1135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/348245a0","article-title":"Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease","volume":"348","author":"Jacobson","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2020.06.006_bib1140","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T cell exhaustion during chronic viral infection and Cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu. Rev. Immunol."},{"issue":"7741","key":"10.1016\/j.semcancer.2020.06.006_bib1145","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","article-title":"A defined commensal consortium elicits CD8 T cells and anti-cancer immunity","volume":"565","author":"Tanoue","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib1150","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2017.09.016","article-title":"Wild mouse gut microbiota promotes host fitness and improves disease resistance","volume":"171","author":"Rosshart","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.semcancer.2020.06.006_bib1155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/cr.2017.150","article-title":"Wild gut microbiota protects from disease","volume":"28","author":"Gazzaniga","year":"2018","journal-title":"Cell Res."},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib1160","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrc.2016.91","article-title":"Mouse models in oncoimmunology","volume":"16","author":"Zitvogel","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.semcancer.2020.06.006_bib1165","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/s41564-019-0491-9","article-title":"Modelling approaches for studying the microbiome","volume":"4","author":"Kumar","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"12","key":"10.1016\/j.semcancer.2020.06.006_bib1170","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41579-019-0242-1","article-title":"Simple animal models for microbiome research","volume":"17","author":"Douglas","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.semcancer.2020.06.006_bib1175","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/path.5236","article-title":"Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms","volume":"247","author":"Hamada","year":"2019","journal-title":"J. Pathol."}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X20301425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X20301425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T23:44:19Z","timestamp":1760917459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X20301425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":235,"alternative-id":["S1044579X20301425"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2020.06.006","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota contributes towards immunomodulation against cancer: New frontiers in precision cancer therapeutics","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2020.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}