{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:30:39Z","timestamp":1789425039714,"version":"build-2803163510"},"reference-count":200,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.semcancer.2021.01.006","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T01:25:10Z","timestamp":1611451510000},"page":"265-293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Pomegranate bioactive constituents target multiple oncogenic and oncosuppressive signaling for cancer prevention and intervention"],"prefix":"10.1016","volume":"73","author":[{"given":"Tin Lok","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla R.","family":"Strandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-5793","authenticated-orcid":false,"given":"Courtney R.","family":"Croley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyan C.","family":"Nagulapalli Venkata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Fimognari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-960X","authenticated-orcid":false,"given":"Anupam","family":"Bishayee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2021.01.006_bib0005","first-page":"128","article-title":"Therapeutic applications of pomegranate (Punica granatum L.): a review","volume":"13","author":"Jurenka","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1541-4337.2010.00131.x","article-title":"Pomegranate and its many functional components as related to human health: a review","volume":"9","author":"Viuda-Martos","year":"2010","journal-title":"Comp. Rev. Food Sci. Food Safety"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0015","series-title":"Genetic Diversity of Pomegranate Genotypes in Iran","author":"Shahr Babaki","year":"1997"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jep.2006.09.006","article-title":"Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer","volume":"109","author":"Lansky","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/2156587215598039","article-title":"A review study on Punica granatum L","volume":"21","author":"Shaygannia","year":"2016","journal-title":"J. Evid-Based Complemt. Alternat. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0030","first-page":"31","article-title":"Pomegranate (Punica granatum) plant genetic resources in Turkmenistan","volume":"97","author":"Levin","year":"1994","journal-title":"Plant Genet. Resour. Newsl."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1142\/S0192415X84000039","article-title":"Outline of the beginning of alchemy and its antecedents","volume":"12","author":"Mahdihassan","year":"1984","journal-title":"Am. J. Chin. Med."},{"issue":"7269","key":"10.1016\/j.semcancer.2021.01.006_bib0040","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1136\/bmj.321.7269.1153","article-title":"Why a pomegranate?","volume":"321","author":"Langley","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0045","first-page":"221","article-title":"Antibacterial, anti-fungal and antihelmintic investigations of Indian medicinal plants","volume":"62","author":"Naqvi","year":"1991","journal-title":"Fitoterapia"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0050","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2012.01.003","article-title":"Anti-urolithiatic effects of Punica granatum in male rats","volume":"140","author":"Rathod","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0055","first-page":"3","article-title":"Dentistry and Ayurveda V - an evidence based approach","volume":"2","author":"Amrutesh","year":"2011","journal-title":"Int. J. Clin. Dent. Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0060","first-page":"28","article-title":"Medicinal uses of Punica granatum and its health benefits","volume":"1","author":"Bhowmik","year":"2013","journal-title":"J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0065","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/107555304323062365","article-title":"Role of selected Indian plants in management of type 2 diabetes: a review","volume":"10","author":"Saxena","year":"2004","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0070","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/ptr.4913","article-title":"A comparative study on the inhibitory effects of different parts and chemical constituents of pomegranate on \u03b1-amylase and \u03b1-glucosidase","volume":"27","author":"Kam","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0378-8741(90)90051-T","article-title":"A study of plant crude drugs of Rayalaseema, Andhra Pradesh, India","volume":"29","author":"Nagaraju","year":"1990","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0378-8741(87)90050-X","article-title":"Screening of antimicrobial activity of plants popularly used in Guatemala for the treatment of dermatomucosal diseases","volume":"20","author":"C\u00e1ceres","year":"1987","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0085","first-page":"260","article-title":"Contribution to the study of plants used in traditional medicine in Tunisia","volume":"16","author":"Boukef","year":"1982","journal-title":"Plant Med. Phytother."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0090","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jn\/134.3.613","article-title":"Concentrations of proanthocyanidins in common foods and estimations of normal consumption","volume":"134","author":"Gu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0095","series-title":"Pomegranate: The Most Medicinal Fruit","author":"Newman","year":"2007"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-food-030810-153709","article-title":"Pomegranate as functional food and nutraceutical source","volume":"2","author":"Johanningsmeier","year":"2011","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0105","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/jf000404a","article-title":"Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing","volume":"48","author":"Gil","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0110","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1021\/jf0255735","article-title":"Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models","volume":"50","author":"Chidambara Murthy","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nutres.2007.12.001","article-title":"Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects","volume":"28","author":"Guo","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0120","series-title":"Herbal Medicine: Biomolecular and Clinical Aspects","first-page":"201","article-title":"Pomegranate ellagitannins","author":"Heber","year":"2011"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1753-4887.2008.00133.x","article-title":"Pomegranate juice: a heart-healthy fruit juice","volume":"67","author":"Basu","year":"2009","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0130","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/10408391003748100","article-title":"The bioactivity of pomegranate: impact on health and disease","volume":"51","author":"Faria","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0135","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jep.2012.07.004","article-title":"Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects","volume":"143","author":"Ismail","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0140","doi-asserted-by":"crossref","first-page":"789764","DOI":"10.1155\/2013\/789764","article-title":"Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents","volume":"2013","author":"Viladomiu","year":"2013","journal-title":"Evid-Based Complement. Altern. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0145","doi-asserted-by":"crossref","first-page":"686921","DOI":"10.1155\/2014\/686921","article-title":"Pomegranate fruit as a rich source of biologically active compounds","volume":"2014","author":"Sreekumar","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0150","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.3390\/molecules22101606","article-title":"Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum)","volume":"22","author":"Wu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0155","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3389\/fphar.2018.00544","article-title":"Vasculoprotective effects of pomegranate (Punica granatum L.)","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0160","doi-asserted-by":"crossref","first-page":"e1800773","DOI":"10.1002\/mnfr.201800773","article-title":"Beneficial effects of pomegranate on lipid metabolism in metabolic disorders","volume":"63","author":"Hou","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0165","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2174\/1381612825666190708183941","article-title":"Composition and potential health benefits of pomegranate: a review","volume":"25","author":"Vu\u010di\u0107","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0170","series-title":"Pomegranates Ancient Roots to Modern Medicine","first-page":"3","article-title":"Pomegranate phytochemicals","author":"Seeram","year":"2006"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0175","first-page":"385","article-title":"A comprehensive review of Punica granatum (Pomegranate) properties in toxicological, pharmacological, cellular and molecular biology researches","volume":"11","author":"Rahimi","year":"2012","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0180","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2174\/1871520611313080003","article-title":"Pomegranate extracts and cancer prevention: molecular and cellular activities","volume":"13","author":"Syed","year":"2013","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0185","doi-asserted-by":"crossref","first-page":"938475","DOI":"10.1155\/2015\/938475","article-title":"Potential effects of pomegranate polyphenols in cancer prevention and therapy","volume":"2015","author":"Turrini","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/molecules22010177","article-title":"Pomegranate for prevention and treatment of cancer: an update","volume":"22","author":"Sharma","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0195","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ptr.5784","article-title":"Anticancer activity of Punica granatum (Pomegranate): a review","volume":"31","author":"Panth","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0200","first-page":"345","article-title":"Punica granatum (Pomegranate) activity in health promotion and cancer prevention","volume":"12","author":"Bassiri-Jahromi","year":"2018","journal-title":"Oncol. Rev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0205","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.phrs.2018.04.021","article-title":"Possible use of Punica granatum (Pomegranate) in cancer therapy","volume":"133","author":"Khwairakpam","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0210","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1753-4887.2009.00268.x","article-title":"Pomegranate and breast cancer: possible mechanisms of prevention","volume":"68","author":"Sturgeon","year":"2010","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/biof.1206","article-title":"Punica granatum and its therapeutic implications on breast carcinogenesis: a review","volume":"41","author":"Vini","year":"2015","journal-title":"Biofactors"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0220","first-page":"346","article-title":"The role of pomegranate (Punica granatum L.) in colon cancer","volume":"22","author":"Khan","year":"2009","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0225","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.3748\/wjg.v20.i16.4618","article-title":"Role of pomegranate and citrus fruit juices in colon cancer prevention","volume":"20","author":"Jaganathan","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0230","doi-asserted-by":"crossref","first-page":"14949","DOI":"10.3390\/ijms150914949","article-title":"Pomegranate and its components as alternative treatment for prostate cancer","volume":"15","author":"Wang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0235","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/pcan.2017.19","article-title":"A review of pomegranate in prostate cancer","volume":"20","author":"Paller","year":"2017","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0240","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/ptr.6565","article-title":"Anti-inflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: evidence from cellular, animal, and clinical studies","volume":"34","author":"Baradaran Rahimi","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0245","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/food.19900340706","article-title":"Chemical composition of juice and seeds of pomegranate fruit","volume":"7","author":"El-Nemr","year":"1990","journal-title":"Die Nahrung"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0250","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ijbiomac.2017.06.022","article-title":"Phytochemical content, fatty acids composition and antioxidant potential of different pomegranate parts: comparison between edible and non-edible varieties grown in Tunisia","volume":"104","author":"Amri","year":"2017","journal-title":"Intl. J. Biol. Macromol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0255","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.foodchem.2018.04.039","article-title":"Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L) peel: a review","volume":"261","author":"Singh","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0260","first-page":"492","article-title":"Determination of phenolic compounds in pomegranate juice by HPLC","volume":"8","author":"Artik","year":"1998","journal-title":"Fruit Proc."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0265","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF02273936","article-title":"Polyphenols of pomegranate peel show marked antitumor and antiviral activity","volume":"33","author":"Mavlyanov","year":"1997","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0270","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1021\/jf302600q","article-title":"Ellagic acid and polyhydroxylated urolithins are potent catalytic inhibitors of human topoisomerase II: an in vitro study","volume":"60","author":"Furlanetto","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0275","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2621.1975.tb02217.x","article-title":"Anthocyanins of pomegranate, Punica granatum","volume":"40","author":"Du","year":"1975","journal-title":"J. Food Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0280","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/jf010865b","article-title":"Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models","volume":"50","author":"Singh","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0285","first-page":"123","article-title":"Studies on pomegranate seed oil","volume":"85","author":"El-Shaarawy","year":"1983","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-8741(98)00222-0","article-title":"Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids","volume":"66","author":"Schubert","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0295","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1248\/cpb.34.650","article-title":"Tannins and related compounds IL. Revision of structures of punicalin and punicalagin and isolation and characterization of 2-O-galloylpunicalin from the bark of Punica granatum L","volume":"34","author":"Tanaka","year":"1986","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0300","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0031-9422(00)89820-9","article-title":"NMR spectral analysis of polyphenols from Punica granatum L","volume":"36","author":"Nawwar","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0305","first-page":"389","article-title":"Alkaloids in the bark of Punica granatum L. (pomegranate) from Yugoslovia","volume":"48","author":"Neuhofer","year":"1993","journal-title":"Pharmazie"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0310","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jep.2003.09.001","article-title":"Studies on the toxicity of Punica granatum L. (Puniceae) whole fruit extracts","volume":"89","author":"Vidal","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0315","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0021-9673(00)00625-7","article-title":"High-performance of liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits","volume":"891","author":"Amakura","year":"2000","journal-title":"J. Chromatrograph. A"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0320","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0031-9422(00)84654-3","article-title":"Crystalline chemical components of some vegetable drugs","volume":"12","author":"Batta","year":"1973","journal-title":"Phytochemistry"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0325","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"21","author":"Liberati","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0330","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1014405730585","article-title":"Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer","volume":"71","author":"Kim","year":"2002","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0335","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/B:AGEN.0000011802.81320.e4","article-title":"Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo","volume":"6","author":"Toi","year":"2003","journal-title":"Angiogenesis"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0340","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/jmf.2005.8.469","article-title":"Anticancer activities of pomegranate extracts and genistein in human breast cancer cells","volume":"8","author":"Louis Jeune","year":"2005","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0345","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/1534735409341405","article-title":"Pomegranate fruit extract impairs invasion and motility in human breast cancer","volume":"8","author":"Khan","year":"2009","journal-title":"Integ. Cancer Ther."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0350","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10549-012-2264-5","article-title":"Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer","volume":"136","author":"Rocha","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0355","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1080\/01635581.2017.1359318","article-title":"Pomegranate extract alters breast cancer stem cell properties in association with inhibition of epithelial-to-mesenchymal transition","volume":"69","author":"Nallanthighal","year":"2017","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0360","first-page":"102","article-title":"Gene expression changes in pomegranate peel extract-treated triple-negative breast cancer cells","volume":"7","author":"Ahmadiankia","year":"2018","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0365","doi-asserted-by":"crossref","first-page":"86","DOI":"10.14715\/cmb\/2018.64.7.15","article-title":"Pomegranate peel extract inhibits expression of \u03b2-catenin, epithelial mesenchymal transition, and metastasis in triple negative breast cancer cells","volume":"64","author":"Bagheri","year":"2018","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0370","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1158\/1940-6207.CAPR-08-0225","article-title":"Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro","volume":"3","author":"Adams","year":"2010","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/07435800903524161","article-title":"Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity","volume":"35","author":"Tran","year":"2010","journal-title":"Endocr. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0380","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jnutbio.2011.03.015","article-title":"Pomegranate extract demonstrate a selective estrogen receptor modulator profile in human tumor cell lines and in vivo models of estrogen deprivation","volume":"23","author":"Sreeja","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0385","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/iub.1465","article-title":"Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27 hydroxylcholesterol","volume":"68","author":"Vini","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0390","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.carbpol.2013.07.023","article-title":"A galactomannan polysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity","volume":"98","author":"Joseph","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0395","first-page":"1087","article-title":"Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro","volume":"24","author":"Dai","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0400","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1021\/jf903762h","article-title":"Colon cancer chemopreventive activities of pomegranate ellagitannins and Urolithins","volume":"58","author":"Kasimsetty","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0405","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12079-011-0138-y","article-title":"Pomegranate sensitizes tamoxifen action in ER-alpha positive breast cancer cells","volume":"5","author":"Banerjee","year":"2011","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0410","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1089\/jmf.2011.0062","article-title":"The antioxidant potency of Punica granatum L. fruit peel reduces cell proliferation and induces apoptosis on breast cancer cells","volume":"14","author":"Dikmen","year":"2011","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0415","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.7314\/APJCP.2015.16.14.5697","article-title":"AntiTumoral properties of Punica granatum (Pomegranate) peel extract on different human cancer cells","volume":"16","author":"Modaeinama","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0420","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1039\/C8FO01394B","article-title":"Finding solutions for agricultural wastes: antioxidant and antitumor properties of pomegranate Akko peel extracts and \u03b2-glucan recovery","volume":"9","author":"Fazio","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0425","first-page":"688","article-title":"Antioxidant and cancer chemopreventive activities of cistus and pomegranate polyphenols","volume":"74","author":"Moreira","year":"2017","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0430","first-page":"489","article-title":"Evaluation of antioxidant, antitumor and immunomodulatory properties of polysaccharide isolated from fruit rind of Punica granatum","volume":"5","author":"Joseph","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0435","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodres.2012.07.059","article-title":"Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk","volume":"49","author":"Aqil","year":"2012","journal-title":"Food Res. Int."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0440","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/mc.21995","article-title":"Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks","volume":"53","author":"Shirode","year":"2014","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0445","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10549-012-2224-0","article-title":"Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and in vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation","volume":"136","author":"Banerjee","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0450","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.3390\/molecules19068644","article-title":"Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines","volume":"19","author":"Costantini","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0455","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.foodchem.2014.06.123","article-title":"Punica granatum cv. Dente di Cavallo seed ethanolic extract: antioxidant and antiproliferative activities","volume":"167","author":"Lucci","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0460","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.7314\/APJCP.2016.17.3.1119","article-title":"AntiTumoral properties of Punica granatum (Pomegranate) seed extract in different human cancer cells","volume":"17","author":"Seidi","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0465","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1089\/jmf.2012.0275","article-title":"Chemical composition and antioxidant, anti-inflammatory, and antiproliferation activities of pomegranate (Punica granatum) flowers","volume":"16","author":"Bekir","year":"2013","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0470","first-page":"475","article-title":"Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention","volume":"10","author":"Shirode","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0475","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jbiotec.2017.09.012","article-title":"Investigation of the effect of pomegranate extract and monodisperse silver nanoparticle combination on MCF-7 cell line","volume":"260","author":"\u015eahin","year":"2017","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0480","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.colsurfb.2017.12.042","article-title":"Cytotoxic effects of platinum nanoparticles obtained from pomegranate extract by the green synthesis method on the MCF-7 cell line","volume":"163","author":"\u015eahin","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0485","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.2147\/IJN.S154033","article-title":"Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study","volume":"13","author":"Badawi","year":"2018","journal-title":"Int. J. Nanomed. Nanosurg."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0490","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/01.cej.0000136571.70998.5a","article-title":"Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture","volume":"13","author":"Mehta","year":"2004","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0495","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/01635581.2016.1115094","article-title":"Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis","volume":"68","author":"Bishayee","year":"2016","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0500","doi-asserted-by":"crossref","first-page":"22315","DOI":"10.3390\/molecules201219853","article-title":"Mechanism of breast cancer preventive action of pomegranate: disruption of estrogen receptor and wnt\/\u03b2-catenin signaling pathways","volume":"20","author":"Mandal","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0505","doi-asserted-by":"crossref","first-page":"E436","DOI":"10.3390\/nu9050436","article-title":"Anti-inflammatory mechanism involved in pomegranate-mediated prevention of breast cancer: the role of NF-\u03baB and Nrf2 signaling pathways","volume":"9","author":"Mandal","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0510","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.prostaglandins.2019.03.005","article-title":"Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract","volume":"142","author":"Lepionka","year":"2019","journal-title":"Prostaglandins Lipid Mediat."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0515","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jnutbio.2005.01.006","article-title":"In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice","volume":"16","author":"Seeram","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0520","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2174\/187152010794474000","article-title":"Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells","volume":"10","author":"Weisburg","year":"2010","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0525","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/carcin\/bgt295","article-title":"Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126\/VCAM-1 and miR-126\/PI3K\/AKT\/mTOR","volume":"34","author":"Banerjee","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0530","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1021\/acs.jafc.8b02458","article-title":"Ellagitannins from pomegranate ameliorates 5-Fluorouracil-Induced intestinal mucositis in rats while enhancing its chemotoxicity against HT-29 colorectal cancer cells through intrinsic apoptosis induction","volume":"66","author":"Chen","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0535","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.ijbiomac.2018.06.194","article-title":"Galactomannan endowed biogenic silver nanoparticles exposed enhanced cancer cytotoxicity with excellent biocompatibility","volume":"118","author":"Padinjarathil","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0540","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jnutbio.2005.09.004","article-title":"The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway","volume":"17","author":"Larrosa","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0545","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s11671-018-2731-y","article-title":"Antimicrobial and cytotoxicity effects of synthesized silver nanoparticles from Punica granatum peel extract","volume":"13","author":"Devanesan","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0550","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1349-7006.2004.tb03236.x","article-title":"Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats","volume":"95","author":"Kohno","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0555","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.fct.2006.10.019","article-title":"Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats","volume":"45","author":"Boateng","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0560","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.7314\/APJCP.2012.13.8.4051","article-title":"Pomegranate (Punica granatum) peel extract efficacy as a dietary antioxidant against azoxymethane-induced colon cancer in rat","volume":"13","author":"Waly","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"2014","key":"10.1016\/j.semcancer.2021.01.006_bib0565","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1472-6882-14-60","article-title":"Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts","volume":"14","author":"Waly","year":"2014","journal-title":"BMC Complement. Alternat. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0570","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/01635581.2017.1263745","article-title":"Red wine and pomegranate extracts suppress cured meat promotion of colonic mucin-depleted foci in carcinogen-induced rats","volume":"69","author":"Bastide","year":"2017","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0575","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s10620-013-2704-z","article-title":"Inhibitory effect of a standardized pomegranate fruit extract onwnt signalling in 1,2-dimethylhydrazine induced rat colon carcinogenesis","volume":"58","author":"Sadik","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0580","doi-asserted-by":"crossref","first-page":"1700401","DOI":"10.1002\/mnfr.201700401","article-title":"Pomegranate by-products in colorectal cancer chemoprevention: effects in Apc-mutated Pirc rats and mechanistic studies in vitro and ex vivo","volume":"62","author":"Tortora","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0585","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1186\/s40064-016-2639-x","article-title":"A systematic determination of polyphenols constituents and cytotoxic ability in fruit parts of pomegranates derived from five Chinese cultivars","volume":"5","author":"Li","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0590","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.fct.2016.04.020","article-title":"Pomegranate peel extract polyphenols induced apoptosis in human hepatoma cells by mitochondrial pathway","volume":"93","author":"Song","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0595","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/21691401.2017.1337031","article-title":"Exploiting antidiabetic activity of silver nanoparticles synthesized using Punica granatum leaves and anticancer potential against human liver cancer cells (HepG2)","volume":"46","author":"Saratale","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0600","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/carcin\/bgr045","article-title":"Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms","volume":"32","author":"Bishayee","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0605","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jnutbio.2012.04.009","article-title":"Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis","volume":"24","author":"Bishayee","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0610","first-page":"371813","article-title":"Pomegranate bioactive constituents suppress cell proliferation and induce apoptosis in an experimental model of hepatocellular carcinoma: role of wnt\/\u03b2 -catenin signaling pathway","volume":"2013","author":"Bhatia","year":"2013","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0615","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1080\/01635581.2016.1192205","article-title":"Effect of pomegranate hull extract on liver neoplastic changes in rats: more than an antioxidant","volume":"68","author":"El-Ashmawy","year":"2016","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0620","first-page":"2699","article-title":"Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells","volume":"31","author":"Nair","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0625","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1021\/jf073469n","article-title":"Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro","volume":"56","author":"McDougall","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0630","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.12659\/MSM.898658","article-title":"Inhibition of cervical cancer by promoting IGFBP7 expression using ellagic acid from pomegranate peel","volume":"22","author":"Guo","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0635","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3892\/mmr.2017.6687","article-title":"Punicalagin suppresses the proliferation and invasion of cervical cancer cells through inhibition of the \u03b2-catenin pathway","volume":"16","author":"Tang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0640","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1080\/15384047.2017.1394542","article-title":"Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9","volume":"18","author":"Liu","year":"2017","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0645","first-page":"306","article-title":"Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro","volume":"26","author":"Settheetham","year":"1995","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0650","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/109662004322984644","article-title":"Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells","volume":"7","author":"Kawaii","year":"2004","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0655","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/01635581.2012.630155","article-title":"Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia","volume":"64","author":"Dahlawi","year":"2012","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0660","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/fsn3.26","article-title":"Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines","volume":"1","author":"Dahlawi","year":"2013","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0665","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/mnfr.201000528","article-title":"Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects","volume":"55","author":"Li","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0670","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/2229-516X.157154","article-title":"Growth inhibitory effects of crude pomegranate peel extract on chronic myeloid leukemia, K562 cells","volume":"5","author":"Asmaa","year":"2015","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0675","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s13277-015-3962-5","article-title":"Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells","volume":"37","author":"Kiraz","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0680","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3390\/nu8100611","article-title":"Antiproliferative and antiangiogenic effects of Punica granatum juice (PGJ) in multiple myeloma (MM)","volume":"8","author":"Tibullo","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0685","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/carcin\/bgl145","article-title":"Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice","volume":"28","author":"Khan","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0690","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.biopha.2016.03.023","article-title":"Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro","volume":"80","author":"Li","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0695","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1021\/jf0626720","article-title":"In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin","volume":"55","author":"Kulkarni","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0700","doi-asserted-by":"crossref","first-page":"467465","DOI":"10.1155\/2014\/467465","article-title":"Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts","volume":"2014","author":"Zahin","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0705","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1158\/0008-5472.CAN-06-3941","article-title":"Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice","volume":"67","author":"Khan","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0710","doi-asserted-by":"crossref","first-page":"6063201","DOI":"10.1155\/2017\/6063201","article-title":"Pomegranate juice prevents the formation of lung nodules secondary to chronic cigarette smoke exposure in an animal model","volume":"2017","author":"Husari","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0715","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/aps.2013.98","article-title":"Punicalagin induces apoptotic and autophagic cell death in human U87MG glioma cells","volume":"34","author":"Wang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0720","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.colsurfb.2015.04.023","article-title":"Ketoprofen-loaded pomegranate seed oil nanoemulsion stabilized by pullulan: selective antiglioma formulation for intravenous administration","volume":"130","author":"Ferreira","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0725","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1080\/13880209.2016.1199039","article-title":"Pomegranate seed oil nanoemulsions with selective antiglioma activity: optimization and evaluation of cytotoxicity, genotoxicity and oxidative effects on mononuclear cells","volume":"54","author":"Ferreira","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0730","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/10966200360716553","article-title":"Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice","volume":"6","author":"Hora","year":"2003","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0735","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ijc.20587","article-title":"Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-\u03baB pathways and inhibits skin tumorigenesis in CD-1 mice","volume":"113","author":"Afaq","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0740","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.fct.2011.03.040","article-title":"Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs\/NF-\u03baB and reduced cell proliferation","volume":"49","author":"George","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0745","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.foodchem.2016.01.106","article-title":"Evaluation of different extraction methods from pomegranate whole fruit or peels and the antioxidant and antiproliferative activity of the polyphenolic fraction","volume":"202","author":"Masci","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0750","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/ptr.5267","article-title":"Anti-proliferative effects of polyphenols from pomegranate rind (Punica granatum L.) on EJ bladder cancer cells via regulation of p53\/miR-34a axis","volume":"29","author":"Zhou","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0755","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/1472-6882-13-364","article-title":"Suppression of urinary bladder urothelial carcinoma cell by the ethanol extract of pomegranate fruit through cell cycle arrest and apoptosis","volume":"13","author":"Lee","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0760","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12906-016-1071-7","article-title":"Clarification of the molecular pathway of Taiwan local pomegranate fruit juice underlying the inhibition of urinary bladder urothelial carcinoma cell by proteomics strategy","volume":"16","author":"Wu","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0765","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/nu10050543","article-title":"Deciphering the molecular mechanism underlying the inhibitory efficacy of taiwanese local pomegranate peels against urinary bladder urothelial carcinoma","volume":"10","author":"Chang","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0770","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1089\/jmf.2004.7.274","article-title":"Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells","volume":"7","author":"Albrecht","year":"2004","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0775","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/B:DRUG.0000047101.02178.07","article-title":"Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions","volume":"23","author":"Lansky","year":"2005","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0780","doi-asserted-by":"crossref","first-page":"14813","DOI":"10.1073\/pnas.0505870102","article-title":"Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer","volume":"102","author":"Malik","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0785","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jnutbio.2007.11.006","article-title":"Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor","volume":"19","author":"Hong","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0790","first-page":"475","article-title":"Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo","volume":"32","author":"Sartippour","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0795","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1158\/1535-7163.MCT-08-0136","article-title":"Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-\u03baB-dependent mechanism","volume":"7","author":"Rettig","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0800","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ghir.2009.09.003","article-title":"Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis","volume":"20","author":"Koyama","year":"2010","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0805","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1039\/c0ib00122h","article-title":"Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells","volume":"3","author":"Wang","year":"2011","journal-title":"Integr. Biol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0810","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1593\/tlo.12190","article-title":"Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis","volume":"5","author":"Wang","year":"2012","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0815","first-page":"547942","article-title":"Studies on the cytotoxic activities of Punica granatum L. var. spinosa (Apple Punice) extract on prostate cell line by induction of apoptosis","volume":"2012","author":"Sepehr","year":"2012","journal-title":"ISRN Pharm."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0820","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.biopha.2017.07.008","article-title":"The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells","volume":"93","author":"Deng","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0825","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1021\/jf071303g","article-title":"Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland","volume":"55","author":"Seeram","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0830","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/carcin\/bgu145","article-title":"Luteolin, ellagic acid and punicic acid are natural products that inhibit prostate cancer metastasis","volume":"35","author":"Wang","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0835","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/carcin\/bgr308","article-title":"Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model","volume":"33","author":"Adhami","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0840","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1080\/01635581.2015.1073756","article-title":"Effects of pomegranate juice on hormonal biomarkers of breast cancer risk","volume":"67","author":"Kapoor","year":"2015","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0845","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/mnfr.201300931","article-title":"Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients","volume":"58","author":"Nu\u00f1ez-S\u00e1nchez","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0850","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1002\/mnfr.201500357","article-title":"MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: critical issues to discern between modulatory effects and potential artefacts","volume":"59","author":"Nu\u00f1ez-S\u00e1nchez","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0855","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jnutbio.2017.01.014","article-title":"Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial","volume":"42","author":"Nu\u00f1ez-S\u00e1nchez","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0860","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1039\/C8FO00264A","article-title":"Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial","volume":"9","author":"Gonz\u00e1lez-Sarr\u00edas","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0865","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1158\/1078-0432.CCR-05-2290","article-title":"Phase II study of Pomegranate Juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer","volume":"12","author":"Pantuck","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0870","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/pcan.2015.32","article-title":"A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer","volume":"18","author":"Pantuck","year":"2015","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0875","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pcan.2012.20","article-title":"A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer","volume":"16","author":"Paller","year":"2013","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0880","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1158\/1940-6207.CAPR-12-0423","article-title":"A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy","volume":"6","author":"Freedland","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0885","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/mnfr.200900152","article-title":"Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice","volume":"54","author":"Gonzalez-Sarrias","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0890","doi-asserted-by":"crossref","first-page":"597","DOI":"10.7150\/jca.7123","article-title":"Daily pomegranate intake has no impact on PSA Levels in patients with advanced prostate cancer - results of a phase IIb randomized controlled trial","volume":"4","author":"Stenner-Liewen","year":"2013","journal-title":"J. Cancer"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0895","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/pcan.2014.6","article-title":"A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer\u2013the U. K. NCRN Pomi-T study","volume":"17","author":"Thomas","year":"2014","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0900","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1021\/jf020842c","article-title":"Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic","volume":"51","author":"Cerd\u00e1","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0905","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00394-003-0396-4","article-title":"Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice","volume":"42","author":"Cerd\u00e1","year":"2003","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0910","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1021\/jf0723864","article-title":"Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans","volume":"55","author":"Esp\u00edn","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0915","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cccn.2004.04.029","article-title":"Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice","volume":"348","author":"Seeram","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0920","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/jn\/136.10.2481","article-title":"Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours","volume":"136","author":"Seeram","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0925","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1089\/jmf.2007.650","article-title":"Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects","volume":"11","author":"Seeram","year":"2008","journal-title":"J. Med. Food"},{"key":"10.1016\/j.semcancer.2021.01.006_bib0930","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00394-004-0461-7","article-title":"The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans","volume":"43","author":"Cerd\u00e1","year":"2004","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0935","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1021\/jf050384i","article-title":"Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds","volume":"53","author":"Cerd\u00e1","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0940","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1021\/jf061674h","article-title":"Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers","volume":"54","author":"Mertens-Talcott","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0945","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.1021\/acs.jafc.9b04435","article-title":"Identification of novel urolithin metabolites in human feces and urine after the intake of a pomegranate extract","volume":"67","author":"Garc\u00eda-Villalba","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0950","doi-asserted-by":"crossref","first-page":"258598","DOI":"10.1155\/2015\/258598","article-title":"Efficacy and safety of pomegranate medicinal products for cancer","volume":"2015","author":"Vlachojannis","year":"2015","journal-title":"Evid-Based Complement. Alternat. Med."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0955","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jep.2007.10.011","article-title":"Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts","volume":"115","author":"S\u00e1nchez-Lamar","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0960","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.fct.2009.01.031","article-title":"Toxicological evaluation of pomegranate seed oil","volume":"47","author":"Meerts","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0965","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fct.2017.07.050","article-title":"Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid","volume":"108","author":"Heilman","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0970","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1016\/j.fct.2008.04.035","article-title":"Safety assessment of pomegranate fruit extract: acute and subchronic toxicity studies","volume":"46","author":"Patel","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0975","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1590\/S1984-82502010000100014","article-title":"Assessment of mutagenic and antimutagenic effects of Punica granatum in mice","volume":"46","author":"Valadares","year":"2010","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0980","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1021\/jf8000857","article-title":"Safety evaluation of an oak-flavored milk powder containing ellagitannins upon oral administration in the rat","volume":"56","author":"Azor\u00edn-Ortu\u00f1o","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0985","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/sj.ijir.3901570","article-title":"Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study","volume":"19","author":"Forest","year":"2007","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0990","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1053\/j.jrn.2014.07.006","article-title":"A pilot randomized crossover trial assessing the safety and short-term effects of pomegranate supplementation in hemodialysis patients","volume":"25","author":"Rivara","year":"2015","journal-title":"J. Ren. Nutr."},{"key":"10.1016\/j.semcancer.2021.01.006_bib0995","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nutres.2017.07.007","article-title":"Evidence for the effectiveness of pomegranate supplementation for blood pressure management is weak: a systematic review of randomized clinical trials","volume":"46","author":"Gbinigie","year":"2017","journal-title":"Nutr. Res."},{"key":"10.1016\/j.semcancer.2021.01.006_bib1000","doi-asserted-by":"crossref","first-page":"10050","DOI":"10.1021\/jf071689v","article-title":"Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size","volume":"55","author":"Heber","year":"2007","journal-title":"J. Agric. Food Chem."}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X21000122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X21000122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T23:50:51Z","timestamp":1760917851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X21000122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":200,"alternative-id":["S1044579X21000122"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2021.01.006","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pomegranate bioactive constituents target multiple oncogenic and oncosuppressive signaling for cancer prevention and intervention","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2021.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}