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Cancer Res."},{"key":"10.1016\/j.semcancer.2021.03.038_bib0345","doi-asserted-by":"crossref","DOI":"10.1177\/1179064418767882","article-title":"CD133 promotes adhesion to the ovarian cancer metastatic niche","volume":"11","author":"Roy","year":"2018","journal-title":"Cancer Growth Metastasis"},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0350","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s004010050442","article-title":"CD24, a glycosylphosphatidylinositol-anchored molecules is transiently expressed during the development of human central nervous system and is a marker of human neural cell lineage tumors","volume":"91","author":"Poncet","year":"1996","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.semcancer.2021.03.038_bib0355","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/cmi.2009.119","article-title":"CD24: from A to Z","volume":"7","author":"Fang","year":"2010","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0360","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1002\/jcp.27581","article-title":"Overview of CD24 as a new molecular marker in ovarian cancer","volume":"234","author":"Tarhriz","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"20","key":"10.1016\/j.semcancer.2021.03.038_bib0365","first-page":"4717","article-title":"Cloning and expression of CD24 gene in human hepatocellular carcinoma: a potential early tumor marker gene correlates with p53 mutation and tumor differentiation","volume":"55","author":"Huang","year":"1995","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0370","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","article-title":"Identification of pancreatic cancer stem cells","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res."},{"issue":"18","key":"10.1016\/j.semcancer.2021.03.038_bib0375","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1038\/onc.2010.35","article-title":"CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells","volume":"29","author":"Gao","year":"2010","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.semcancer.2021.03.038_bib0380","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1158\/1535-7163.MCT-14-0607","article-title":"CD24+ ovarian Cancer cells are enriched for cancer-initiating cells and dependent on JAK2 signaling for growth and metastasis","volume":"14","author":"Burgos-Ojeda","year":"2015","journal-title":"Mol. Cancer Ther."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0385","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1073\/pnas.76.3.1438","article-title":"Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies","volume":"76","author":"Herlyn","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.semcancer.2021.03.038_bib0390","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ncb1824","article-title":"Nuclear signalling by tumour-associated antigen EpCAM","volume":"11","author":"Maetzel","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.semcancer.2021.03.038_bib0395","first-page":"143","article-title":"On the abundance of EpCAM on cancer stem cells, Nature reviews","volume":"9","author":"Gires","year":"2009","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0400","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/carcin\/bgq187","article-title":"EpCAM in carcinogenesis: the good, the bad or the ugly","volume":"31","author":"van der Gun","year":"2010","journal-title":"Carcinogenesis"},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0405","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/carcin\/bgr183","article-title":"Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells","volume":"32","author":"Motohara","year":"2011","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0410","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/pr.111.005538","article-title":"Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application","volume":"64","author":"Koppaka","year":"2012","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0415","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/1479-7364-5-4-283","article-title":"Update on the aldehyde dehydrogenase gene (ALDH) superfamily","volume":"5","author":"Jackson","year":"2011","journal-title":"Hum. Genomics"},{"issue":"10","key":"10.1016\/j.semcancer.2021.03.038_bib0420","doi-asserted-by":"crossref","first-page":"11018","DOI":"10.18632\/oncotarget.6920","article-title":"Aldehyde dehydrogenase 1A1 in stem cells and cancer","volume":"7","author":"Tomita","year":"2016","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0425","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1016\/j.celrep.2019.02.032","article-title":"A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells","volume":"26","author":"Chefetz","year":"2019","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.semcancer.2021.03.038_bib0430","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1158\/1535-7163.MCT-10-0563","article-title":"Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer","volume":"9","author":"Landen","year":"2010","journal-title":"Mol. Cancer Ther."},{"issue":"21","key":"10.1016\/j.semcancer.2021.03.038_bib0435","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1158\/0008-5472.CAN-16-0225","article-title":"EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells","volume":"76","author":"Bai","year":"2016","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0440","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1158\/0008-5472.CAN-10-3175","article-title":"Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival","volume":"71","author":"Silva","year":"2011","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.semcancer.2021.03.038_bib0445","first-page":"221","article-title":"ALDH enzymatic activity and CD133 positivity and response to chemotherapy in ovarian cancer patients","volume":"3","author":"Ricci","year":"2013","journal-title":"Am. J. Cancer Res."},{"issue":"50","key":"10.1016\/j.semcancer.2021.03.038_bib0450","doi-asserted-by":"crossref","first-page":"E6882","DOI":"10.1073\/pnas.1507899112","article-title":"Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2","volume":"112","author":"Choi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcancer.2021.03.038_bib0455","doi-asserted-by":"crossref","first-page":"84","DOI":"10.12688\/f1000research.9977.1","article-title":"Recent advances in understanding, diagnosing, and treating ovarian cancer","volume":"6","author":"Mills","year":"2017","journal-title":"F1000Research"},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0460","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1172\/JCI41004","article-title":"The therapeutic promise of the cancer stem cell concept","volume":"120","author":"Frank","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0465","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s12015-011-9344-5","article-title":"Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches","volume":"8","author":"Aguilar-Gallardo","year":"2012","journal-title":"Stem Cell Rev. Rep."},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0470","first-page":"275","article-title":"Tumour stem cells and drug resistance, Nature reviews","volume":"5","author":"Dean","year":"2005","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0475","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.18632\/oncotarget.3220","article-title":"Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer","volume":"6","author":"Gao","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0480","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4161\/cc.8.1.7533","article-title":"Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance","volume":"8","author":"Alvero","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcancer.2021.03.038_bib0485","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.biocel.2015.02.001","article-title":"Differential activation of NF-kappaB signaling is associated with platinum and taxane resistance in MyD88 deficient epithelial ovarian cancer cells","volume":"61","author":"Gaikwad","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"24","key":"10.1016\/j.semcancer.2021.03.038_bib0490","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1158\/0008-5472.CAN-17-0366","article-title":"NFkappaB promotes ovarian tumorigenesis via classical pathways that support proliferative cancer cells and alternative pathways that support ALDH(+) cancer stem-like cells","volume":"77","author":"House","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2021.03.038_bib0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biocel.2018.03.015","article-title":"Blockade of nuclear factor-kappaB (NF-kappaB) pathway inhibits growth and induces apoptosis in chemoresistant ovarian carcinoma cells","volume":"99","author":"Momeny","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0500","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.arcmed.2017.08.001","article-title":"NF-kappaB participates in the stem cell phenotype of ovarian cancer cells","volume":"48","author":"Gonzalez-Torres","year":"2017","journal-title":"Arch. Med. Res."},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0505","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1600-0897.2010.00914.x","article-title":"Regulation of inflammation by the NF-kappaB pathway in ovarian cancer stem cells","volume":"65","author":"Leizer","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"issue":"27","key":"10.1016\/j.semcancer.2021.03.038_bib0510","doi-asserted-by":"crossref","first-page":"23720","DOI":"10.18632\/oncotarget.4690","article-title":"Critical role of Wnt\/beta-catenin signaling in driving epithelial ovarian cancer platinum resistance","volume":"6","author":"Nagaraj","year":"2015","journal-title":"Oncotarget"},{"issue":"27","key":"10.1016\/j.semcancer.2021.03.038_bib0515","doi-asserted-by":"crossref","first-page":"44312","DOI":"10.18632\/oncotarget.17871","article-title":"The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer","volume":"8","author":"Tayama","year":"2017","journal-title":"Oncotarget"},{"issue":"16","key":"10.1016\/j.semcancer.2021.03.038_bib0520","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1038\/s41388-017-0106-y","article-title":"Aggressive serous epithelial ovarian cancer is potentially propagated by EpCAM(+)CD45(+) phenotype","volume":"37","author":"Akhter","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.semcancer.2021.03.038_bib0525","first-page":"153","article-title":"Primary surgery or neoadjuvant chemotherapy in advanced ovarian cancer: the debate continues, American society of clinical oncology educational book","volume":"35","author":"Leary","year":"2016","journal-title":"Am. Soc. Clin. Oncol. Ann. Meet."},{"issue":"12","key":"10.1016\/j.semcancer.2021.03.038_bib0530","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S1470-2045(18)30566-7","article-title":"Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials","volume":"19","author":"Vergote","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.semcancer.2021.03.038_bib0535","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejca.2020.02.020","article-title":"Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III\/IV ovarian, tubal and peritoneal cancers in phase III randomised trial","volume":"130","author":"Onda","year":"2020","journal-title":"Eur. J. Cancer"},{"issue":"9","key":"10.1016\/j.semcancer.2021.03.038_bib0540","doi-asserted-by":"crossref","first-page":"8614","DOI":"10.18632\/oncotarget.23808","article-title":"The role of neoadjuvant chemotherapy followed by interval debulking surgery in advanced ovarian cancer: a systematic review and meta-analysis of randomized controlled trials and observational studies","volume":"9","author":"Qin","year":"2018","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.semcancer.2021.03.038_bib0545","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1056\/NEJMoa0908806","article-title":"Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer","volume":"363","author":"Vergote","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"9990","key":"10.1016\/j.semcancer.2021.03.038_bib0550","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(14)62223-6","article-title":"Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial","volume":"386","author":"Kehoe","year":"2015","journal-title":"Lancet"},{"issue":"32","key":"10.1016\/j.semcancer.2021.03.038_bib0555","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1200\/JCO.2016.68.1239","article-title":"Use and effectiveness of neoadjuvant chemotherapy for treatment of ovarian cancer","volume":"34","author":"Meyer","year":"2016","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0560","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ygyno.2013.01.009","article-title":"Platinum resistance after neoadjuvant chemotherapy compared to primary surgery in patients with advanced epithelial ovarian carcinoma","volume":"129","author":"Rauh-Hain","year":"2013","journal-title":"Gynecol. Oncol."},{"issue":"18","key":"10.1016\/j.semcancer.2021.03.038_bib0565","doi-asserted-by":"crossref","first-page":"16437","DOI":"10.18632\/oncotarget.4103","article-title":"Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer","volume":"6","author":"Ayub","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcancer.2021.03.038_bib0570","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-12-24","article-title":"Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden","volume":"12","author":"Abubaker","year":"2013","journal-title":"Mol. 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Pathol."},{"issue":"7035","key":"10.1016\/j.semcancer.2021.03.038_bib0585","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.semcancer.2021.03.038_bib0590","doi-asserted-by":"crossref","first-page":"E2939","DOI":"10.1073\/pnas.1206400109","article-title":"Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy","volume":"109","author":"McAuliffe","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0595","first-page":"797","article-title":"Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells","volume":"39","author":"Ray","year":"2011","journal-title":"Int. J. Oncol."},{"issue":"8","key":"10.1016\/j.semcancer.2021.03.038_bib0600","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrclinonc.2015.61","article-title":"Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update","volume":"12","author":"Takebe","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.semcancer.2021.03.038_bib0605","first-page":"625","article-title":"Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer","volume":"53","author":"Chen","year":"2014","journal-title":"Mol. Carcinog."},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0610","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/s41416-020-0825-7","article-title":"Chemotherapy exacerbates ovarian cancer cell migration and cancer stem cell-like characteristics through GLI1","volume":"122","author":"Zhao","year":"2020","journal-title":"Br. J. 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Oncol."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0630","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.semcancer.2021.03.038_bib0635","doi-asserted-by":"crossref","first-page":"C444","DOI":"10.1152\/ajpcell.00188.2015","article-title":"Cellular and molecular processes in ovarian cancer metastasis. A review in the theme: cell and molecular processes in cancer metastasis","volume":"309","author":"Yeung","year":"2015","journal-title":"Am. J. Physiol. 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Oncol."},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0660","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084941","article-title":"Ovarian cancer spheroid cells with stem cell-like properties contribute to tumor generation, metastasis and chemotherapy resistance through hypoxia-resistant metabolism","volume":"9","author":"Liao","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.semcancer.2021.03.038_bib0665","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046858","article-title":"Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors","volume":"7","author":"Latifi","year":"2012","journal-title":"PLoS One"},{"issue":"37","key":"10.1016\/j.semcancer.2021.03.038_bib0670","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1038\/s41388-018-0317-x","article-title":"Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer","volume":"37","author":"Al Habyan","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0675","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bcp.2014.08.011","article-title":"Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: a therapeutic implication","volume":"92","author":"Suh","year":"2014","journal-title":"Biochem. 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Signal."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0720","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1158\/1078-0432.CCR-11-1916","article-title":"Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors","volume":"18","author":"Klopp","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.semcancer.2021.03.038_bib0725","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s12192-014-0491-x","article-title":"Induction of multipotency in umbilical cord-derived mesenchymal stem cells cultivated under suspension conditions","volume":"19","author":"Amiri","year":"2014","journal-title":"Cell Stress Chaperones"},{"issue":"10","key":"10.1016\/j.semcancer.2021.03.038_bib0730","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1073\/pnas.0900244106","article-title":"The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells","volume":"106","author":"Coffelt","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.semcancer.2021.03.038_bib0735","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1172\/JCI45273","article-title":"Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production","volume":"121","author":"McLean","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.semcancer.2021.03.038_bib0740","first-page":"392","article-title":"Fibroblasts in cancer, Nature reviews","volume":"6","author":"Kalluri","year":"2006","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.semcancer.2021.03.038_bib0745","first-page":"582","article-title":"The biology and function of fibroblasts in cancer, Nature reviews","volume":"16","author":"Kalluri","year":"2016","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.semcancer.2021.03.038_bib0750","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092256","article-title":"Activated fibroblast program orchestrates tumor initiation and progression; molecular mechanisms and the associated therapeutic strategies","volume":"20","author":"Yoshida","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0755","first-page":"174","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts, Nature reviews","volume":"20","author":"Sahai","year":"2020","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.semcancer.2021.03.038_bib0760","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1101\/gad.279737.116","article-title":"Carcinoma-associated fibroblasts: orchestrating the composition of malignancy","volume":"30","author":"Gascard","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.semcancer.2021.03.038_bib0765","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1038\/ncomms4472","article-title":"Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.semcancer.2021.03.038_bib0770","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","article-title":"CD10(+)GPR77(+) cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0775","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/biom6010003","article-title":"Targeting stromal-cancer cell crosstalk networks in ovarian cancer treatment","volume":"6","author":"Yeung","year":"2016","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0780","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1634\/stemcells.2007-0742","article-title":"Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells","volume":"26","author":"Jeon","year":"2008","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.semcancer.2021.03.038_bib0785","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ygyno.2011.08.005","article-title":"Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts","volume":"123","author":"Cho","year":"2011","journal-title":"Gynecol. Oncol."},{"issue":"10","key":"10.1016\/j.semcancer.2021.03.038_bib0790","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1172\/JCI62229","article-title":"HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts","volume":"122","author":"Ko","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.semcancer.2021.03.038_bib0795","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1158\/2159-8290.CD-12-0206","article-title":"MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer","volume":"2","author":"Mitra","year":"2012","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0800","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41467-018-03348-z","article-title":"miR200-regulated CXCL12beta promotes fibroblast heterogeneity and immunosuppression in ovarian cancers","volume":"9","author":"Givel","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0805","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13046-020-01611-0","article-title":"Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways","volume":"39","author":"Yoshida","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0810","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1084\/jem.20180765","article-title":"Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer","volume":"216","author":"Gao","year":"2019","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0815","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/bjc.2017.356","article-title":"TAMeless traitors: macrophages in cancer progression and metastasis","volume":"117","author":"Aras","year":"2017","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0820","first-page":"71","article-title":"Tumour-educated macrophages promote tumour progression and metastasis, Nature reviews","volume":"4","author":"Pollard","year":"2004","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.semcancer.2021.03.038_bib0825","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3390\/cancers6031670","article-title":"Tumor-associated macrophages as major players in the tumor microenvironment","volume":"6","author":"Chanmee","year":"2014","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.semcancer.2021.03.038_bib0830","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ejca.2006.01.003","article-title":"Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy","volume":"42","author":"Sica","year":"2006","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0835","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2159-8274.CD-10-0028","article-title":"Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy","volume":"1","author":"DeNardo","year":"2011","journal-title":"Cancer Discov."},{"issue":"12","key":"10.1016\/j.semcancer.2021.03.038_bib0840","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrd.2018.169","article-title":"Targeting macrophages: therapeutic approaches in cancer, Nature reviews","volume":"17","author":"Cassetta","year":"2018","journal-title":"Drug Discovery"},{"issue":"11","key":"10.1016\/j.semcancer.2021.03.038_bib0845","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/neuonc\/noq082","article-title":"Glioma cancer stem cells induce immunosuppressive macrophages\/microglia","volume":"12","author":"Wu","year":"2010","journal-title":"Neuro Oncol."},{"issue":"30","key":"10.1016\/j.semcancer.2021.03.038_bib0850","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1073\/pnas.1106645108","article-title":"Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem\/initiating cells","volume":"108","author":"Jinushi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0855","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ygyno.2018.01.014","article-title":"Tumor associated macrophages in gynecologic cancers","volume":"149","author":"Krishnan","year":"2018","journal-title":"Gynecol. Oncol."},{"issue":"12","key":"10.1016\/j.semcancer.2021.03.038_bib0860","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1158\/0008-5472.CAN-06-4375","article-title":"Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice","volume":"67","author":"Robinson-Smith","year":"2007","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.semcancer.2021.03.038_bib0865","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ijc.28335","article-title":"Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse","volume":"134","author":"Reinartz","year":"2014","journal-title":"Int. J. 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