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Neurochem."},{"issue":"6","key":"10.1016\/j.semcancer.2021.06.013_bib0365","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/glia.21164","article-title":"H-ferritin is the major source of iron for oligodendrocytes","volume":"59","author":"Todorich","year":"2011","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.semcancer.2021.06.013_bib0370","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/1097-4547(20000701)61:1<52::AID-JNR6>3.0.CO;2-T","article-title":"Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis","volume":"61","author":"Hulet","year":"2000","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.semcancer.2021.06.013_bib0375","first-page":"1","article-title":"Gene expression of transferrin and transferrin receptor in brains of control vs. Iron-deficient rats","volume":"6","author":"Han","year":"2003","journal-title":"Nutr. 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Rev."},{"issue":"4","key":"10.1016\/j.semcancer.2021.06.013_bib0425","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/(SICI)1097-4547(19981115)54:4<486::AID-JNR6>3.0.CO;2-I","article-title":"Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid","volume":"54","author":"Moos","year":"1998","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.semcancer.2021.06.013_bib0430","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jnr.1256","article-title":"Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat","volume":"66","author":"Burdo","year":"2001","journal-title":"J. Neurosci. 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Invest."},{"issue":"12","key":"10.1016\/j.semcancer.2021.06.013_bib0465","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1093\/hmg\/5.12.1989","article-title":"Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia","volume":"5","author":"Klomp","year":"1996","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.semcancer.2021.06.013_bib0470","doi-asserted-by":"crossref","first-page":"G425","DOI":"10.1152\/ajpgi.00453.2009","article-title":"Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic \u03b2-cells","volume":"298","author":"Hudson","year":"2009","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.semcancer.2021.06.013_bib0475","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10571-017-0568-z","article-title":"The ferroxidase hephaestin but not amyloid precursor protein is required for ferroportin-supported Iron efflux in primary hippocampal neurons","volume":"38","author":"Ji","year":"2018","journal-title":"Cell Mol. Neurobiol."},{"issue":"37","key":"10.1016\/j.semcancer.2021.06.013_bib0480","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1523\/JNEUROSCI.2838-11.2011","article-title":"Iron efflux from oligodendrocytes is differentially regulated in gray and white matter","volume":"31","author":"Schulz","year":"2011","journal-title":"J. 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J."},{"issue":"5","key":"10.1016\/j.semcancer.2021.06.013_bib1030","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/hep.22498","article-title":"Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury","volume":"48","author":"Uchiyama","year":"2008","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.semcancer.2021.06.013_bib1035","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.biocel.2011.08.016","article-title":"The role of lysosomes in iron metabolism and recycling","volume":"43","author":"Kurz","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.semcancer.2021.06.013_bib1040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1211\/0022357991772231","article-title":"Cellular uptake and release of two contrasting iron chelators","volume":"51","author":"Cable","year":"1999","journal-title":"J Pharm. 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Sinica"},{"issue":"8","key":"10.1016\/j.semcancer.2021.06.013_bib1190","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1074\/jbc.M110.210047","article-title":"Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production","volume":"286","author":"Hamacher-Brady","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.semcancer.2021.06.013_bib1195","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00253-021-11094-4","article-title":"Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story","volume":"105","author":"Gasmi","year":"2021","journal-title":"Appl. Microbiol. 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