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Clin. Invest."},{"key":"10.1016\/j.semcancer.2021.09.016_bib0595","article-title":"Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients","author":"Baruch","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2021.09.016_bib0600","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.abf3363","article-title":"Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients","volume":"371","author":"Davar","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2021.09.016_bib0605","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.aan4236","article-title":"Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients","volume":"359","author":"Gopalakrishnan","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2021.09.016_bib0610","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.aao3290","article-title":"The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients","volume":"359","author":"Matson","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2021.09.016_bib0615","first-page":"1","article-title":"Zeb2 drives invasive and microbiota-dependent colon carcinoma","author":"Slowicka","year":"2020","journal-title":"Nat. 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