{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:30:39Z","timestamp":1792441839769,"version":"4.5.0"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["HYDSYTB202305"],"award-info":[{"award-number":["HYDSYTB202305"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.semcancer.2024.10.003","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:27:26Z","timestamp":1729052846000},"page":"156-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Ferroptosis and immunosenescence in colorectal cancer"],"prefix":"10.1016","volume":"106-107","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbaixue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoutian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1186\/s12885-024-12508-y","article-title":"Mindfulness intervention, homogeneous medical concept, and concentrated solution nursing for colorectal cancer patients: a retrospective study","volume":"24","author":"Feng","year":"2024","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.32604\/or.2023.028657","article-title":"Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals","volume":"31","author":"Wu","year":"2023","journal-title":"Oncol. Res."},{"key":"10.1016\/j.semcancer.2024.10.003_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.935500","article-title":"Clinical significance of serum haptoglobin and protein disulfide-isomerase A3 in the screening, diagnosis, and staging of colorectal cancer","volume":"13","author":"Niu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6851900","article-title":"Application of prognostic models based on psoas muscle index, stage, pathological grade, and preoperative carcinoembryonic antigen level in stage II-III colorectal cancer patients undergoing adjuvant chemotherapy","volume":"2022","author":"Shan","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3389\/fcell.2020.00812","article-title":"MicroRNA: another pharmacological avenue for colorectal cancer?","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib7","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3892\/or.2020.7882","article-title":"Novel quinazolinone MJ-33 induces AKT\/mTOR-mediated autophagy-associated apoptosis in 5FU-resistant colorectal cancer cells","volume":"45","author":"Ha","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.semcancer.2024.10.003_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12935-020-01304-w","article-title":"The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review","volume":"20","author":"Liu","year":"2020","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.semcancer.2024.10.003_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tips.2023.01.003","article-title":"Metastatic colorectal cancer: mechanisms and emerging therapeutics","volume":"44","author":"Shin","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.semcancer.2024.10.003_bib10","first-page":"1","article-title":"Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance","author":"Zheng","year":"2024","journal-title":"Nat. Cancer"},{"issue":"21","key":"10.1016\/j.semcancer.2024.10.003_bib11","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.3390\/cancers15215209","article-title":"Harnessing ferroptosis to overcome drug resistance in colorectal cancer: promising therapeutic approaches","volume":"15","author":"Cheng","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.semcancer.2024.10.003_bib12","first-page":"1","article-title":"The cell biology of ferroptosis","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2024.10.003_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2021.04.001","article-title":"editor Role of iron in cancer","author":"Salnikow","year":"2021","journal-title":"Semin Cancer Biol."},{"issue":"4","key":"10.1016\/j.semcancer.2024.10.003_bib15","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.molcel.2021.12.001","article-title":"Persister cancer cells: Iron addiction and vulnerability to ferroptosis","volume":"82","author":"Rodriguez","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcancer.2024.10.003_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2023.09.001","article-title":"Extracellular vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment","volume":"73","author":"Giovannetti","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"issue":"Pt 2)","key":"10.1016\/j.semcancer.2024.10.003_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcancer.2022.09.005","article-title":"Unraveling tumor microenvironment of small-cell lung cancer: Implications for immunotherapy","volume":"86","author":"Li","year":"2022","journal-title":"Semin Cancer Biol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.880478","article-title":"Development of a prognostic alternative splicing signature associated with tumor microenvironment immune profiles in lung adenocarcinoma","volume":"12","author":"Bao","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-018-0769-1","article-title":"Targeting Gas6\/TAM in cancer cells and tumor microenvironment","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1021\/acs.analchem.1c03104","article-title":"Deep-tissue fluorescence imaging study of reactive oxygen species in a tumor microenvironment","volume":"94","author":"Wu","year":"2021","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.semcancer.2024.10.003_bib21","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1111\/cas.15068","article-title":"Reactive oxygen species in cancer: Current findings and future directions","volume":"112","author":"Nakamura","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.semcancer.2024.10.003_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.semcancer.2024.10.003_bib23","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41419-020-03194-2","article-title":"Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo","volume":"11","author":"Xia","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.semcancer.2024.10.003_bib24","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.62347\/MEYW3975","article-title":"Loss of Lipocalin2 confers cisplatin vulnerability through modulating NF-\u0138B mediated ferroptosis via ferroportin","volume":"14","author":"Feng","year":"2024","journal-title":"Am. J. Cancer Res."},{"issue":"7679","key":"10.1016\/j.semcancer.2024.10.003_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.semcancer.2024.10.003_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167210","article-title":"Ketogenesis attenuated KLF5 disrupts iron homeostasis via LIF to confer oxaliplatin vulnerability in colorectal cancer","volume":"1870","author":"Jiang","year":"2024","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"7664","key":"10.1016\/j.semcancer.2024.10.003_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2024.10.003_bib28","article-title":"Ferroptosis: a critical moderator in the life cycle of immune cells","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/geront\/4.4.195","article-title":"The immunologic theory of aging","volume":"4","author":"Walford","year":"1964","journal-title":"Gerontologist"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41467-017-02689-5","article-title":"Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.semcancer.2024.10.003_bib32","doi-asserted-by":"crossref","DOI":"10.4161\/2162402X.2014.994398","article-title":"Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy","volume":"4","author":"Ye","year":"2015","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2018.09.020","article-title":"TLR8-mediated metabolic control of human treg function: a mechanistic target for cancer immunotherapy","volume":"29","author":"Li","year":"2019","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.semcancer.2024.10.003_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001536","article-title":"Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity","volume":"9","author":"Gao","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.semcancer.2024.10.003_bib36","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.ccell.2023.05.006","article-title":"Senescent alveolar macrophages promote early-stage lung tumorigenesis","volume":"41","author":"Prieto LI","year":"2023","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.semcancer.2024.10.003_bib37","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.ccell.2023.05.004","article-title":"Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer","volume":"41","author":"Haston","year":"2023","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41232-022-00197-8","article-title":"The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?","volume":"42","author":"Ohtani","year":"2022","journal-title":"Inflamm. Regen."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib39","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/s41467-018-04010-4","article-title":"The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.semcancer.2024.10.003_bib40","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3390\/cancers12082134","article-title":"Senescence and cancer: a review of clinical implications of senescence and senotherapies","volume":"12","author":"Wyld","year":"2020","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-017-0006-x","article-title":"The twilight of immunity: emerging concepts in aging of the immune system","volume":"19","author":"Nikolich-\u017dugich","year":"2018","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13045-020-00986-z","article-title":"Immunosenescence: a key player in cancer development","volume":"13","author":"Lian","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3389\/fphar.2018.01371","article-title":"RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer","volume":"9","author":"Sui","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"24","key":"10.1016\/j.semcancer.2024.10.003_bib44","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1158\/0008-5472.CAN-21-1547","article-title":"A dual PI3K\/HDAC inhibitor induces immunogenic ferroptosis to potentiate cancer immune checkpoint therapy","volume":"81","author":"Fan","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib45","first-page":"61","article-title":"Review on the role of glutathione on oxidative stress and infertility","volume":"22","author":"Adeoye","year":"2018","journal-title":"JBRA Assist Reprod."},{"key":"10.1016\/j.semcancer.2024.10.003_bib46","article-title":"Recent progress of ferroptosis in cancers and drug discovery","author":"Wang","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.semcancer.2024.10.003_bib47","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1080\/14728222.2021.2011206","article-title":"The mechanisms and therapeutic targets of ferroptosis in cancer","volume":"25","author":"Ye","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.semcancer.2024.10.003_bib48","unstructured":"F\u0131rat A.A. Ferroptosis: Can Iron Be the Downfall of a Cell? Iron Metabolism-A Double-Edged Sword: IntechOpen; 2021."},{"issue":"16","key":"10.1016\/j.semcancer.2024.10.003_bib49","doi-asserted-by":"crossref","first-page":"11201","DOI":"10.1021\/acs.jmedchem.3c00659","article-title":"Marine alkaloid lepadins E and H induce ferroptosis for cancer chemotherapy","volume":"66","author":"Wang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.semcancer.2024.10.003_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.105948","article-title":"Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression","volume":"134","author":"Wang","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.semcancer.2024.10.003_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030685","article-title":"Vitamin C restricts the emergence of acquired resistance to EGFR-targeted therapies in colorectal cancer","volume":"12","author":"Lorenzato","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.semcancer.2024.10.003_bib52","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.semcancer.2024.10.003_bib53","first-page":"8735","article-title":"Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors","volume":"15","author":"Nishizawa","year":"2018","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.semcancer.2024.10.003_bib54","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim Biophys. Acta"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13020-023-00735-7","article-title":"Neurobiological effects of gallic acid: Current perspectives","volume":"18","author":"Bhuia","year":"2023","journal-title":"Chin. Med."},{"issue":"7","key":"10.1016\/j.semcancer.2024.10.003_bib56","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11655-021-3345-2","article-title":"Gallic acid: A potential anti-cancer agent","volume":"28","author":"Jiang","year":"2022","journal-title":"Chin. J. Integr. Med."},{"issue":"4","key":"10.1016\/j.semcancer.2024.10.003_bib57","doi-asserted-by":"crossref","first-page":"942","DOI":"10.7150\/ijbs.57164","article-title":"Ferroptosis-related genes for overall survival prediction in patients with colorectal cancer can be inhibited by gallic acid","volume":"17","author":"Hong","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.semcancer.2024.10.003_bib58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"issue":"1-2","key":"10.1016\/j.semcancer.2024.10.003_bib59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2024.10.003_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105450","article-title":"Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis","volume":"152","author":"Xu","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.semcancer.2024.10.003_bib61","article-title":"System Xc\u2212\/GSH\/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114905","article-title":"Discovery and optimization of 2-(trifluoromethyl) benzimidazole derivatives as novel ferroptosis inducers in vitro and in vivo","volume":"245","author":"Fang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.semcancer.2024.10.003_bib63","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/iub.1621","article-title":"Ferritin, cellular iron storage and regulation","volume":"69","author":"Arosio","year":"2017","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib64","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcancer.2024.10.003_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"7769","key":"10.1016\/j.semcancer.2024.10.003_bib66","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2024.10.003_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.16400","article-title":"Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells","author":"Ye","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"36","key":"10.1016\/j.semcancer.2024.10.003_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303484","article-title":"Inhibition of CARM1-mediated methylation of ACSL4 promotes ferroptosis in colorectal cancer","volume":"10","author":"Feng","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib69","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.semcancer.2024.10.003_bib70","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/19768354.2018.1512521","article-title":"Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis","volume":"22","author":"Park","year":"2018","journal-title":"Anim. Cells Syst. (Seoul. )"},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib71","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051162","article-title":"The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity","volume":"22","author":"Song","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.semcancer.2024.10.003_bib72","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2147\/CMAR.S274631","article-title":"Apatinib promotes ferroptosis in colorectal cancer cells by targeting ELOVL6\/ACSL4 signaling","volume":"13","author":"Tian","year":"2021","journal-title":"Cancer Manag Res."},{"issue":"24","key":"10.1016\/j.semcancer.2024.10.003_bib73","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.7150\/jca.34650","article-title":"Dichloroacetate overcomes oxaliplatin chemoresistance in colorectal cancer through the miR-543\/PTEN\/Akt\/mTOR Pathway","volume":"10","author":"Liang","year":"2019","journal-title":"J. Cancer"},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib74","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.semcancer.2024.10.003_bib75","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s10495-023-01849-x","article-title":"Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin","volume":"28","author":"Li","year":"2023","journal-title":"Apoptosis"},{"issue":"7","key":"10.1016\/j.semcancer.2024.10.003_bib76","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1111\/jog.14779","article-title":"Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo","volume":"47","author":"Cheng","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"10","key":"10.1016\/j.semcancer.2024.10.003_bib77","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/carcin\/bgaa090","article-title":"Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of \u03b2-catenin\/Wnt-signaling pathways in colorectal cancer","volume":"41","author":"Sharma","year":"2020","journal-title":"Carcinogenesis"},{"issue":"11","key":"10.1016\/j.semcancer.2024.10.003_bib78","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.7150\/thno.44705","article-title":"Combinative treatment of \u03b2-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib79","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-019-0981-7","article-title":"Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.semcancer.2024.10.003_bib80","article-title":"Suppressing the KIF20A\/NUAK1\/Nrf2\/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin","volume":"13","author":"Yang","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib81","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13045-020-00986-z","article-title":"Immunosenescence: a key player in cancer development","volume":"13","author":"Lian","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib82","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41408-024-01071-1","article-title":"Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship","volume":"14","author":"Kientega","year":"2024","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.semcancer.2024.10.003_bib83","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12979-020-0173-8","article-title":"Contributions of age-related thymic involution to immunosenescence and inflammaging","volume":"17","author":"Thomas","year":"2020","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.semcancer.2024.10.003_bib84","doi-asserted-by":"crossref","DOI":"10.1002\/oby.24013","article-title":"Adipocyte-derived inflammatory molecules induce senescent B cells through metabolic pathways","author":"Frasca","year":"2024","journal-title":"Obes. (Silver Spring)"},{"issue":"6","key":"10.1016\/j.semcancer.2024.10.003_bib85","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00262-024-03695-5","article-title":"Neutrophil-activating secretome characterizes palbociclib-induced senescence of breast cancer cells","volume":"73","author":"Favaretto","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"4","key":"10.1016\/j.semcancer.2024.10.003_bib86","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2174\/1573394717666210715165127","article-title":"Oxidative stress and cellular senescence: the key tumor-promoting factors in colon cancer and beneficial effects of polyphenols in colon cancer prevention","volume":"17","author":"Bhatiya","year":"2021","journal-title":"Curr. Cancer Ther. Rev."},{"key":"10.1016\/j.semcancer.2024.10.003_bib87","article-title":"Cell senescence-related genes as biomarkers for prognosis and immunotherapeutic response in colon cancer","author":"Haibo","year":"2024","journal-title":"Biochem. Genet."},{"issue":"26","key":"10.1016\/j.semcancer.2024.10.003_bib88","doi-asserted-by":"crossref","first-page":"17267","DOI":"10.1021\/acsnano.4c04901","article-title":"Lipid nanoparticular codelivery system for enhanced antitumor effects by ferroptosis-apoptosis synergistic with programmed cell death-ligand 1 downregulation","volume":"18","author":"Cao","year":"2024","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.semcancer.2024.10.003_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/biom9100637","article-title":"Antioxidant barrier, redox status, and oxidative damage to biomolecules in patients with colorectal cancer. can malondialdehyde and catalase be markers of colorectal cancer advancement?","volume":"9","author":"Zi\u0144czuk","year":"2019","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.semcancer.2024.10.003_bib90","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14069","article-title":"Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages","volume":"23","author":"Zhang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcancer.2024.10.003_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2023.106479","article-title":"Immunosenescence and macrophages: from basics to therapeutics","author":"Zhu","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.semcancer.2024.10.003_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114111","article-title":"Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome","volume":"43","author":"Wu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcancer.2024.10.003_bib93","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.778329","article-title":"Colorectal cancer-associated immune exhaustion involves T and B lymphocytes and conventional NK cells and correlates with a shorter overall survival","volume":"12","author":"Sorrentino","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.908449","article-title":"Senescent tumor cells in the peritoneal carcinomatosis drive immunosenescence in the tumor microenvironment","volume":"13","author":"Braum\u00fcller","year":"2022","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.semcancer.2024.10.003_bib95","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1002\/1878-0261.13268","article-title":"Cellular senescence and the tumour microenvironment","volume":"16","author":"Takasugi","year":"2022","journal-title":"Mol. Oncol."},{"issue":"12","key":"10.1016\/j.semcancer.2024.10.003_bib96","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.devcel.2023.05.010","article-title":"Reshaping of the tumor microenvironment by cellular senescence: an opportunity for senotherapies","volume":"58","author":"D\u2019Ambrosio","year":"2023","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.semcancer.2024.10.003_bib97","doi-asserted-by":"crossref","first-page":"14522","DOI":"10.1021\/acsnano.1c04068","article-title":"Dual inhibition of endoplasmic reticulum stress and oxidation stress manipulates the polarization of macrophages under hypoxia to sensitize immunotherapy","volume":"15","author":"Jiang","year":"2021","journal-title":"ACS Nano"},{"issue":"12","key":"10.1016\/j.semcancer.2024.10.003_bib98","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/s41590-022-01349-1","article-title":"Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function","volume":"23","author":"Zhang","year":"2022","journal-title":"Nat. Immunol."},{"issue":"21","key":"10.1016\/j.semcancer.2024.10.003_bib99","article-title":"Inflammation-targeted nanomedicines alleviate oxidative stress and reprogram macrophages polarization for myocardial infarction treatment","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.semcancer.2024.10.003_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1119369","article-title":"Ferroptosis and tumor immunotherapy: A promising combination therapy for tumors","volume":"13","author":"Cai","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117298","article-title":"Firing up \u201ccold\u201d tumors: Ferroptosis causes immune activation by improving T cell infiltration","volume":"179","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"7755","key":"10.1016\/j.semcancer.2024.10.003_bib102","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12094-021-02669-8","article-title":"Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy","volume":"24","author":"Li","year":"2022","journal-title":"Clin. Transl. Oncol."},{"issue":"5","key":"10.1016\/j.semcancer.2024.10.003_bib104","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.semcancer.2024.10.003_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcancer.2024.10.003_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176124","article-title":"Ferroptosis and tumor immunity: In perspective of the major cell components in the tumor microenvironment","volume":"961","author":"Zhu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.semcancer.2024.10.003_bib107","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.7150\/thno.44705","article-title":"Combinative treatment of \u03b2-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.semcancer.2024.10.003_bib108","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41419-021-04367-3","article-title":"Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2\/HO-1 signalling pathway in KRAS mutant colorectal cancer","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib109","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1366957","article-title":"Lysionotin induces ferroptosis to suppress development of colorectal cancer via promoting Nrf2 degradation","volume":"2022","author":"Gao","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib110","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/01635581.2022.2139398","article-title":"Curcumin represses colorectal cancer cell proliferation by triggering ferroptosis via PI3K\/Akt\/mTOR signaling","volume":"75","author":"Chen","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib111","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10495-023-01891-9","article-title":"Advancing the frontiers of colorectal cancer treatment: harnessing ferroptosis regulation","volume":"29","author":"Liu","year":"2024","journal-title":"Apoptosis"},{"issue":"15","key":"10.1016\/j.semcancer.2024.10.003_bib112","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X(c)(-) activity.","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib113","doi-asserted-by":"crossref","DOI":"10.1111\/imm.13789","article-title":"A review on comprehending immunotherapeutic approaches inducing ferroptosis: Managing tumour immunity","author":"Chattopadhyay","year":"2024","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib114","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"7784","key":"10.1016\/j.semcancer.2024.10.003_bib115","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.semcancer.2024.10.003_bib116","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.tips.2023.06.005","article-title":"Ferroptosis of immune cells in the tumor microenvironment","volume":"44","author":"Kim","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.semcancer.2024.10.003_bib117","article-title":"Impact and potential value of immunosenescence on solid gastrointestinal tumors","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.semcancer.2024.10.003_bib118","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.arr.2017.07.002","article-title":"Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules","volume":"38","author":"Gardner","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.semcancer.2024.10.003_bib119","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.arr.2017.03.008","article-title":"Aging and cancer: The role of macrophages and neutrophils","volume":"36","author":"Jackaman","year":"2017","journal-title":"Ageing Res. Rev."},{"issue":"8","key":"10.1016\/j.semcancer.2024.10.003_bib120","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00109-019-01795-9","article-title":"AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging","volume":"97","author":"Salminen","year":"2019","journal-title":"J. Mol. Med. (Berl. )"},{"issue":"1","key":"10.1016\/j.semcancer.2024.10.003_bib121","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1158\/2159-8290.CD-18-0168","article-title":"Age-related changes in HAPLN1 increase lymphatic permeability and affect routes of melanoma metastasis","volume":"9","author":"Ecker","year":"2019","journal-title":"Cancer Discov."},{"issue":"12","key":"10.1016\/j.semcancer.2024.10.003_bib122","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.7150\/jca.93542","article-title":"The effects of aging, sex, and tumor burden on the peripheral blood immune cell profile and absolute counts","volume":"15","author":"Xu","year":"2024","journal-title":"J. Cancer"},{"issue":"2","key":"10.1016\/j.semcancer.2024.10.003_bib123","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000501963","article-title":"Inflammation and the alteration of B-cell physiology in aging","volume":"66","author":"Hagen","year":"2020","journal-title":"Gerontology"},{"key":"10.1016\/j.semcancer.2024.10.003_bib124","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fimmu.2013.00316","article-title":"The effect of age on thymic function","volume":"4","author":"Palmer","year":"2013","journal-title":"Front. Immunol."},{"issue":"7787","key":"10.1016\/j.semcancer.2024.10.003_bib125","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-019-1836-5","article-title":"An intra-tumoral niche maintains and differentiates stem-like CD8 T cells","volume":"576","author":"Jansen","year":"2019","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1016\/j.semcancer.2025.11.012","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000}}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X24000816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X24000816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:38:12Z","timestamp":1766144292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X24000816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":125,"alternative-id":["S1044579X24000816"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2024.10.003","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis and immunosenescence in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2024.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}