{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:29:18Z","timestamp":1792384158389,"version":"4.4.0"},"reference-count":197,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017642","name":"National Plan for Scientific and Technical Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cancer Biology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.semcancer.2025.09.002","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:20:32Z","timestamp":1757514032000},"page":"45-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Bile acids in liver and gastrointestinal cancer"],"prefix":"10.1016","volume":"116","author":[{"given":"Maria J.","family":"Monte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"F\u00e0brega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta R.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro G.","family":"Temprano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Kaplowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garcia-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J.G.","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Fernandez-Checa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcancer.2025.09.002_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1389200216666151103115454","article-title":"Bile acids in physiology, pathology and pharmacology","volume":"17","author":"J.G. Marin","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.semcancer.2025.09.002_bib2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/physrev.00049.2019","article-title":"Molecular physiology of bile acid signaling in health, disease, and aging","volume":"101","author":"Perino","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.semcancer.2025.09.002_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-nutr-082018-124344","article-title":"Bile acids as metabolic regulators and nutrient sensors","volume":"39","author":"Chiang","year":"2019","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.semcancer.2025.09.002_bib4","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.2741\/3399","article-title":"The enterohepatic circulation of bile acids in mammals: form and functions","author":"Hofmann","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.37349\/edd.2022.00008","article-title":"Etiopathogenesis and pathophysiology of cholestasis","volume":"5","author":"Asensio","year":"2022","journal-title":"Explor. Dig. Dis."},{"key":"10.1016\/j.semcancer.2025.09.002_bib6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2024.09.032","article-title":"Bile acid metabolism and signalling in liver disease","volume":"82","author":"Fuchs","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.120004","article-title":"The bile acid profile","volume":"565","author":"Liu","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.semcancer.2025.09.002_bib8","first-page":"1","article-title":"Hepatocellular carcinoma: novel understandings and therapeutic strategies based on bile acids (Review)","volume":"61","author":"Wenyu","year":"2022","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib9","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1194\/jlr.R049437","article-title":"Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades","volume":"55","author":"Hofmann","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib11","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.3748\/wjg.14.5617","article-title":"How we have learned about the complexity of physiology, pathobiology and pharmacology of bile acids and biliary secretion","volume":"14","author":"Marin","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3748\/wjg.15.804","article-title":"Bile acids: chemistry, physiology, and pathophysiology","volume":"15","author":"Monte","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib13","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib14","article-title":"Lithocholic acid phenocopies anti-ageing effects of calorie restriction","volume":"638","author":"Qu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2025.09.002_bib15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0022-2275(20)42749-X","article-title":"Bile acid metabolism in early life: studies of amniotic fluid","volume":"31","author":"Nakagawa","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2017.00617","article-title":"Bile acid signaling pathways from the enterohepatic circulation to the central nervous system","volume":"11","author":"Mertens","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib17","doi-asserted-by":"crossref","first-page":"41690","DOI":"10.1074\/jbc.M105117200","article-title":"Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcancer.2025.09.002_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.steroids.2012.02.006","article-title":"27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols","volume":"77","author":"Fakheri","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.semcancer.2025.09.002_bib19","doi-asserted-by":"crossref","first-page":"16637","DOI":"10.1016\/S0021-9258(18)37438-6","article-title":"Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile","volume":"263","author":"Setchell","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcancer.2025.09.002_bib20","first-page":"910","article-title":"Overexpression of cholesterol transporter StAR increasesin vivo rates of bile acid synthesis in the rat and mouse","volume":"40","author":"Ren","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib21","article-title":"Stard1 promotes cholestatic liver injury and disease progression by sensitizing to bile acid hepatotoxicity","author":"Conde de la Rosa","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100757","article-title":"Liver specific transgenic expression of CYP7B1 attenuates early Western diet-induced MASLD progression","volume":"66","author":"Kakiyama","year":"2025","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0080994","article-title":"Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction","volume":"8","author":"Perreault","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcancer.2025.09.002_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfn268","article-title":"Bile acid sulfation: a pathway of bile acid elimination and detoxification","volume":"108","author":"Alnouti","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib25","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.semcancer.2025.09.002_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-642-14541-4_4","article-title":"Role of the intestinal bile acid transporters in bile acid and drug disposition","volume":"201","author":"Dawson","year":"2011","journal-title":"Handb. Exp. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2007-1007226","article-title":"Sinusoidal (basolateral) bile salt uptake systems of hepatocytes","volume":"16","author":"Hagenbuch","year":"1996","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.semcancer.2025.09.002_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00805-21","article-title":"Dominant bacterial phyla from the human gut show widespread ability to transform and conjugate bile acids","volume":"6","author":"Lucas","year":"2021","journal-title":"MSystems"},{"key":"10.1016\/j.semcancer.2025.09.002_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-2275(20)38331-0","article-title":"Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions","volume":"30","author":"Heuman","year":"1989","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41586-020-2047-9","article-title":"Global chemical effects of the microbiome include new bile-acid conjugations","volume":"579","author":"Quinn","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.semcancer.2025.09.002_bib32","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001441","article-title":"Gut-to-Bile transfer of microbially amidated minor bile acids in patients with hepatopancreatobiliary disorders","author":"Temprano","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1194\/jlr.RA119000395","article-title":"Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition","volume":"61","author":"Honda","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.livres.2019.05.001","article-title":"The acidic pathway of bile acid synthesis: not just an alternative pathway","volume":"3","author":"Pandak","year":"2019","journal-title":"Liver Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00018-017-2693-8","article-title":"Mouse models for human intestinal microbiota research: a critical evaluation","volume":"75","author":"Hugenholtz","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib36","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","article-title":"Differential regulation of bile acid homeostasis by the farnesoid x receptor in liver and intestine","volume":"48","author":"Kim","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib37","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJM199910283411807","article-title":"Biliary tract cancers","volume":"341","author":"de Groen","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcancer.2025.09.002_bib39","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/hep.29689","article-title":"New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases","volume":"67","author":"Win","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib40","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep.28486","article-title":"c-Jun N-terminal kinase mediates mouse liver injury through a novel sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial src","volume":"63","author":"Win","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tips.2013.01.009","article-title":"Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria","volume":"34","author":"Han","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib42","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1053\/jhep.2002.33200","article-title":"Regulation of oxysterol 7\u03b1-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes","volume":"35","author":"Pandak","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cmet.2024.09.008","article-title":"Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress","volume":"37","author":"Song","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcancer.2025.09.002_bib44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.semcancer.2025.09.002_bib45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF-Dependent spontaneous HCC development","volume":"26","author":"Nakagawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2025.09.002_bib46","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcmgh.2016.11.006","article-title":"Endoplasmic reticulum stress regulates hepatic bile acid metabolism in mice","volume":"3","author":"Henkel","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib47","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nm.4357","article-title":"Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis","volume":"23","author":"Worthmann","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1470-2045(02)00849-5","article-title":"Overweight, obesity, and cancer risk","volume":"3","author":"Bianchini","year":"2002","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib49","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults","volume":"348","author":"Calle","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib50","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca. Cancer J. Clin."},{"key":"10.1016\/j.semcancer.2025.09.002_bib51","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lance"},{"key":"10.1016\/j.semcancer.2025.09.002_bib52","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1053\/j.gastro.2015.12.041","article-title":"Evidence-Based diagnosis, staging, and treatment of patients with hepatocellular carcinoma","volume":"150","author":"Bruix","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib53","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3390\/cancers11111677","article-title":"Models for understanding resistance to chemotherapy in liver cancer","volume":"11","author":"Marin","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.semcancer.2025.09.002_bib54","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/hep.29359","article-title":"The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids","volume":"67","author":"Puri","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib55","doi-asserted-by":"crossref","first-page":"G91","DOI":"10.1152\/ajpgi.00027.2015","article-title":"Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling","volume":"311","author":"Sun","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib56","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/carcin\/bgl249","article-title":"Spontaneous hepatocarcinogenesis in farnesoid x receptor-null mice","volume":"28","author":"Kim","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2025.09.002_bib57","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1158\/0008-5472.CAN-06-1078","article-title":"Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid x receptor","volume":"67","author":"Yang","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib58","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/mc.23255","article-title":"Longitudinal change of metabolite profile and its relation to multiple risk factors for the risk of developing hepatitis B-related hepatocellular carcinoma","volume":"59","author":"Huang","year":"2020","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.semcancer.2025.09.002_bib59","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.4254\/wjh.v14.i9.1730","article-title":"Bile acids as drivers and biomarkers of hepatocellular carcinoma","volume":"14","author":"Colosimo","year":"2022","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib60","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ijc.33236","article-title":"Metabolic perturbations prior to hepatocellular carcinoma diagnosis: findings from a prospective observational cohort study","volume":"148","author":"Stepien","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2025.09.002_bib61","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000545","article-title":"Serum levels of total bile acids are associated with an increased risk of HCC in patients with cirrhosis","volume":"8","author":"El-Serag","year":"2024","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.semcancer.2025.09.002_bib62","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000606","article-title":"High-fat\/high-sucrose diet results in a high rate of MASH with HCC in a mouse model of human-like bile acid composition","volume":"9","author":"Ueda","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.semcancer.2025.09.002_bib63","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jhep.2021.01.028","article-title":"STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway","volume":"74","author":"Conde de la Rosa","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib64","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jhep.2008.12.016","article-title":"Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH","volume":"50","author":"Caballero","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib65","first-page":"1","article-title":"Targeting FDFT1 reduces cholesterol and bile acid production and delays hepatocellular carcinoma progression through the HNF4A\/ALDOB\/AKT1 axis","volume":"2411719","author":"Cai","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib66","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1053\/j.gastro.2019.04.023","article-title":"Endoplasmic reticulum Stress-Induced upregulation of STARD1 promotes Acetaminophen-Induced acute liver failure","volume":"157","author":"Torres","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib67","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.3748\/wjg.15.3329","article-title":"Bile acids as endogenous etiologic agents in gastrointestinal cancer","volume":"15","author":"Bernstein","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib68","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3349\/ymj.2006.47.6.817","article-title":"Bile acid analysis in biliary tract cancer","volume":"47","author":"Park","year":"2006","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.semcancer.2025.09.002_bib69","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.3748\/wjg.v12.i22.3553","article-title":"G. Lesage, bile acid interactions with cholangiocyte","volume":"12","author":"Xia","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib70","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/carcin\/14.11.2415","article-title":"Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation","volume":"14","author":"Thamavit","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2025.09.002_bib71","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1053\/j.gastro.2011.03.044","article-title":"A mouse model of Cholestasis-Associated cholangiocarcinoma and transcription factors involved in progression","volume":"141","author":"Yang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib72","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1021\/mp300028a","article-title":"No correlation between the expression of FXR and genes involved in multidrug resistance phenotype of primary liver tumors","volume":"9","author":"Martinez-Becerra","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib73","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.bbamcr.2013.05.006","article-title":"Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds","volume":"1833","author":"Vaquero","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1158\/1541-7786.MCR-13-0503","article-title":"Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development","volume":"12","author":"Lozano","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib75","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/hep.30319","article-title":"Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma, and primary sclerosing cholangitis","volume":"70","author":"Banales","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib76","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ijc.34906","article-title":"Post-diagnosis dietary factors, supplement use and colorectal cancer prognosis: a global cancer update programme ( <scp>CUP<\/scp> Global) systematic literature review and meta-analysis","volume":"155","author":"Chan","year":"2024","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2025.09.002_bib77","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ijc.34903","article-title":"Post-diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: a global cancer update programme ( <scp>CUP<\/scp> Global) systematic literature review and meta-analysis","volume":"155","author":"Markozannes","year":"2024","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2025.09.002_bib78","doi-asserted-by":"crossref","first-page":"577","DOI":"10.12998\/wjcc.v6.i13.577","article-title":"Role of bile acids in colon carcinogenesis","volume":"6","author":"Nguyen","year":"2018","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.semcancer.2025.09.002_bib79","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.semcancer.2020.10.003","article-title":"Dietary fat, bile acid metabolism and colorectal cancer","volume":"73","author":"Ocvirk","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib80","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/gwat.12816","article-title":"Sensitivity of simulated hyporheic exchange to river bathymetry: the steinlach river test site","volume":"57","author":"Chow","year":"2019","journal-title":"Groundwater"},{"key":"10.1016\/j.semcancer.2025.09.002_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-024-46265-0","article-title":"Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of westernization and colorectal cancer","volume":"15","author":"Ramaboli","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcancer.2025.09.002_bib82","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/carcin\/22.6.957","article-title":"Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation","volume":"22","author":"Qiao","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2025.09.002_bib83","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1091\/mbc.e03-12-0894","article-title":"Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness","volume":"15","author":"Pai","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.semcancer.2025.09.002_bib84","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00394-008-0725-8","article-title":"Genotoxic effect of bile acids on human normal and tumour colon cells and protection by dietary antioxidants and butyrate","volume":"47","author":"Rosignoli","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.semcancer.2025.09.002_bib85","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.yexcr.2008.11.003","article-title":"Akt-dependent NF-\u03baB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis","volume":"315","author":"Shant","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib86","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jcp.21332","article-title":"Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K\/Akt signaling","volume":"215","author":"Raufman","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048461","article-title":"Src-mediated cross-talk between farnesoid x and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis","volume":"7","author":"Peng","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.semcancer.2025.09.002_bib88","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/carcin\/bgq050","article-title":"Sodium taurocholate inhibits intestinal adenoma formation in APCMin\/+ mice, potentially through activation of the farnesoid x receptor","volume":"31","author":"Smith","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcancer.2025.09.002_bib89","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7326\/0003-4819-134-2-200101160-00008","article-title":"Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis","volume":"134","author":"Tung","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib90","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/jhep.2003.50311","article-title":"Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: an observational study","volume":"38","author":"Serfaty","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib91","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/jnci\/dji144","article-title":"Phoenix and tucson gastroenterologist networks, phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence","volume":"97","author":"Alberts","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.semcancer.2025.09.002_bib92","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41590-020-0761-y","article-title":"Regulation and modulation of antitumor immunity in pancreatic cancer","volume":"21","author":"Leinwand","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib93","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41575-018-0005-x","article-title":"Therapeutic developments in pancreatic cancer: current and future perspectives","volume":"15","author":"Neoptolemos","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-79181-6","article-title":"Bile accelerates carcinogenic processes in pancreatic ductal adenocarcinoma cells through the overexpression of MUC4","volume":"10","author":"G\u00e1l","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcancer.2025.09.002_bib95","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2174\/0115680096281168231215060301","article-title":"The role of bile acids in pancreatic cancer","volume":"24","author":"Wang","year":"2024","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.semcancer.2025.09.002_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/metabo14070348","article-title":"Bile acids in pancreatic carcinogenesis","volume":"14","author":"Sharma","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.semcancer.2025.09.002_bib97","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/0016-5085(94)90744-7","article-title":"Premicellar taurocholate enhances calcium uptake from all regions of rat small intestine","volume":"106","author":"Sanyal","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2017.00992","article-title":"The role of ferroptosis in cancer development and treatment response","volume":"8","author":"Lu","year":"2018","journal-title":"Front. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166811","article-title":"Farnesoid x receptor activation inhibits pancreatic carcinogenesis","volume":"1869","author":"Xu","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.semcancer.2025.09.002_bib100","first-page":"1","article-title":"The role of metabolic reprogramming in kidney cancer","volume":"14","author":"Chen","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib101","article-title":"Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma","volume":"10","author":"Chen","year":"2011","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.semcancer.2025.09.002_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020919","article-title":"Establishment and validation of novel prognostic subtypes in hepatocellular carcinoma based on bile acid metabolism gene signatures using bulk and Single-Cell RNA-Seq data","volume":"25","author":"Qu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib103","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/bjc.1964.53","article-title":"Bile acids and other lipids in the gall-bladder biles of africans with primary cancer of the liver","author":"MIRVISH","year":"1964","journal-title":"Br. J. Cancer 13"},{"key":"10.1016\/j.semcancer.2025.09.002_bib104","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/ijc.33885","article-title":"Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma","volume":"150","author":"Stepien","year":"2022","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2025.09.002_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13112648","article-title":"Association between Pre-Diagnostic serum bile acids and hepatocellular carcinoma: the Singapore Chinese health study","volume":"13","author":"Thomas","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.semcancer.2025.09.002_bib106","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/jgh.15709","article-title":"Altered bile acid glycine: taurine ratio in the progression of chronic liver disease","volume":"37","author":"Chen","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib107","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1111\/j.1440-1746.2006.04363.x","article-title":"Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes","volume":"21","author":"Hirano","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib108","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.bbamem.2017.08.019","article-title":"Planar bile acids in health and disease","volume":"1859","author":"Shiffka","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.semcancer.2025.09.002_bib109","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/cs1000499","article-title":"Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma","volume":"100","author":"EL-Mir","year":"2001","journal-title":"Clin. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/CS20050035","article-title":"Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis","volume":"109","author":"Monte","year":"2005","journal-title":"Clin. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib111","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2362.2008.02059.x","article-title":"Foetal \u2018flat\u2019 bile acids reappear during human liver regeneration after surgery","volume":"39","author":"St\u00e4rkel","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.semcancer.2025.09.002_bib112","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbalip.2005.02.006","article-title":"Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration","volume":"1734","author":"Monte","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.semcancer.2025.09.002_bib113","first-page":"1","article-title":"Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma","volume":"8","author":"Song","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcancer.2025.09.002_bib114","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2217\/bmm-2015-0062","article-title":"Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile","volume":"10","author":"Wang","year":"2016","journal-title":"Biomark. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612794","article-title":"Plasma bile acid profiling and modulation of secreted mucin 5AC in cholangiocarcinoma","volume":"24","author":"Danese","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib116","doi-asserted-by":"crossref","first-page":"211","DOI":"10.21037\/hbsn.2019.10.11","article-title":"Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma","volume":"9","author":"Herraez","year":"2020","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.semcancer.2025.09.002_bib117","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41577-024-01057-x","article-title":"How bile acids and the microbiota interact to shape host immunity","volume":"24","author":"Lee","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib118","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41575-024-00896-2","article-title":"Another renaissance for bile acid gastrointestinal microbiology","volume":"21","author":"Ridlon","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib119","first-page":"1463","article-title":"Regulation of intestinal barrier function by microbial metabolites","volume":"11","author":"Ghosh","year":"2021","journal-title":"Cmgh"},{"key":"10.1016\/j.semcancer.2025.09.002_bib120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-015-0286-9","article-title":"Transcriptional analysis of porcine intestinal mucosa infected with salmonella typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum","volume":"47","author":"Uribe","year":"2016","journal-title":"Vet. Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib121","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib122","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2240031","article-title":"Unveiling the complex relationship between gut microbiota and liver cancer: opportunities for novel therapeutic interventions","volume":"15","author":"Rajapakse","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.semcancer.2025.09.002_bib123","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hep.30036","article-title":"Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease","volume":"69","author":"Ponziani","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib124","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41467-020-20422-7","article-title":"Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma","volume":"12","author":"Behary","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcancer.2025.09.002_bib125","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcancer.2025.09.002_bib126","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.clinre.2012.12.005","article-title":"Bile acids and liver carcinogenesis: TGR5 as a novel piece in the puzzle?","volume":"37","author":"P\u00e9an","year":"2013","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2023.115985","article-title":"Pharmacological modulation of cholesterol 7\u03b1-hydroxylase (CYP7A1) as a therapeutic strategy for hypercholesterolemia","volume":"220","author":"Yu Cai Lim","year":"2024","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib128","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2265028","article-title":"Current insights on the roles of gut microbiota in inflammatory bowel disease-associated extra-intestinal manifestations: pathophysiology and therapeutic targets","volume":"15","author":"Tie","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.semcancer.2025.09.002_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/jb.00180-23","article-title":"The microbial-derived bile acid lithocholate and its epimers inhibit clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota","volume":"205","author":"Kisthardt","year":"2023","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib130","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3164\/jcbn.18-80","article-title":"Human-specific dual regulations of FXR-activation for reduction of fatty liver using in vitro cell culture model","volume":"64","author":"Miyazaki","year":"2019","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.semcancer.2025.09.002_bib131","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000371670","article-title":"Bile acids as hormones: the FXR-FGF15\/19 pathway","volume":"33","author":"Kliewer","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.semcancer.2025.09.002_bib132","doi-asserted-by":"crossref","first-page":"10120","DOI":"10.1158\/0008-5472.CAN-06-2399","article-title":"The farnesoid x receptor is expressed in breast cancer and regulates apoptosis and aromatase expression","volume":"66","author":"Swales","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib133","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.phrs.2012.07.005","article-title":"Up-regulation of FXR isoforms is not required for stimulation of the expression of genes involved in the lack of response of colon cancer to chemotherapy","volume":"66","author":"Martinez-Becerra","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.semcancer.2025.09.002_bib134","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1023\/B:DDAS.0000034558.78747.98","article-title":"The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer","volume":"49","author":"De Gottardi","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib135","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.18632\/oncotarget.2899","article-title":"Farnesoid x receptor associates with \u03b2-catenin and inhibits its activity in hepatocellular carcinoma","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcancer.2025.09.002_bib136","doi-asserted-by":"crossref","first-page":"G295","DOI":"10.1152\/ajpgi.00134.2015","article-title":"Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis","volume":"310","author":"Kong","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib137","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41575-020-00404-2","article-title":"The role of farnesoid x receptor in metabolic diseases, and gastrointestinal and liver cancer","volume":"18","author":"Sun","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19071898","article-title":"Farnesoid x receptor activation enhances transforming growth factor \u03b2-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells","volume":"19","author":"Kainuma","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib139","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/ajpgi.00155.2013","article-title":"Mechanisms of STAT3 activation in the liver of FXR knockout mice","volume":"305","author":"Li","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib140","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/s41598-017-12629-4","article-title":"The FXR agonist, obeticholic acid, suppresses HCC proliferation & metastasis: role of IL-6\/STAT3 signalling pathway","volume":"7","author":"Attia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcancer.2025.09.002_bib141","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.1038\/s41598-018-25569-4","article-title":"Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of gi protein, muscarinic receptors and TGR5","volume":"8","author":"Ibrahim","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcancer.2025.09.002_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sji.13361","article-title":"The role of bile acid receptor TGR5 in regulating inflammatory signalling","volume":"99","author":"Ye","year":"2024","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-31141-6","article-title":"Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-\u03b2 degradation","volume":"13","author":"Shen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcancer.2025.09.002_bib144","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1033145","article-title":"Deregulated bile acids May drive hepatocellular carcinoma metastasis by inducing an immunosuppressive microenvironment","volume":"12","author":"Xia","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib145","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib146","first-page":"1","article-title":"TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.semcancer.2025.09.002_bib147","article-title":"MDM2 binding protein induces the resistance of hepatocellular carcinoma cells to molecular targeting agents via enhancing the transcription factor activity of the pregnane x receptor","volume":"11","author":"Jiang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib148","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/toxsci\/kfu099","article-title":"Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR","volume":"140","author":"Braeuning","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.semcancer.2025.09.002_bib149","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tox.2018.02.001","article-title":"Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)\/pregnane x receptor (PXR) mice and in cultured mouse, rat and human hepatocytes","author":"Haines","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1217847","article-title":"CAR requires Gadd45\u03b2 to promote phenobarbital-induced mouse liver tumors in early stage","volume":"13","author":"Hori","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib151","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin d receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science (80)"},{"key":"10.1016\/j.semcancer.2025.09.002_bib152","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1053\/j.gastro.2013.12.027","article-title":"Vitamin d receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol","volume":"146","author":"Chow","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib153","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/hep.30937","article-title":"Vitamin d receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice","volume":"71","author":"Dong","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib154","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.gene.2018.02.024","article-title":"Vitamin d receptor gene methylation in hepatocellular carcinoma","volume":"653","author":"Abdalla","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.semcancer.2025.09.002_bib155","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ccell.2016.09.004","article-title":"p62\/SQSTM1 by binding to vitamin d receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer","volume":"30","author":"Duran","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2025.09.002_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.semcancer.2025.09.002_bib157","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2022.02.030","article-title":"Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis","volume":"77","author":"Sun","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib158","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1007\/s00432-020-03374-9","article-title":"Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma","volume":"146","author":"Nguyen","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib159","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/19490976.2020.1743492","article-title":"Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota","volume":"11","author":"Singh","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.semcancer.2025.09.002_bib160","doi-asserted-by":"crossref","first-page":"8779","DOI":"10.2147\/IJN.S150196","article-title":"Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel","volume":"12","author":"Zhang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.semcancer.2025.09.002_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111510","article-title":"\u03b2-Cyclodextrin-cholic acid-hyaluronic acid polymer coated Fe3O4-graphene oxide nanohybrids as local chemo-photothermal synergistic agents for enhanced liver tumor therapy","volume":"199","author":"Wen","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.semcancer.2025.09.002_bib162","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/164_2019_241","article-title":"UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications","volume":"256","author":"Cabrera","year":"2019","journal-title":"Handb. Exp. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib163","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121471","article-title":"Tauroursodeoxycholate\u2014bile acid with chaperoning activity: molecular and cellular effects and therapeutic perspectives","volume":"8","author":"Kusaczuk","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.semcancer.2025.09.002_bib164","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jhep.2005.01.026","article-title":"A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid","volume":"42","author":"Castro","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib165","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/hep.20870","article-title":"Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-\u03b21-induced apoptosis in rat hepatocytes","volume":"42","author":"Sol\u00e1","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib166","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.599067","article-title":"Evaluation of the anticancer activity of a bile Acid-Dihydroartemisinin hybrid Ursodeoxycholic-Dihydroartemisinin in hepatocellular carcinoma cells","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib167","first-page":"2551","article-title":"Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK","volume":"42","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143473","article-title":"Abnormal metabolism in the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma: mechanistic insights to chemoprevention","volume":"13","author":"Orabi","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.semcancer.2025.09.002_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114497","article-title":"Activation of FXR modulates SOCS3\/Jak2\/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model","volume":"186","author":"Attia","year":"2021","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib170","doi-asserted-by":"crossref","DOI":"10.1002\/pds.70084","article-title":"A Real-World pharmacovigilance study of FDA adverse event reporting system events for obeticholic acid","volume":"34","author":"Hai","year":"2025","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.semcancer.2025.09.002_bib171","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1053\/gast.1997.v113.pm9322525","article-title":"Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas","volume":"113","author":"Kullak-Ublick","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semcancer.2025.09.002_bib172","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1365-2362.1996.tb02383.x","article-title":"Bile acid transport systems as pharmaceutical targets","volume":"26","author":"KRAMER","year":"1996","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.semcancer.2025.09.002_bib173","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0168-8278(99)80046-4","article-title":"Further evidence of the usefulness of bile acids as molecules for shuttling cytostatic drugs toward liver tumors","volume":"31","author":"Monte","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib174","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0022-3565(24)29639-7","article-title":"Low in vivo toxicity of a novel cisplatin-ursodeoxycholic derivative (Bamet-UD2) with enhanced cytostatic activity versus liver tumors","volume":"297","author":"Dominguez","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.semcancer.2025.09.002_bib175","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/aps.2011.7","article-title":"Novel liver-specific cholic acid-cytarabine conjugates with potent antitumor activities: synthesis and biological characterization","volume":"32","author":"Chen","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.semcancer.2025.09.002_bib176","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ardp.200900075","article-title":"Synthesis and characterization of new liver targeting 5-fluorouracil-cholic acid conjugates","volume":"342","author":"Qian","year":"2009","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib177","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.bcp.2006.12.027","article-title":"Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases","volume":"73","author":"Vallejo","year":"2007","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.semcancer.2025.09.002_bib178","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1021\/bc970061v","article-title":"Synthesis and characterization of the new cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate","volume":"8","author":"Criado","year":"1997","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.semcancer.2025.09.002_bib179","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0162-0134(01)00172-6","article-title":"Structural characterization and cytostatic activity of chlorobischolylglycinatogold(III)","volume":"84","author":"Carrasco","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.semcancer.2025.09.002_bib180","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<346::AID-IJC15>3.0.CO;2-4","article-title":"DNA interaction and cytostatic activity of the new liver organotropic complex of cisplatin with glycocholic acid: Bamet-R2","volume":"78","author":"Marin","year":"1998","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2025.09.002_bib181","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/10611860108997927","article-title":"Liver organotropism and biotransformation of a novel Platinum-Ursodeoxycholate derivative, Bamet-UD2, with enhanced antitumour activity","volume":"9","author":"Larena","year":"2001","journal-title":"J. Drug Target"},{"key":"10.1016\/j.semcancer.2025.09.002_bib182","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/1097-0215(20001015)88:2<287::AID-IJC22>3.0.CO;2-U","article-title":"Overcoming cisplatin resistance in vitro by a free and liposome-encapsulated bile acid derivative: Bamet-R2","volume":"88","author":"Briz","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcancer.2025.09.002_bib183","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2015.08.022","article-title":"Enhanced antitumour drug delivery to cholangiocarcinoma through the apical sodium-dependent bile acid transporter (ASBT)","volume":"216","author":"Lozano","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.semcancer.2025.09.002_bib184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25030655","article-title":"Synthesis of new cisplatin derivatives from bile acids","volume":"25","author":"Seroka","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.semcancer.2025.09.002_bib185","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.4c01549","article-title":"Ursodeoxycholic acid Platinum(IV) conjugates as antiproliferative and antimetastatic agents: remodel the tumor microenvironment through suppressing JAK2\/STAT3 signaling","author":"Chen","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.semcancer.2025.09.002_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112200","article-title":"Synthesis and biological evaluation of cholic acid-conjugated oxaliplatin as a new prodrug for liver cancer","volume":"243","author":"Jiang","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.semcancer.2025.09.002_bib187","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.105.086165","article-title":"Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism","volume":"315","author":"Monte","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.semcancer.2025.09.002_bib188","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1021\/acs.nanolett.1c01360","article-title":"Manipulating liver bile acid signaling by nanodelivery of bile acid receptor modulators for liver cancer immunotherapy","volume":"21","author":"Ji","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.semcancer.2025.09.002_bib189","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-11549-7","article-title":"Long-term administration of nuclear bile acid receptor FXR agonist prevents spontaneous hepatocarcinogenesis in Abcb4-\/- mice","volume":"7","author":"Cariello","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcancer.2025.09.002_bib190","author":"Pfister","year":"2021","journal-title":"NASH Limits antiTumour Surveill. Immunother. Treat. HCC"},{"key":"10.1016\/j.semcancer.2025.09.002_bib191","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1001\/jamaoncol.2020.4564","article-title":"Efficacy and safety of nivolumab plus ipilimumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib: the CheckMate 040 randomized clinical trial","volume":"6","author":"Yau","year":"2020","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib192","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.semcancer.2025.09.002_bib193","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1126\/science.adl4100","article-title":"Bile acid synthesis impedes tumor-specific t cell responses during liver cancer","volume":"387","author":"Varanasi","year":"2025","journal-title":"Science (80)"},{"key":"10.1016\/j.semcancer.2025.09.002_bib194","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jhep.2021.06.028","article-title":"Single-cell Atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma","volume":"75","author":"Ma","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.semcancer.2025.09.002_bib195","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccell.2019.08.007","article-title":"Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer","volume":"36","author":"Ma","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcancer.2025.09.002_bib196","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1136\/gutjnl-2023-331117","article-title":"Targeting squalene epoxidase restores anti-PD-1 efficacy in metabolic dysfunction-associated steatohepatitis-induced hepatocellular carcinoma","volume":"73","author":"Wen","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.semcancer.2025.09.002_bib197","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1136\/gutjnl-2024-332766","article-title":"Cholesterol\u2019s new tricks propel MASH-HCC: impact in immunotherapy","volume":"73","author":"Garcia-Ruiz","year":"2024","journal-title":"Gut"}],"container-title":["Seminars in Cancer Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X2500118X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044579X2500118X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:53:46Z","timestamp":1773096826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044579X2500118X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":197,"alternative-id":["S1044579X2500118X"],"URL":"https:\/\/doi.org\/10.1016\/j.semcancer.2025.09.002","relation":{},"ISSN":["1044-579X"],"issn-type":[{"value":"1044-579X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bile acids in liver and gastrointestinal cancer","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cancer Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcancer.2025.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}