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The gatekeeper for eliminating excess tissue cholesterol","volume":"42","author":"Oram","year":"2001","journal-title":"J Lipid Res"},{"key":"10.1016\/j.semcdb.2005.01.005_bib152","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.289.5484.1524","article-title":"Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers","volume":"289","author":"Repa","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2005.01.005_bib153","doi-asserted-by":"crossref","first-page":"40987","DOI":"10.1074\/jbc.M407963200","article-title":"ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE","volume":"279","author":"Wahrle","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2005.01.005_bib154","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0197-4580(02)00094-5","article-title":"ABCA1 modulates CSF cholesterol levels and influences the age at onset of 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