{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:51:19Z","timestamp":1792673479622,"version":"4.5.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.semcdb.2006.12.004","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T10:12:23Z","timestamp":1166609543000},"page":"101-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":282,"title":["Model systems for the study of heart development and disease"],"prefix":"10.1016","volume":"18","author":[{"given":"Mary R.","family":"Hutson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2006.12.004_bib1","series-title":"The neural crest. Its properties and derivatives in the light of experimental research","author":"Horstadius","year":"1950"},{"key":"10.1016\/j.semcdb.2006.12.004_bib2","series-title":"The neural crest","author":"Le Douarin","year":"1999"},{"key":"10.1016\/j.semcdb.2006.12.004_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ar.1092130112","article-title":"Characterization of conotruncal malformations following ablation of \u201ccardiac\u201d neural crest","volume":"213","author":"Kirby","year":"1985","journal-title":"Anat Rec"},{"key":"10.1016\/j.semcdb.2006.12.004_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/dbio.1997.8529","article-title":"Absence of neural crest cell regeneration from the postotic neural tube","volume":"184","author":"Suzuki","year":"1997","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.6606851","article-title":"Dependence of thymus development on derivatives of the neural crest","volume":"223","author":"Bockman","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2006.12.004_bib6","first-page":"125","article-title":"Mesenchymal derivatives of the neural crest. Analysis of chimaeric quail and chick embryos","volume":"34","author":"Le Lievre","year":"1975","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib7","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.6844926","article-title":"Neural crest cells contribute to aorticopulmonary septation","volume":"220","author":"Kirby","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2006.12.004_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.1999.9219","article-title":"Connexin 43 expression reflects neural crest patterns during cardiovascular development","volume":"208","author":"Waldo","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1161\/01.RES.0000227505.19472.69","article-title":"Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system","volume":"98","author":"Nakamura","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.semcdb.2006.12.004_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0012-1606(83)90100-8","article-title":"Neural crest origin of cardiac ganglion cells in the chick embryo: identification and extirpation","volume":"97","author":"Kirby","year":"1983","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/dbio.1998.9166","article-title":"A subpopulation of apoptosis-prone cardiac neural crest cells targets to the venous pole: multiple functions in heart development","volume":"207","author":"Poelmann","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.semcdb.2005.06.001","article-title":"Genetic network during neural crest induction: from cell specification to cell survival","volume":"16","author":"Steventon","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1534-5807(02)00221-6","article-title":"Association between the cell cycle and neural crest delamination through specific regulation of G1\/S transition","volume":"3","author":"Burstyn-Cohen","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.semcdb.2006.12.004_bib14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/bdrc.10002","article-title":"Neural crest and cardiovascular development: a 20-year perspective","volume":"69","author":"Hutson","year":"2003","journal-title":"Birth Defects Res, Part C Embryo Today"},{"key":"10.1016\/j.semcdb.2006.12.004_bib15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.CIR.75.1.255","article-title":"Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation","volume":"75","author":"Nishibatake","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2006.12.004_bib16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.CIR.0000023044.44974.8A","article-title":"Shortened outflow tract leads to altered cardiac looping after neural crest ablation","volume":"106","author":"Yelbuz","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2006.12.004_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.RES.60.1.27","article-title":"Analysis of cranial neural crest distribution in the developing heart using quail-chick chimeras","volume":"60","author":"Phillips","year":"1987","journal-title":"Circ Res"},{"key":"10.1016\/j.semcdb.2006.12.004_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/aja.1001920109","article-title":"Temporospatial study of the migration and distribution of cardiac neural crest in quail-chick chimeras","volume":"192","author":"Miyagawa-Tomita","year":"1991","journal-title":"Am J Anat"},{"key":"10.1016\/j.semcdb.2006.12.004_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/dbio.1998.8860","article-title":"Cardiac neural crest cells provide new insight into septation of the cardiac outflow tract: aortic sac to ventricular septal closure","volume":"196","author":"Waldo","year":"1998","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00338048","article-title":"Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos","volume":"268","author":"Fukiishi YMorriss-Kay","year":"1992","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.semcdb.2006.12.004_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1520-6408(1997)20:2<119::AID-DVG5>3.0.CO;2-A","article-title":"Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells","volume":"20","author":"Lo","year":"1997","journal-title":"Dev Genet"},{"key":"10.1016\/j.semcdb.2006.12.004_bib22","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1242\/dev.128.16.3071","article-title":"PlexinA2 and semaphorin signaling during cardiac neural crest development","volume":"128","author":"Brown","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib23","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/dev.127.8.1607","article-title":"Fate of the mammalian cardiac neural crest","volume":"127","author":"Jiang","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/mcne.1996.0589","article-title":"P0 is constitutively expressed in the rat neural crest and embryonic nerves and is negatively and positively regulated by axons to generate non-myelin-forming and myelin-forming Schwann cells, respectively","volume":"8","author":"Lee","year":"1997","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.semcdb.2006.12.004_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0012-1606(03)00037-X","article-title":"Cardiac neural crest contributes to cardiomyogenesis in zebrafish","volume":"257","author":"Sato MYost","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib26","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/dvdy.10264","article-title":"Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function","volume":"226","author":"Li","year":"2003","journal-title":"Dev Dyn"},{"key":"10.1016\/j.semcdb.2006.12.004_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ydbio.2005.02.012","article-title":"Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart","volume":"281","author":"Waldo","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ydbio.2005.02.011","article-title":"Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field","volume":"281","author":"Waldo","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ydbio.2006.02.052","article-title":"Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx","volume":"295","author":"Hutson","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib30","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/aja.1001800403","article-title":"Effect of neural crest ablation on development of the heart and arch arteries in the chick","volume":"180","author":"Bockman","year":"1987","journal-title":"Am J Anat"},{"key":"10.1016\/j.semcdb.2006.12.004_bib31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ar.1092250306","article-title":"Alteration of early vascular development after ablation of cranial neural crest","volume":"225","author":"Bockman","year":"1989","journal-title":"Anat Rec"},{"key":"10.1016\/j.semcdb.2006.12.004_bib32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1097-0177(199603)205:3<281::AID-AJA8>3.0.CO;2-E","article-title":"Cardiac neural crest is essential for the persistence rather than the formation of an arch artery","volume":"205","author":"Waldo","year":"1996","journal-title":"Dev Dyn"},{"key":"10.1016\/j.semcdb.2006.12.004_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/aja.1001910302","article-title":"Initial migration and distribution of the cardiac neural crest in the avian embryo: an introduction to the concept of the circumpharyngeal crest","volume":"191","author":"Kuratani","year":"1991","journal-title":"Am J Anat"},{"key":"10.1016\/j.semcdb.2006.12.004_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ar.1092340213","article-title":"Migration and distribution of circumpharyngeal crest cells in the chick embryo. Formation of the circumpharyngeal ridge and E\/C8+ crest cells in the vertebrate head region","volume":"234","author":"Kuratani","year":"1992","journal-title":"Anat Rec"},{"key":"10.1016\/j.semcdb.2006.12.004_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1172\/JCI118033","article-title":"Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1","volume":"96","author":"Kurihara","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2006.12.004_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI2698","article-title":"Role of endothelin-1\/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice","volume":"102","author":"Yanagisawa","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2006.12.004_bib37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0012-1606(03)00128-3","article-title":"Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development","volume":"261","author":"Clouthier","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib38","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1242\/dev.125.24.4931","article-title":"Pharmacological inactivation of the endothelin type A receptor in the early chick embryo: a model of mispatterning of the branchial arch derivatives","volume":"125","author":"Kempf","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/dbio.2002.0818","article-title":"Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo","volume":"251","author":"Ballard","year":"2002","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/dbio.1999.9527","article-title":"Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice","volume":"217","author":"Clouthier","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib41","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1101\/gad.931701","article-title":"Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer","volume":"15","author":"Charite","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.semcdb.2006.12.004_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/35065105","article-title":"Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice","volume":"410","author":"Lindsay","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2006.12.004_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1101\/gad.1048903","article-title":"Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer","volume":"17","author":"Yamagishi","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.semcdb.2006.12.004_bib44","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1242\/dev.00850","article-title":"Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development","volume":"130","author":"Macatee","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib45","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/01.CIR.81.3.1047","article-title":"Microcinephotography of the developing heart in neural crest-ablated chick embryos","volume":"81","author":"Leatherbury","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2006.12.004_bib46","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1203\/00006450-199112000-00002","article-title":"Hemodynamic changes and compensatory mechanisms during early cardiogenesis after neural crest ablation in chick embryos","volume":"30","author":"Leatherbury","year":"1991","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semcdb.2006.12.004_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.physiol.60.1.267","article-title":"Role of cardiac neural crest cells in cardiovascular development","volume":"60","author":"Creazzo","year":"1998","journal-title":"Ann Rev Physiol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib48","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1172\/JCI9317","article-title":"FGF-8 in the ventral pharynx alters development of myocardial calcium transients after neural crest ablation","volume":"107","author":"Farrell","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2006.12.004_bib49","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ng768","article-title":"Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator","volume":"29","author":"Bamforth","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.semcdb.2006.12.004_bib50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0925-4773(01)00579-2","article-title":"Requirement for AP-2\u03b1 in cardiac outflow tract morphogenesis","volume":"110","author":"Brewer","year":"2002","journal-title":"Mech Dev"},{"key":"10.1016\/j.semcdb.2006.12.004_bib51","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1242\/dev.128.16.3061","article-title":"Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption","volume":"128","author":"Feiner","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib52","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1006\/jmcc.1997.0499","article-title":"Neural crest is involved in development of abnormal myocardial function","volume":"29","author":"Conway","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.124.2.505","article-title":"Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant","volume":"124","author":"Conway","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0008-6363(97)00172-7","article-title":"Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse","volume":"36","author":"Conway","year":"1997","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.semcdb.2006.12.004_bib55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1050-1738(96)00110-7","article-title":"Pax3, neural crest and cardiovascular development","volume":"6","author":"Epstein","year":"1996","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.semcdb.2006.12.004_bib56","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF00305120","article-title":"Persistent truncus arteriosus in the Splotch mutant mouse","volume":"180","author":"Franz","year":"1989","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.semcdb.2006.12.004_bib57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1242\/dev.115.1.133","article-title":"A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells","volume":"115","author":"Morrison-Graham","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib58","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jez.1401270206","article-title":"Analysis of the developmental effects of a lethal mutation in the house mouse","volume":"127","author":"Auerbach","year":"1954","journal-title":"J Exp Zool"},{"key":"10.1016\/j.semcdb.2006.12.004_bib59","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1242\/dev.127.9.1869","article-title":"Migration of cardiac neural crest cells in Splotch embryos","volume":"127","author":"Epstein","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib60","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1242\/dev.129.2.527","article-title":"Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest","volume":"129","author":"Kwang","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib61","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/S100050010061","article-title":"Cardiac defects associated with the absence of the platelet-derived growth factor alpha receptor in the Patch mouse","volume":"7","author":"Price","year":"2001","journal-title":"Microsc Microanal"},{"key":"10.1016\/j.semcdb.2006.12.004_bib62","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/dbio.1999.9373","article-title":"Diminished matrix metalloproteinase-2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration","volume":"212","author":"Robbins","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib63","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/350473a0","article-title":"Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5","volume":"350","author":"Chisaka","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2006.12.004_bib64","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/dbio.2002.0689","article-title":"Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos","volume":"247","author":"Kameda","year":"2002","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib65","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1242\/dev.121.7.1989","article-title":"The role of Hoxa-3 in mouse thymus and thyroid development","volume":"121","author":"Manley","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib66","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/(SICI)1097-0177(199701)208:1<34::AID-AJA4>3.0.CO;2-2","article-title":"Normal development of the cardiac outflow tract is not dependent on normal patterning of the aortic arch arteries","volume":"208","author":"Kirby","year":"1997","journal-title":"Dev Dyn"},{"key":"10.1016\/j.semcdb.2006.12.004_bib67","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s004290000152","article-title":"Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse","volume":"203","author":"Van Gijn","year":"2001","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.semcdb.2006.12.004_bib68","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1242\/dev.00164","article-title":"Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure","volume":"129","author":"Hamblet","year":"2002","journal-title":"Dev Dis"},{"key":"10.1016\/j.semcdb.2006.12.004_bib69","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1242\/dev.01086","article-title":"BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium","volume":"131","author":"Stottmann","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib70","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1242\/dev.01214","article-title":"Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells","volume":"131","author":"Kaartinen","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib71","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1050-1738(03)00039-2","article-title":"The role of Pitx2 during cardiac development\u2014linking left-right signaling and congenital heart diseases","volume":"13","author":"Franco","year":"2003","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.semcdb.2006.12.004_bib72","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)01084-X","article-title":"Identification of a Wnt\/Dvl\/beta-Catenin\u2192Pitx2 pathway mediating cell-type-specific proliferation during development","volume":"111","author":"Kioussi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2006.12.004_bib73","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1242\/dev.129.21.5081","article-title":"Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions","volume":"129","author":"Liu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib74","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1242\/dev.126.21.4895","article-title":"A requirement for neuropilin-1 in embryonic vessel formation","volume":"126","author":"Kawasaki","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib75","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI27363","article-title":"GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis","volume":"116","author":"Lepore","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2006.12.004_bib76","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1050-1738(99)00015-8","article-title":"Gap junction communication and the modulation of cardiac neural crest cells","volume":"9","author":"Lo","year":"1999","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.semcdb.2006.12.004_bib77","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1126\/science.7892609","article-title":"Cardiac malformation in neonatal mice lacking connexin43","volume":"267","author":"Reaume","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2006.12.004_bib78","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1083\/jcb.143.6.1725","article-title":"Gap junction-mediated cell\u2013cell communication modulates mouse neural crest migration","volume":"143","author":"Huang","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib79","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/dev.124.7.1281","article-title":"Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene","volume":"124","author":"Ewart","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib80","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1242\/dev.02374","article-title":"Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube","volume":"133","author":"Liu","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib81","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/01.RES.83.10.986","article-title":"Sox4-deficiency syndrome in mice is an animal model for common trunk","volume":"83","author":"Ya","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.semcdb.2006.12.004_bib82","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1242\/dev.01287","article-title":"Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation","volume":"131","author":"Wang","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib83","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1242\/dev.124.22.4627","article-title":"Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis","volume":"124","author":"Iida","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib84","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/dbio.1999.9382","article-title":"Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles","volume":"213","author":"Winnier","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib85","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1101\/gad.907301","article-title":"The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis","volume":"15","author":"Kume","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.semcdb.2006.12.004_bib86","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ydbio.2006.06.012","article-title":"Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract","volume":"296","author":"Seo","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib87","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1242\/dev.129.19.4613","article-title":"Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse","volume":"129","author":"Abu-Issa","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib88","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ydbio.2003.10.024","article-title":"Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse","volume":"267","author":"Brown","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib89","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/85845","article-title":"DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1","volume":"27","author":"Jerome","year":"2001","journal-title":"Nature Genet"},{"key":"10.1016\/j.semcdb.2006.12.004_bib90","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/S0140-6736(03)14632-6","article-title":"Role of TBX1 in human del22q11.2 syndrome","volume":"362","author":"Yagi","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.semcdb.2006.12.004_bib91","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1242\/dev.01174","article-title":"Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract","volume":"131","author":"Xu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib92","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/(SICI)1096-8628(19980207)81:1<41::AID-AJMG8>3.0.CO;2-Q","article-title":"Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and \u201cmultidimensionally impaired\u201d","volume":"81","author":"Yan","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.semcdb.2006.12.004_bib93","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0002-9149(86)90256-0","article-title":"Cardiovascular anomalies in DiGeorge syndrome and importance of neural crest as a possible pathogenetic factor","volume":"58","author":"Van Mierop","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib94","first-page":"56","article-title":"A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: velo-cardio-facial syndrome","volume":"15","author":"Shprintzen","year":"1978","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.semcdb.2006.12.004_bib95","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1242\/dev.01174","article-title":"Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract","volume":"131","author":"Xu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib96","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/dbio.2001.0283","article-title":"Tbx1, a DiGeorge syndrome candidate gene, is regulated by Sonic hedgehog during pharyngeal arch development","volume":"235","author":"Garg","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib97","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1242\/dev.02539","article-title":"Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development","volume":"133","author":"Zhang","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib98","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1242\/dev.01399","article-title":"Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors","volume":"131","author":"Hu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib99","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1242\/dev.129.19.4605","article-title":"A genetic link between Tbx1 and fibroblast growth factor signaling","volume":"129","author":"Vitelli","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib100","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1242\/dev.02309","article-title":"Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field","volume":"133","author":"Nowotschin","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2006.12.004_bib101","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.devcel.2005.12.002","article-title":"Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome","volume":"10","author":"Guris","year":"2006","journal-title":"Dev Cell"},{"key":"10.1016\/j.semcdb.2006.12.004_bib102","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/dvdy.20268","article-title":"Retinoic acid down-regulates Tbx1 expression in vivo and in vitro","volume":"232","author":"Roberts","year":"2005","journal-title":"Dev Dyn"},{"key":"10.1016\/j.semcdb.2006.12.004_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm819","article-title":"VEGF: a modifier of the del22q11 (DiGeorge) syndrome?","volume":"9","author":"Stalmans","year":"2003","journal-title":"Nature Med"},{"key":"10.1016\/j.semcdb.2006.12.004_bib104","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/85855","article-title":"Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome","volume":"27","author":"Guris","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.semcdb.2006.12.004_bib105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.devcel.2005.12.003","article-title":"Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes","volume":"10","author":"Moon","year":"2006","journal-title":"Dev Cell"},{"key":"10.1016\/j.semcdb.2006.12.004_bib106","series-title":"Cardiac development","author":"Kirby","year":"2007"},{"key":"10.1016\/j.semcdb.2006.12.004_bib107","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ydbio.2004.05.016","article-title":"Heart fields: one, two or more?","volume":"272","author":"Abu-Issa","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2006.12.004_bib108","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2005.05.003","article-title":"Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia","volume":"284","author":"Ward","year":"2005","journal-title":"Dev Biol"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952106001327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952106001327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:46:02Z","timestamp":1761065162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952106001327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":108,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1084952106001327"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2006.12.004","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Model systems for the study of heart development and disease","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2006.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}