{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:07:41Z","timestamp":1791068861308,"version":"4.1.0"},"reference-count":109,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":896,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Wellcome Trust Project","award":["082640"],"award-info":[{"award-number":["082640"]}]},{"name":"NC3Rs","award":["G0900775"],"award-info":[{"award-number":["G0900775"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.semcdb.2010.11.002","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T09:36:18Z","timestamp":1290245778000},"page":"105-113","source":"Crossref","is-referenced-by-count":37,"title":["Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder"],"prefix":"10.1016","volume":"22","author":[{"given":"Marthe H.R.","family":"Ludtmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Boeckeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin S.B.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/scientificamerican0295-62","article-title":"Manic-depressive illness and creativity","volume":"272","author":"Jamison","year":"1995","journal-title":"Sci Am"},{"issue":"Suppl. 2","key":"10.1016\/j.semcdb.2010.11.002_bib0010","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0924-977X(03)00077-4","article-title":"Diagnostic issues in bipolar disorder","volume":"13","author":"Angst","year":"2003","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00406-003-0433-6","article-title":"Frequency of bipolar spectrum in 111 private practice depression outpatients","volume":"253","author":"Benazzi","year":"2003","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4088\/JCP.v64n0412","article-title":"Impact of bipolar disorder on a US community sample","volume":"64","author":"Calabrese","year":"2003","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0006-3223(03)00639-5","article-title":"Mood disorders and medical illness: a major public health problem","volume":"54","author":"Evans","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0030","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.4088\/JCP.8125tx11c","article-title":"Diagnostic features, prevalence, and impact of bipolar disorder","volume":"71","author":"Ketter","year":"2010","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0035","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1017\/S0033291703001491","article-title":"Higher socio-economic status of parents may increase risk for bipolar disorder in the offspring","volume":"34","author":"Tsuchiya","year":"2004","journal-title":"Psychol Med"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-0179-5-3","article-title":"A systematic review of the evidence of the burden of bipolar disorder in Europe","volume":"5","author":"Fajutrao","year":"2009","journal-title":"Clin Pract Epidemiol Ment Health"},{"issue":"1","key":"10.1016\/j.semcdb.2010.11.002_bib0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11920-008-0012-7","article-title":"Bipolar disorder and suicide: research synthesis and clinical translation","volume":"10","author":"McIntyre","year":"2008","journal-title":"Curr Psychiatry Rep"},{"issue":"9","key":"10.1016\/j.semcdb.2010.11.002_bib0050","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archpsyc.64.9.1032","article-title":"National trends in the outpatient diagnosis and treatment of bipolar disorder in youth","volume":"64","author":"Moreno","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0055","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/sj.ejhg.5201549","article-title":"Genetics of affective (mood) disorders","volume":"14","author":"Craddock","year":"2006","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/187152707780619308","article-title":"Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway","volume":"6","author":"Gould","year":"2007","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0065","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/0269881108097905","article-title":"Models of mania: from facets to domains and from animal models to model animals","volume":"24","author":"Flaisher-Grinberg","year":"2010","journal-title":"J Psychopharmacol"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tig.2008.12.002","article-title":"Genetics of bipolar disorder: successful start to a long journey","volume":"25","author":"Craddock","year":"2009","journal-title":"Trends Genet"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.mp.4002012","article-title":"A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder","volume":"13","author":"Baum","year":"2008","journal-title":"Mol Psychiatry"},{"issue":"11","key":"10.1016\/j.semcdb.2010.11.002_bib0080","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/mp.2010.62","article-title":"Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype","volume":"15","author":"Craddock","year":"2010","journal-title":"Mol Psychiatry"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0085","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/archgenpsychiatry.2008.541","article-title":"Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder","volume":"66","author":"van der Schot","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0090","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4088\/JCP.07m03745","article-title":"A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients","volume":"70","author":"Moore","year":"2009","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0095","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/09540260902962081","article-title":"The structural neuroimaging of bipolar disorder","volume":"21","author":"Emsell","year":"2009","journal-title":"Int Rev Psychiatry"},{"issue":"12","key":"10.1016\/j.semcdb.2010.11.002_bib0100","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1093\/hmg\/ddl118","article-title":"Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation","volume":"15","author":"Nakatani","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0105","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1399-5618.2004.00100.x","article-title":"Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients","volume":"6","author":"Breen","year":"2004","journal-title":"Bipolar Disord"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0110","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.biopsych.2005.07.024","article-title":"Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder","volume":"59","author":"Bazinet","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0115","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/mp.2008.117","article-title":"Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to \u2018switching\u2019 in bipolar disorder?","volume":"15","author":"Lee","year":"2010","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0120","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0959-437X(94)90128-P","article-title":"Differentiation and patterning in Dictyostelium","volume":"4","author":"Kay","year":"1994","journal-title":"Curr Opin Genet Dev"},{"issue":"Suppl. 1","key":"10.1016\/j.semcdb.2010.11.002_bib0125","doi-asserted-by":"crossref","first-page":"S277","DOI":"10.1111\/j.1440-169X.2008.01013.x","article-title":"Developmental biology of the social amoeba: history, current knowledge and prospects","volume":"50","author":"Urushihara","year":"2008","journal-title":"Dev Growth Differ"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0130","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.gde.2004.08.001","article-title":"Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response","volume":"14","author":"Kimmel","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0135","first-page":"10","article-title":"Cytokinesis through biochemical\u2013mechanical feedback loops","author":"Surcel","year":"2010","journal-title":"Semin Cell Dev Biol"},{"issue":"16","key":"10.1016\/j.semcdb.2010.11.002_bib0140","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.cub.2009.06.058","article-title":"Quantification of social behavior in D. discoideum reveals complex fixed and facultative strategies","volume":"19","author":"Buttery","year":"2009","journal-title":"Curr Biol"},{"issue":"7038","key":"10.1016\/j.semcdb.2010.11.002_bib0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature03481","article-title":"The genome of the social amoeba Dictyostelium discoideum","volume":"435","author":"Eichinger","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0150","doi-asserted-by":"crossref","first-page":"D515","DOI":"10.1093\/nar\/gkn844","article-title":"DictyBase\u2014a Dictyostelium bioinformatics resource update","volume":"37","author":"Fey","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0155","first-page":"201","article-title":"Restriction enzyme-mediated integration (REMI) mutagenesis","volume":"346","author":"Kuspa","year":"2006","journal-title":"Methods Mol Biol"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/genetics\/138.3.665","article-title":"REMI-RFLP mapping in the Dictyostelium genome","volume":"138","author":"Kuspa","year":"1994","journal-title":"Genetics"},{"issue":"18","key":"10.1016\/j.semcdb.2010.11.002_bib0165","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1073\/pnas.89.18.8803","article-title":"Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA","volume":"89","author":"Kuspa","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0170","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.pnpbp.2005.03.020","article-title":"Pharmacogenetics in model systems: defining a common mechanism of action for mood stabilisers","volume":"29","author":"Williams","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"19","key":"10.1016\/j.semcdb.2010.11.002_bib0175","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1093\/nar\/gnh136","article-title":"A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system","volume":"32","author":"Faix","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/j.semcdb.2010.11.002_bib0180","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cub.2007.04.004","article-title":"Chemotaxis in the absence of PIP3 gradients","volume":"17","author":"Hoeller","year":"2007","journal-title":"Curr Biol"},{"issue":"10","key":"10.1016\/j.semcdb.2010.11.002_bib0185","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.febslet.2006.03.082","article-title":"Visualizing cytoskeleton dynamics in mammalian cells using a humanized variant of monomeric red fluorescent protein","volume":"580","author":"Fischer","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0190","first-page":"435","article-title":"Pharmacodynamic properties of N-dipropylacetic acid","volume":"18","author":"Meunier","year":"1963","journal-title":"Therapie"},{"issue":"7","key":"10.1016\/j.semcdb.2010.11.002_bib0195","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/sj.npp.1300190","article-title":"Maintenance efficacy of divalproex in the prevention of bipolar depression","volume":"28","author":"Gyulai","year":"2003","journal-title":"Neuropsychopharmacology"},{"issue":"Suppl. 2","key":"10.1016\/j.semcdb.2010.11.002_bib0200","first-page":"67","article-title":"Divalproex in the treatment of bipolar disorder","volume":"37","author":"Keck","year":"2003","journal-title":"Psychopharmacol Bull"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0205","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tips.2007.02.005","article-title":"Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms","volume":"28","author":"Calabresi","year":"2007","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0210","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/01.STR.0000217303.22856.38","article-title":"Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia","volume":"37","author":"Costa","year":"2006","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0215","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/med.20027","article-title":"Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies","volume":"25","author":"Blaheta","year":"2005","journal-title":"Med Res Rev"},{"issue":"12","key":"10.1016\/j.semcdb.2010.11.002_bib0220","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1084\/jem.20081588","article-title":"Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models","volume":"205","author":"Qing","year":"2008","journal-title":"J Exp Med"},{"issue":"9485","key":"10.1016\/j.semcdb.2010.11.002_bib0225","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0140-6736(05)67098-5","article-title":"Depletion of latent HIV-1 infection in vivo: a proof-of-concept study","volume":"366","author":"Lehrman","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0230","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.surg.2009.04.007","article-title":"Surviving blood loss without blood transfusion in a swine poly-trauma model","volume":"146","author":"Alam","year":"2009","journal-title":"Surgery"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0235","doi-asserted-by":"crossref","first-page":"e11383","DOI":"10.1371\/journal.pone.0011383","article-title":"Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats","volume":"5","author":"Dash","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.semcdb.2010.11.002_bib0240","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/bst0130075","article-title":"Valproic acid teratogenicity: demonstration that the biochemical mechanism differs from that of valproate hepatotoxicity","volume":"13","author":"Brown","year":"1985","journal-title":"Biochem Soc Trans"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0245","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.reprotox.2010.03.005","article-title":"Surveillance of adverse fetal effects of medications (SAFE-Med): findings from the international Clearinghouse of birth defects surveillance and research","volume":"29","author":"Lisi","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0250","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/gut.25.6.673","article-title":"Hepatotoxicity to sodium valproate: a review","volume":"25","author":"Powell-Jackson","year":"1984","journal-title":"Gut"},{"issue":"Pt 5","key":"10.1016\/j.semcdb.2010.11.002_bib0255","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1042\/BST0371126","article-title":"Structure-function studies for the panacea, valproic acid","volume":"37","author":"Terbach","year":"2009","journal-title":"Biochem Soc Trans"},{"issue":"Suppl. 1","key":"10.1016\/j.semcdb.2010.11.002_bib0260","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1034\/j.1399-5618.4.s1.2.x","article-title":"Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs","volume":"4","author":"Agam","year":"2002","journal-title":"Bipolar Disord"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0265","first-page":"402","article-title":"Effect of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing","volume":"59","author":"Shaltiel","year":"2007","journal-title":"Pharmacol Rep"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0270","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(89)90026-3","article-title":"Neural and developmental actions of lithium: a unifying hypothesis","volume":"59","author":"Berridge","year":"1989","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.semcdb.2010.11.002_bib0275","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0028-3908(03)00270-3","article-title":"Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro","volume":"45","author":"Cunningham","year":"2003","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.semcdb.2010.11.002_bib0280","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00213-005-0272-4","article-title":"Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder","volume":"184","author":"Bazinet","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"issue":"29","key":"10.1016\/j.semcdb.2010.11.002_bib0285","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","article-title":"Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis","volume":"24","author":"Hao","year":"2004","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0290","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.2000.0721327.x","article-title":"The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3","volume":"72","author":"Chen","year":"1999","journal-title":"J Neurochem"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0295","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1124\/mol.104.009308","article-title":"Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure","volume":"67","author":"Eickholt","year":"2005","journal-title":"Mol Pharmacol"},{"issue":"39","key":"10.1016\/j.semcdb.2010.11.002_bib0300","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.semcdb.2010.11.002_bib0305","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0028-3908(02)00215-0","article-title":"Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium","volume":"43","author":"DeSarno","year":"2002","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0310","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1021\/tx0502241","article-title":"Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives","volume":"19","author":"Eikel","year":"2006","journal-title":"Chem Res Toxicol"},{"issue":"10","key":"10.1016\/j.semcdb.2010.11.002_bib0315","doi-asserted-by":"crossref","first-page":"349","DOI":"10.5694\/j.1326-5377.1949.tb36912.x","article-title":"Lithium salts in the treatment of psychotic excitement","volume":"2","author":"Cade","year":"1949","journal-title":"Med J Aust"},{"issue":"6938","key":"10.1016\/j.semcdb.2010.11.002_bib0320","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature01640","article-title":"GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides","volume":"423","author":"Phiel","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0325","doi-asserted-by":"crossref","unstructured":"Williams RS, Harwood AJ. Lithium metallotherapeutics. Metallotherapeutic drugs and metal-based diagnostic agents: the use of metals in medicine. Wiley; 2005.","DOI":"10.1002\/0470864052.ch1"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0330","first-page":"59","article-title":"Evidence-based mental health use of anticonvulsants during pregnancy","volume":"37","author":"Gagliardi","year":"2003","journal-title":"Psychopharmacol Bull"},{"issue":"Pt 7","key":"10.1016\/j.semcdb.2010.11.002_bib0335","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/jcs.00384","article-title":"GSK-3: tricks of the trade for a multi-tasking kinase","volume":"116","author":"Doble","year":"2003","journal-title":"J Cell Sci"},{"issue":"11","key":"10.1016\/j.semcdb.2010.11.002_bib0340","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.2174\/1389450110607011421","article-title":"Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions","volume":"7","author":"Jope","year":"2006","journal-title":"Curr Drug Targets"},{"issue":"12","key":"10.1016\/j.semcdb.2010.11.002_bib0345","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.biopsych.2005.11.004","article-title":"Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder","volume":"59","author":"Einat","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"5\u20136","key":"10.1016\/j.semcdb.2010.11.002_bib0350","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1242\/dmm.001271","article-title":"The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells","volume":"2","author":"King","year":"2009","journal-title":"Dis Model Mech"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0355","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1385\/MN:32:2:173","article-title":"Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics","volume":"32","author":"Bachmann","year":"2005","journal-title":"Mol Neurobiol"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0360","first-page":"5","article-title":"Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics","volume":"35","author":"Manji","year":"2001","journal-title":"Psychopharmacol Bull"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0365","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0959-4388(00)00203-8","article-title":"Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders","volume":"11","author":"Drevets","year":"2001","journal-title":"Curr Opin Neurobiol"},{"issue":"9","key":"10.1016\/j.semcdb.2010.11.002_bib0370","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1176\/appi.ajp.162.9.1697","article-title":"Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task","volume":"162","author":"Strakowski","year":"2005","journal-title":"Am J Psychiatry"},{"issue":"9","key":"10.1016\/j.semcdb.2010.11.002_bib0375","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0006-3223(01)01080-0","article-title":"Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder","volume":"49","author":"Rajkowska","year":"2001","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0380","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1471-4159.1999.720879.x","article-title":"The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS","volume":"72","author":"Chen","year":"1999","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.semcdb.2010.11.002_bib0385","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s002130100871","article-title":"Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain","volume":"158","author":"Fukumoto","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"10.1016\/j.semcdb.2010.11.002_bib0390","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1358\/dnp.2003.16.7.829357","article-title":"Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice","volume":"16","author":"Einat","year":"2003","journal-title":"Drug News Perspect"},{"issue":"19","key":"10.1016\/j.semcdb.2010.11.002_bib0395","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1523\/JNEUROSCI.23-19-07311.2003","article-title":"The role of the extracellular signal-regulated kinase signaling pathway in mood modulation","volume":"23","author":"Einat","year":"2003","journal-title":"J Neurosci"},{"issue":"34","key":"10.1016\/j.semcdb.2010.11.002_bib0400","doi-asserted-by":"crossref","first-page":"31674","DOI":"10.1074\/jbc.M104309200","article-title":"The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth","volume":"276","author":"Yuan","year":"2001","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.semcdb.2010.11.002_bib0405","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/sj.npp.1301652","article-title":"Novel drugs and therapeutic targets for severe mood disorders","volume":"33","author":"Mathew","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"9\u201310","key":"10.1016\/j.semcdb.2010.11.002_bib0410","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ejcb.2006.04.013","article-title":"The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum","volume":"85","author":"Boeckeler","year":"2006","journal-title":"Eur J Cell Biol"},{"issue":"9","key":"10.1016\/j.semcdb.2010.11.002_bib0415","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.cellsig.2008.02.022","article-title":"Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility","volume":"20","author":"Gerits","year":"2008","journal-title":"Cell Signal"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0420","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0090-9556(25)08205-4","article-title":"In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analog 4-pentenoic acid","volume":"21","author":"Kassahun","year":"1993","journal-title":"Drug Metab Dispos"},{"issue":"14","key":"10.1016\/j.semcdb.2010.11.002_bib0425","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.bmc.2004.05.003","article-title":"Characterization of the anticonvulsant profile of valpromide derivatives","volume":"12","author":"Tasso","year":"2004","journal-title":"Bioorg Med Chem"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0430","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neuropharm.2006.09.017","article-title":"Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement","volume":"52","author":"Gotfryd","year":"2007","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0435","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.mehy.2006.09.040","article-title":"Is hippocampal atrophy a future drug target?","volume":"68","author":"Dhikav","year":"2007","journal-title":"Med Hypotheses"},{"issue":"4","key":"10.1016\/j.semcdb.2010.11.002_bib0440","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1017\/S1461145707008395","article-title":"Lithium preferentially inhibits adenylyl cyclase V and VII isoforms","volume":"11","author":"Mann","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"issue":"8","key":"10.1016\/j.semcdb.2010.11.002_bib0445","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1399-5618.2009.00762.x","article-title":"Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect","volume":"11","author":"Mann","year":"2009","journal-title":"Bipolar Disord"},{"issue":"5","key":"10.1016\/j.semcdb.2010.11.002_bib0450","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1471-4159.2005.03654.x","article-title":"The interaction between dopamine D2-like and beta-adrenergic receptors in the prefrontal cortex is altered by mood-stabilizing agents","volume":"96","author":"Montezinho","year":"2006","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0455","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1399-5618.2007.00354.x","article-title":"Effects of mood stabilizers on the inhibition of adenylate cyclase via dopamine D(2)-like receptors","volume":"9","author":"Montezinho","year":"2007","journal-title":"Bipolar Disord"},{"issue":"1","key":"10.1016\/j.semcdb.2010.11.002_bib0460","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ntt.2003.07.013","article-title":"Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression","volume":"26","author":"Gallagher","year":"2004","journal-title":"Neurotoxicol Teratol"},{"issue":"6886","key":"10.1016\/j.semcdb.2010.11.002_bib0465","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/417292a","article-title":"A common mechanism of action for three mood-stabilizing drugs","volume":"417","author":"Williams","year":"2002","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.semcdb.2010.11.002_bib0470","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1016\/S0021-9258(19)70391-3","article-title":"The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain","volume":"255","author":"Hallcher","year":"1980","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.semcdb.2010.11.002_bib0475","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/emboj\/18.10.2734","article-title":"Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate","volume":"18","author":"Williams","year":"1999","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.semcdb.2010.11.002_bib0480","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1083\/jcb.200504035","article-title":"Lithium induces autophagy by inhibiting inositol monophosphatase","volume":"170","author":"Sarkar","year":"2005","journal-title":"J Cell Biol"},{"issue":"23","key":"10.1016\/j.semcdb.2010.11.002_bib0485","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1046\/j.1432-1033.2002.03297.x","article-title":"Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition","volume":"269","author":"Schulz","year":"2002","journal-title":"Eur J Biochem"},{"issue":"3\u20134","key":"10.1016\/j.semcdb.2010.11.002_bib0490","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cnr.2004.09.015","article-title":"Prolyl oligopeptidase and bipolar disorder","volume":"4","author":"Williams","year":"2004","journal-title":"Clinical Neuroscience Research"},{"issue":"3","key":"10.1016\/j.semcdb.2010.11.002_bib0495","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1124\/mol.106.030601","article-title":"The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior","volume":"71","author":"Shimshoni","year":"2007","journal-title":"Mol Pharmacol"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0500","doi-asserted-by":"crossref","first-page":"e11151","DOI":"10.1371\/journal.pone.0011151","article-title":"Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes","volume":"5","author":"King","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0505","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/sj.mp.4001460","article-title":"Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder","volume":"9","author":"Sjoholt","year":"2004","journal-title":"Mol Psychiatry"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0510","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.mp.4000681","article-title":"A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients","volume":"5","author":"Sjoholt","year":"2000","journal-title":"Mol Psychiatry"},{"issue":"8","key":"10.1016\/j.semcdb.2010.11.002_bib0515","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/sj.npp.1301307","article-title":"A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription","volume":"32","author":"Ohnishi","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.semcdb.2010.11.002_bib0520","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/EC.00104-06","article-title":"Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid","volume":"6","author":"Xu","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.semcdb.2010.11.002_bib0525","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-1-60761-198-1_19","article-title":"Quantifying in vivo phosphoinositide turnover in chemotactically competent Dictyostelium cells","volume":"571","author":"Pawolleck","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"8","key":"10.1016\/j.semcdb.2010.11.002_bib0530","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1176\/ajp.150.8.1252","article-title":"Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania","volume":"150","author":"Brown","year":"1993","journal-title":"Am J Psychiatry"},{"issue":"2-3","key":"10.1016\/j.semcdb.2010.11.002_bib0535","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0165-1781(96)03022-3","article-title":"Platelet membrane phosphatidylinositol-4,5-bisphosphate alterations in bipolar disorder--evidence from a single case study","volume":"69","author":"Soares","year":"1997","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.semcdb.2010.11.002_bib0540","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s002139900341","article-title":"Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study","volume":"149","author":"Soares","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.semcdb.2010.11.002_bib0545","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jpsychires.2006.11.004","article-title":"Decreased protein kinase C (PKC) in platelets of pediatric bipolar patients: effect of treatment with mood stabilizing drugs","volume":"42","author":"Pandey","year":"2008","journal-title":"J Psychiatr Res"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108495211000193X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108495211000193X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T03:07:49Z","timestamp":1740712069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108495211000193X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S108495211000193X"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2010.11.002","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}