{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:57:56Z","timestamp":1790665076221,"version":"4.1.0"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.semcdb.2014.11.003","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T23:13:47Z","timestamp":1416525227000},"page":"117-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: What can we learn from the eye?"],"prefix":"10.1016","volume":"38","author":[{"given":"Deniz","family":"Hos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona L.","family":"Schlereth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig M.","family":"Heindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2014.11.003_bib0005","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","article-title":"Lymphangiogenesis in development and human disease","volume":"438","author":"Alitalo","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0010","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0015","first-page":"2127","article-title":"Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin","volume":"43","author":"Cursiefen","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000099253","article-title":"Immune privilege and angiogenic privilege of the cornea","volume":"92","author":"Cursiefen","year":"2007","journal-title":"Chem Immunol Allergy"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","article-title":"Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology","volume":"22","author":"Cursiefen","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0030","doi-asserted-by":"crossref","first-page":"e26253","DOI":"10.1371\/journal.pone.0026253","article-title":"Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels","volume":"6","author":"Steven","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0035","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm.2018","article-title":"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth","volume":"15","author":"Albuquerque","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0040","doi-asserted-by":"crossref","first-page":"11658","DOI":"10.1073\/pnas.0404272101","article-title":"Dose-dependent response of FGF-2 for lymphangiogenesis","volume":"101","author":"Chang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0045","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1084\/jem.20092277","article-title":"Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes","volume":"208","author":"Cursiefen","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0050","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0055","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCRESAHA.111.250738","article-title":"CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo","volume":"109","author":"Bos","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0060","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1097\/00007890-199906270-00001","article-title":"The immune privilege of corneal allografts","volume":"67","author":"Niederkorn","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0065","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0041-1345(99)00010-X","article-title":"Anterior chamber-associated immune deviation, ocular immune privilege, and orthotopic corneal allografts","volume":"31","author":"Streilein","year":"1999","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/ACI.0b013e32833dfa11","article-title":"High-risk corneal allografts and why they lose their immune privilege","volume":"10","author":"Niederkorn","year":"2010","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0075","first-page":"2485","article-title":"Loss and restoration of immune privilege in eyes with corneal neovascularization","volume":"37","author":"Dana","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2010.01.039","article-title":"Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis","volume":"117","author":"Bachmann","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0085","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.0903180","article-title":"Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation","volume":"184","author":"Dietrich","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0090","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/01.ASN.0000113316.52371.2E","article-title":"Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates","volume":"15","author":"Kerjaschki","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0095","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nm1340","article-title":"Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants","volume":"12","author":"Kerjaschki","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0100","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.109.910703","article-title":"Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts","volume":"121","author":"Nykanen","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0105","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1167\/iovs.08-2935","article-title":"Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension","volume":"50","author":"Heindl","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0110","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1167\/iovs.11-7902","article-title":"Tumor-associated lymphangiogenesis in the development of conjunctival melanoma","volume":"52","author":"Heindl","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0115","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ophtha.2010.01.032","article-title":"Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma","volume":"117","author":"Heindl","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0120","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/bjo.2008.147355","article-title":"Tumour-associated lymphangiogenesis in conjunctival malignant melanoma","volume":"93","author":"Zimmermann","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0125","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ophtha.2009.06.057","article-title":"Intraocular tumor-associated lymphangiogenesis a novel prognostic factor for ciliary body melanomas with extraocular extension?","volume":"117","author":"Heindl","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0130","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/archophthalmol.2010.143","article-title":"Intraocular lymphatics in ciliary body melanomas with extraocular extension: functional for lymphatic spread?","volume":"128","author":"Heindl","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0135","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.ophtha.2011.05.025","article-title":"Prognostic significance of tumor-associated lymphangiogenesis in malignant melanomas of the conjunctiva","volume":"118","author":"Heindl","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0140","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exer.2008.07.013","article-title":"Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis","volume":"87","author":"Hos","year":"2008","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0145","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/01.ico.0000183485.85636.ff","article-title":"Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation","volume":"25","author":"Cursiefen","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.preteyeres.2013.01.001","article-title":"Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases","volume":"34","author":"Bock","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0155","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1167\/iovs.08-1721","article-title":"The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages","volume":"49","author":"Schroedl","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0160","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1167\/iovs.13-13453","article-title":"Enrichment of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1)-positive macrophages around blood vessels in the normal human sclera","volume":"55","author":"Schlereth","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0165","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.exer.2014.06.010","article-title":"Absence of lymphatic vessels in the developing human sclera","volume":"125C","author":"Schlereth","year":"2014","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0170","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1167\/iovs.12-9507","article-title":"Invasion of lymphatic vessels into the eye after open globe injuries","volume":"53","author":"Wessel","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0175","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/01.ico.0000214230.21238.3d","article-title":"Absence of blood and lymphatic vessels in the developing human cornea","volume":"25","author":"Cursiefen","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0180","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature05249","article-title":"Corneal avascularity is due to soluble VEGF receptor-1","volume":"443","author":"Ambati","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0185","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1182\/blood-2012-08-453043","article-title":"Soluble vascular endothelial growth factor receptor-3 is essential for corneal alymphaticity","volume":"121","author":"Singh","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0190","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.0506112103","article-title":"Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision","volume":"103","author":"Cursiefen","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0945-053X(03)00005-2","article-title":"Thrombospondins 1 and 2 function as inhibitors of angiogenesis","volume":"22","author":"Armstrong","year":"2003","journal-title":"Matrix Biol: J Int Soc Matrix Biol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0200","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1167\/iovs.03-0940","article-title":"Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0205","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/35107085","article-title":"Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression","volume":"414","author":"Makino","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0210","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2353\/ajpath.2010.090794","article-title":"Genetic heterogeneity of lymphangiogenesis in different mouse strains","volume":"177","author":"Regenfuss","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0215","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.exer.2008.08.007","article-title":"Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts","volume":"87","author":"Bock","year":"2008","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0220","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.exer.2009.02.021","article-title":"Additional parameters for the morphometry of angiogenesis and lymphangiogenesis in corneal flat mounts","volume":"89","author":"Blacher","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0225","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1073\/pnas.91.9.4082","article-title":"Thalidomide is an inhibitor of angiogenesis","volume":"91","author":"D\u2019Amato","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0230","doi-asserted-by":"crossref","first-page":"E2665","DOI":"10.1073\/pnas.1206036109","article-title":"Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis","volume":"109","author":"Schulz","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0235","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0240","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1167\/iovs.07-1314","article-title":"Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation","volume":"49","author":"Hos","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0245","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1073\/pnas.78.2.1176","article-title":"Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone","volume":"78","author":"Gross","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0250","first-page":"1625","article-title":"A model of angiogenesis in the mouse cornea","volume":"37","author":"Kenyon","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0255","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1182\/blood-2011-01-332049","article-title":"A novel pro-lymphangiogenic function for Th17\/IL-17","volume":"118","author":"Chauhan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0260","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1167\/iovs.14-14093","article-title":"A novel pro-angiogenic function for interferon-gamma-secreting natural killer cells","volume":"55","author":"Lee","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0265","first-page":"2176","article-title":"Fate of orthotopic corneal allografts in eyes that cannot support anterior chamber-associated immune deviation induction","volume":"36","author":"Sano","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0270","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archophthalmol.2011.42","article-title":"Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids","volume":"129","author":"Hos","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0275","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1167\/iovs.09-4505","article-title":"Differential distribution of blood and lymphatic vessels in the murine cornea","volume":"51","author":"Ecoiffier","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0280","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-3-7091-1646-3_10","article-title":"Lymphatic vessels in the development of tissue and organ rejection","volume":"214","author":"Hos","year":"2014","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0285","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1167\/iovs.10-6816","article-title":"Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis","volume":"52","author":"Hos","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0290","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ophtha.2009.04.016","article-title":"GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial","volume":"116","author":"Cursiefen","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2014.03.038","article-title":"Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for transplantation: the I-CAN study","author":"Cursiefen","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0300","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.ophtha.2014.03.016","article-title":"High-dose subconjunctival cyclosporine A implants do not affect corneal neovascularization after high-risk keratoplasty","volume":"121","author":"Bock","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0305","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00003226-199811000-00008","article-title":"Angiogenesis in corneal diseases: histopathologic evaluation of 254 human corneal buttons with neovascularization","volume":"17","author":"Cursiefen","year":"1998","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0310","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archophthalmol.2010.124","article-title":"Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity?","volume":"128","author":"Goyal","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0315","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1084\/jem.20091385","article-title":"VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis","volume":"207","author":"Wuest","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0320","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/08830185.2012.748052","article-title":"Dry eye as a mucosal autoimmune disease","volume":"32","author":"Stern","year":"2013","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0325","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.preteyeres.2012.02.003","article-title":"Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease","volume":"31","author":"Barabino","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0330","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","article-title":"Dry eye disease: an immune-mediated ocular surface disorder","volume":"130","author":"Stevenson","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0335","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mi.2009.5","article-title":"IL-17 disrupts corneal barrier following desiccating stress","volume":"2","author":"De Paiva","year":"2009","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0340","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.4049\/jimmunol.176.7.3950","article-title":"Desiccating stress induces T cell-mediated Sjogren's Syndrome-like lacrimal keratoconjunctivitis","volume":"176","author":"Niederkorn","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0345","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.1101442","article-title":"Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis","volume":"187","author":"Schaumburg","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0350","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archophthalmol.2011.266","article-title":"Blockade of prolymphangiogenic vascular endothelial growth factor C in dry eye disease","volume":"130","author":"Goyal","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0355","doi-asserted-by":"crossref","first-page":"672381","DOI":"10.1155\/2013\/672381","article-title":"An important role of blood and lymphatic vessels in inflammation and allergy","volume":"2013","author":"Zgraggen","year":"2013","journal-title":"J Allergy"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0360","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jtos.2013.10.007","article-title":"The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation","volume":"12","author":"Saban","year":"2014","journal-title":"Ocular Surf."},{"key":"10.1016\/j.semcdb.2014.11.003_bib0365","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.ajpath.2012.02.015","article-title":"Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis","volume":"180","author":"Schlereth","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0370","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages","volume":"115","author":"Maruyama","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0375","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/08820530500509358","article-title":"Angiogenesis and lymphangiogenesis-implications for corneal immunity","volume":"21","author":"Dana","year":"2006","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0380","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/08820530902801320","article-title":"Corneal lymphangiogenesis: implications in immunity","volume":"24","author":"Patel","year":"2009","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0385","first-page":"1293","article-title":"The critical role of lymph nodes in corneal alloimmunization and graft rejection","volume":"42","author":"Yamagami","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0390","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00003226-200205000-00014","article-title":"Draining lymph nodes play an essential role in alloimmunity generated in response to high-risk corneal transplantation","volume":"21","author":"Yamagami","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0395","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00417-007-0683-5","article-title":"Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation","volume":"246","author":"Bock","year":"2008","journal-title":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0400","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2353\/ajpath.2007.060896","article-title":"Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade","volume":"171","author":"Dietrich","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0405","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00417-007-0684-4","article-title":"Bevacizumab (Avastin) eye drops inhibit corneal neovascularization","volume":"246","author":"Bock","year":"2008","journal-title":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0410","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/ICO.0b013e3182775f8d","article-title":"Topical ranibizumab as a treatment of corneal neovascularization","volume":"32","author":"Ferrari","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0415","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00055735-200108000-00002","article-title":"Corneal neovascularization","volume":"12","author":"Chang","year":"2001","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0420","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s00417-009-1099-1","article-title":"Short- and long-term safety profile and efficacy of topical bevacizumab (Avastin) eye drops against corneal neovascularization","volume":"247","author":"Koenig","year":"2009","journal-title":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0425","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1167\/iovs.12-10856","article-title":"Sunitinib inhibits inflammatory corneal lymphangiogenesis","volume":"54","author":"Detry","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0430","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1755-3768.2012.02525.x","article-title":"Topical ranibizumab inhibits inflammatory corneal hem- and lymphangiogenesis","volume":"92","author":"Bucher","year":"2012","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0435","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s004170100313","article-title":"Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty","volume":"239","author":"Cursiefen","year":"2001","journal-title":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0440","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1167\/iovs.11-7871","article-title":"Corneal penetration of topical and subconjunctival bevacizumab","volume":"52","author":"Dastjerdi","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0445","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archophthalmol.2009.18","article-title":"Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study","volume":"127","author":"Dastjerdi","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2012.06.007","article-title":"Short-term topical bevacizumab in the treatment of stable corneal neovascularization","volume":"154","author":"Cheng","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0455","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1167\/iovs.05-0105","article-title":"Downregulation of IRS-1 expression causes inhibition of corneal angiogenesis","volume":"46","author":"Andrieu-Soler","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0460","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1167\/iovs.11-9064","article-title":"Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration","volume":"53","author":"Cloutier","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0465","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/bjo.2008.145128","article-title":"Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation","volume":"93","author":"Bachmann","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0470","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/ICO.0b013e31823f8f7a","article-title":"Angioregressive pretreatment of mature corneal blood vessels before keratoplasty: fine-needle vessel coagulation combined with anti-VEGFs","volume":"31","author":"Koenig","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0475","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/bjo.2003.035071","article-title":"Photodynamic therapy for corneal neovascularisation and lipid degeneration","volume":"88","author":"Brooks","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0480","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1182\/blood-2004-08-3382","article-title":"Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation","volume":"105","author":"Morisada","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0485","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbrc.2012.02.009","article-title":"Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells","volume":"419","author":"Song","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0490","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1167\/iovs.02-0572","article-title":"Photodynamic therapy with verteporfin in a rabbit model of corneal neovascularization","volume":"44","author":"Holzer","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0495","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/02713680600559564","article-title":"Experimental inhibition of corneal neovascularization by photodynamic therapy with verteporfin","volume":"31","author":"Yoon","year":"2006","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0500","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001699","article-title":"Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis","volume":"3","author":"Tammela","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0505","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/bjophthalmol-2013-303887","article-title":"Regression of mature lymphatic vessels in the cornea by photodynamic therapy","volume":"98","author":"Bucher","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0510","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00002341-199907000-00006","article-title":"Identification of human orbital lymphatics","volume":"15","author":"Gausas","year":"1999","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0515","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00006982-200001000-00014","article-title":"Intraocular melanoma spread to regional lymph nodes: report of two cases","volume":"20","author":"Dithmar","year":"2000","journal-title":"Retina"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0520","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.1071420","article-title":"Lymphatic metastasis in the absence of functional intratumor lymphatics","volume":"296","author":"Padera","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0525","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1073\/pnas.95.2.548","article-title":"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)","volume":"95","author":"Achen","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0530","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1136\/bjophthalmol-2013-303671","article-title":"Prospective study of sentinel lymph node biopsy for conjunctival melanoma","volume":"97","author":"Cohen","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0535","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/IOP.0b013e31827472c5","article-title":"Sentinel lymph node biopsy for eyelid and conjunctival tumors: what have we learned in the past decade?","volume":"29","author":"Pfeiffer","year":"2013","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0540","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/oxfordjournals.bmb.a072453","article-title":"Cancer metastasis","volume":"47","author":"Fidler","year":"1991","journal-title":"Br Med Bull"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0545","doi-asserted-by":"crossref","first-page":"639058","DOI":"10.1155\/2014\/639058","article-title":"Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis","volume":"2014","author":"Schlereth","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0550","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1478-811X-9-18","article-title":"Interaction of tumor cells with the microenvironment","volume":"9","author":"Ungefroren","year":"2011","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0555","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","article-title":"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1","volume":"87","author":"Barleon","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0560","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.193.6.727","article-title":"Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy","volume":"193","author":"Lin","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0565","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0570","doi-asserted-by":"crossref","first-page":"204946","DOI":"10.1155\/2012\/204946","article-title":"Tumor lymphangiogenesis as a potential therapeutic target","volume":"2012","author":"Duong","year":"2012","journal-title":"J Oncol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0575","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis","volume":"161","author":"Schoppmann","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0580","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1167\/iovs.10-5979","article-title":"Detection of M2-macrophages in uveal melanoma and relation with survival","volume":"52","author":"Bronkhorst","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0585","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.4049\/jimmunol.0903479","article-title":"In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages","volume":"185","author":"Ly","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0590","first-page":"1414","article-title":"Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma","volume":"42","author":"Makitie","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0595","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1167\/iovs.11-9280","article-title":"Different subsets of tumor-infiltrating lymphocytes correlate with macrophage influx and monosomy 3 in uveal melanoma","volume":"53","author":"Bronkhorst","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0600","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-065X.2011.01007.x","article-title":"Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication","volume":"241","author":"Quezada","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0605","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ccr.2004.08.034","article-title":"PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis","volume":"6","author":"Cao","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0610","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1749-6632.2002.tb04872.x","article-title":"Lymphangiogenesis new mechanisms","volume":"979","author":"Chang","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0615","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(02)00217-4","article-title":"Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1","volume":"3","author":"Gale","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0620","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.062040199","article-title":"Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea","volume":"99","author":"Kubo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0625","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0630","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)64328-3","article-title":"Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival","volume":"162","author":"Dadras","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0635","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrc1693","article-title":"emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis","volume":"5","author":"Cao","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0640","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1038\/sj.onc.1206457","article-title":"Angiogenesis, lymphangiogenesis, and melanoma metastasis","volume":"22","author":"Streit","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0645","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1096\/fj.03-0935fje","article-title":"Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis","volume":"18","author":"Darash-Yahana","year":"2004","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0650","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35065016","article-title":"Involvement of chemokine receptors in breast cancer metastasis","volume":"410","author":"Muller","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0655","first-page":"291","article-title":"The importance of the CXCL12\u2013CXCR4 chemokine ligand\u2013receptor interaction in prostate cancer metastasis","volume":"4","author":"Arya","year":"2004","journal-title":"J Exp Ther Oncol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0660","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1196\/annals.1413.020","article-title":"Molecular control of lymphatic metastasis","volume":"1131","author":"Achen","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0665","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/jnci\/94.11.819","article-title":"Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling","volume":"94","author":"He","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0670","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1158\/0008-5472.CAN-09-3488","article-title":"Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor\u2013immunoglobulin fusion protein","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0675","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jbiotec.2006.01.007","article-title":"Tumor-induced lymphangiogenesis: a target for cancer therapy?","volume":"124","author":"Thiele","year":"2006","journal-title":"J Biotechnol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0680","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1189\/jlb.1105623","article-title":"Anti-CCR7 monoclonal antibodies as a novel tool for the treatment of chronic lymphocyte leukemia","volume":"79","author":"Alfonso-Perez","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0685","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1756-8722-6-89","article-title":"Anti-CCR7 therapy exerts a potent anti-tumor activity in a xenograft model of human mantle cell lymphoma","volume":"6","author":"Somovilla-Crespo","year":"2013","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0690","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.athoracsur.2010.03.013","article-title":"Lymph angiogenesis after lung transplantation and relation to acute organ rejection in humans","volume":"90","author":"Dashkevich","year":"2010","journal-title":"Ann Thoracic Surg"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0695","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1016\/j.transproceed.2010.09.081","article-title":"Lymphangiogenesis associated with acute cellular rejection in rat liver transplantation","volume":"42","author":"Ishii","year":"2010","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0700","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/tri.12005","article-title":"Sirolimus inhibits lymphangiogenesis in rat renal allografts, a novel mechanism to prevent chronic kidney allograft injury","volume":"26","author":"Palin","year":"2013","journal-title":"Transpl Int: Off J Eur Soc Organ Transplant"},{"key":"10.1016\/j.semcdb.2014.11.003_bib0705","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/TP.0b013e31821d2661","article-title":"Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival","volume":"92","author":"Yin","year":"2011","journal-title":"Transplantation"}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952114003139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952114003139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T02:20:19Z","timestamp":1598494819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952114003139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":141,"alternative-id":["S1084952114003139"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2014.11.003","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: What can we learn from the eye?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2014.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}