{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:42:20Z","timestamp":1790552540054,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["628946"],"award-info":[{"award-number":["628946"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Research Council Future Fellow","award":["FT100100560"],"award-info":[{"award-number":["FT100100560"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.semcdb.2015.02.007","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T05:38:22Z","timestamp":1424410702000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":190,"special_numbering":"C","title":["Extracellular vesicles \u2013 Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases"],"prefix":"10.1016","volume":"40","author":[{"given":"Bradley M.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-2354","authenticated-orcid":false,"given":"Andrew F.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2015.02.007_bib0705","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphys.2012.00124","article-title":"Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?","volume":"3","author":"Bellingham","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0710","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fgene.2013.00150","article-title":"The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies","volume":"4","author":"Cheng","year":"2013","journal-title":"Front Genet"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0715","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1016\/S0021-9258(18)48095-7","article-title":"Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)","volume":"262","author":"Johnstone","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0720","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/intimm\/dxh267","article-title":"Exosomal-like vesicles are present in human blood plasma","volume":"17","author":"Caby","year":"2005","journal-title":"Int Immunol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0725","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0730","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1248\/bpb.31.1059","article-title":"Exosome-like vesicles with dipeptidyl peptidase IV in human saliva","volume":"31","author":"Ogawa","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0735","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1601-0825.2009.01604.x","article-title":"Exosomes from human saliva as a source of microRNA biomarkers","volume":"16","author":"Michael","year":"2010","journal-title":"Oral Dis"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0740","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.vetimm.2008.04.002","article-title":"Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid","volume":"124","author":"Vella","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0745","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0955-0674(95)80013-1","article-title":"Membrane transport in the endocytic pathway","volume":"7","author":"Gruenberg","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0750","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrm1360","article-title":"The biogenesis of multivesicular endosomes","volume":"5","author":"Gruenberg","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0755","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/35056583","article-title":"Protein regulation by monoubiquitin","volume":"2","author":"Hicke","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"Pt 16","key":"10.1016\/j.semcdb.2015.02.007_bib0760","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1242\/jcs.110.16.1867","article-title":"Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation","volume":"110","author":"Vidal","year":"1997","journal-title":"J Cell Sci"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0765","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1371\/journal.pbio.0050158","article-title":"Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes","volume":"5","author":"Fang","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0770","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","article-title":"Lipid raft-associated protein sorting in exosomes","volume":"102","author":"de Gassart","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0775","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1091\/mbc.E08-03-0239","article-title":"In vitro budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101","volume":"19","author":"Falguieres","year":"2008","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0780","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0785","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1158\/0008-5472.CAN-09-2470","article-title":"Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation","volume":"70","author":"Nazarenko","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0790","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Thery","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0795","doi-asserted-by":"crossref","first-page":"10963","DOI":"10.1074\/jbc.M207550200","article-title":"Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation","volume":"278","author":"Wubbolts","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0800","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biochi.2006.10.014","article-title":"Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies","volume":"89","author":"Subra","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0805","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1126\/science.308.5730.1862","article-title":"Cell biology: the ins and outs of exosomes","volume":"308","author":"Couzin","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0810","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/85438","article-title":"Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming","volume":"7","author":"Wolfers","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0815","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0598-594","article-title":"Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes","volume":"4","author":"Zitvogel","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0820","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0825","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0830","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/glia.22558","article-title":"Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system","volume":"61","author":"Lopez-Verrilli","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0835","doi-asserted-by":"crossref","first-page":"e1001874","DOI":"10.1371\/journal.pbio.1001874","article-title":"Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation","volume":"12","author":"Ridder","year":"2014","journal-title":"PLoS Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0840","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"Prusiner","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0845","doi-asserted-by":"crossref","first-page":"14945","DOI":"10.1073\/pnas.93.25.14945","article-title":"Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains","volume":"93","author":"Vey","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0850","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/09687860500449994","article-title":"The prion protein and lipid rafts (Review)","volume":"23","author":"Taylor","year":"2006","journal-title":"Mol Membr Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0855","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1073\/pnas.94.6.2333","article-title":"COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform","volume":"94","author":"Kaneko","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0860","doi-asserted-by":"crossref","first-page":"15922","DOI":"10.1016\/S0021-9258(18)82340-7","article-title":"A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells","volume":"268","author":"Shyng","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0865","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nm0901-976","article-title":"Transepithelial prion transport by M cells","volume":"7","author":"Heppner","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0870","doi-asserted-by":"crossref","first-page":"e1002449","DOI":"10.1371\/journal.ppat.1002449","article-title":"Prion uptake in the gut: identification of the first uptake and replication sites","volume":"7","author":"Kujala","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0875","doi-asserted-by":"crossref","first-page":"11280","DOI":"10.1523\/JNEUROSCI.2864-04.2004","article-title":"Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine","volume":"24","author":"Mishra","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0880","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijpharm.2005.02.042","article-title":"Role of gut macrophages in mice orally contaminated with scrapie or BSE","volume":"298","author":"Maignien","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0885","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1099\/0022-1317-83-1-267","article-title":"Migrating intestinal dendritic cells transport PrP(Sc) from the gut","volume":"83","author":"Huang","year":"2002","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0890","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1128\/JVI.65.11.6292-6295.1991","article-title":"Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt\u2013Jakob disease","volume":"65","author":"Kitamoto","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0895","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(98)12075-5","article-title":"Investigation of variant Creutzfeldt\u2013Jakob disease and other human prion diseases with tonsil biopsy samples","volume":"353","author":"Hill","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0900","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1099\/0022-1317-83-10-2617","article-title":"PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer","volume":"83","author":"Sigurdson","year":"2002","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0905","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/JVI.74.7.3338-3344.2000","article-title":"Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie","volume":"74","author":"Mabbott","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0910","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1096-9896(200007)191:3<323::AID-PATH629>3.0.CO;2-Z","article-title":"Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy","volume":"191","author":"Jeffrey","year":"2000","journal-title":"J Pathol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0915","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/86562","article-title":"Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie","volume":"7","author":"Mabbott","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0920","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1128\/JVI.79.3.1888-1897.2005","article-title":"Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells","volume":"79","author":"Mohan","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0925","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1126\/science.288.5469.1257","article-title":"Impaired prion replication in spleens of mice lacking functional follicular dendritic cells","volume":"288","author":"Montrasio","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0930","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1128\/JVI.77.12.6845-6854.2003","article-title":"Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility","volume":"77","author":"Mabbott","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0935","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3940(99)00223-2","article-title":"Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie","volume":"265","author":"McBride","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0940","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1128\/JVI.75.19.9320-9327.2001","article-title":"Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves","volume":"75","author":"McBride","year":"2001","journal-title":"J Virol"},{"issue":"Pt 5","key":"10.1016\/j.semcdb.2015.02.007_bib0945","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1099\/0022-1317-78-5-1187","article-title":"Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord","volume":"78","author":"Baldauf","year":"1997","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0950","doi-asserted-by":"crossref","first-page":"8821","DOI":"10.1128\/JVI.71.11.8821-8831.1997","article-title":"A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis","volume":"71","author":"Schatzl","year":"1997","journal-title":"J Virol"},{"issue":"Pt 5","key":"10.1016\/j.semcdb.2015.02.007_bib0955","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1099\/0022-1317-68-5-1391","article-title":"Characterization of scrapie infection in mouse neuroblastoma cells","volume":"68","author":"Race","year":"1987","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0960","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1099\/vir.0.82336-0","article-title":"Efficient dissemination of prions through preferential transmission to nearby cells","volume":"88","author":"Paquet","year":"2007","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0965","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0960-9822(02)00722-4","article-title":"Transfer of scrapie prion infectivity by cell contact in culture","volume":"12","author":"Kanu","year":"2002","journal-title":"Curr Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0970","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/emboj\/21.5.1031","article-title":"Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes","volume":"21","author":"Baron","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0975","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ncb1841","article-title":"Prions hijack tunnelling nanotubes for intercellular spread","volume":"11","author":"Gousset","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0980","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/BJ20100698","article-title":"Characterization of the role of dendritic cells in prion transfer to primary neurons","volume":"431","author":"Langevin","year":"2010","journal-title":"Biochem J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0985","doi-asserted-by":"crossref","first-page":"e5057","DOI":"10.1371\/journal.pone.0005057","article-title":"Paracrine diffusion of PrP(C) and propagation of prion infectivity by plasma membrane-derived microvesicles","volume":"4","author":"Mattei","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0990","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1073\/pnas.0308413101","article-title":"Cells release prions in association with exosomes","volume":"101","author":"Fevrier","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib0995","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/path.2145","article-title":"Packaging of prions into exosomes is associated with a novel pathway of PrP processing","volume":"211","author":"Vella","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1000","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/sj.emboj.7601162","article-title":"Retrovirus infection strongly enhances scrapie infectivity release in cell culture","volume":"25","author":"Leblanc","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1005","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1093133","article-title":"Nanotubular highways for intercellular organelle transport","volume":"303","author":"Rustom","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1010","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.yexcr.2012.05.013","article-title":"Tunneling nanotubes: emerging view of their molecular components and formation mechanisms","volume":"318","author":"Kimura","year":"2012","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1015","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ceb.2008.03.005","article-title":"Intercellular transfer mediated by tunneling nanotubes","volume":"20","author":"Gerdes","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1020","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1073\/pnas.0507995103","article-title":"Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection","volume":"103","author":"Wiley","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.7541557","article-title":"In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium","volume":"269","author":"Kooyman","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1030","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1096\/fasebj.10.5.8621057","article-title":"Cell-surface engineering with GPI-anchored proteins","volume":"10","author":"Medof","year":"1996","journal-title":"FASEB J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1035","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1128\/JVI.80.5.2106-2117.2006","article-title":"Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res","volume":"80","author":"Baron","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10456-011-9241-1","article-title":"Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion","volume":"15","author":"Mineo","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1045","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1073\/pnas.1831413100","article-title":"The Trojan exosome hypothesis","volume":"100","author":"Gould","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1050","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1600-0854.2008.00734.x","article-title":"Exosome function: from tumor immunology to pathogen biology","volume":"9","author":"Schorey","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1055","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jinf.2013.07.024","article-title":"Exosome release from infected dendritic cells: a clue for a fast spread of prions in the periphery","volume":"67","author":"Klohn","year":"2013","journal-title":"J Infect"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1060","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/BC20080025","article-title":"Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles","volume":"100","author":"Alais","year":"2008","journal-title":"Biol Cell"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1065","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.mcn.2005.12.003","article-title":"Exosomes are released by cultured cortical neurones","volume":"31","author":"Faure","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1070","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1182\/blood-2005-02-0802","article-title":"Cellular prion protein is released on exosomes from activated platelets","volume":"107","author":"Robertson","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1075","doi-asserted-by":"crossref","first-page":"e1002538","DOI":"10.1371\/journal.ppat.1002538","article-title":"Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection","volume":"8","author":"Castro-Seoane","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1080","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M114.589564","article-title":"First demonstration of PrPTSE in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification of misfolded prion protein","author":"Saa","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1085","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/S0140-6736(06)69835-8","article-title":"Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt\u2013Jakob disease associated with blood transfusion: a case report","volume":"368","author":"Wroe","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1090","first-page":"622","article-title":"Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells","volume":"65","author":"McKinley","year":"1991","journal-title":"Lab Invest"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1095","doi-asserted-by":"crossref","first-page":"18217","DOI":"10.1016\/S0021-9258(18)55257-1","article-title":"The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive","volume":"266","author":"Caughey","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejcb.2008.08.001","article-title":"Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy","volume":"88","author":"Veith","year":"2009","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1105","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/path.1711760412","article-title":"The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain","volume":"176","author":"Arnold","year":"1995","journal-title":"J Pathol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1110","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1096\/fj.11-202077","article-title":"Prion-infected cells regulate the release of exosomes with distinct ultrastructural features","volume":"26","author":"Coleman","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1115","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/308032a0","article-title":"Cryo-electron microscopy of viruses","volume":"308","author":"Adrian","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1120","first-page":"2","article-title":"Cryo-electron microscopy of extracellular vesicles in fresh plasma","author":"Yuana","year":"2013","journal-title":"J Extracell Ves"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1125","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1093\/nar\/gks656","article-title":"MicroRNAs are exported from malignant cells in customized particles","volume":"40","author":"Palma","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1130","first-page":"847","article-title":"Proteomic analysis of exosome-like vesicles derived from breast cancer cells","volume":"32","author":"Palazzolo","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1135","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.cub.2009.09.059","article-title":"ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles","volume":"19","author":"Muralidharan-Chari","year":"2009","journal-title":"Curr Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cellbi.2008.10.001","article-title":"Exosomal sorting of the cytoplasmic domain of bovine leukemia virus TM Env protein","volume":"33","author":"De Gassart","year":"2009","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1145","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.bcp.2011.12.037","article-title":"The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities","volume":"83","author":"Pant","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1462-5822.2010.01537.x","article-title":"Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes","volume":"13","author":"Silverman","year":"2011","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.virusres.2008.07.003","article-title":"Extracellular vesicles containing virus-encoded membrane proteins are a byproduct of infection with modified vaccinia virus Ankara","volume":"137","author":"Spehner","year":"2008","journal-title":"Virus Res"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1160","article-title":"Prion strains are differentially released through the exosomal pathway","author":"Arellano-Anaya","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0006-291X(02)00430-8","article-title":"Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1\u201342 mutants of familial Alzheimer's disease at positions 21\u201323","volume":"294","author":"Murakami","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1170","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1126\/science.8424174","article-title":"Release of excess amyloid \u03b2 protein from a mutant amyloid \u03b2 protein precursor","volume":"259","author":"Cai","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/jmbi.2000.3650","article-title":"Direct visualisation of the \u03b2-sheet structure of synthetic Alzheimer's amyloid","volume":"299","author":"Serpell","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1180","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0925-4439(00)00034-X","article-title":"Approaches to discovery and characterization of inhibitors of amyloid \u03b2-peptide polymerization","volume":"1502","author":"Findeis","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1185","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/361260a0","article-title":"Secretion of \u03b2-amyloid precursor protein cleaved at the amino terminus of the \u03b2-amyloid peptide","volume":"361","author":"Seubert","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1190","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/physrev.1997.77.4.1081","article-title":"Cellular actions of \u03b2-amyloid precursor protein and its soluble and fibrillogenic derivatives [review]","volume":"77","author":"Mattson","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1195","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1101\/SQB.1996.061.01.059","article-title":"Cell biology of the \u03b2-amyloid precursor protein and the genetics of Alzheimer's disease","volume":"61","author":"Selkoe","year":"1996","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1200","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1242\/jcs.109.5.999","article-title":"Trafficking of cell-surface amyloid \u03b2-protein precursor. 2. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization","volume":"109","author":"Yamazaki","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1205","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer's disease beta-amyloid peptides are released in association with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1210","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1096\/fj.07-9357com","article-title":"Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes","volume":"22","author":"Sharples","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1215","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M609475200","article-title":"Alkalizing drugs induce accumulation of amyloid precursor protein byproducts in lumenal vesicles of multivesicular bodies","author":"Vingtdeux","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000007917","article-title":"Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression \u2013 inverse correlation with dementia severity","volume":"39","author":"Hock","year":"1998","journal-title":"Eur Neurol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1225","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1073\/pnas.89.7.2551","article-title":"Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients","volume":"89","author":"Van Nostrand","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1230","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00001756-200301200-00030","article-title":"Abeta levels in serum, CSF and brain, and cognitive deficits in APP+PS1 transgenic mice","volume":"14","author":"Liu","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1235","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/0006-291X(90)90635-Z","article-title":"Detection of soluble forms of the beta-amyloid precursor protein in human plasma","volume":"167","author":"Podlisny","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1240","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1001\/archneur.57.1.100","article-title":"Plasma and cerebrospinal fluid levels of amyloid beta proteins 1\u201340 and 1\u201342 in Alzheimer disease","volume":"57","author":"Mehta","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1245","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neurobiolaging.2004.04.008","article-title":"Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain","volume":"26","author":"Kokubo","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1756-6606-6-47","article-title":"Exosomes neutralize synaptic-plasticity-disrupting activity of Abeta assemblies in vivo","volume":"6","author":"An","year":"2013","journal-title":"Mol Brain"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1255","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1074\/jbc.M111.324616","article-title":"Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia","volume":"287","author":"Yuyama","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1260","doi-asserted-by":"crossref","first-page":"24488","DOI":"10.1074\/jbc.M114.577213","article-title":"Decreased amyloid-beta pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice","volume":"289","author":"Yuyama","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1265","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1074\/jbc.M111.277061","article-title":"Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease","volume":"287","author":"Saman","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1270","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2007.09.024","article-title":"Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis","volume":"428","author":"Gomes","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1275","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1073\/pnas.1017275108","article-title":"Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells","volume":"108","author":"Munch","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1280","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1073\/pnas.1312245111","article-title":"Intercellular propagated misfolding of wild-type Cu\/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms","volume":"111","author":"Grad","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1285","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1290","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nsmb.2053","article-title":"An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity","volume":"18","author":"Guo","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1295","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.celrep.2013.06.007","article-title":"Prion-like properties of pathological TDP-43 aggregates from diseased brains","volume":"4","author":"Nonaka","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2015.02.007_bib1300","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/21678421.2014.905606","article-title":"Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases","volume":"15","author":"Feneberg","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1305","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF02778005","article-title":"Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy","volume":"8","author":"Baker","year":"1994","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1310","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1901","article-title":"Transmission and spreading of tauopathy in transgenic mouse brain","volume":"11","author":"Clavaguera","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1315","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nm1747","article-title":"Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease","volume":"14","author":"Kordower","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1320","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm1746","article-title":"Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation","volume":"14","author":"Li","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1325","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI43366","article-title":"\u03b1-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells","volume":"121","author":"Hansen","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1330","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1096\/fj.03-1449com","article-title":"Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease","volume":"20","author":"El-Agnaf","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1335","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1212\/WNL.0b013e318219dd92","article-title":"Detection of elevated levels of alpha-synuclein oligomers in CSF from patients with Parkinson disease","volume":"77","author":"Bruggink","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1340","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/j.1471-4159.1993.tb09823.x","article-title":"Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay","volume":"61","author":"Vandermeeren","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1345","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/WNL.0b013e3181fd613b","article-title":"Detection of elevated levels of alpha-synuclein oligomers in CSF from patients with Parkinson disease","volume":"75","author":"Tokuda","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1350","doi-asserted-by":"crossref","first-page":"43108","DOI":"10.1074\/jbc.M112.404467","article-title":"The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space","volume":"287","author":"Perez-Gonzalez","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1355","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1479-5876-10-5","article-title":"Identification and proteomic profiling of exosomes in human cerebrospinal fluid","volume":"10","author":"Street","year":"2012","journal-title":"J Transl Med"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1360","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jprot.2014.04.028","article-title":"Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset","volume":"106","author":"Chiasserini","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1365","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1093\/hmg\/ddt346","article-title":"LRRK2 secretion in exosomes is regulated by 14-3-3","volume":"22","author":"Fraser","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1370","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-014-1314-y","article-title":"Plasma exosomal alpha-synuclein is likely CNS-derived and increased in Parkinson's disease","author":"Shi","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1375","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2014.06.008","article-title":"Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case\u2013control study","author":"Fiandaca","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1380","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.imlet.2006.09.005","article-title":"Exosomes: from biogenesis and secretion to biological function","volume":"107","author":"Keller","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1385","doi-asserted-by":"crossref","first-page":"e3694","DOI":"10.1371\/journal.pone.0003694","article-title":"Detection of microRNA expression in human peripheral blood microvesicles","volume":"3","author":"Hunter","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1390","first-page":"3","article-title":"Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood","author":"Cheng","year":"2014","journal-title":"J Extracell Ves"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1395","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks832","article-title":"Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells","author":"Bellingham","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2015.02.007_bib1400","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-1759(00)00321-5","article-title":"Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry","volume":"247","author":"Clayton","year":"2001","journal-title":"J Immunol Methods"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952115000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952115000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T08:01:58Z","timestamp":1651305718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952115000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":140,"alternative-id":["S1084952115000348"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2015.02.007","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles \u2013 Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2015.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}