{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:17:31Z","timestamp":1777576651097,"version":"3.51.4"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003002","name":"Dynasty Foundation","doi-asserted-by":"publisher","award":["DP-B-11\/14 (EP)"],"award-info":[{"award-number":["DP-B-11\/14 (EP)"]}],"id":[{"id":"10.13039\/501100003002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Russian Ministry of Science","award":["11.G34.31.0056"],"award-info":[{"award-number":["11.G34.31.0056"]}]},{"name":"Russian Scientific Fund","award":["14-25-00024"],"award-info":[{"award-number":["14-25-00024"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.semcdb.2015.03.010","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T04:58:57Z","timestamp":1428296337000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease"],"prefix":"10.1016","volume":"40","author":[{"given":"Polina","family":"Egorova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Popugaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Bezprozvanny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.semcdb.2015.03.010_bib0490","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1358\/dof.2009.034.12.1443434","article-title":"Therapeutic prospects for spinocerebellar ataxia type 2 and 3","volume":"34","author":"Bezprozvanny","year":"2010","journal-title":"Drugs Future"},{"issue":"5","key":"10.1016\/j.semcdb.2015.03.010_bib0495","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1474-4422(04)00737-9","article-title":"Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis","volume":"3","author":"Schols","year":"2004","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.1016\/j.semcdb.2015.03.010_bib0500","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s004150050385","article-title":"Spinocerebellar ataxia type 2 in southern Italy: a clinical and molecular study of 30 families","volume":"246","author":"Filla","year":"1999","journal-title":"J Neurol"},{"issue":"2","key":"10.1016\/j.semcdb.2015.03.010_bib0505","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12311-008-0019-y","article-title":"Spinocerebellar ataxia 2 (SCA2)","volume":"7","author":"Lastres-Becker","year":"2008","journal-title":"Cerebellum"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0510","first-page":"842","article-title":"The prevalence and wide clinical spectrum of the spinocerebellar ataxia type 2 trinucleotide repeat in patients with autosomal dominant cerebellar ataxia","volume":"60","author":"Geschwind","year":"1997","journal-title":"Am J Hum Genet"},{"issue":"Pt 5","key":"10.1016\/j.semcdb.2015.03.010_bib0515","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/brain\/119.5.1497","article-title":"Autosomal dominant cerebellar ataxia type I clinical features and MRI in families with SCA1, SCA2 and SCA3","volume":"119","author":"Burk","year":"1996","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0520","first-page":"265","article-title":"Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts?","volume":"36","author":"Rubinsztein","year":"1999","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0525","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S0033291799002871","article-title":"The molecular biology of Huntington's disease","volume":"31","author":"Ho","year":"2001","journal-title":"Psychol Med"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0530","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/B978-0-444-51892-7.00041-3","article-title":"Dentatorubral\u2013pallidoluysian atrophy","volume":"103","author":"Tsuji","year":"2012","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0535","doi-asserted-by":"crossref","first-page":"672536","DOI":"10.1155\/2012\/672536","article-title":"Functional annotation of small noncoding RNAs target genes provides evidence for a deregulated ubiquitin-proteasome pathway in spinocerebellar ataxia type 1","volume":"2012","author":"Persengiev","year":"2012","journal-title":"J Nucleic Acids"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0540","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nbd.2014.09.020","article-title":"A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3\/MJD","volume":"73","author":"Switonski","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0545","doi-asserted-by":"crossref","first-page":"e28859","DOI":"10.4161\/rdis.28859","article-title":"Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7","volume":"2","author":"Mohan","year":"2014","journal-title":"Rare Dis"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0550","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/147342202320883551","article-title":"\u2018New\u2019 functions for \u2018old\u2019 proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice","volume":"1","author":"Schwaller","year":"2002","journal-title":"Cerebellum"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0555","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1152\/jn.00635.2009","article-title":"Compensatory regulation of Cav2.1 Ca2+ channels in cerebellar Purkinje neurons lacking parvalbumin and calbindin D-28k","volume":"103","author":"Kreiner","year":"2010","journal-title":"J Neurophysiol"},{"issue":"Pt 13","key":"10.1016\/j.semcdb.2015.03.010_bib0560","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1113\/jphysiol.2012.248252","article-title":"Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development","volume":"591","author":"Kano","year":"2013","journal-title":"J Physiol"},{"issue":"36","key":"10.1016\/j.semcdb.2015.03.010_bib0565","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.1523\/JNEUROSCI.2579-11.2011","article-title":"Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice","volume":"31","author":"Barnes","year":"2011","journal-title":"J Neurosci"},{"issue":"31","key":"10.1016\/j.semcdb.2015.03.010_bib0570","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1073\/pnas.1411251111","article-title":"Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor","volume":"111","author":"Long","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 7","key":"10.1016\/j.semcdb.2015.03.010_bib0575","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1113\/jphysiol.2012.245787","article-title":"Gating of long-term depression by Ca2+\/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells","volume":"591","author":"Kawaguchi","year":"2013","journal-title":"J Physiol"},{"issue":"7","key":"10.1016\/j.semcdb.2015.03.010_bib0580","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1007\/s11064-010-0393-y","article-title":"Role of inositol 1,4,5-trisphosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxias","volume":"36","author":"Bezprozvanny","year":"2011","journal-title":"Neurochem Res"},{"issue":"6561","key":"10.1016\/j.semcdb.2015.03.010_bib0585","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/379168a0","article-title":"Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor","volume":"379","author":"Matsumoto","year":"1996","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcdb.2015.03.010_bib0590","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1523\/JNEUROSCI.17-02-00635.1997","article-title":"The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse","volume":"17","author":"Street","year":"1997","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.semcdb.2015.03.010_bib0595","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1371\/journal.pgen.0030108","article-title":"Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans","volume":"3","author":"van de Leemput","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0600","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1752-0509-6-70","article-title":"Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia","volume":"6","author":"Brown","year":"2012","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0605","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/B978-0-444-51892-7.00037-1","article-title":"Spinocerebellar ataxia type 15","volume":"103","author":"Storey","year":"2012","journal-title":"Handb Clin Neurol"},{"issue":"8","key":"10.1016\/j.semcdb.2015.03.010_bib0610","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1212\/01.wnl.0000311277.71046.a0","article-title":"Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families","volume":"71","author":"Hara","year":"2008","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.semcdb.2015.03.010_bib0615","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/mds.22970","article-title":"Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series","volume":"25","author":"van de Leemput","year":"2010","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.semcdb.2015.03.010_bib0620","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archneurol.2011.81","article-title":"SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia","volume":"68","author":"Marelli","year":"2011","journal-title":"Arch Neurol"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0625","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng1196-269","article-title":"Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2","volume":"14","author":"Pulst","year":"1996","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0630","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/79162","article-title":"Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human","volume":"26","author":"Huynh","year":"2000","journal-title":"Nat Genet"},{"issue":"29","key":"10.1016\/j.semcdb.2015.03.010_bib0635","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1523\/JNEUROSCI.0660-09.2009","article-title":"Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2","volume":"29","author":"Liu","year":"2009","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0640","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.expneurol.2008.09.020","article-title":"Ataxin-2 associates with rough endoplasmic reticulum","volume":"215","author":"van de Loo","year":"2009","journal-title":"Exp Neurol"},{"issue":"37","key":"10.1016\/j.semcdb.2015.03.010_bib0645","doi-asserted-by":"crossref","first-page":"12786","DOI":"10.1523\/JNEUROSCI.1643-12.2012","article-title":"Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice","volume":"32","author":"Kasumu","year":"2012","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0650","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ana.410410408","article-title":"Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain","volume":"41","author":"Paulson","year":"1997","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0655","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/sj.ejhg.5200403","article-title":"Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology","volume":"8","author":"Stevanin","year":"2000","journal-title":"Eur J Hum Genet"},{"issue":"7","key":"10.1016\/j.semcdb.2015.03.010_bib0660","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1212\/WNL.28.7.703","article-title":"Autosomal dominant system degeneration in Portuguese families of the Azores Islands. A new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions","volume":"28","author":"Coutinho","year":"1978","journal-title":"Neurology"},{"issue":"23","key":"10.1016\/j.semcdb.2015.03.010_bib0665","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/hmg\/ddg344","article-title":"The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity","volume":"12","author":"Burnett","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"44","key":"10.1016\/j.semcdb.2015.03.010_bib0670","doi-asserted-by":"crossref","first-page":"11474","DOI":"10.1523\/JNEUROSCI.2053-06.2006","article-title":"Ataxin-3 represses transcription via chromatin binding: interaction with histone deacetylase 3, and histone deacetylation","volume":"26","author":"Evert","year":"2006","journal-title":"J Neurosci"},{"issue":"26","key":"10.1016\/j.semcdb.2015.03.010_bib0675","doi-asserted-by":"crossref","first-page":"18851","DOI":"10.1074\/jbc.M611914200","article-title":"Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3","volume":"282","author":"Haacke","year":"2007","journal-title":"J Biol Chem"},{"issue":"48","key":"10.1016\/j.semcdb.2015.03.010_bib0680","doi-asserted-by":"crossref","first-page":"12713","DOI":"10.1523\/JNEUROSCI.3909-08.2008","article-title":"Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3","volume":"28","author":"Chen","year":"2008","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0685","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s12311-010-0182-9","article-title":"Deranged calcium signaling in purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias","volume":"11","author":"Kasumu","year":"2012","journal-title":"Cerebellum (Lond, Engl)"},{"issue":"5","key":"10.1016\/j.semcdb.2015.03.010_bib0690","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tins.2010.02.005","article-title":"Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling","volume":"33","author":"Schorge","year":"2010","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0695","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1989.tb12485.x","article-title":"Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview","volume":"568","author":"Khachaturian","year":"1989","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0700","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1210951","article-title":"A phase 3 trial of semagacestat for treatment of Alzheimer's disease","volume":"369","author":"Doody","year":"2013","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0705","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(03)00205-8","article-title":"Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex","volume":"38","author":"De Strooper","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0710","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-pharmtox-010814-124309","article-title":"Learning by failing: ideas and concepts to tackle gamma-secretases in Alzheimer's disease and beyond","volume":"55","author":"De Strooper","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"10","key":"10.1016\/j.semcdb.2015.03.010_bib0715","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1185\/03007995.2014.939167","article-title":"Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings","volume":"30","author":"Henley","year":"2014","journal-title":"Curr Med Res Opin"},{"issue":"46","key":"10.1016\/j.semcdb.2015.03.010_bib0720","doi-asserted-by":"crossref","first-page":"16507","DOI":"10.1523\/JNEUROSCI.3647-11.2011","article-title":"Robust central reduction of amyloid-beta in humans with an orally available: non-peptidic beta-secretase inhibitor","volume":"31","author":"May","year":"2011","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0725","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tips.2013.01.008","article-title":"beta-Secretase: its biology as a therapeutic target in diseases","volume":"34","author":"Wang","year":"2013","journal-title":"Trends Pharmacol Sci"},{"issue":"11","key":"10.1016\/j.semcdb.2015.03.010_bib0730","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1021\/jm301659n","article-title":"Structure-based design of beta-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease","volume":"56","author":"Yuan","year":"2013","journal-title":"J Med Chem"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0735","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1474-4422(13)70276-X","article-title":"Targeting the beta secretase BACE1 for Alzheimer's disease therapy","volume":"13","author":"Yan","year":"2014","journal-title":"Lancet Neurol"},{"issue":"11","key":"10.1016\/j.semcdb.2015.03.010_bib0740","doi-asserted-by":"crossref","first-page":"10542","DOI":"10.1074\/jbc.M310001200","article-title":"Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1","volume":"279","author":"Li","year":"2004","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.semcdb.2015.03.010_bib0745","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/nn1797","article-title":"Bace1 modulates myelination in the central and peripheral nervous system","volume":"9","author":"Hu","year":"2006","journal-title":"Nat Neurosci"},{"issue":"5799","key":"10.1016\/j.semcdb.2015.03.010_bib0750","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.1132341","article-title":"Control of peripheral nerve myelination by the beta-secretase BACE1","volume":"314","author":"Willem","year":"2006","journal-title":"Science"},{"issue":"46","key":"10.1016\/j.semcdb.2015.03.010_bib0755","doi-asserted-by":"crossref","first-page":"38408","DOI":"10.1074\/jbc.M112.415505","article-title":"beta-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects","volume":"287","author":"Hitt","year":"2012","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.semcdb.2015.03.010_bib0760","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ncb1602","article-title":"BACE1 regulates voltage-gated sodium channels and neuronal activity","volume":"9","author":"Kim","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0765","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/alzrt82","article-title":"The beta-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease","volume":"3","author":"Vassar","year":"2011","journal-title":"Alzheimers Res Therapy"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0770","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/srep00231","article-title":"The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease","volume":"2","author":"Cao","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0775","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1750-1326-6-88","article-title":"The Alzheimer's beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb","volume":"6","author":"Rajapaksha","year":"2011","journal-title":"Mol Neurodegener"},{"issue":"50","key":"10.1016\/j.semcdb.2015.03.010_bib0780","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1523\/JNEUROSCI.2766-05.2005","article-title":"BACE1: a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions","volume":"25","author":"Laird","year":"2005","journal-title":"J Neurosci"},{"issue":"14","key":"10.1016\/j.semcdb.2015.03.010_bib0785","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1073\/pnas.0710373105","article-title":"Alteration of BACE1-dependent NRG1\/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice","volume":"105","author":"Savonenko","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"35","key":"10.1016\/j.semcdb.2015.03.010_bib0790","doi-asserted-by":"crossref","first-page":"30797","DOI":"10.1074\/jbc.M505249200","article-title":"Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice","volume":"280","author":"Dominguez","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0795","article-title":"Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions","author":"Filser","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0800","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cell.2006.06.059","article-title":"Presenilins form ER calcium leak channels, a function disrupted by mutations linked to familial Alzheimer's disease","volume":"126","author":"Tu","year":"2006","journal-title":"Cell"},{"issue":"25","key":"10.1016\/j.semcdb.2015.03.010_bib0805","doi-asserted-by":"crossref","first-page":"22339","DOI":"10.1074\/jbc.M111.243063","article-title":"Mutagenesis mapping of the presenilin 1 calcium leak conductance pore","volume":"286","author":"Nelson","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0810","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1074\/jbc.M111.300491","article-title":"Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels","volume":"287","author":"Shilling","year":"2012","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.semcdb.2015.03.010_bib0815","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.bbamcr.2012.05.023","article-title":"Capacitative and non-capacitative signaling complexes in human platelets","volume":"1823","author":"Berna-Erro","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"283","key":"10.1016\/j.semcdb.2015.03.010_bib0820","doi-asserted-by":"crossref","first-page":"pe24","DOI":"10.1126\/scisignal.2004296","article-title":"Presenilins and calcium signaling-systems biology to the rescue","volume":"6","author":"Bezprozvanny","year":"2013","journal-title":"Sci Signal"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0825","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3233\/JAD-2010-100159","article-title":"Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes","volume":"21","author":"Nelson","year":"2010","journal-title":"J Alzheimers Dis"},{"issue":"25","key":"10.1016\/j.semcdb.2015.03.010_bib0830","doi-asserted-by":"crossref","first-page":"8566","DOI":"10.1523\/JNEUROSCI.1554-10.2010","article-title":"Role of presenilins in neuronal calcium homeostasis","volume":"30","author":"Zhang","year":"2010","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.semcdb.2015.03.010_bib0835","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2008.04.015","article-title":"Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP(3) receptor channel gating","volume":"58","author":"Cheung","year":"2008","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.semcdb.2015.03.010_bib0840","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0306-4522(99)00042-1","article-title":"Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies","volume":"92","author":"Kelliher","year":"1999","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.semcdb.2015.03.010_bib0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.03.011","article-title":"Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease","volume":"33","author":"Bruno","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"19","key":"10.1016\/j.semcdb.2015.03.010_bib0850","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1523\/JNEUROSCI.0739-06.2006","article-title":"Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young: adult, and aged Alzheimer's disease mice","volume":"26","author":"Stutzmann","year":"2006","journal-title":"J Neurosci"},{"issue":"30","key":"10.1016\/j.semcdb.2015.03.010_bib0855","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1523\/JNEUROSCI.2047-09.2009","article-title":"Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice","volume":"29","author":"Chakroborty","year":"2009","journal-title":"J Neurosci"},{"issue":"24","key":"10.1016\/j.semcdb.2015.03.010_bib0860","doi-asserted-by":"crossref","first-page":"8341","DOI":"10.1523\/JNEUROSCI.0936-12.2012","article-title":"Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice","volume":"32","author":"Chakroborty","year":"2012","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.semcdb.2015.03.010_bib0865","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neulet.2012.04.008","article-title":"Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice","volume":"516","author":"Peng","year":"2012","journal-title":"Neurosci Lett"},{"issue":"12","key":"10.1016\/j.semcdb.2015.03.010_bib0870","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052056","article-title":"Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease","volume":"7","author":"Chakroborty","year":"2012","journal-title":"PLoS ONE"},{"issue":"34","key":"10.1016\/j.semcdb.2015.03.010_bib0875","doi-asserted-by":"crossref","first-page":"11820","DOI":"10.1523\/JNEUROSCI.0875-12.2012","article-title":"Ryanodine receptor blockade reduces amyloid-beta load and memory impairments in Tg2576 mouse model of Alzheimer disease","volume":"32","author":"Oules","year":"2012","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0880","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2044.2004.03658.x","article-title":"Dantrolene \u2013 a review of its pharmacology: therapeutic use and new developments","volume":"59","author":"Krause","year":"2004","journal-title":"Anaesthesia"},{"issue":"5","key":"10.1016\/j.semcdb.2015.03.010_bib0885","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/CIRCEP.108.788349","article-title":"Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel","volume":"1","author":"Wang","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"2","key":"10.1016\/j.semcdb.2015.03.010_bib0890","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1152\/physrev.00057.2003","article-title":"Store-operated calcium channels","volume":"85","author":"Parekh","year":"2005","journal-title":"Physiol Rev"},{"issue":"5","key":"10.1016\/j.semcdb.2015.03.010_bib0895","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1152\/jn.00118.2006","article-title":"A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia","volume":"96","author":"Kachoei","year":"2006","journal-title":"J Neurophysiol"},{"issue":"1","key":"10.1016\/j.semcdb.2015.03.010_bib0900","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(01)00190-8","article-title":"Calcium stores in hippocampal synaptic boutons mediate short-term plasticity: store-operated Ca2+ entry, and spontaneous transmitter release","volume":"29","author":"Emptage","year":"2001","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.semcdb.2015.03.010_bib0905","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1073\/pnas.0611692104","article-title":"Orai proteins interact with TRPC channels and confer responsiveness to store depletion","volume":"104","author":"Liao","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0910","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1083\/jcb.149.4.793","article-title":"Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice","volume":"149","author":"Leissring","year":"2000","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0915","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0896-6273(00)00066-0","article-title":"Presenilin-mediated modulation of capacitative calcium entry","volume":"27","author":"Yoo","year":"2000","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0920","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1074\/jbc.M206769200","article-title":"Capacitive calcium entry is directly attenuated by mutant presenilin-1: independent of the expression of the amyloid precursor protein","volume":"278","author":"Herms","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.semcdb.2015.03.010_bib0925","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbadis.2007.03.006","article-title":"Transient receptor potential channels in Alzheimer's disease","volume":"1772","author":"Yamamoto","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"10.1016\/j.semcdb.2015.03.010_bib0930","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.7863\/ultra.32.9.1682","article-title":"Viable delivery after conservative management of a cesarean scar pregnancy","volume":"32","author":"Nishida","year":"2013","journal-title":"J Ultrasound Med"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0935","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.conb.2007.04.009","article-title":"Do thin spines learn to be mushroom spines that remember?","volume":"17","author":"Bourne","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0940","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1750-1326-8-23","article-title":"The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration","volume":"8","author":"Bezprozvanny","year":"2013","journal-title":"Mol Neurodegener"},{"issue":"11","key":"10.1016\/j.semcdb.2015.03.010_bib0945","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1523\/JNEUROSCI.21-11-04066.2001","article-title":"Calcineurin links Ca2+ dysregulation with brain aging","volume":"21","author":"Foster","year":"2001","journal-title":"J Neurosci"},{"issue":"2\u20133","key":"10.1016\/j.semcdb.2015.03.010_bib0950","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jphysparis.2005.12.009","article-title":"A role for the protein phosphatase 2B in altered hippocampal synaptic plasticity in the aged rat","volume":"99","author":"Jouvenceau","year":"2006","journal-title":"J Physiol Paris"},{"issue":"4","key":"10.1016\/j.semcdb.2015.03.010_bib0955","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1471-4159.2011.07447.x","article-title":"Dysregulated phosphorylation of Ca(2+)\/calmodulin-dependent protein kinase II-alpha in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease","volume":"119","author":"Reese","year":"2011","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.semcdb.2015.03.010_bib0960","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3233\/JAD-2010-1302","article-title":"Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice","volume":"19","author":"Auffret","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.semcdb.2015.03.010_bib0965","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1091\/mbc.5.1.97","article-title":"Caffeine-induced inhibition of inositol (1,4,5)-trisphosphate-gated calcium channels from cerebellum","volume":"5","author":"Bezprozvanny","year":"1994","journal-title":"Mol Biol Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2015.03.010_bib0970","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1172\/JCI22466","article-title":"Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium","volume":"116","author":"Schlecker","year":"2006","journal-title":"J Clin Invest"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952115000646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952115000646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T20:43:31Z","timestamp":1566506611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952115000646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":97,"alternative-id":["S1084952115000646"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2015.03.010","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2015.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}