{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:59:36Z","timestamp":1786996776240,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.semcdb.2015.11.006","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T20:38:15Z","timestamp":1448138295000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"C","title":["Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis"],"prefix":"10.1016","volume":"49","author":[{"given":"Geoffrey N.","family":"Hendy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Canaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2015.11.006_bib0300","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.beem.2013.02.006","article-title":"Role of the calcium-sensing receptor in extracellular calcium homeostasis","volume":"27","author":"Brown","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0305","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1877-1173(09)89003-0","article-title":"Calcium-sensing receptor and associated diseases","volume":"89","author":"Hendy","year":"2009","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0310","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.beem.2013.04.007","article-title":"Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism","volume":"27","author":"Hannan","year":"2013","journal-title":"Best Prac. Metab. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0315","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00003246-199202000-00014","article-title":"Hypocalcemia in critically ill patients","volume":"20","author":"Zaloga","year":"1992","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0320","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0272-6386(01)80116-5","article-title":"Hypocalcemia: A pervasive metabolic abnormality in the critically ill","volume":"37","author":"Zivin","year":"2001","journal-title":"Am. J. Kid. Dis."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0325","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/cc12756","article-title":"Assessment and clinical course of hypocalcemia in critical illness","volume":"17","author":"Steele","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0330","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1210\/jcem.84.8.5889","article-title":"Hypocalcemia induced during major and minor abdominal surgery in humans","volume":"84","author":"Lepage","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0335","doi-asserted-by":"crossref","first-page":"938","DOI":"10.2460\/ajvr.2001.62.938","article-title":"Comparison of serum parathyroid hormone and ionized calcium and magnesium concentrations and fractional urinary calcium clearance of calcium and phosphorous in healthy horses and horses with enterocolitis","volume":"62","author":"Toribio","year":"2001","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0340","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00003246-200001000-00015","article-title":"Hypocalcemia and parathyroid secretion in critically ill patients","volume":"28","author":"Lind","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0345","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1365-2362.2000.00714.x","article-title":"Disordered calcium homeostasis of sepsis: association with calcitonin precursors","volume":"30","author":"Muller","year":"2000","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0350","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1210\/jc.2002-021444","article-title":"Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors","volume":"89","author":"Becker","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0355","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1476-5381.2009.00433.x","article-title":"Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target","volume":"159","author":"Becker","year":"2010","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0360","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004630-199711000-00010","article-title":"Pathogenesis of fever in a rat burn model: the role of cytokines and lipopolysaccharide","volume":"18","author":"Caldwell","year":"1997","journal-title":"J. Burn Care Rehabil."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0365","first-page":"357","article-title":"Interleukin-2 and interleukin-6 in relation to burn wound in the acute phase of thermal injury","volume":"178","author":"Kowal-Vern","year":"1994","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0370","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/8756-3282(95)00279-1","article-title":"Histomorphometric and biochemical characterization of bone following acute severe burns in children","volume":"17","author":"Klein","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0375","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00024382-200206000-00004","article-title":"Six at six: interleukin-6 measured 6h after the initiation of sepsis predicts mortality over 3 days","volume":"17","author":"Remick","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0380","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1006\/bbrc.1993.2655","article-title":"Systemic production of interleukin-6 following acute inflammation","volume":"197","author":"Ohzato","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0385","first-page":"761","article-title":"Interleukin-6 and its relation to the humoral immune response and clinical parameters in burned paients","volume":"109","author":"Nijsten","year":"1991","journal-title":"Surgery"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0390","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0305-4179(96)00052-6","article-title":"Plasma cytokine levels in patients with severe burn injury\u2013\u2013with reference to the relationship between infection and prognosis","volume":"22","author":"Yamada","year":"1996","journal-title":"Burns"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0395","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1097\/00005373-199112000-00017","article-title":"Interleukin-6\u2013\u2013a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cells","volume":"31","author":"Schluter","year":"1991","journal-title":"J. Trauma"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0400","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0090-1229(90)90050-Z","article-title":"Increased levels of circulating interleukin 6 in burn patients","volume":"54","author":"Guo","year":"1990","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0405","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2265.1990.tb00873.x","article-title":"Impaired secretion of parathyroid hormone in patients with rheumatoid arthritis: relationship to inflammatory activity","volume":"32","author":"af Ekenstam","year":"1990","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0410","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1020146023812","article-title":"Interleukin-6 induced suppression of bovine parathyroid hormone secretion","volume":"19","author":"Carlstedt","year":"1999","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0415","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1006\/bbrc.1997.7207","article-title":"Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA","volume":"238","author":"Nielsen","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0420","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1097\/00003246-200012000-00024","article-title":"Up-regulation of the parathyroid calcium-sensing receptor after burn injury in sheep: a potential contributory factor to post-burn hypocalcemia","volume":"28","author":"Murphey","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0425","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1359\/jbmr.1998.13.8.1232","article-title":"The chemokine interleukin-8 regulates parathyroid secretion","volume":"13","author":"Angeletti","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0430","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0303-7207(02)00289-7","article-title":"Parathyroid hormone (PTH) secretion, PTH mRNA and calcium-sensing receptor mRNA expression in equine parathyroid cells, and effects of interleukin (IL)-1, IL-6 and tumor necrosis factor on equine parathyroid function cell function","volume":"199","author":"Toribio","year":"2003","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0435","doi-asserted-by":"crossref","first-page":"14177","DOI":"10.1074\/jbc.M408587200","article-title":"Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1\u03b2","volume":"280","author":"Canaff","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0440","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.M708087200","article-title":"The proinflammatory cytokine, interleukin-6, upregulates calcium-sensing receptor gene transcription via Stat 1\/3 and Sp 1\/3","volume":"283","author":"Canaff","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0445","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1939-1676.2009.0275.x","article-title":"Calcium regulating hormones and serum and magnesium concentrations in septic and critically ill foals and their association with survival","volume":"23","author":"Hurcombe","year":"2009","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0450","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/jcp.1041530125","article-title":"Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclases in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors","volume":"153","author":"Katz","year":"1992","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0455","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0022-3476(97)70161-6","article-title":"Dysregulation of calcium homeostasis after severe burn injury in children: possible role of magnesium depletion","volume":"131","author":"Klein","year":"1997","journal-title":"J. Pediatr."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0460","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jsbmb.2013.10.015","article-title":"Regulation of the calcium-sensing receptor expression by 1,25-dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor alpha in colon cancer cells","volume":"144 PtA","author":"Fetahu","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0465","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fphys.2011.00017","article-title":"Extracellular calcium-sensing receptor inhibition of intestinal epithelial TNF signalling requires CaSR-mediated Wnt5a\/Ror2 interaction","volume":"2","author":"Kelly","year":"2011","journal-title":"Front. Physiol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0470","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1074\/jbc.270.21.12919","article-title":"Molecular cloning and functional expression of human calcium-sensing receptor cDNAs","volume":"270","author":"Garrett","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0475","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1006\/bbrc.1995.2318","article-title":"Molecular cloning of a putative Ca2+- sensing receptor cDNA from human kidney","volume":"214","author":"Aida","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0480","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1074\/jbc.275.11.7553","article-title":"Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas","volume":"270","author":"Chikatsu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0485","doi-asserted-by":"crossref","first-page":"30337","DOI":"10.1074\/jbc.M201804200","article-title":"Human calcium-sensing receptor gene Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25- dihydroxyvitamin D","volume":"277","author":"Canaff","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0490","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.beem.2013.02.009","article-title":"The CASR gene: Alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: Structure and ligand binding sites","volume":"27","author":"Hendy","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0495","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/humu.20827","article-title":"Glial cells missing-2 transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism","volume":"30","author":"Canaff","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0500","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappaB and Rel proteins: Evolutionarily conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0505","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI11891","article-title":"Series introduction: The transcription factor NF-\u03baB and human disease","volume":"107","author":"Baldwin","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0510","first-page":"496","article-title":"STAT proteins and transcriptional responses to extracellular signals","volume":"25","author":"Horvath","year":"2000","journal-title":"TIBS"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0515","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"STATS: Transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0525","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1523\/JNEUROSCI.3947-10.2010","article-title":"IL-6-and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex","author":"Melemedjian","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0530","article-title":"The calcium-sensing receptor as a mediator of inflammation","author":"Klein","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0535","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1359\/jbmr.1997.12.12.1959","article-title":"Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells","volume":"12","author":"House","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0540","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1006\/bbrc.1998.8648","article-title":"Expression of extracellular calcium (Cao2+)-sensing receptor in human peripheral blood monocytes","volume":"246","author":"Yamaguchi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0545","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI9799","article-title":"Extracellular calcium elicits a chemokinetic response from monocytes in vitro and vivo","volume":"105","author":"Olszak","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0550","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1359\/jbmr.1997.12.2.228","article-title":"Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium","volume":"12","author":"Bornefalk","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0555","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/emmm.201201771","article-title":"Of inflammasomes and pathogens\u2013sensing of microbes by the inflammasome","volume":"5","author":"Bauernfeind","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0560","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/j.1460-2075.1990.tb08268.x","article-title":"A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence","volume":"9","author":"Rubartelli","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0565","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL1\u03b2 secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0570","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0575","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ncomms2339","article-title":"Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors","volume":"3","author":"Rossol","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0580","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.4049\/jimmunol.1101737","article-title":"Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models","volume":"189","author":"McGeough","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.semcdb.2015.11.006_bib0585","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.immuni.2009.02.005","article-title":"The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA","volume":"30","author":"Allen","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.semcdb.2015.11.006_bib0590","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2009.02.006","article-title":"The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1","volume":"30","author":"Thomas","year":"2009","journal-title":"Immunity"}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952115300069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952115300069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T16:22:31Z","timestamp":1572452551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952115300069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":59,"alternative-id":["S1084952115300069"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2015.11.006","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2015.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}