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A."},{"key":"10.1016\/j.semcdb.2017.06.021_bib0535","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.4049\/jimmunol.1202769","article-title":"The role of IL-1\u03b2 in the early tumor cell-induced angiogenic response","volume":"190","author":"Carmi","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.semcdb.2017.06.021_bib0540","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00441-003-0749-6","article-title":"Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis","volume":"314","author":"Thurston","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.semcdb.2017.06.021_bib0545","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1167\/iovs.07-1206","article-title":"The angiopoietin\/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy","volume":"49","author":"Cai","year":"2008","journal-title":"Invest. Ophthalmol. Vis. 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