{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:59:33Z","timestamp":1775919573237,"version":"3.50.1"},"reference-count":126,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002923","name":"NIH-CONICET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.semcdb.2018.11.004","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T22:24:23Z","timestamp":1543616663000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Signaling within the pineal gland: A parallelism with the central nervous system"],"prefix":"10.1016","volume":"95","author":[{"given":"Luz E.","family":"Farias Altamirano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos L.","family":"Freites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"V\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-1535","authenticated-orcid":false,"given":"Estela M.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0005","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/pr.55.2.2","article-title":"Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters","volume":"55","author":"Simonneaux","year":"2003","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tem.2007.03.001","article-title":"The mammalian pineal gland: known facts, unknown facets","volume":"18","author":"Maronde","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1749-6632.2009.04435.x","article-title":"Structural and functional evolution of the pineal melatonin system in vertebrates","volume":"1163","author":"Falcon","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0020","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/joa.12771","article-title":"The origins of the circumventricular organs","volume":"232","author":"Kiecker","year":"2018","journal-title":"J. Anat."},{"issue":"1-2","key":"10.1016\/j.semcdb.2018.11.004_bib0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/07420520500545839","article-title":"Evolution of the vertebrate pineal gland: the AANAT hypothesis","volume":"23","author":"Klein","year":"2006","journal-title":"Chronobiol. Int."},{"issue":"6","key":"10.1016\/j.semcdb.2018.11.004_bib0030","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s11064-012-0906-y","article-title":"Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance","volume":"38","author":"Rath","year":"2013","journal-title":"Neurochem. Res."},{"issue":"7","key":"10.1016\/j.semcdb.2018.11.004_bib0035","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1074\/jbc.R600036200","article-title":"Arylalkylamine N-acetyltransferase: \"the Timezyme\"","volume":"282","author":"Klein","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0040","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00441-002-0580-5","article-title":"The anatomy and innervation of the mammalian pineal gland","volume":"309","author":"M\u00f8ller","year":"2002","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0045","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneumeth.2010.07.007","article-title":"A standardized surgical technique for rat superior cervical ganglionectomy","volume":"192","author":"Savastano","year":"2010","journal-title":"J. Neurosci. Methods"},{"issue":"12","key":"10.1016\/j.semcdb.2018.11.004_bib0050","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1074\/jbc.M808394200","article-title":"Night\/day changes in pineal expression of &600 genes: central role of adrenergic\/cAMP signaling","volume":"284","author":"Bailey","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.semcdb.2018.11.004_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137548","article-title":"Neurotranscriptomics: the effects of neonatal stimulus deprivation on the rat pineal transcriptome","volume":"10","author":"Hartley","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.semcdb.2018.11.004_bib0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205883","article-title":"Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression","volume":"13","author":"Mays","year":"2018","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.semcdb.2018.11.004_bib0065","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1523\/JNEUROSCI.19-09-03326.1999","article-title":"Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis","volume":"19","author":"Maronde","year":"1999","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0070","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0026-895X(25)08563-3","article-title":"Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor\/cyclic AMP mechanism","volume":"47","author":"Roseboom","year":"1995","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00319113","article-title":"Norepinephrine-induced phosphorylation of the transcription factor CREB in isolated rat pinealocytes: an immunocytochemical study","volume":"282","author":"Tamotsu","year":"1995","journal-title":"Cell Tissue Res."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-079X.1999.tb00613.x","article-title":"CREB phosphorylation and melatonin biosynthesis in the rat pineal gland: involvement of cyclic AMP dependent protein kinase type II","volume":"27","author":"Maronde","year":"1999","journal-title":"J. Pineal Res."},{"issue":"50","key":"10.1016\/j.semcdb.2018.11.004_bib0085","doi-asserted-by":"crossref","first-page":"31969","DOI":"10.1016\/S0021-9258(18)31790-3","article-title":"Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters","volume":"269","author":"Rodriguez","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.semcdb.2018.11.004_bib0090","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.272.11.6979","article-title":"The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex","volume":"272","author":"Baler","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.semcdb.2018.11.004_bib0095","first-page":"699","article-title":"Rat arylalkylamine N-acetyltransferase gene: upstream and intronic components of a bipartite promoter","volume":"91","author":"Baler","year":"1999","journal-title":"Biol. Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0100","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/endo.140.3.6552","article-title":"Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity","volume":"140","author":"Ribelayga","year":"1999","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.semcdb.2018.11.004_bib0105","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0166-2236(97)01109-0","article-title":"Rhythmic transcription: the molecular basis of circadian melatonin synthesis","volume":"20","author":"Foulkes","year":"1997","journal-title":"Trends Neurosci."},{"issue":"6444","key":"10.1016\/j.semcdb.2018.11.004_bib0110","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/365314a0","article-title":"Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland","volume":"365","author":"Stehle","year":"1993","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.mce.2009.07.010","article-title":"Pineal function: impact of microarray analysis","volume":"314","author":"Klein","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0120","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1038\/srep10662","article-title":"Single-molecule imaging reveals dynamics of CREB transcription factor bound to its target sequence","volume":"5","author":"Sugo","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.0943-16.2016","article-title":"Activity-dependent dynamics of the transcription factor of cAMP-Response element binding protein in cortical neurons revealed by single-molecule imaging","volume":"37","author":"Kitagawa","year":"2017","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","article-title":"CREB: a multifaceted regulator of neuronal plasticity and protection","volume":"116","author":"Sakamoto","year":"2011","journal-title":"J. Neurochem."},{"issue":"5512","key":"10.1016\/j.semcdb.2018.11.004_bib0135","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.1056784","article-title":"Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity","volume":"291","author":"Nucifora","year":"2001","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng882","article-title":"Disruption of CREB function in brain leads to neurodegeneration","volume":"31","author":"Mantamadiotis","year":"2002","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0145","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1523\/JNEUROSCI.3493-03.2004","article-title":"CRE-mediated transcription is increased in Huntington\u2019s disease transgenic mice","volume":"24","author":"Obrietan","year":"2004","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.semcdb.2018.11.004_bib0150","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1242\/dev.121.10.3279","article-title":"Forebrain and midbrain regions are deleted in Otx2-\/- mutants due to a defective anterior neuroectoderm specification during gastrulation","volume":"121","author":"Acampora","year":"1995","journal-title":"Development"},{"issue":"21","key":"10.1016\/j.semcdb.2018.11.004_bib0155","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1101\/gad.9.21.2646","article-title":"Mouse Otx2 functions in the formation and patterning of rostral head","volume":"9","author":"Matsuo","year":"1995","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0925-4773(01)00527-5","article-title":"The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ","volume":"109","author":"Estivill-Torrus","year":"2001","journal-title":"Mech. Dev."},{"issue":"5","key":"10.1016\/j.semcdb.2018.11.004_bib0165","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/ana.10576","article-title":"Polymicrogyria and absence of pineal gland due to PAX6 mutation","volume":"53","author":"Mitchell","year":"2003","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.semcdb.2018.11.004_bib0170","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/nn1155","article-title":"Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development","volume":"6","author":"Nishida","year":"2003","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0175","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1471-4159.2006.03773.x","article-title":"Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland","volume":"97","author":"Rath","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0180","first-page":"2074","article-title":"PAX6 aniridia and interhemispheric brain anomalies","volume":"15","author":"Abouzeid","year":"2009","journal-title":"Mol. Vis."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0185","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1210\/en.2008-0882","article-title":"Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3\u2019,5\u2019-monophosphate signaling","volume":"150","author":"Rath","year":"2009","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0190","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s00429-014-0740-x","article-title":"The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus","volume":"220","author":"Yamazaki","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"11","key":"10.1016\/j.semcdb.2018.11.004_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167063","article-title":"Cellular basis of pineal gland development: emerging role of microglia as phenotype regulator","volume":"11","author":"Iba\u00f1ez Rodriguez","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0200","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1242\/dev.113.4.1435","article-title":"Pax-6, a murine paired box gene, is expressed in the developing CNS","volume":"113","author":"Walther","year":"1991","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0205","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0888-7543(91)90151-4","article-title":"Pax: a murine multigene family of paired box-containing genes","volume":"11","author":"Walther","year":"1991","journal-title":"Genomics"},{"key":"10.1016\/j.semcdb.2018.11.004_bib0210","article-title":"The role of Pax6 in brain development and its impact on pathogenesis of autism spectrum disorder","author":"Kikkawa","year":"2018","journal-title":"Brain Res."},{"issue":"8-9","key":"10.1016\/j.semcdb.2018.11.004_bib0215","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1387\/ijdb.041900wg","article-title":"Historical perspective on the development and evolution of eyes and photoreceptors","volume":"48","author":"Gehring","year":"2004","journal-title":"Int. J. Dev. Biol."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0220","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cne.23866","article-title":"Transcriptional and epigenetic mechanisms of early cortical development: an examination of how Pax6 coordinates cortical development","volume":"524","author":"Ypsilanti","year":"2016","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.semcdb.2018.11.004_bib0225","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/cercor\/9.6.627","article-title":"The transcription factor, Pax6, is required for cell proliferation and differentiation in the developing cerebral cortex","volume":"9","author":"Warren","year":"1999","journal-title":"Cereb. Cortex"},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0230","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1242\/dev.129.2.455","article-title":"Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors","volume":"129","author":"Estivill-Torrus","year":"2002","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0235","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nn828","article-title":"Glial cells generate neurons: the role of the transcription factor Pax6","volume":"5","author":"Heins","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.semcdb.2018.11.004_bib0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000511","article-title":"The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis","volume":"5","author":"Sansom","year":"2009","journal-title":"PLoS Genet."},{"issue":"8","key":"10.1016\/j.semcdb.2018.11.004_bib0245","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/gtc.12061","article-title":"Dmrta1 regulates proneural gene expression downstream of Pax6 in the mammalian telencephalon","volume":"18","author":"Kikkawa","year":"2013","journal-title":"Genes Cells"},{"issue":"5","key":"10.1016\/j.semcdb.2018.11.004_bib0250","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1242\/dev.082875","article-title":"Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation","volume":"140","author":"Walcher","year":"2013","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054507","article-title":"Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain","volume":"8","author":"Xie","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0260","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13072-016-0087-z","article-title":"Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers","volume":"9","author":"Sun","year":"2016","journal-title":"Epigenetics Chromatin"},{"issue":"7","key":"10.1016\/j.semcdb.2018.11.004_bib0265","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1634\/stemcells.2007-0884","article-title":"Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator","volume":"26","author":"Osumi","year":"2008","journal-title":"Stem Cells"},{"issue":"18","key":"10.1016\/j.semcdb.2018.11.004_bib0270","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1523\/JNEUROSCI.5074-07.2008","article-title":"The neurogenesis-controlling factor, Pax6, inhibits proliferation and promotes maturation in murine astrocytes","volume":"28","author":"Sakurai","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0275","first-page":"95","article-title":"Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse","volume":"97","author":"Hogan","year":"1986","journal-title":"J. Embryol. Exp. Morphol."},{"issue":"6354","key":"10.1016\/j.semcdb.2018.11.004_bib0280","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/354522a0","article-title":"Mouse small eye results from mutations in a paired-like homeobox-containing gene","volume":"354","author":"Hill","year":"1991","journal-title":"Nature"},{"issue":"Pt 1","key":"10.1016\/j.semcdb.2018.11.004_bib0285","first-page":"45","article-title":"Postnatal evolution of the rat pineal gland: light microscopy","volume":"138","author":"Calvo","year":"1984","journal-title":"J. Anat."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0290","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12328","article-title":"GABAergic signaling in the rat pineal gland","author":"Yu","year":"2016","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0295","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1242\/dev.102608","article-title":"GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors","volume":"141","author":"Giachino","year":"2014","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00441-017-2668-y","article-title":"Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis","volume":"371","author":"Catavero","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2018.01.007","article-title":"Generation of Pax6-IRES-EGFP knock-in mouse via the cloning-free CRISPR\/Cas9 system to reliably visualize neurodevelopmental dynamics","volume":"132","author":"Inoue","year":"2018","journal-title":"Neurosci. Res."},{"issue":"11","key":"10.1016\/j.semcdb.2018.11.004_bib0310","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1242\/dev.00452","article-title":"Ash1a and Neurogenin1 function downstream of floating head to regulate epiphysial neurogenesis","volume":"130","author":"Cau","year":"2003","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0315","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1471-4159.2007.04605.x","article-title":"NeuroD1: developmental expression and regulated genes in the rodent pineal gland","volume":"102","author":"Mu\u00f1oz","year":"2007","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0320","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1471-4159.2012.07870.x","article-title":"NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies","volume":"123","author":"Ochocinska","year":"2012","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0325","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/jpi.12228","article-title":"Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland","volume":"58","author":"Castro","year":"2015","journal-title":"J. Pineal Res."},{"issue":"5212","key":"10.1016\/j.semcdb.2018.11.004_bib0330","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.7754368","article-title":"Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein","volume":"268","author":"Lee","year":"1995","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.semcdb.2018.11.004_bib0335","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1101\/gad.9.8.1009","article-title":"Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor","volume":"9","author":"Naya","year":"1995","journal-title":"Genes Dev."},{"issue":"18","key":"10.1016\/j.semcdb.2018.11.004_bib0340","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1101\/gad.11.18.2323","article-title":"Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2\/neuroD-deficient mice","volume":"11","author":"Naya","year":"1997","journal-title":"Genes Dev."},{"issue":"13","key":"10.1016\/j.semcdb.2018.11.004_bib0345","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1101\/gad.13.13.1647","article-title":"NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus","volume":"13","author":"Miyata","year":"1999","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0350","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1016-8478(23)13113-X","article-title":"NeuroD: the predicted and the surprising","volume":"18","author":"Chae","year":"2004","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0355","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1385\/MN:30:1:035","article-title":"The role of BETA2\/NeuroD1 in the development of the nervous system","volume":"30","author":"Cho","year":"2004","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0360","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuroscience.2010.08.022","article-title":"Neurogenesis in the R6\/2 mouse model of Huntington\u2019s disease is impaired at the level of NeuroD1","volume":"173","author":"Fedele","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.semcdb.2018.11.004_bib0365","first-page":"124","article-title":"Ophthalmological phenotype associated with homozygous null mutation in the NEUROD1 gene","volume":"21","author":"Orosz","year":"2015","journal-title":"Mol. Vis."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0370","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1523\/JNEUROSCI.23-02-00453.2003","article-title":"BETA2\/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration","volume":"23","author":"Pennesi","year":"2003","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.semcdb.2018.11.004_bib0375","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1073\/pnas.94.8.3560","article-title":"The basic helix-loop-helix transcription factor BETA2\/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression","volume":"94","author":"Mutoh","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.semcdb.2018.11.004_bib0380","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1128\/MCB.17.11.6673","article-title":"NeuroD1\/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene","volume":"17","author":"Poulin","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"24","key":"10.1016\/j.semcdb.2018.11.004_bib0385","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1038\/sj.emboj.7601923","article-title":"Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers","volume":"26","author":"Seo","year":"2007","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0390","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/bi701527r","article-title":"Crystal structure of E47-NeuroD1\/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition","volume":"47","author":"Longo","year":"2008","journal-title":"Biochemistry"},{"issue":"19","key":"10.1016\/j.semcdb.2018.11.004_bib0395","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1091\/mbc.e10-10-0809","article-title":"Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors","volume":"22","author":"Mehmood","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.semcdb.2018.11.004_bib0400","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/B978-0-12-405943-6.00005-1","article-title":"Id proteins: small molecules, mighty regulators","volume":"110","author":"Ling","year":"2014","journal-title":"Curr. Top. Dev. Biol."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0405","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.devcel.2015.10.019","article-title":"Helix-loop-Helix partners in development and disease","volume":"35","author":"Wang","year":"2015","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0410","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.0007-1331.2001.00738.x","article-title":"cDNA array analysis of pineal gene expression reveals circadian rhythmicity of the dominant negative helix-loop-helix protein-encoding gene, Id-1","volume":"14","author":"Humphries","year":"2002","journal-title":"J. Neuroendocrinol."},{"issue":"3-4","key":"10.1016\/j.semcdb.2018.11.004_bib0415","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1020946631937","article-title":"Id-1 expression defines a subset of vimentin\/S-100beta-positive, GFAP-negative astrocytes in the adult rat pineal gland","volume":"34","author":"Kofler","year":"2002","journal-title":"Histochem. J."},{"issue":"Pt 3","key":"10.1016\/j.semcdb.2018.11.004_bib0420","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj20031021","article-title":"The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD\/BETA2","volume":"376","author":"Marsich","year":"2003","journal-title":"Biochem. J."},{"issue":"43","key":"10.1016\/j.semcdb.2018.11.004_bib0425","doi-asserted-by":"crossref","first-page":"33381","DOI":"10.1074\/jbc.M110.147215","article-title":"Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function","volume":"285","author":"Gosmain","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0430","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0896-6273(03)00841-9","article-title":"A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis","volume":"41","author":"Gaudilliere","year":"2004","journal-title":"Neuron"},{"issue":"21","key":"10.1016\/j.semcdb.2018.11.004_bib0435","doi-asserted-by":"crossref","first-page":"15589","DOI":"10.1074\/jbc.M701762200","article-title":"Glucose mediates the translocation of NeuroD1 by O-linked glycosylation","volume":"282","author":"Andrali","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.semcdb.2018.11.004_bib0440","doi-asserted-by":"crossref","first-page":"9796","DOI":"10.1074\/jbc.M307577200","article-title":"Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression","volume":"279","author":"Qiu","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.semcdb.2018.11.004_bib0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176950","article-title":"Identifying biologically relevant putative mechanisms in a given phenotype comparison","volume":"12","author":"Hanoudi","year":"2017","journal-title":"PLoS One"},{"issue":"1-2","key":"10.1016\/j.semcdb.2018.11.004_bib0450","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0006-8993(96)00664-6","article-title":"Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system","volume":"736","author":"Schechter","year":"1996","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0455","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1523\/JNEUROSCI.4082-13.2014","article-title":"GABAergic neurogliaform cells represent local sources of insulin in the cerebral cortex","volume":"34","author":"Molnar","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0460","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fendo.2015.00013","article-title":"Insulin, aging, and the brain: mechanisms and implications","volume":"6","author":"Akintola","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"8","key":"10.1016\/j.semcdb.2018.11.004_bib0465","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00125-016-3996-2","article-title":"Cerebral cortex: a target and source of insulin?","volume":"59","author":"Csajbok","year":"2016","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.semcdb.2018.11.004_bib0470","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12513","article-title":"Insulin action in the brain: roles in energy and glucose homeostasis","volume":"29","author":"Dodd","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0475","doi-asserted-by":"crossref","DOI":"10.1111\/cns.12866","article-title":"Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment","author":"Pomytkin","year":"2018","journal-title":"CNS Neurosci. Ther."},{"issue":"6","key":"10.1016\/j.semcdb.2018.11.004_bib0480","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1210\/en.2009-1299","article-title":"Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki rats","volume":"151","author":"Bach","year":"2010","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0485","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1600-079X.2010.00804.x","article-title":"Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats","volume":"49","author":"Peschke","year":"2010","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jpi.12240","article-title":"Experimental and clinical aspects of melatonin and clock genes in diabetes","volume":"59","author":"Peschke","year":"2015","journal-title":"J. Pineal Res."},{"issue":"10","key":"10.1016\/j.semcdb.2018.11.004_bib0495","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.tins.2014.07.006","article-title":"Oscillatory control of bHLH factors in neural progenitors","volume":"37","author":"Imayoshi","year":"2014","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0500","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuron.2014.03.018","article-title":"bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells","volume":"82","author":"Imayoshi","year":"2014","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.semcdb.2018.11.004_bib0505","doi-asserted-by":"crossref","DOI":"10.1242\/dev.159426","article-title":"All in the family: proneural bHLH genes and neuronal diversity","volume":"145","author":"Baker","year":"2018","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0510","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15252\/embj.201591206","article-title":"NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program","volume":"35","author":"Pataskar","year":"2016","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.semcdb.2018.11.004_bib0515","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tins.2005.09.001","article-title":"Like cops on the beat: the active role of resting microglia","volume":"28","author":"Raivich","year":"2005","journal-title":"Trends Neurosci."},{"issue":"12","key":"10.1016\/j.semcdb.2018.11.004_bib0520","doi-asserted-by":"crossref","first-page":"R506","DOI":"10.1016\/j.cub.2008.04.047","article-title":"Microglia","volume":"18","author":"Soulet","year":"2008","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0525","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"issue":"10","key":"10.1016\/j.semcdb.2018.11.004_bib0530","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","article-title":"Microglia regulate the number of neural precursor cells in the developing cerebral cortex","volume":"33","author":"Cunningham","year":"2013","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0535","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","article-title":"Microglia: actively surveying and shaping neuronal circuit structure and function","volume":"36","author":"Wake","year":"2013","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.semcdb.2018.11.004_bib0540","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tcb.2016.02.006","article-title":"Microglia: architects of the developing nervous system","volume":"26","author":"Frost","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0545","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fnhum.2016.00566","article-title":"The indispensable roles of microglia and astrocytes during brain development","volume":"10","author":"Reemst","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0550","article-title":"Microglia: an intrinsic component of the proliferative zones in the fetal Rhesus monkey (Macaca mulatta) cerebral cortex","author":"Barger","year":"2018","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0555","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.3703","article-title":"Ontogeny and homeostasis of CNS myeloid cells","volume":"18","author":"Prinz","year":"2017","journal-title":"Nat. Immunol."},{"issue":"15","key":"10.1016\/j.semcdb.2018.11.004_bib0560","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/cne.24505","article-title":"Differential response of pineal microglia to surgical versus pharmacological stimuli","volume":"526","author":"Iba\u00f1ez Rodriguez","year":"2018","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0565","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial brain region-dependent diversity and selective regional sensitivities to aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.semcdb.2018.11.004_bib0570","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nn.4547","article-title":"New fate mapping system reveals context-dependent random or clonal expansion of microglia","volume":"20","author":"Tay","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.semcdb.2018.11.004_bib0575","first-page":"1929","article-title":"Microglia across the lifespan: from origin to function in brain development, plasticity and cognition","volume":"595","author":"Tay","year":"2017","journal-title":"J. Physiol. (Paris)"},{"issue":"2","key":"10.1016\/j.semcdb.2018.11.004_bib0580","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00302731","article-title":"Immunocytochemical and electron-microscopic characterization of macrophage\/microglia cells and expression of class II major histocompatibility complex in the pineal gland of the rat","volume":"272","author":"Pedersen","year":"1993","journal-title":"Cell Tissue Res."},{"issue":"4","key":"10.1016\/j.semcdb.2018.11.004_bib0585","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0168-0102(97)01164-4","article-title":"Macrophages\/microglia as\u2019 sensors\u2019 of injury in the pineal gland of rats following a non-penetrative blast","volume":"27","author":"Kaur","year":"1997","journal-title":"Neurosci. Res."},{"issue":"1-2","key":"10.1016\/j.semcdb.2018.11.004_bib0590","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-5728(97)00038-6","article-title":"Enriched immune-environment of blood-brain barrier deficient areas of normal adult rats","volume":"76","author":"Pedersen","year":"1997","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0595","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-079X.2004.00170.x","article-title":"Reactive changes of interstitial glia and pinealocytes in the rat pineal gland challenged with cell wall components from gram-positive and -negative bacteria","volume":"38","author":"Jiang-Shieh","year":"2005","journal-title":"J. Pineal Res."},{"issue":"1-2","key":"10.1016\/j.semcdb.2018.11.004_bib0600","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/07420520500521855","article-title":"The perivascular phagocyte of the mouse pineal gland: an antigen-presenting cell","volume":"23","author":"M\u00f8ller","year":"2006","journal-title":"Chronobiol. Int."},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0605","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/glia.20452","article-title":"Expression of tranferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment","volume":"55","author":"Kaur","year":"2007","journal-title":"Glia"},{"issue":"7","key":"10.1016\/j.semcdb.2018.11.004_bib0610","doi-asserted-by":"crossref","first-page":"e40142","DOI":"10.1371\/journal.pone.0040142","article-title":"Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF)","volume":"7","author":"da Silveira Cruz-Machado","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.semcdb.2018.11.004_bib0615","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-079X.1997.tb00315.x","article-title":"Immunohistochemical and tracer studies of macrophages\/microglia in the pineal gland of postnatal rats","volume":"22","author":"Kaur","year":"1997","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0620","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-079X.1999.tb00595.x","article-title":"Interleukin-1beta expression in the pineal gland of the rat","volume":"27","author":"Tsai","year":"1999","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.semcdb.2018.11.004_bib0625","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1034\/j.1600-079X.2003.00054.x","article-title":"Regional heterogeneity in immunoreactive macrophages\/microglia in the rat pineal gland","volume":"35","author":"Jiang-Shieh","year":"2003","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.semcdb.2018.11.004_bib0630","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fendo.2011.00010","article-title":"Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor","volume":"2","author":"Carvalho-Sousa","year":"2011","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952118300636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952118300636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:54:06Z","timestamp":1761065646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952118300636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":126,"alternative-id":["S1084952118300636"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2018.11.004","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling within the pineal gland: A parallelism with the central nervous system","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2018.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}