{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:14:04Z","timestamp":1790399644398,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/17\/14\/33085"],"award-info":[{"award-number":["RG\/17\/14\/33085"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.semcdb.2019.01.010","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T13:49:52Z","timestamp":1548424192000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability"],"prefix":"10.1016","volume":"94","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0005","doi-asserted-by":"crossref","DOI":"10.1113\/jphysiol.1883.sp000120","article-title":"A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart","volume":"4","author":"Ringer","year":"1883","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BST20110766","article-title":"Calcium signalling remodelling and disease","volume":"40","author":"Berridge","year":"2012","journal-title":"Biochem. Soc. Trans."},{"issue":"15","key":"10.1016\/j.semcdb.2019.01.010_bib0015","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0020","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.molcel.2017.05.028","article-title":"Intracellular Ca(2+) sensing: its role in calcium homeostasis and signaling","volume":"66","author":"Bagur","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcdb.2019.01.010_bib0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0030","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The physiology pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0035","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.RES.69.2.325","article-title":"cGMP inhibits the activity of single calcium channels in embryonic chick heart cells","volume":"69","author":"Tohse","year":"1991","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.semcdb.2019.01.010_bib0040","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1074\/jbc.275.9.6135","article-title":"Regulation of cloned cardiac L-type calcium channels by cGMP-dependent protein kinase","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annu. Rev. Biochem."},{"issue":"11","key":"10.1016\/j.semcdb.2019.01.010_bib0050","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/CIRCRESAHA.106.144501","article-title":"cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology","volume":"100","author":"Zaccolo","year":"2007","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BST20110655","article-title":"cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function","volume":"40","author":"Stangherlin","year":"2012","journal-title":"Biochem. Soc. Trans."},{"issue":"8","key":"10.1016\/j.semcdb.2019.01.010_bib0060","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/CIRCRESAHA.110.230698","article-title":"cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes","volume":"108","author":"Stangherlin","year":"2011","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0065","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions","volume":"91","author":"Francis","year":"2011","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0070","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0075","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","article-title":"Role of the autonomic nervous system in modulating cardiac arrhythmias","volume":"114","author":"Shen","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0080","series-title":"Levick\u2019s Introduction to Cardiovascular Physiology","author":"Herring","year":"2018"},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0085","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/sj.bjp.0705338","article-title":"Muscarinic regulation of cardiac ion channels","volume":"139","author":"Harvey","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0090","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.yjmcc.2007.09.005","article-title":"Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neurons","volume":"43","author":"Wang","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0095","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.yjmcc.2008.12.013","article-title":"Targeting cardiac sympatho-vagal imbalance using gene transfer of nitric oxide synthase","volume":"46","author":"Danson","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1113\/expphysiol.2008.044776","article-title":"Neuromodulators of peripheral cardiac sympatho-vagal balance","volume":"94","author":"Herring","year":"2009","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0105","doi-asserted-by":"crossref","DOI":"10.1113\/JP271827","article-title":"Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness","author":"Li","year":"2016","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/ehf2.12223","article-title":"Autonomic dysfunction is associated with cardiac remodelling in heart failure patients","volume":"5","author":"Ali","year":"2018","journal-title":"ESC Heart Fail."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccl.2013.09.010","article-title":"The sympathetic nervous system and heart failure","volume":"32","author":"Zhang","year":"2014","journal-title":"Cardiol. Clin."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0120","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13085","article-title":"Remote ischemic preconditioning triggers changes in autonomic nervous system activity: implications for cardioprotection","volume":"5","author":"Abdul-Ghani","year":"2017","journal-title":"Physiol. Rep."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0125","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1161\/HYPERTENSIONAHA.111.186460","article-title":"Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats","volume":"59","author":"Li","year":"2012","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.semcdb.2019.01.010_bib0130","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98694","article-title":"Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity","volume":"3","author":"Liu","year":"2018","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L","article-title":"Gross and microscopic anatomy of the human intrinsic cardiac nervous system","volume":"247","author":"Armour","year":"1997","journal-title":"Anat. Rec."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/1097-0185(20000801)259:4<353::AID-AR10>3.0.CO;2-R","article-title":"Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart","volume":"259","author":"Pauza","year":"2000","journal-title":"Anat. Rec."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1838(89)90146-X","article-title":"Organization of the sympathetic postganglionic innervation of the rat heart","volume":"28","author":"Pardini","year":"1989","journal-title":"J. Auton. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0150","doi-asserted-by":"crossref","first-page":"C132","DOI":"10.1152\/ajpcell.00223.2013","article-title":"Heart failure-induced changes of voltage-gated Ca2+ channels and cell excitability in rat cardiac postganglionic neurons","volume":"306","author":"Tu","year":"2014","journal-title":"Am. J. Physiol., Cell Physiol."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0155","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1161\/CIRCHEARTFAILURE.114.001964","article-title":"Autonomic modulation for the management of patients with chronic heart failure","volume":"8","author":"Schwartz","year":"2015","journal-title":"Circ. Heart Fail."},{"issue":"5","key":"10.1016\/j.semcdb.2019.01.010_bib0160","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.hrthm.2015.01.045","article-title":"Remodeling of stellate ganglion neurons after spatially targeted myocardial infarction: neuropeptide and morphologic changes","volume":"12","author":"Ajijola","year":"2015","journal-title":"Heart Rhythm"},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0165","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/CIRCRESAHA.116.303604","article-title":"The sympathetic nervous system alterations in human hypertension","volume":"116","author":"Grassi","year":"2015","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.semcdb.2019.01.010_bib0170","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1113\/JP271840","article-title":"Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease","volume":"594","author":"Habecker","year":"2016","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0175","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0180","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/HYPERTENSIONAHA.111.00105","article-title":"Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats","volume":"61","author":"Li","year":"2013","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.semcdb.2019.01.010_bib0185","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4065\/84.8.718","article-title":"Beta-blocker use for the stages of heart failure","volume":"84","author":"Klapholz","year":"2009","journal-title":"Mayo Clin. Proc."},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0190","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nrcardio.2014.19","article-title":"Cardiac sympathetic denervation to prevent life-threatening arrhythmias","volume":"11","author":"Schwartz","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.semcdb.2019.01.010_bib0195","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/0735-1097(92)90629-2","article-title":"Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors","volume":"19","author":"Lubbe","year":"1992","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0200","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.me.41.020190.001311","article-title":"Cellular mechanism for ischemic ventricular arrhythmias","volume":"41","author":"Opie","year":"1990","journal-title":"Annu. Rev. Med."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0205","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0002-9149(87)90795-8","article-title":"Decreased heart rate variability and its association with increased mortality after acute myocardial infarction","volume":"59","author":"Kleiger","year":"1987","journal-title":"Am. J. Cardiol."},{"issue":"9101","key":"10.1016\/j.semcdb.2019.01.010_bib0210","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(97)11144-8","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators","volume":"351","author":"La Rovere","year":"1998","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.semcdb.2019.01.010_bib0215","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/01.CIR.98.15.1510","article-title":"Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart)","volume":"98","author":"Nolan","year":"1998","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0220","doi-asserted-by":"crossref","first-page":"599","DOI":"10.7326\/0003-4819-100-4-599","article-title":"Silent myocardial ischemia: concern is justified for the patient with known coronary artery disease","volume":"100","author":"Leighton","year":"1984","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0225","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.HYP.29.2.613","article-title":"Spontaneously hypertensive rat Y chromosome increases indexes of sympathetic nervous system activity","volume":"29","author":"Ely","year":"1997","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0230","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1113\/expphysiol.2008.046334","article-title":"Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)-salt hypertension in rats","volume":"95","author":"Yemane","year":"2010","journal-title":"Exp. Physiol."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0235","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/01.HYP.0000233383.04280.3c","article-title":"Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer","volume":"48","author":"Heaton","year":"2006","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.semcdb.2019.01.010_bib0240","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/01.HYP.36.5.824","article-title":"Phenotypic evidence of faulty neuronal norepinephrine reuptake in essential hypertension","volume":"36","author":"Rumantir","year":"2000","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.semcdb.2019.01.010_bib0245","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/00004872-200307000-00026","article-title":"Increased cardiac norepinephrine release in spontaneously hypertensive rats: role of presynaptic alpha-2A adrenoceptors","volume":"21","author":"Zugck","year":"2003","journal-title":"J. Hypertens."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0250","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00255.2013","article-title":"Cardiac sympathetic dysfunction in the pre-hypertensive spontaneously hypertensive rat","author":"Shanks","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0255","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.18.4.416","article-title":"Functional distribution of right and left stellate innervation to the ventricles. Production of neurogenic electrocardiographic changes by unilateral alteration of sympathetic tone","volume":"18","author":"Yanowitz","year":"1966","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0260","doi-asserted-by":"crossref","first-page":"H691","DOI":"10.1152\/ajpheart.01321.2007","article-title":"Ectopic atrial arrhythmias arising from canine thoracic veins during in vivo stellate ganglia stimulation","volume":"295","author":"Tan","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.01.010_bib0265","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.hrthm.2009.01.035","article-title":"Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution","volume":"6","author":"Ng","year":"2009","journal-title":"Heart Rhythm"},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0270","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/CIRCEP.112.972273","article-title":"Recent insights into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system","volume":"5","author":"Arora","year":"2012","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"7 Pt B","key":"10.1016\/j.semcdb.2019.01.010_bib0275","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.bbamcr.2016.01.009","article-title":"Putting together the clues of the everlasting neuro-cardiac liaison","volume":"1863","author":"Franzoso","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.semcdb.2019.01.010_bib0280","doi-asserted-by":"crossref","first-page":"38898","DOI":"10.1038\/srep38898","article-title":"Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease","volume":"6","author":"Larsen","year":"2016","journal-title":"Sci. Rep."},{"issue":"5101","key":"10.1016\/j.semcdb.2019.01.010_bib0285","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/215651a0","article-title":"Ionic requirements of synaptic transmitter release","volume":"215","author":"Katz","year":"1967","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0290","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0295","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1994.74.3.595","article-title":"Molecular and cellular physiology of intracellular calcium stores","volume":"74","author":"Pozzan","year":"1994","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0300","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/HYPERTENSIONAHA.115.05290","article-title":"CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension","volume":"65","author":"Lu","year":"2015","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0305","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/cvr\/cvu185","article-title":"Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure","volume":"104","author":"Yamada","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"33","key":"10.1016\/j.semcdb.2019.01.010_bib0310","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1523\/JNEUROSCI.1059-16.2016","article-title":"Dysregulation of neuronal Ca2+ channel linked to heightened sympathetic phenotype in prohypertensive states","volume":"36","author":"Larsen","year":"2016","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0315","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1046\/j.1471-4159.2001.00623.x","article-title":"Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain?","volume":"79","author":"Paschen","year":"2001","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0320","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/dneu.22560","article-title":"The axonal endoplasmic reticulum: one organelle-many functions in development, maintenance, and plasticity","volume":"78","author":"Luarte","year":"2018","journal-title":"Dev. Neurobiol."},{"issue":"April","key":"10.1016\/j.semcdb.2019.01.010_bib0325","article-title":"Overexpression of SERCA2a promotes cardiac sympathetic neurotransmission via abnormal endoplasmic reticulum and mitochondria Ca2+ regulation","author":"Shanks","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.semcdb.2019.01.010_bib0330","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fnins.2017.00220","article-title":"Endoplasmic reticulum malfunction in the nervous system","volume":"11","author":"Jung","year":"2017","journal-title":"Front. Neurosci."},{"issue":"37","key":"10.1016\/j.semcdb.2019.01.010_bib0335","doi-asserted-by":"crossref","first-page":"26955","DOI":"10.1074\/jbc.M113.473355","article-title":"Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease beta-amyloid peptide secretion","volume":"288","author":"Zeiger","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0340","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1750-1326-8-23","article-title":"The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration","volume":"8","author":"Bezprozvanny","year":"2013","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0345","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1172\/JCI62834","article-title":"Calcium cycling proteins and heart failure: mechanisms and therapeutics","volume":"123","author":"Marks","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.semcdb.2019.01.010_bib0350","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.jacc.2016.02.049","article-title":"Intratracheal gene delivery of SERCA2a ameliorates chronic post-capillary pulmonary hypertension: a large animal model","volume":"67","author":"Aguero","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.01.010_bib0355","doi-asserted-by":"crossref","first-page":"H2046","DOI":"10.1152\/ajpheart.2001.280.5.H2046","article-title":"Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy","volume":"280","author":"Meyer","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.semcdb.2019.01.010_bib0360","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/01.CIR.103.11.1577","article-title":"Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure","volume":"103","author":"Hobai","year":"2001","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.semcdb.2019.01.010_bib0365","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/CIRCULATIONAHA.113.001585","article-title":"Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension","volume":"128","author":"Hadri","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0370","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrn.2017.170","article-title":"Mitochondria at the neuronal presynapse in health and disease","volume":"19","author":"Devine","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0375","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ceca.2017.05.003","article-title":"Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death","volume":"69","author":"Marchi","year":"2018","journal-title":"Cell Calcium"},{"issue":"9","key":"10.1016\/j.semcdb.2019.01.010_bib0380","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0385","first-page":"698","article-title":"Stoichiometric relationships between accumulation of ions by mitochondria and the energy-coupling sites in the respiratory chain","volume":"338","author":"Rossi","year":"1963","journal-title":"Biochem. Z."},{"issue":"16","key":"10.1016\/j.semcdb.2019.01.010_bib0390","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1523\/JNEUROSCI.22-16-06962.2002","article-title":"Mitochondrial Ca2+ uptake regulates the excitability of myenteric neurons","volume":"22","author":"Vanden Berghe","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceca.2008.02.001","article-title":"Mitochondria and calcium in health and disease","volume":"44","author":"Duchen","year":"2008","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0400","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1172\/JCI24405","article-title":"Mitochondrial energy metabolism in heart failure: a question of balance","volume":"115","author":"Huss","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"36","key":"10.1016\/j.semcdb.2019.01.010_bib0405","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.semcdb.2019.01.010_bib0410","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00395-006-0602-7","article-title":"Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway","volume":"101","author":"Menon","year":"2006","journal-title":"Basic Res. Cardiol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.01.010_bib0415","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10741-012-9340-0","article-title":"Mitochondrial dysfunction in heart failure","volume":"18","author":"Rosca","year":"2013","journal-title":"Heart Fail. Rev."},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0420","doi-asserted-by":"crossref","first-page":"H665","DOI":"10.1152\/ajpheart.00467.2011","article-title":"Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin","volume":"302","author":"Izem-Meziane","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0425","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrcardio.2016.203","article-title":"Expert consensus document: mitochondrial function as a therapeutic target in heart failure","volume":"14","author":"Brown","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0430","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21374","article-title":"PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP\/PKA signalling","volume":"6","author":"Monterisi","year":"2017","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.semcdb.2019.01.010_bib0435","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use","volume":"58","author":"Bender","year":"2006","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.semcdb.2019.01.010_bib0440","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nrd4228","article-title":"Advances in targeting cyclic nucleotide phosphodiesterases","volume":"13","author":"Maurice","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0445","article-title":"Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes","volume":"5","author":"Pavlaki","year":"2018","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"11","key":"10.1016\/j.semcdb.2019.01.010_bib0450","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1074\/jbc.M115.638585","article-title":"Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2","volume":"290","author":"Ahmad","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0455","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCRESAHA.111.300003","article-title":"Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart","volume":"112","author":"Beca","year":"2013","journal-title":"Circ. Res."},{"issue":"41","key":"10.1016\/j.semcdb.2019.01.010_bib0460","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1073\/pnas.0506489102","article-title":"A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis","volume":"102","author":"Ding","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2019.01.010_bib0465","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pharmthera.2016.03.014","article-title":"Novel approaches to targeting PDE3 in cardiovascular disease","volume":"163","author":"Movsesian","year":"2016","journal-title":"Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.semcdb.2019.01.010_bib0470","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1080\/13543776.2016.1203902","article-title":"Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present)","volume":"26","author":"Trabanco","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"issue":"10","key":"10.1016\/j.semcdb.2019.01.010_bib0475","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/syn.21840","article-title":"Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus","volume":"69","author":"Fernandez-Fernandez","year":"2015","journal-title":"Synapse"},{"issue":"2","key":"10.1016\/j.semcdb.2019.01.010_bib0480","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neurobiolaging.2014.08.028","article-title":"Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress","volume":"36","author":"Xu","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"38","key":"10.1016\/j.semcdb.2019.01.010_bib0485","doi-asserted-by":"crossref","first-page":"25782","DOI":"10.1074\/jbc.M109.017194","article-title":"Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes","volume":"284","author":"Russwurm","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"31","key":"10.1016\/j.semcdb.2019.01.010_bib0490","doi-asserted-by":"crossref","first-page":"E7428","DOI":"10.1073\/pnas.1800996115","article-title":"Phosphodiesterase 2 inhibition preferentially promotes NO\/guanylyl cyclase\/cGMP signaling to reverse the development of heart failure","volume":"115","author":"Baliga","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.semcdb.2019.01.010_bib0495","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1161\/HYPERTENSIONAHA.114.05054","article-title":"Efficacy of B-Type natriuretic peptide is coupled to phosphodiesterase 2A in cardiac sympathetic neurons","volume":"66","author":"Li","year":"2015","journal-title":"Hypertension"},{"issue":"35","key":"10.1016\/j.semcdb.2019.01.010_bib0500","doi-asserted-by":"crossref","first-page":"30423","DOI":"10.1074\/jbc.M111.266379","article-title":"A phosphodiesterase 2A isoform localized to mitochondria regulates respiration","volume":"286","author":"Acin-Perez","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108495211830082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108495211830082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:51:49Z","timestamp":1761065509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108495211830082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":100,"alternative-id":["S108495211830082X"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.01.010","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}