{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:47:25Z","timestamp":1761162445645,"version":"build-2065373602"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004051","name":"Kato Memorial Bioscience Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008608","name":"Sumitomo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005945","name":"Hirosaki University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.semcdb.2019.04.006","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T08:20:14Z","timestamp":1557735614000},"page":"16-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Chromatin dynamics underlying the precise regeneration of a vertebrate limb \u2013 Epigenetic regulation and cellular memory"],"prefix":"10.1016","volume":"97","author":[{"given":"Shinichi","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1440-169X.2011.01323.x","article-title":"Survey of the differences between regenerative and non-regenerative animals","volume":"54","author":"Agata","year":"2012","journal-title":"Dev. Growth Differ."},{"issue":"3","key":"10.1016\/j.semcdb.2019.04.006_bib0010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tree.2009.08.005","article-title":"Evolution of animal regeneration: re-emergence of a field","volume":"25","author":"Bely","year":"2010","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0015","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1100\/tsw.2011.113","article-title":"From hydra regeneration to human brain structural plasticity: a long trip through narrowing roads","volume":"11","author":"Bonfanti","year":"2011","journal-title":"ScientificWorldJournal"},{"issue":"5309","key":"10.1016\/j.semcdb.2019.04.006_bib0020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.276.5309.81","article-title":"Amphibian limb regeneration: rebuilding a complex structure","volume":"276","author":"Brockes","year":"1997","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.semcdb.2019.04.006_bib0025","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrn2707","article-title":"Considering the evolution of regeneration in the central nervous system","volume":"10","author":"Tanaka","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"11","key":"10.1016\/j.semcdb.2019.04.006_bib0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tig.2013.07.003","article-title":"The zebrafish as a model for complex tissue regeneration","volume":"29","author":"Gemberling","year":"2013","journal-title":"Trends Genet."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jmor.1051100105","article-title":"Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad","volume":"110","author":"Dent","year":"1962","journal-title":"J. Morphol."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2016.09.054","article-title":"The African clawed frog Xenopus laevis: a model organism to study regeneration of the central nervous system","volume":"652","author":"Lee-Liu","year":"2017","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.semcdb.2019.04.006_bib0045","first-page":"887","article-title":"Vertebrate limb regeneration and the origin of limb stem cells","volume":"46","author":"Bryant","year":"2002","journal-title":"Int. J. Dev. Biol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.04.006_bib0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1084952102000903","article-title":"The molecular basis of amphibian limb regeneration: integrating the old with the new","volume":"13","author":"Gardiner","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1440-169X.2007.00973.x","article-title":"Initiation of limb regeneration: the critical steps for regenerative capacity","volume":"50","author":"Yokoyama","year":"2008","journal-title":"Dev. Growth Differ."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1440-169X.2009.01144.x","article-title":"Limb blastema cell: a stem cell for morphological regeneration","volume":"52","author":"Tamura","year":"2010","journal-title":"Dev. Growth Differ."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/dbio.1997.8732","article-title":"FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus","volume":"192","author":"Christen","year":"1997","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0070","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/dbio.2000.9641","article-title":"Analysis of gene expressions during Xenopus forelimb regeneration","volume":"220","author":"Endo","year":"2000","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1085>3.0.CO;2-8","article-title":"Expression patterns of Fgf-8 during development and limb regeneration of the axolotl","volume":"220","author":"Han","year":"2001","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ydbio.2007.03.014","article-title":"Wnt\/beta-catenin signaling has an essential role in the initiation of limb regeneration","volume":"306","author":"Yokoyama","year":"2007","journal-title":"Dev. Biol."},{"issue":"7","key":"10.1016\/j.semcdb.2019.04.006_bib0085","doi-asserted-by":"crossref","first-page":"e21721","DOI":"10.1371\/journal.pone.0021721","article-title":"Different requirement for Wnt\/beta-catenin signaling in limb regeneration of larval and adult Xenopus","volume":"6","author":"Yokoyama","year":"2011","journal-title":"PLOS ONE"},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/(SICI)1097-0177(199706)209:2<227::AID-AJA8>3.0.CO;2-K","article-title":"Shh expression in developing and regenerating limb buds of Xenopus laevis","volume":"209","author":"Endo","year":"1997","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ydbio.2014.01.018","article-title":"Yap1, transcription regulator in the Hippo signaling pathway, is required for Xenopus limb bud regeneration","volume":"388","author":"Hayashi","year":"2014","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0100","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/dvdy.20363","article-title":"Expression of Xenopus XlSALL4 during limb development and regeneration","volume":"233","author":"Neff","year":"2005","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0105","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ydbio.2009.11.026","article-title":"Analysis of hoxa11 and hoxa13 expression during patternless limb regeneration in Xenopus","volume":"338","author":"Ohgo","year":"2010","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0110","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ydbio.2007.01.019","article-title":"Transgenic Xenopus with prx1 limb enhancer reveals crucial contribution of MEK\/ERK and PI3K\/AKT pathways in blastema formation during limb regeneration","volume":"304","author":"Suzuki","year":"2007","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/dbio.1999.9587","article-title":"Mesenchyme with fgf-10 expression is responsible for regenerative capacity in Xenopus limb buds","volume":"219","author":"Yokoyama","year":"2000","journal-title":"Dev. Biol."},{"issue":"9","key":"10.1016\/j.semcdb.2019.04.006_bib0120","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.mod.2006.07.001","article-title":"Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles","volume":"123","author":"Beck","year":"2006","journal-title":"Mech. Dev."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/dbio.2001.0180","article-title":"FGF-10 stimulates limb regeneration ability in Xenopus laevis","volume":"233","author":"Yokoyama","year":"2001","journal-title":"Dev. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.semcdb.2019.04.006_bib0130","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1100\/tsw.2006.325","article-title":"Limb regeneration in Xenopus laevis froglet","volume":"6","author":"Suzuki","year":"2006","journal-title":"ScientificWorldJournal"},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0135","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ydbio.2007.09.022","article-title":"Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians","volume":"312","author":"Yakushiji","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0140","series-title":"Developmental Biology","first-page":"31","article-title":"Differential Gene Expression in Development","author":"Gilbert","year":"2014"},{"issue":"10","key":"10.1016\/j.semcdb.2019.04.006_bib0145","doi-asserted-by":"crossref","first-page":"e26382","DOI":"10.1371\/journal.pone.0026382","article-title":"HDAC activity is required during Xenopus tail regeneration","volume":"6","author":"Tseng","year":"2011","journal-title":"PLOS ONE"},{"issue":"9\u201312","key":"10.1016\/j.semcdb.2019.04.006_bib0150","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mod.2012.08.001","article-title":"Histone deacetylases are required for amphibian tail and limb regeneration but not development","volume":"129","author":"Taylor","year":"2012","journal-title":"Mech. Dev."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0155","first-page":"75","article-title":"Histone lysine methylation and demethylation pathways in cancer","volume":"1815","author":"Varier","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0160","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ydbio.2015.08.013","article-title":"Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration","volume":"406","author":"Hayashi","year":"2015","journal-title":"Dev. Biol."},{"issue":"47","key":"10.1016\/j.semcdb.2019.04.006_bib0165","doi-asserted-by":"crossref","first-page":"19889","DOI":"10.1073\/pnas.0904132106","article-title":"A histone demethylase is necessary for regeneration in zebrafish","volume":"106","author":"Stewart","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7013","key":"10.1016\/j.semcdb.2019.04.006_bib0170","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature03071","article-title":"Baf60c is essential for function of BAF chromatin remodelling complexes in heart development","volume":"432","author":"Lickert","year":"2004","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/dgd.12281","article-title":"Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice","volume":"58","author":"Nakamura","year":"2016","journal-title":"Dev. Growth Differ."},{"issue":"3","key":"10.1016\/j.semcdb.2019.04.006_bib0180","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/bfgp\/elt011","article-title":"Epigenetic memory in the context of nuclear reprogramming and cancer","volume":"12","author":"Halley-Stott","year":"2013","journal-title":"Brief. Funct. Genomics"},{"issue":"7","key":"10.1016\/j.semcdb.2019.04.006_bib0185","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0190","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1242\/dev.01613","article-title":"Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb","volume":"132","author":"Sagai","year":"2005","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0195","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"issue":"6599","key":"10.1016\/j.semcdb.2019.04.006_bib0200","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0205","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1002\/dvdy.20985","article-title":"Characterization of Xenopus digits and regenerated limbs of the froglet","volume":"235","author":"Satoh","year":"2006","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0210","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/dbio.2001.0161","article-title":"Nerve-independence of limb regeneration in larval Xenopus laevis is correlated to the level of fgf-2 mRNA expression in limb tissues","volume":"231","author":"Cannata","year":"2001","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.04.006_bib0215","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/dvdy.22555","article-title":"Expression of key retinoic acid modulating genes suggests active regulation during development and regeneration of the amphibian limb","volume":"240","author":"McEwan","year":"2011","journal-title":"Dev. Dyn."},{"issue":"7598","key":"10.1016\/j.semcdb.2019.04.006_bib0220","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature17644","article-title":"Modulation of tissue repair by regeneration enhancer elements","volume":"532","author":"Kang","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ydbio.2014.09.018","article-title":"Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration","volume":"396","author":"Hayashi","year":"2014","journal-title":"Dev. Biol."},{"issue":"14","key":"10.1016\/j.semcdb.2019.04.006_bib0230","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0960-9822(00)00596-0","article-title":"Inducible gene expression in transgenic Xenopus embryos","volume":"10","author":"Wheeler","year":"2000","journal-title":"Curr. Biol."},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0235","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1101\/gr.233098.117","article-title":"Damage-responsive elements in Drosophila regeneration","volume":"28","author":"Vizcaya-Molina","year":"2018","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0240","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.devcel.2017.01.013","article-title":"Resolving heart regeneration by replacement histone profiling","volume":"40","author":"Goldman","year":"2017","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0245","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.stem.2016.03.001","article-title":"Suppression of the SWI\/SNF component Arid1a promotes mammalian regeneration","volume":"18","author":"Sun","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"41","key":"10.1016\/j.semcdb.2019.04.006_bib0250","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1073\/pnas.0507408102","article-title":"Heat-shock protein 60 is required for blastema formation and maintenance during regeneration","volume":"102","author":"Makino","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0255","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-213X-8-66","article-title":"Identification of genes associated with regenerative success of Xenopus laevis hindlimbs","volume":"8","author":"Pearl","year":"2008","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0260","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/srep01279","article-title":"Agr genes, missing in amniotes, are involved in the body appendages regeneration in frog tadpoles","volume":"3","author":"Ivanova","year":"2013","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0265","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<225::AID-GENE10>3.0.CO;2-F","article-title":"Identification of a prx1 limb enhancer","volume":"26","author":"Martin","year":"2000","journal-title":"Genesis"},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0270","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0275","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1038\/jid.2011.223","article-title":"Prx-1 expression in Xenopus laevis scarless skin-wound healing and its resemblance to epimorphic regeneration","volume":"131","author":"Yokoyama","year":"2011","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.semcdb.2019.04.006_bib0280","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/dgd.12544","article-title":"Skin regeneration of amphibians: a novel model for skin regeneration as adults","volume":"60","author":"Yokoyama","year":"2018","journal-title":"Dev. Growth Differ."},{"issue":"5","key":"10.1016\/j.semcdb.2019.04.006_bib0285","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/dgd.12136","article-title":"Growth and differentiation of a long bone in limb development, repair and regeneration","volume":"56","author":"Egawa","year":"2014","journal-title":"Dev. Growth Differ."},{"issue":"3","key":"10.1016\/j.semcdb.2019.04.006_bib0290","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/dvdy.23728","article-title":"Bone pattern formation in mouse limbs after amputation at the forearm level","volume":"241","author":"Ide","year":"2012","journal-title":"Dev. Dyn."},{"issue":"5","key":"10.1016\/j.semcdb.2019.04.006_bib0295","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.semcdb.2008.12.007","article-title":"Repatterning in amphibian limb regeneration: a model for study of genetic and epigenetic control of organ regeneration","volume":"20","author":"Yakushiji","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0300","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41580-018-0077-z","article-title":"A changing paradigm of transcriptional memory propagation through mitosis","volume":"20","author":"Palozola","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.04.006_bib0305","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00018-011-0824-1","article-title":"Propagation of histone marks and epigenetic memory during normal and interrupted DNA replication","volume":"69","author":"Sarkies","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"6409","key":"10.1016\/j.semcdb.2019.04.006_bib0310","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.aau0294","article-title":"MCM2 promotes symmetric inheritance of modified histones during DNA replication","volume":"361","author":"Petryk","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.semcdb.2019.04.006_bib0315","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2009.08.005","article-title":"A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos","volume":"17","author":"Akkers","year":"2009","journal-title":"Dev. Cell"},{"issue":"7231","key":"10.1016\/j.semcdb.2019.04.006_bib0320","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nature07730","article-title":"ChIP-seq accurately predicts tissue-specific activity of enhancers","volume":"457","author":"Visel","year":"2009","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.semcdb.2019.04.006_bib0325","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1101\/gr.129817.111","article-title":"Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb","volume":"22","author":"Cotney","year":"2012","journal-title":"Genome Res."},{"issue":"6137","key":"10.1016\/j.semcdb.2019.04.006_bib0330","doi-asserted-by":"crossref","first-page":"1234167","DOI":"10.1126\/science.1234167","article-title":"A switch between topological domains underlies HoxD genes collinearity in mouse limbs","volume":"340","author":"Andrey","year":"2013","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.semcdb.2019.04.006_bib0335","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/dgd.12547","article-title":"Homeotic transformation of tails into limbs in anurans","volume":"60","author":"Morioka","year":"2018","journal-title":"Dev. Growth Differ."},{"issue":"6358","key":"10.1016\/j.semcdb.2019.04.006_bib0340","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/355352a0","article-title":"Limbs generated at site of tail amputation in marbled balloon frog after vitamin A treatment","volume":"355","author":"Mohanty-Hejmadi","year":"1992","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.semcdb.2019.04.006_bib0345","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1073\/pnas.90.15.7230","article-title":"Reversal of muscle differentiation during urodele limb regeneration","volume":"90","author":"Lo","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0350","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ydbio.2009.11.023","article-title":"Neurotrophic regulation of fibroblast dedifferentiation during limb skeletal regeneration in the axolotl (Ambystoma mexicanum)","volume":"337","author":"Satoh","year":"2010","journal-title":"Dev. Biol."},{"issue":"9","key":"10.1016\/j.semcdb.2019.04.006_bib0355","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1440-169X.2008.01072.x","article-title":"Regulation of dermal fibroblast dedifferentiation and redifferentiation during wound healing and limb regeneration in the Axolotl","volume":"50","author":"Satoh","year":"2008","journal-title":"Dev. Growth Differ."},{"issue":"7251","key":"10.1016\/j.semcdb.2019.04.006_bib0360","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature08152","article-title":"Cells keep a memory of their tissue origin during axolotl limb regeneration","volume":"460","author":"Kragl","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0365","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0012-1606(74)90281-4","article-title":"The inheritance of cell differentiation during limb regeneration in the axolotl","volume":"41","author":"Namenwirth","year":"1974","journal-title":"Dev. Biol."},{"issue":"Pt A","key":"10.1016\/j.semcdb.2019.04.006_bib0370","first-page":"433","article-title":"Positional memory in vertebrate limb development and regeneration","volume":"110","author":"Carlson","year":"1983","journal-title":"Prog. Clin. Biol. Res."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0375","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0012-1606(86)90393-3","article-title":"Retinoic acid modifies positional memory in the anteroposterior axis of regenerating axolotl limbs","volume":"114","author":"Kim","year":"1986","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0380","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0012-1606(90)90051-J","article-title":"The effect of retinoic acid on positional memory in the dorsoventral axis of regenerating axolotl limbs","volume":"140","author":"Ludolph","year":"1990","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0385","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ar.1091180410","article-title":"A study of regenerates emanating from limb transplants with reversed proximodistal polarity in the adult newt","volume":"118","author":"Dent","year":"1954","journal-title":"Anat. Rec."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0390","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jmor.1050960204","article-title":"Regeneration of the urodele forelimb after reversal of its proximo-distal axis","volume":"96","author":"Butler","year":"1955","journal-title":"J. Morphol."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0395","series-title":"Principles of Development","first-page":"535","article-title":"Regeneration","author":"Wolpert","year":"2011"},{"issue":"4257","key":"10.1016\/j.semcdb.2019.04.006_bib0400","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1126\/science.948762","article-title":"Pattern regulation in epimorphic fields","volume":"193","author":"French","year":"1976","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0405","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/dvdy.24685","article-title":"Newts can normalize duplicated proximal-distal disorder during limb regeneration","volume":"247","author":"Koriyama","year":"2018","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0410","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1440-169X.2007.00919.x","article-title":"Unifying principles of regeneration I: Epimorphosis versus morphallaxis","volume":"49","author":"Agata","year":"2007","journal-title":"Dev. Growth Differ."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0415","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/dvdy.10345","article-title":"Intercalary and supernumerary regeneration in the limbs of the frog, Xenopus laevis","volume":"227","author":"Shimizu-Nishikawa","year":"2003","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0420","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0012-1606(82)90257-3","article-title":"The structure of 180 degrees supernumerary limbs and a hypothesis of their formation","volume":"93","author":"Maden","year":"1982","journal-title":"Dev. Biol."},{"issue":"8","key":"10.1016\/j.semcdb.2019.04.006_bib0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005465","article-title":"YAP1 exerts its transcriptional control via TEAD-mediated activation of enhancers","volume":"11","author":"Stein","year":"2015","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0430","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.molcel.2005.04.008","article-title":"The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage","volume":"18","author":"Strano","year":"2005","journal-title":"Mol. Cell"},{"issue":"26","key":"10.1016\/j.semcdb.2019.04.006_bib0435","doi-asserted-by":"crossref","first-page":"22089","DOI":"10.1074\/jbc.M111.334714","article-title":"A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents","volume":"287","author":"Hata","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.semcdb.2019.04.006_bib0440","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1242\/dev.035204","article-title":"Regulation of leg size and shape by the Dachsous\/Fat signalling pathway during regeneration","volume":"136","author":"Bando","year":"2009","journal-title":"Development"},{"issue":"17","key":"10.1016\/j.semcdb.2019.04.006_bib0445","first-page":"2916","article-title":"Leg regeneration is epigenetically regulated by histone H3K27 methylation in the cricket Gryllus bimaculatus","volume":"142","author":"Hamada","year":"2015","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.semcdb.2019.04.006_bib0450","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1242\/dev.02723","article-title":"Polycomb\/Trithorax response elements and epigenetic memory of cell identity","volume":"134","author":"Ringrose","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2019.04.006_bib0455","first-page":"695","article-title":"Comparative study of the carcinogenic activity of nitrosamines","volume":"27","author":"Argus","year":"1961","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.semcdb.2019.04.006_bib0460","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/bjc.1972.28","article-title":"The lethal and hepatocarcinogenic effects of dimethylnitrosamine injection in the newt Triturus helveticus","volume":"26","author":"Ingram","year":"1972","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.semcdb.2019.04.006_bib0465","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1046\/j.1432-0436.1997.6150285.x","article-title":"Simultaneous demonstration of lens regeneration from dorsal iris and tumour production from ventral iris in the same newt eye after carcinogen administration","volume":"61","author":"Okamoto","year":"1997","journal-title":"Differentiation"},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0470","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2017.03.042","article-title":"Stem cell lineage infidelity drives wound repair and cancer","volume":"169","author":"Ge","year":"2017","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0475","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"issue":"Pt 17","key":"10.1016\/j.semcdb.2019.04.006_bib0480","first-page":"3929","article-title":"The bright and the dark sides of activin in wound healing and cancer","volume":"125","author":"Antsiferova","year":"2012","journal-title":"J. Cell Sci."},{"issue":"26","key":"10.1016\/j.semcdb.2019.04.006_bib0485","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","article-title":"Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing","volume":"315","author":"Dvorak","year":"1986","journal-title":"N. Engl. J. Med."},{"issue":"51","key":"10.1016\/j.semcdb.2019.04.006_bib0490","doi-asserted-by":"crossref","first-page":"20609","DOI":"10.1073\/pnas.1118017108","article-title":"Mouse digit tip regeneration is mediated by fate-restricted progenitor cells","volume":"108","author":"Lehoczky","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.semcdb.2019.04.006_bib0495","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1242\/dev.01155","article-title":"Cell lineage tracing during Xenopus tail regeneration","volume":"131","author":"Gargioli","year":"2004","journal-title":"Development"},{"issue":"5978","key":"10.1016\/j.semcdb.2019.04.006_bib0500","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.1183670","article-title":"The genome of the Western clawed frog Xenopus tropicalis","volume":"328","author":"Hellsten","year":"2010","journal-title":"Science"},{"issue":"7625","key":"10.1016\/j.semcdb.2019.04.006_bib0505","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature19840","article-title":"Genome evolution in the allotetraploid frog Xenopus laevis","volume":"538","author":"Session","year":"2016","journal-title":"Nature"},{"issue":"7690","key":"10.1016\/j.semcdb.2019.04.006_bib0510","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature25458","article-title":"The axolotl genome and the evolution of key tissue formation regulators","volume":"554","author":"Nowoshilow","year":"2018","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.semcdb.2019.04.006_bib0515","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nm1479","article-title":"Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors","volume":"12","author":"Minetti","year":"2006","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0520","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.stem.2010.08.013","article-title":"TNF\/p38alpha\/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration","volume":"7","author":"Palacios","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.semcdb.2019.04.006_bib0525","series-title":"Regenerative Biology and Medicine","first-page":"285","article-title":"Regenerative Medicine of Neural Tissues","author":"Stocum","year":"2012"},{"issue":"50","key":"10.1016\/j.semcdb.2019.04.006_bib0530","doi-asserted-by":"crossref","first-page":"19664","DOI":"10.1523\/JNEUROSCI.0589-13.2013","article-title":"Epigenetic regulation of sensory axon regeneration after spinal cord injury","volume":"33","author":"Finelli","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0535","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1038\/ncomms4527","article-title":"PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system","volume":"5","author":"Puttagunta","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.semcdb.2019.04.006_bib0540","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jcb.22250","article-title":"Stability of histone modifications across mammalian genomes: implications for \u2018epigenetic\u2019 marking","volume":"108","author":"Lee","year":"2009","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0545","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg3682","article-title":"Transcriptional enhancers: from properties to genome-wide predictions","volume":"15","author":"Shlyueva","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"7078","key":"10.1016\/j.semcdb.2019.04.006_bib0550","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature04431","article-title":"The Polycomb group protein EZH2 directly controls DNA methylation","volume":"439","author":"Vire","year":"2006","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.semcdb.2019.04.006_bib0555","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1101\/gr.114843.110","article-title":"Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis","volume":"21","author":"Bogdanovic","year":"2011","journal-title":"Genome Res."},{"issue":"7690","key":"10.1016\/j.semcdb.2019.04.006_bib0560","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature25473","article-title":"The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms","volume":"554","author":"Grohme","year":"2018","journal-title":"Nature"},{"issue":"7446","key":"10.1016\/j.semcdb.2019.04.006_bib0565","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.semcdb.2019.04.006_bib0570","doi-asserted-by":"crossref","first-page":"17484","DOI":"10.1073\/pnas.1215421109","article-title":"Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)","volume":"109","author":"Lei","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2019.04.006_bib0575","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13578-015-0006-1","article-title":"Targeted gene disruption in Xenopus laevis using CRISPR\/Cas9","volume":"5","author":"Wang","year":"2015","journal-title":"Cell Biosci."},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0580","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/dvg.22720","article-title":"Simple and efficient CRISPR\/Cas9-mediated targeted mutagenesis in Xenopus tropicalis","volume":"51","author":"Nakayama","year":"2013","journal-title":"Genesis"},{"issue":"12","key":"10.1016\/j.semcdb.2019.04.006_bib0585","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/dvg.22719","article-title":"Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR\/Cas system","volume":"51","author":"Blitz","year":"2013","journal-title":"Genesis"},{"issue":"11","key":"10.1016\/j.semcdb.2019.04.006_bib0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142946","article-title":"The expression of TALEN before fertilization provides a rapid knock-out phenotype in Xenopus laevis founder embryos","volume":"10","author":"Miyamoto","year":"2015","journal-title":"PLOS ONE"},{"issue":"4","key":"10.1016\/j.semcdb.2019.04.006_bib0595","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/gtc.12349","article-title":"In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration","volume":"21","author":"Suzuki","year":"2016","journal-title":"Genes Cells"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952118301964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952118301964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:56:55Z","timestamp":1761065815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952118301964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":119,"alternative-id":["S1084952118301964"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.04.006","relation":{},"ISSN":["1084-9521"],"issn-type":[{"type":"print","value":"1084-9521"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromatin dynamics underlying the precise regeneration of a vertebrate limb \u2013 Epigenetic regulation and cellular memory","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}