{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:56:49Z","timestamp":1790272609664,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.semcdb.2019.05.010","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T11:28:42Z","timestamp":1558524522000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["The multifaceted effects of metformin on tumor microenvironment"],"prefix":"10.1016","volume":"98","author":[{"given":"Ivana","family":"Kurelac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikkitha","family":"Umesh Ganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Porcelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Gasparre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2019.05.010_bib0005","article-title":"Metformin for cancer prevention: a reason for optimism","author":"Chan","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0010","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02242.019","article-title":"Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis","author":"Wheaton","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0015","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.38415.708634.F7","article-title":"Metformin and reduced risk of cancer in diabetic patients","author":"Evans","year":"2005","journal-title":"Br. Med. J."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0020","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0025","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.CL119.008628","article-title":"The mystery of metformin","author":"Spiering","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0030","article-title":"Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain","author":"Owen","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0035","doi-asserted-by":"crossref","DOI":"10.1042\/BJ20140620","article-title":"Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria","author":"Bridges","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0040","doi-asserted-by":"crossref","DOI":"10.1186\/2049-3002-2-12","article-title":"Metformin directly acts on mitochondria to alter cellular bioenergetics","author":"Andrzejewski","year":"2014","journal-title":"Cancer Metab."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2012.12.001","article-title":"AMPK is a negative regulator of the warburg effect and suppresses tumor growth in vivo","author":"Faubert","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2017.02.006","article-title":"Mitochondrial metabolism and energy sensing in tumor progression","author":"Iommarini","year":"2017","journal-title":"Biochim. Biophys. Acta \u2013 Bioenerg."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41556-018-0125-0","article-title":"M.G. Vander Heiden, Aspartate is an endogenous metabolic limitation for tumour growth","author":"Sullivan","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2016.09.006","article-title":"M.G. Vander Heiden, environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines Cancer cell sensitivity to metformin","author":"Gui","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002309","article-title":"Metformin antagonizes Cancer cell proliferation by suppressing mitochondrial-dependent biosynthesis","author":"Griss","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0070","article-title":"Metformin suppresses hypoxia-induced stabilization of HIF-1alpha through reprogramming of oxygen metabolism in hepatocellular carcinoma","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0075","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.10842","article-title":"Metformin increases PDH and suppresses HIF-1 alpha under hypoxic conditions and induces cell death in oral squamous cell carcinoma","author":"Guimaraes","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0080","doi-asserted-by":"crossref","DOI":"10.1007\/s11523-016-0423-z","article-title":"The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development","author":"Gong","year":"2016","journal-title":"Target. Oncol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0085","doi-asserted-by":"crossref","DOI":"10.1111\/apha.12644","article-title":"Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium","author":"Triggle","year":"2017","journal-title":"Acta Physiol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.03.007","article-title":"Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3b-MCL-1 Axis","author":"Elgendy","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0095","doi-asserted-by":"crossref","DOI":"10.3892\/or.2018.6751","article-title":"Metformin suppresses hypoxia-induced migration via the HIF-1\u03b1\/VEGF pathway in gallbladder cancer in vitro and in vivo","author":"Ye","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0100","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.6373","article-title":"Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2\/HIF-1\u03b1\/VEGF secretion axis","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0105","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.29193","article-title":"The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells","author":"Orecchioni","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0110","first-page":"1","article-title":"Inducing indolence in aggressive cancers by targeting mitochondrial complex I is counteracted by macrophage-mediated adaptive responses","author":"Kurelac","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.112","article-title":"A highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I","author":"Ellinghaus","year":"2013","journal-title":"Cancer Med."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2016.11.040","article-title":"AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1\u03b1 stabilization","author":"Bastian","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0125","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2017.00286","article-title":"Non-canonical mechanisms regulating hypoxia-inducible factor 1 alpha in Cancer","author":"Iommarini","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0130","doi-asserted-by":"crossref","DOI":"10.1007\/s10549-008-9916-5","article-title":"Therapeutic metformin\/AMPK activation promotes the angiogenic phenotype in the ER\u03b1 negative MDA-MB-435 breast cancer model","author":"Phoenix","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0135","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-11-0280","article-title":"Metformin accelerates the growth of BRAFV600E -driven melanoma by upregulating VEGF-A","author":"Martin","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0140","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.0000163633.10240.3b","article-title":"AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle","author":"Ouchi","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0145","doi-asserted-by":"crossref","DOI":"10.1093\/carcin\/bgu001","article-title":"Paradoxic effects of metformin on endothelial cells and angiogenesis","author":"Dallaglio","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0150","doi-asserted-by":"crossref","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0155","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00590","article-title":"Blocking autophagy in cancer-associated fibroblasts supports chemotherapy of pancreatic cancer cells","author":"Zhang","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0160","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-17-0927","article-title":"Metformin suppresses tumor progression by inactivating stromal fibroblasts in ovarian cancer","author":"Xu","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0165","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.2012","article-title":"Metformin limits the adipocyte tumor-promoting effect on ovarian cancer","author":"Tebbe","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0170","article-title":"Metformin suppresses gastric cancer progression through calmodulin-like protein 3 secreted from tumor-associated fibroblasts","author":"Chen","year":"2019","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0175","doi-asserted-by":"crossref","DOI":"10.4161\/cc.23058","article-title":"Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin","author":"Sanchez-Alvarez","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0180","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12075","article-title":"Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK\/NF-\u03baB activation","author":"Moiseeva","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0185","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M114.577908","article-title":"Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction","author":"Kim","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0190","doi-asserted-by":"crossref","DOI":"10.1038\/icb.2014.22","article-title":"Tumour-educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion","author":"Karnevi","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0195","doi-asserted-by":"crossref","DOI":"10.2337\/db14-1225","article-title":"Metformin inhibits monocyte- To-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis","author":"Vasamsetti","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0200","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M115.662114","article-title":"Metformin inhibits the production of reactive oxygen species from NADH: ubiquinone oxidoreductase to limit induction of interleukin-1\u03b2 (IL-1\u03b2) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages","author":"Kelly","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0205","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-018-0013-x","article-title":"Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype","author":"Yan","year":"2018","journal-title":"Mol. Med."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2017.09.025","article-title":"Metformin improves obesity-associated inflammation by altering macrophages polarization","author":"Jing","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0215","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2761","article-title":"Metformin affects the features of a human hepatocellular cell line (HepG2) by regulating macrophage polarization in a co-culture microenviroment","author":"Chen","year":"2015","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0220","article-title":"Metformin inhibits prostate cancer progression by targeting tumor-associated inflammatory infiltration","author":"Liu","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0225","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.5541","article-title":"Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages","author":"Ding","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0230","article-title":"Metformin\u2019s antitumour and anti-angiogenic activities are mediated by skewing macrophage polarization","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141392","article-title":"Metformin reduces desmoplasia in pancreatic cancer by reprogramming stellate cells and tumor-associated macrophages","author":"Incio","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0240","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1700600114","article-title":"Metabolic origins of spatial organization in the tumor microenvironment","author":"Carmona-Fontaine","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0245","doi-asserted-by":"crossref","DOI":"10.1038\/nrclinonc.2017.88","article-title":"Monitoring immune-checkpoint blockade: response evaluation and biomarker development","author":"Nishino","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0250","doi-asserted-by":"crossref","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer-immune set point","author":"Chen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0255","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1417636112","article-title":"Immune-mediated antitumor effect by type 2 diabetes drug, metformin","author":"Eikawa","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.07.030","article-title":"Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1","author":"Cha","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0265","article-title":"Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response","author":"Kaech","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0270","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-15-1839","article-title":"PlGF\/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity","author":"Incio","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0275","doi-asserted-by":"crossref","DOI":"10.1158\/2326-6066.CIR-16-0103","article-title":"Efficacy of PD-1 blockade is potentiated by metformin-induced reduction of tumor hypoxia","author":"Scharping","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0280","article-title":"Metformin-induced reduction of CD39 and CD73 blocks myeloid-derived suppressor cell activity in patients with ovarian cancer","author":"Li","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0285","article-title":"Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-tumor activity of PD-1 blockade in melanoma","author":"Kim","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0290","doi-asserted-by":"crossref","DOI":"10.4161\/cc.8.13.8814","article-title":"Metformin induces unique biological and molecular responses in triple negative breast cancer cells","author":"Liu","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0295","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1221055110","article-title":"Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth","author":"Hirsch","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcdb.2019.05.010_bib0300","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.29305","article-title":"Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma","author":"Zhao","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2017.10.009","article-title":"Attenuation of CD4+CD25+Regulatory t cells in the tumor microenvironment by metformin, a type 2 diabetes drug","author":"Kunisada","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.semcdb.2019.05.010_bib0310","article-title":"Immunometabolism in cancer at a glance","author":"Ho","year":"2018","journal-title":"Dis. Model. Mech."}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119300771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119300771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:51:40Z","timestamp":1761065500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952119300771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":62,"alternative-id":["S1084952119300771"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.05.010","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The multifaceted effects of metformin on tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}