{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:35:56Z","timestamp":1779316556750,"version":"3.51.4"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008980","name":"Medical College of Wisconsin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.semcdb.2019.09.004","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T08:35:57Z","timestamp":1570610157000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration"],"prefix":"10.1016","volume":"100","author":[{"given":"Michael A.","family":"Flinn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Link","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin C.","family":"O\u2019Meara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2010.165","article-title":"Epidemiology and risk profile of heart failure","volume":"8","author":"Bui","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0010","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCRESAHA.116.304269","article-title":"Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration","volume":"116","author":"O\u2019Meara","year":"2015","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14797\/mdcj-9-1-3","article-title":"The treatment of heart failure in the 21st century: is the glass half empty or half full?","volume":"9","author":"Bozkurt","year":"2013","journal-title":"Methodist Debakey Cardiovasc. J."},{"issue":"30","key":"10.1016\/j.semcdb.2019.09.004_bib0020","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/eurheartj\/ehx343","article-title":"Cardiomyocyte renewal in the human heart: insights from the fall-out","volume":"38","author":"Lazar","year":"2017","journal-title":"Eur. Heart J."},{"issue":"7432","key":"10.1016\/j.semcdb.2019.09.004_bib0025","doi-asserted-by":"crossref","DOI":"10.1038\/nature11682","article-title":"Mammalian heart renewal by pre-existing cardiomyocytes","volume":"493","author":"Senyo","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0030","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/dvdy.22553","article-title":"Looking proximally and distally: 100 years of limb regeneration and beyond","volume":"240","author":"Stocum","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.semcdb.2019.09.004_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gde.2016.05.009","article-title":"Retina regeneration in zebrafish","volume":"40","author":"Wan","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"2","key":"10.1016\/j.semcdb.2019.09.004_bib0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jez.1401870208","article-title":"Response of the adult newt ventricle to injury","volume":"187","author":"Oberpriller","year":"1974","journal-title":"J. Exp. Zool."},{"issue":"5601","key":"10.1016\/j.semcdb.2019.09.004_bib0045","doi-asserted-by":"crossref","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"issue":"6020","key":"10.1016\/j.semcdb.2019.09.004_bib0050","doi-asserted-by":"crossref","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.semcdb.2019.09.004_bib0055","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12115","article-title":"Early postnatal rat ventricle resection leads to long-term preserved cardiac function despite tissue hypoperfusion","volume":"2","author":"Zogbi","year":"2014","journal-title":"Physiol. Rep."},{"issue":"8","key":"10.1016\/j.semcdb.2019.09.004_bib0060","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msr065","article-title":"The evolutionary history of YAP and the hippo\/YAP pathway","volume":"28","author":"Hilman","year":"2011","journal-title":"Mol. Biol. Evol."},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0070","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb1050","article-title":"Hippo promotes proliferation arrest and apoptosis in the Salvador\/Warts pathway","volume":"5","author":"Udan","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.semcdb.2019.09.004_bib0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00549-X","article-title":"Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0080","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.devcel.2011.08.028","article-title":"Tao-1 phosphorylates Hippo\/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway","volume":"21","author":"Boggiano","year":"2011","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.str.2013.07.008","article-title":"Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5","volume":"21","author":"Ni","year":"2013","journal-title":"Structure"},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0090","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.devcel.2011.09.012","article-title":"The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway","volume":"21","author":"Poon","year":"2011","journal-title":"Dev. Cell"},{"issue":"48","key":"10.1016\/j.semcdb.2019.09.004_bib0095","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M110.152942","article-title":"The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase","volume":"285","author":"Liu","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"issue":"21","key":"10.1016\/j.semcdb.2019.09.004_bib0105","doi-asserted-by":"crossref","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0110","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5483\/BMBRep.2018.51.3.015","article-title":"DNA binding partners of YAP\/TAZ","volume":"51","author":"Kim","year":"2018","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/wdev.335","article-title":"The regulation and function of the Hippo pathway in heart regeneration","volume":"8","author":"Liu","year":"2019","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"issue":"11","key":"10.1016\/j.semcdb.2019.09.004_bib0120","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","article-title":"The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"23","key":"10.1016\/j.semcdb.2019.09.004_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"issue":"Pt 23","key":"10.1016\/j.semcdb.2019.09.004_bib0135","article-title":"Hippo signaling at a glance","volume":"123","author":"Zhao","year":"2010","journal-title":"J. Cell. Sci."},{"issue":"11","key":"10.1016\/j.semcdb.2019.09.004_bib0140","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41569-018-0086-9","article-title":"The deployment of cell lineages that form the mammalian heart","volume":"15","author":"Meilhac","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0145","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41569-018-0031-y","article-title":"Transcriptional regulation of the cardiac conduction system","volume":"15","author":"van Eif","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ydbio.2018.04.026","article-title":"Endocardial Hippo signaling regulates myocardial growth and cardiogenesis","volume":"440","author":"Artap","year":"2018","journal-title":"Dev. Biol."},{"issue":"7","key":"10.1016\/j.semcdb.2019.09.004_bib0155","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.celrep.2016.04.027","article-title":"Hippo signaling mediators yap and taz are required in the epicardium for coronary vasculature development","volume":"15","author":"Singh","year":"2016","journal-title":"Cell Rep."},{"issue":"34","key":"10.1016\/j.semcdb.2019.09.004_bib0160","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6028","key":"10.1016\/j.semcdb.2019.09.004_bib0165","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"issue":"196","key":"10.1016\/j.semcdb.2019.09.004_bib0170","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002278","article-title":"Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size","volume":"4","author":"Xin","year":"2011","journal-title":"Sci. Signal."},{"issue":"7","key":"10.1016\/j.semcdb.2019.09.004_bib0175","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1116136109","article-title":"YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy","volume":"109","author":"von Gise","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.semcdb.2019.09.004_bib0180","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.yjmcc.2007.01.006","article-title":"Can the cardiomyocyte cell cycle be reprogrammed?","volume":"42","author":"Bicknell","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5923","key":"10.1016\/j.semcdb.2019.09.004_bib0185","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0190","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"issue":"7675","key":"10.1016\/j.semcdb.2019.09.004_bib0195","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","article-title":"Hippo pathway deficiency reverses systolic heart failure after infarction","volume":"550","author":"Leach","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0200","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.devcel.2019.01.017","article-title":"YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in vivo","volume":"48","author":"Monroe","year":"2019","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0205","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1172\/JCI88759","article-title":"Epicardial YAP\/TAZ orchestrate an immunosuppressive response following myocardial infarction","volume":"127","author":"Ramjee","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0210","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/cvr\/cvy243","article-title":"Yap is required for scar formation but not myocyte proliferation during heart regeneration in zebrafish","volume":"115","author":"Flinn","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0220","doi-asserted-by":"crossref","DOI":"10.1242\/dev.159467","article-title":"Mechanical strain regulates the Hippo pathway in Drosophila","volume":"145","author":"Fletcher","year":"2018","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0225","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.devcel.2017.02.004","article-title":"Kibra and Merlin activate the hippo pathway spatially distinct from and independent of expanded","volume":"40","author":"Su","year":"2017","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.semcdb.2019.09.004_bib0230","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.devcel.2009.12.012","article-title":"Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded","volume":"18","author":"Yu","year":"2010","journal-title":"Dev. Cell"},{"issue":"7","key":"10.1016\/j.semcdb.2019.09.004_bib0235","doi-asserted-by":"crossref","first-page":"940","DOI":"10.15252\/embj.201489642","article-title":"The Spectrin cytoskeleton regulates the Hippo signalling pathway","volume":"34","author":"Fletcher","year":"2015","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0240","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/CIRCRESAHA.116.308586","article-title":"NF2 activates hippo signaling and promotes Ischemia\/Reperfusion injury in the heart","volume":"119","author":"Matsuda","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0245","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","article-title":"The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals","volume":"19","author":"Zhang","year":"2010","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0250","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCRESAHA.114.302810","article-title":"The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy","volume":"114","author":"Chen","year":"2014","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.semcdb.2019.09.004_bib0255","doi-asserted-by":"crossref","DOI":"10.1038\/sj.onc.1207142","article-title":"Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function","volume":"23","author":"Surace","year":"2004","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.semcdb.2019.09.004_bib0260","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/onc.2011.224","article-title":"Willin\/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP","volume":"31","author":"Angus","year":"2012","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0265","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.devcel.2009.01.010","article-title":"The FERM-domain protein expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie","volume":"16","author":"Badouel","year":"2009","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0270","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ydbio.2009.08.026","article-title":"Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling","volume":"335","author":"Oh","year":"2009","journal-title":"Dev. Biol. (Basel)"},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0275","doi-asserted-by":"crossref","DOI":"10.1038\/onc.2013.82","article-title":"An evolutionary shift in the regulation of the Hippo pathway between mice and flies","volume":"33","author":"Bossuyt","year":"2014","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.semcdb.2019.09.004_bib0280","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.C110.212621","article-title":"Hippo pathway-independent restriction of TAZ and YAP by angiomotin","volume":"286","author":"Chan","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0285","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.152.6.1247","article-title":"Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation","volume":"152","author":"Troyanovsky","year":"2001","journal-title":"J. Cell Biol."},{"issue":"47","key":"10.1016\/j.semcdb.2019.09.004_bib0290","doi-asserted-by":"crossref","first-page":"18230","DOI":"10.1074\/jbc.RA118.004187","article-title":"Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling","volume":"293","author":"Mana-Capelli","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"52","key":"10.1016\/j.semcdb.2019.09.004_bib0295","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.527598","article-title":"Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation","volume":"288","author":"Chan","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.semcdb.2019.09.004_bib0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2013.05.014","article-title":"Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos","volume":"23","author":"Hirate","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2019.09.004_bib0305","first-page":"6","article-title":"Regulation of localization and function of the transcriptional co-activator YAP by angiomotin","author":"Moleirinho","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2019.09.004_bib0310","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14582","article-title":"Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth","volume":"8","author":"Ragni","year":"2017","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.semcdb.2019.09.004_bib0315","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.466193","article-title":"The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks","volume":"288","author":"Van Itallie","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0320","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI90429","article-title":"Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis","volume":"128","author":"Zhou","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"7662","key":"10.1016\/j.semcdb.2019.09.004_bib0325","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.semcdb.2019.09.004_bib0330","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.0000126574.61061.25","article-title":"The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma","volume":"94","author":"Lapidos","year":"2004","journal-title":"Circ. Res."},{"issue":"7662","key":"10.1016\/j.semcdb.2019.09.004_bib0335","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature22979","article-title":"Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation","volume":"547","author":"Morikawa","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0340","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2353\/jmoldx.2010.090074","article-title":"One hundred twenty-one dystrophin point mutations detected from stored DNA samples by combinatorial denaturing high-performance liquid chromatography","volume":"12","author":"Torella","year":"2010","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.semcdb.2019.09.004_bib0345","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00432.2018","article-title":"Differential YAP nuclear signaling in healthy and dystrophic skeletal muscle","author":"Iyer","year":"2019","journal-title":"Am. J. Physiol., Cell Physiol."},{"issue":"375","key":"10.1016\/j.semcdb.2019.09.004_bib0350","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005781","article-title":"Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice","volume":"8","author":"Morikawa","year":"2015","journal-title":"Sci. Signal."},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0355","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.celrep.2017.02.041","article-title":"Agrin as a mechanotransduction signal regulating YAP through the Hippo Pathway","volume":"18","author":"Chakraborty","year":"2017","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0360","doi-asserted-by":"crossref","first-page":"E507","DOI":"10.21037\/jtd.2017.03.179","article-title":"The emerging role of YAP\/TAZ in mechanotransduction","volume":"9","author":"Mohri","year":"2017","journal-title":"J. Thorac. Dis."},{"issue":"7350","key":"10.1016\/j.semcdb.2019.09.004_bib0365","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"issue":"Pt 4","key":"10.1016\/j.semcdb.2019.09.004_bib0370","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1242\/jcs.140103","article-title":"The Hippo-YAP signaling pathway and contact inhibition of growth","volume":"127","author":"Gumbiner","year":"2014","journal-title":"J. Cell. Sci."},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0375","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","article-title":"Force triggers YAP nuclear entry by regulating transport across nuclear pores","volume":"171","author":"Elosegui-Artola","year":"2017","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.semcdb.2019.09.004_bib0380","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1172\/JCI0215429","article-title":"The cadherin-catenin adhesion system in signaling and cancer","volume":"109","author":"Conacci-Sorrell","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0385","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2055","article-title":"Alpha-Catenin as a tension transducer that induces adherens junction development","volume":"12","author":"Yonemura","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0390","doi-asserted-by":"crossref","DOI":"10.1242\/dev.149823","article-title":"Alpha-Catenin-dependent cytoskeletal tension controls Yap activity in the heart","volume":"145","author":"Vite","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2019.09.004_bib0395","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/624719","article-title":"Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes","volume":"2010","author":"Geisler","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0400","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.0000156274.72390.2c","article-title":"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure","volume":"96","author":"Kostetskii","year":"2005","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.semcdb.2019.09.004_bib0405","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.06188-11","article-title":"Loss of cadherin-binding proteins beta-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis","volume":"32","author":"Swope","year":"2012","journal-title":"Mol. Cell. Biol."},{"issue":"Pt 4","key":"10.1016\/j.semcdb.2019.09.004_bib0410","article-title":"Loss of alphaT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia","volume":"125","author":"Li","year":"2012","journal-title":"J. Cell. Sci."},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0415","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.106.634469","article-title":"alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture","volume":"114","author":"Sheikh","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0420","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/CIRCRESAHA.116.304472","article-title":"Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity","volume":"116","author":"Li","year":"2015","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0425","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.cell.2011.02.031","article-title":"Yap1 acts downstream of alpha-catenin to control epidermal proliferation","volume":"144","author":"Schlegelmilch","year":"2011","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.semcdb.2019.09.004_bib0430","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/CIRCRESAHA.110.229062","article-title":"Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis","volume":"108","author":"del Monte","year":"2011","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0435","doi-asserted-by":"crossref","DOI":"10.1242\/dev.159210","article-title":"The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish","volume":"145","author":"Lai","year":"2018","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.semcdb.2019.09.004_bib0440","article-title":"Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.semcdb.2019.09.004_bib0445","article-title":"Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest","volume":"142","author":"Manderfield","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2019.09.004_bib0450","first-page":"5","article-title":"Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis","author":"Esteves de Lima","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2019.09.004_bib0455","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15206","article-title":"YAP\/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate","volume":"8","author":"Totaro","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.semcdb.2019.09.004_bib0460","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.devcel.2006.12.011","article-title":"Notch signaling is essential for ventricular chamber development","volume":"12","author":"Grego-Bessa","year":"2007","journal-title":"Dev. Cell"},{"issue":"47","key":"10.1016\/j.semcdb.2019.09.004_bib0465","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0703113104","article-title":"Distinct roles of Wnt\/beta-catenin and Bmp signaling during early cardiogenesis","volume":"104","author":"Klaus","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.semcdb.2019.09.004_bib0470","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","article-title":"The hippo pathway regulates Wnt\/beta-catenin signaling","volume":"18","author":"Varelas","year":"2010","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.semcdb.2019.09.004_bib0475","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41419-017-0244-8","article-title":"YAP triggers the Wnt\/beta-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury","volume":"9","author":"Deng","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.semcdb.2019.09.004_bib0480","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s11302-013-9374-3","article-title":"P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo","volume":"9","author":"Hochhauser","year":"2013","journal-title":"Purinergic Signal."},{"issue":"11","key":"10.1016\/j.semcdb.2019.09.004_bib0485","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/CIRCRESAHA.117.310812","article-title":"P2Y2 nucleotide receptor prompts human cardiac progenitor cell activation by modulating hippo signaling","volume":"121","author":"Khalafalla","year":"2017","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.semcdb.2019.09.004_bib0490","doi-asserted-by":"crossref","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP","volume":"26","author":"Liu-Chittenden","year":"2012","journal-title":"Genes Dev."},{"issue":"6750","key":"10.1016\/j.semcdb.2019.09.004_bib0495","doi-asserted-by":"crossref","DOI":"10.1038\/45797","article-title":"Function of Rieger syndrome gene in left-right asymmetry and craniofacial development","volume":"401","author":"Lu","year":"1999","journal-title":"Nature"},{"issue":"7605","key":"10.1016\/j.semcdb.2019.09.004_bib0500","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature17959","article-title":"Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury","volume":"534","author":"Tao","year":"2016","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcdb.2019.09.004_bib0505","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.devcel.2018.03.019","article-title":"Hippo signaling plays an essential role in cell state transitions during cardiac fibroblast development","volume":"45","author":"Xiao","year":"2018","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0510","doi-asserted-by":"crossref","DOI":"10.1172\/JCI17459","article-title":"Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy","volume":"111","author":"Yamamoto","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.semcdb.2019.09.004_bib0515","doi-asserted-by":"crossref","DOI":"10.1172\/JCI43569","article-title":"Proapoptotic Rassf1A\/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice","volume":"120","author":"Del Re","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.semcdb.2019.09.004_bib0520","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"150","author":"Yu","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2019.09.004_bib0525","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ydbio.2014.06.023","article-title":"Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst","volume":"394","author":"Kono","year":"2014","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.semcdb.2019.09.004_bib0530","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.214700","article-title":"Tension-dependent regulation of mammalian Hippo signaling through LIMD1","volume":"131","author":"Ibar","year":"2018","journal-title":"J. Cell. Sci."}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952118302854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952118302854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:55:14Z","timestamp":1761065714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952118302854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":106,"alternative-id":["S1084952118302854"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.09.004","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2019.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}