{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:47:09Z","timestamp":1780400829090,"version":"3.54.1"},"reference-count":148,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.semcdb.2020.04.019","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T22:16:08Z","timestamp":1589235368000},"page":"113-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Centrosome dysfunction in human diseases"],"prefix":"10.1016","volume":"110","author":[{"given":"Sonal","family":"Jaiswal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2020.04.019_bib0005","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0469","article-title":"Historical roots of centrosome research: discovery of Boveri\u2019s microscope slides in W\u00fcrzburg","volume":"369","author":"Scheer","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0010","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1242\/jcs.203505","article-title":"Maintaining centrosomes and cilia","volume":"130","author":"Werner","year":"2017","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/nrm3471","article-title":"Order in the pericentriolar material","volume":"13","author":"Baumann","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0020","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1083\/jcb.201011152","article-title":"Tracing the origins of centrioles, cilia, and flagella","volume":"194","author":"Carvalho-Santos","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0025","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/biosci\/biu180","article-title":"A structural basis for how motile cilia beat","volume":"64","author":"Satir","year":"2014","journal-title":"Bioscience"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0030","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0464","article-title":"Centrosomes as signalling centres","volume":"369","author":"Arquint","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0035","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nature04985","article-title":"Mechanism limiting centrosome duplication to once per cell cycle","volume":"442","author":"M-FB","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0040","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.devcel.2007.12.007","article-title":"sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1","volume":"14","author":"Wang","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ncb3076","article-title":"Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing","volume":"17","author":"Pagan","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0050","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cub.2012.03.048","article-title":"Kendrin is a novel substrate for separase involved in the licensing of centriole duplication","volume":"22","author":"Matsuo","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0055","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.4161\/cc.20878","article-title":"Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis","volume":"11","author":"Lee","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0060","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1083\/jcb.151.4.837","article-title":"The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion","volume":"151","author":"Mayor","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200504107","article-title":"Rootletin forms centriole-associated filaments and functions in centrosome cohesion","volume":"171","author":"Bahe","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0070","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.celrep.2013.08.005","article-title":"LRRC45 is a centrosome linker component required for centrosome cohesion","volume":"4","author":"He","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0075","doi-asserted-by":"crossref","first-page":"E4849","DOI":"10.1073\/pnas.1319656110","article-title":"Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152","volume":"110","author":"Kim","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0080","first-page":"3223","article-title":"Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication","volume":"126","author":"Sonnen","year":"2013","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0085","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.201502088","article-title":"Binding of STIL to Plk4 activates kinase activity to promote centriole assembly","volume":"209","author":"Moyer","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0090","doi-asserted-by":"crossref","unstructured":"Arquint C., Gabryjonczyk A.-M., Imseng S., B\u00f6hm R., Sauer E., Hiller S., et al. STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. ELife, n.d., 4. https:\/\/doi.org\/10.7554\/eLife.07888.","DOI":"10.7554\/eLife.07888"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0095","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1242\/jcs.104109","article-title":"STIL is required for centriole duplication in human cells","volume":"125","author":"Vulprecht","year":"2012","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0100","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/emboj.2013.56","article-title":"Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly","volume":"32","author":"Lin","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0105","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.devcel.2016.04.024","article-title":"Centriolar CPAP\/SAS-4 imparts slow processive microtubule growth","volume":"37","author":"Sharma","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0110","doi-asserted-by":"crossref","first-page":"11874","DOI":"10.1038\/ncomms11874","article-title":"Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0115","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cub.2009.05.016","article-title":"Control of centriole length by CPAP and CP110","volume":"19","author":"Schmidt","year":"2009","journal-title":"Curr Biol CB"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0120","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1091\/mbc.e03-02-0108","article-title":"Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles","volume":"14","author":"Faragher","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0125","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1038\/emboj.2008.242","article-title":"Dynein, Lis1 and CLIP\u2010170 counteract Eg5\u2010dependent centrosome separation during bipolar spindle assembly","volume":"27","author":"Tanenbaum","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0130","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ncb3486","article-title":"The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation","volume":"19","author":"Decarreau","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0135","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41467-018-07965-6","article-title":"Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity","volume":"10","author":"Vitiello","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0140","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/path.4406","article-title":"Boveri at 100: boveri, chromosomes and cancer","volume":"234","author":"Heim","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0145","unstructured":"Galeotti, G. Beitrag zum Studium des Chromatins in den Epithelzellen der Carcinome. Beitr. Pathol. Anat. Allg. Pathol., n.d., 14, 249\u2013271."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0150","first-page":"299","article-title":"Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung","volume":"119","author":"Hansemann","year":"1890","journal-title":"Arch F\u00fcr Pathol Anat Physiol F\u00fcr Klin Med"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0155","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/jmg.22.6.431","article-title":"Marcella O\u2019Grady Boveri (1865-1950) and the chromosome theory of cancer","volume":"22","author":"McKusick","year":"1985","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nature13277","article-title":"Oncogene-like induction of cellular invasion from centrosome amplification","volume":"510","author":"Godinho","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0165","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.7150\/ijbs.7.1122","article-title":"A clinical overview of centrosome amplification in human cancers","volume":"7","author":"Chan","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0170","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.cell.2008.05.039","article-title":"Centrosome amplification can initiate tumorigenesis in flies","volume":"133","author":"Basto","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0175","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.onc.1208275","article-title":"Sak\/Plk4 and mitotic fidelity","volume":"24","author":"Swallow","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0180","doi-asserted-by":"crossref","first-page":"E6311","DOI":"10.1073\/pnas.1518376112","article-title":"Epidermal development, growth control, and homeostasis in the face of centrosome amplification","volume":"112","author":"Kulukian","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0185","doi-asserted-by":"crossref","first-page":"E6321","DOI":"10.1073\/pnas.1519388112","article-title":"Chronic centrosome amplification without tumorigenesis","volume":"112","author":"Vitre","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ncb3270","article-title":"Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis","volume":"18","author":"Ser\u00e7in","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0195","doi-asserted-by":"crossref","first-page":"150209","DOI":"10.1098\/rsob.150209","article-title":"Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse","volume":"5","author":"Coelho","year":"2015","journal-title":"Open Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0200","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nature04217","article-title":"Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells","volume":"437","author":"Fujiwara","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0205","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nrc924","article-title":"Centrosome aberrations: cause or consequence of cancer progression?","volume":"2","author":"Nigg","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0210","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nrc2272","article-title":"Cell-to-cell fusion as a link between viruses and cancer","volume":"7","author":"Duelli","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"313\u2013322","key":"10.1016\/j.semcdb.2020.04.019_bib0215","first-page":"e5","article-title":"Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals","volume":"40","author":"Levine","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0220","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrc2249","article-title":"Oncogenes and tumour suppressors take on centrosomes","volume":"7","author":"Fukasawa","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0225","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.onc.1209028","article-title":"Inhibition of BRCA1 in breast cell lines causes the centrosome duplication cycle to be disconnected from the cell cycle","volume":"25","author":"Ko","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0230","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1038\/ncomms9450","article-title":"Loss of KLF14 triggers centrosome amplification and tumorigenesis","volume":"6","author":"Fan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0235","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cub.2008.11.037","article-title":"The SCF\/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK\/PLK4","volume":"19","author":"Cunha-Ferreira","year":"2009","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0240","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.1158\/0008-5472.CAN-09-1284","article-title":"Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels","volume":"69","author":"Korzeniewski","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/mc.20063","article-title":"Regulation of lung cancer cell growth and invasiveness by beta-TRCP","volume":"42","author":"He","year":"2005","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0250","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1093\/emboj\/17.11.3052","article-title":"A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers","volume":"17","author":"Bischoff","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0255","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/2496","article-title":"Tumour amplified kinase STK15\/BTAK induces centrosome amplification, aneuploidy and transformation","volume":"20","author":"Zhou","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0260","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11060-015-1900-4","article-title":"High levels of polo-like kinase 1 and phosphorylated translationally controlled tumor protein indicate poor prognosis in neuroblastomas","volume":"125","author":"Ramani","year":"2015","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129313","article-title":"Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer","volume":"10","author":"Tut","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0270","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3892\/or.2015.3723","article-title":"Misregulation of polo-like protein kinase 1, P53 and P21WAF1 in epithelial ovarian cancer suggests poor prognosis","volume":"33","author":"Zhang","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0275","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature13556","article-title":"Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity","volume":"514","author":"Marusyk","year":"2014","journal-title":"Nature"},{"issue":"409\u2013424","key":"10.1016\/j.semcdb.2020.04.019_bib0280","first-page":"e9","article-title":"Oxidative stress in cells with extra centrosomes drives non-cell-autonomous invasion","volume":"47","author":"Arnandis","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0285","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41598-017-00363-w","article-title":"Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors","volume":"7","author":"Ogden","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0290","doi-asserted-by":"crossref","first-page":"e1006832","DOI":"10.1371\/journal.pcbi.1006832","article-title":"Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome","volume":"15","author":"de Almeida","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0295","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature08136","article-title":"A mechanism linking extra centrosomes to chromosomal instability","volume":"460","author":"Ganem","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0300","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1101\/gad.1700908","article-title":"Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes","volume":"22","author":"Kwon","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0305","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000915","article-title":"Proteins required for centrosome clustering in cancer cells","volume":"2","author":"Leber","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0310","doi-asserted-by":"crossref","first-page":"R526","DOI":"10.1016\/j.cub.2009.05.025","article-title":"The primary cilium as a complex signaling center","volume":"19","author":"Berbari","year":"2009","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0315","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1126\/science.1124534","article-title":"The primary cilium as the cell\u2019s antenna: signaling at a sensory organelle","volume":"313","author":"Singla","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0320","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1083\/jcb.50.1.10","article-title":"The formation of basal bodies (centrioles) in the Rhesus monkey oviduct","volume":"50","author":"Anderson","year":"1971","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0325","doi-asserted-by":"crossref","DOI":"10.3390\/cells7100152","article-title":"Emerging picture of deuterosome-dependent centriole amplification in MCCs","volume":"7","author":"Shahid","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0330","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2009.10.036","article-title":"Centrioles, centrosomes, and cilia in health and disease","volume":"139","author":"Nigg","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0335","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-biochem-013118-111153","article-title":"Mechanism and regulation of centriole and cilium biogenesis","volume":"88","author":"Breslow","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0340","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201101005","article-title":"Regulating the transition from centriole to basal body","volume":"193","author":"Kobayashi","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0345","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1083\/jcb.53.2.494","article-title":"The ciliary necklace. A ciliary membrane specialization","volume":"53","author":"Gilula","year":"1972","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0350","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.tibs.2015.09.003","article-title":"IFT-cargo interactions and protein transport in cilia","volume":"40","author":"Lechtreck","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0355","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1091\/mbc.e08-11-1115","article-title":"Drosophila Bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly","volume":"20","author":"Mottier-Pavie","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0360","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.genom.7.080505.115610","article-title":"The ciliopathies: an emerging class of human genetic disorders","volume":"7","author":"Badano","year":"2006","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0365","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.ejhg.5201933","article-title":"Alstr\u00f6m syndrome","volume":"15","author":"Marshall","year":"2007","journal-title":"Eur. J. Hum. Genet. EJHG"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0370","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nature02030","article-title":"Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome","volume":"425","author":"Ansley","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0375","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1536-0903(03)00137-1","article-title":"Recognition of the clinical signs and symptoms of Joubert syndrome","volume":"3","author":"Merritt","year":"2003","journal-title":"Adv. Neonatal. Care Off. J. Natl. Assoc. Neonatal Nurses"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0380","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1002\/ajmg.a.32032","article-title":"Oral-facial-digital syndromes: review and diagnostic guidelines","volume":"143A","author":"Gurrieri","year":"2007","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0385","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/ajmg.1320180414","article-title":"The Meckel syndrome: clinicopathological findings in 67 patients","volume":"18","author":"Salonen","year":"1984","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0390","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00467-010-1731-7","article-title":"Ciliopathies: an expanding disease spectrum","volume":"26","author":"Waters","year":"2011","journal-title":"Pediatr Nephrol Berl Ger"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00109-018-1714-x","article-title":"ALMS1 and Alstr\u00f6m syndrome: a recessive form of metabolic, neurosensory and cardiac deficits","volume":"97","author":"Hearn","year":"2019","journal-title":"J. Mol. Med. Berl. Ger."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0400","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ajhg.2008.05.004","article-title":"Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle","volume":"82","author":"Tallila","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0405","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ajhg.2008.10.002","article-title":"CC2D2A is mutated in joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290","volume":"83","author":"Gorden","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0410","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ng.1078","article-title":"CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium","volume":"44","author":"Lee","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0415","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/jmedgenet-2016-104166","article-title":"CEP78 is mutated in a distinct type of Usher syndrome","volume":"54","author":"Fu","year":"2017","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0420","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ajhg.2014.05.002","article-title":"Mutations of CEP83 cause infantile nephronophthisis and intellectual disability","volume":"94","author":"Failler","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0425","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2015.09.009","article-title":"Joubert syndrome in French Canadians and identification of mutations in CEP104","volume":"97","author":"Srour","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0430","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/jmedgenet-2016-103832","article-title":"Mutations in CEP120 cause Joubert syndrome as well as complex ciliopathy phenotypes","volume":"53","author":"Roosing","year":"2016","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0435","doi-asserted-by":"crossref","first-page":"e1004594","DOI":"10.1371\/journal.pgen.1004594","article-title":"Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition","volume":"10","author":"Slaats","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0440","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng1805","article-title":"Mutations in CEP290, which encodes a centrosomal protein, cause pleiotropic forms of Joubert syndrome","volume":"38","author":"Valente","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0445","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/jmg.2009.071365","article-title":"Identification of 11 novel mutations in eight BBS genes by high-resolution homozygosity mapping","volume":"47","author":"Harville","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0450","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-4614-3209-8_24","article-title":"FAM161A, a novel centrosomal-ciliary protein implicated in autosomal recessive retinitis pigmentosa","volume":"801","author":"Zach","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0455","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00439-016-1689-z","article-title":"Identification of a homozygous nonsense mutation in KIAA0556 in a consanguineous family displaying Joubert syndrome","volume":"135","author":"Roosing","year":"2016","journal-title":"Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0460","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/humu.22821","article-title":"KIAA0586 is mutated in Joubert syndrome","volume":"36","author":"Bachmann\u2010Gagescu","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0465","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ajhg.2015.06.003","article-title":"Mutations in KIAA0586 cause lethal ciliopathies ranging from a hydrolethalus phenotype to short-rib polydactyly syndrome","volume":"97","author":"Alby","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0470","doi-asserted-by":"crossref","first-page":"16139","DOI":"10.1073\/pnas.1308243110","article-title":"Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene","volume":"110","author":"Nishiguchi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0475","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jmedgenet-2016-104436","article-title":"Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes","volume":"54","author":"Bruel","year":"2017","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0480","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13630-017-0048-6","article-title":"Abnormal glycosylation in Joubert syndrome type 10","volume":"6","author":"Kane","year":"2017","journal-title":"Cilia"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0485","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ng.3122","article-title":"Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy","volume":"46","author":"Martin","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0490","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ajhg.2012.05.025","article-title":"POC1A truncation mutation causes a ciliopathy in humans characterized by primordial dwarfism","volume":"91","author":"Shaheen","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0495","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ajhg.2015.08.009","article-title":"Genetic defects in TAPT1 disrupt ciliogenesis and cause a complex lethal osteochondrodysplasia","volume":"97","author":"Symoens","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0500","doi-asserted-by":"crossref","first-page":"e1007844","DOI":"10.1371\/journal.pgen.1007844","article-title":"Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability","volume":"14","author":"Bowie","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0505","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-5793(02)02865-X","article-title":"The centrosome cycle","volume":"521","author":"Meraldi","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0510","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1091\/mbc.12.6.1687","article-title":"Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes","volume":"12","author":"Nakagawa","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0515","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1242\/jcs.113.17.3013","article-title":"Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein","volume":"113","author":"Mogensen","year":"2000","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0520","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1091\/mbc.e04-10-0939","article-title":"The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles","volume":"16","author":"Guarguaglini","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0525","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.celrep.2018.02.043","article-title":"CEP128 localizes to the subdistal appendages of the mother centriole and regulates TGF-\u03b2\/BMP signaling at the primary cilium","volume":"22","author":"M\u00f6nnich","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0530","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1083\/jcb.201003009","article-title":"Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly","volume":"191","author":"Mahjoub","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0535","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200506185","article-title":"Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication","volume":"171","author":"Zou","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0540","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.cub.2009.07.034","article-title":"Centriole age underlies asynchronous primary cilium growth in mammalian cells","volume":"19","author":"Anderson","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0545","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1083\/jcb.149.2.317","article-title":"The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells","volume":"149","author":"Piel","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0550","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.celrep.2015.12.097","article-title":"The microcephaly-associated protein Wdr62\/CG7337 is required to maintain centrosome asymmetry in Drosophila neuroblasts","volume":"14","author":"Ramdas Nair","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0555","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.cub.2014.05.050","article-title":"The centriolar protein Bld10\/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts","volume":"24","author":"Singh","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0560","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1083\/jcb.201303141","article-title":"PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells","volume":"202","author":"Lerit","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0565","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0896-6273(00)81172-1","article-title":"Radial glial identity is promoted by Notch1 signaling in the murine forebrain","volume":"26","author":"Gaiano","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0570","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nn1475","article-title":"Notch signaling in the mammalian central nervous system: insights from mouse mutants","volume":"8","author":"Yoon","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0575","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuron.2009.07.004","article-title":"Mammalian Par3 regulates progenitor cell asymmetric division via Notch signaling in the developing neocortex","volume":"63","author":"Bultje","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0580","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nature08435","article-title":"Asymmetric centrosome inheritance maintains neural progenitors in the neocortex","volume":"461","author":"Wang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0585","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0468","article-title":"Small organelle, big responsibility: the role of centrosomes in development and disease","volume":"369","author":"Chavali","year":"2014","journal-title":"Philos. Trans. Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0590","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2046-2530-1-6","article-title":"Live imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog response","volume":"1","author":"Piotrowska-Nitsche","year":"2012","journal-title":"Cilia"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0595","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1755-8794-8-S1-S4","article-title":"Molecular genetics of human primary microcephaly: an overview","volume":"8","author":"Faheem","year":"2015","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0600","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/ng.971","article-title":"A primary microcephaly protein complex forms a ring around parental centrioles","volume":"43","author":"Sir","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0605","doi-asserted-by":"crossref","first-page":"E2140","DOI":"10.1210\/jc.2012-2150","article-title":"Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein","volume":"97","author":"Dauber","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0610","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ncb2746","article-title":"Centrosome amplification causes microcephaly","volume":"15","author":"Marthiens","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0615","doi-asserted-by":"crossref","first-page":"18015","DOI":"10.1038\/hgv.2018.15","article-title":"Primary microcephaly caused by novel compound heterozygous mutations in ASPM","volume":"5","author":"Okamoto","year":"2018","journal-title":"Hum. Genome Var."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0620","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/humu.23381","article-title":"Autosomal recessive primary microcephaly due to ASPM mutations: an update","volume":"39","author":"L\u00e9tard","year":"2018","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0625","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ejmg.2017.07.017","article-title":"A novel mutation in CDK5RAP2 gene causes primary microcephaly with speech impairment and sparse eyebrows in a consanguineous Pakistani family","volume":"60","author":"Abdullah","year":"2017","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0630","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ajhg.2012.03.016","article-title":"A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function","volume":"90","author":"Hussain","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0635","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2010.06.003","article-title":"Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4","volume":"87","author":"Guernsey","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0640","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ng.725","article-title":"CEP152 is a genome maintenance protein disrupted in Seckel syndrome","volume":"43","author":"Kalay","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0645","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/jmg.2009.076398","article-title":"A clinical and molecular genetic study of 112 Iranian families with primary microcephaly","volume":"47","author":"Darvish","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0650","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1093\/hmg\/ddu318","article-title":"A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family","volume":"23","author":"Khan","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0655","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ajhg.2009.01.017","article-title":"Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly","volume":"84","author":"Kumar","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0660","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1007\/s12035-017-0778-x","article-title":"The role of WD40-Repeat protein 62 (MCPH2) in brain growth: diverse molecular and cellular mechanisms required for cortical development","volume":"55","author":"Shohayeb","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0665","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1016\/j.bmcl.2015.10.079","article-title":"Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering","volume":"25","author":"Johannes","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0670","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1038\/ncomms4686","article-title":"APC\/C is an essential regulator of centrosome clustering","volume":"5","author":"Drosopoulos","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0675","doi-asserted-by":"crossref","first-page":"e1538","DOI":"10.1038\/cddis.2014.505","article-title":"Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells","volume":"5","author":"Pannu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0680","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12885-015-1329-3","article-title":"Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma","volume":"15","author":"Tamotsu","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0685","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1158\/1535-7163.MCT-14-0960","article-title":"Daurinol enhances the efficacy of radiotherapy in lung cancer via suppression of Aurora kinase A\/B expression","volume":"14","author":"Woo","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0690","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2015.00278","article-title":"Aurora kinase inhibitors: current status and outlook","volume":"5","author":"Bavetsias","year":"2015","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0695","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.3773","article-title":"Alisertib in combination with weekly paclitaxel in patients with advanced breast cancer or recurrent ovarian cancer: a randomized clinical trial","volume":"5","author":"Falchook","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0700","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1172\/JCI98765","article-title":"Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma","volume":"128","author":"Franqui-Machin","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0705","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/jm5005336","article-title":"The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5\u2032-methoxyspiro[cyclopropane-1,3\u2032-indolin]-2\u2032-one (CFI-400945) as a potent, orally active antitumor agent","volume":"58","author":"Sampson","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0710","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1021\/jm400380m","article-title":"The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents","volume":"56","author":"Laufer","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0715","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ccr.2014.05.006","article-title":"Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent","volume":"26","author":"Mason","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0720","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2016-CT066","article-title":"Abstract CT066: first-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors","volume":"76","author":"Bedard","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0725","doi-asserted-by":"crossref","first-page":"7462","DOI":"10.1523\/JNEUROSCI.0084-18.2018","article-title":"Peripheral gene therapeutic rescue of an olfactory ciliopathy restores sensory input, axonal pathfinding, and odor-guided behavior","volume":"38","author":"Green","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0730","doi-asserted-by":"crossref","first-page":"e1003022","DOI":"10.1371\/journal.pgen.1003022","article-title":"Disruption of mouse cenpj, a regulator of centriole biogenesis, phenocopies seckel syndrome","volume":"8","author":"McIntyre","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.04.019_bib0735","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.stemcr.2014.03.011","article-title":"Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice","volume":"2","author":"Assawachananont","year":"2014","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.semcdb.2020.04.019_bib0740","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1073\/pnas.1512590113","article-title":"Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration","volume":"113","author":"Shirai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119301624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119301624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:01:21Z","timestamp":1761066081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952119301624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":148,"alternative-id":["S1084952119301624"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2020.04.019","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Centrosome dysfunction in human diseases","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2020.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}