{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:34:20Z","timestamp":1792892060765,"version":"4.5.0"},"reference-count":142,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000009","name":"NIH","doi-asserted-by":"publisher","award":["R00AR70905"],"award-info":[{"award-number":["R00AR70905"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oregon Health and Science University Medical Research Foundation"},{"DOI":"10.13039\/100011348","name":"University of Oregon","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011348","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.semcdb.2020.07.005","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T07:26:25Z","timestamp":1595057185000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["On being the right shape: Roles for motile cilia and cerebrospinal fluid flow in body and spine morphology"],"prefix":"10.1016","volume":"110","author":[{"given":"Elizabeth A.","family":"Bearce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Grimes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2020.07.005_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-2530-1-1","article-title":"Cilia - the prodigal organelle","volume":"1","author":"Beales","year":"2012","journal-title":"Cilia"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1085\/jgp.201611696","article-title":"Progress in ciliary ion channel physiology","volume":"149","author":"Pablo","year":"2017","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ceb.2016.02.008","article-title":"The primary cilium as a cellular receiver: organizing ciliary GPCR signaling","volume":"39","author":"Hilgendorf","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0020","doi-asserted-by":"crossref","first-page":"R421","DOI":"10.1016\/j.cub.2018.03.010","article-title":"How the ciliary membrane is organized inside-out to communicate outside-in","volume":"28","author":"Garcia","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0025","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028100","article-title":"Axonemal dynein arms","volume":"8","author":"King","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0030","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1242\/jcs.184598","article-title":"Docking-complex-independent alignment of Chlamydomonas outer dynein arms with 24-nm periodicity in vitro","volume":"129","author":"Oda","year":"2016","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0035","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1126\/science.1260214","article-title":"A molecular ruler determines the repeat length in eukaryotic cilia and flagella","volume":"346","author":"Oda","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fcell.2019.00265","article-title":"Motile cilia: innovation and insight from ciliate model organisms","volume":"7","author":"Bayless","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0045","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrm.2017.21","article-title":"The development and functions of multiciliated epithelia","volume":"18","author":"Spassky","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0050","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028175","article-title":"Primary cilia and mammalian hedgehog signaling","volume":"9","author":"Bangs","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0060","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dev.050054","article-title":"Cilia in vertebrate development and disease","volume":"139","author":"Oh","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gde.2019.05.002","article-title":"Cilia and development","volume":"56","author":"Sreekumar","year":"2019","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0070","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1093\/hmg\/ddv009","article-title":"A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation","volume":"24","author":"Grati","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0075","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.ajhg.2016.04.015","article-title":"Mutations in CDC14A, encoding a protein phosphatase involved in hair cell ciliogenesis, cause autosomal-recessive severe to profound deafness","volume":"98","author":"Delmaghani","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0080","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/jcs.066308","article-title":"Sensory reception is an attribute of both primary cilia and motile cilia","volume":"123","author":"Bloodgood","year":"2010","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1477-7827-11-33","article-title":"The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone","volume":"11","author":"Bylander","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0090","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1126\/science.1173869","article-title":"Motile cilia of human airway epithelia are chemosensory","volume":"325","author":"Shah","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0095","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1038\/ncomms10866","article-title":"CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits","volume":"7","author":"Bohm","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0100","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ajhg.2013.07.009","article-title":"Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia","volume":"93","author":"Moore","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0105","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/hmg\/11.10.1215","article-title":"Studies of mechanosensation using the fly","volume":"11","author":"Jarman","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0110","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0163","article-title":"Cilia in the developing zebrafish ear","volume":"375","author":"Whitfield","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cub.2018.11.059","article-title":"Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development","volume":"29","author":"Olstad","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0120","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.cub.2018.05.079","article-title":"The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis","volume":"28","author":"Cantaut-Belarif","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0125","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1038\/ncomms10002","article-title":"Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3","volume":"7","author":"Jalalvand","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0130","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47699","article-title":"Origin and role of the cerebrospinal fluid bidirectional flow in the central canal","volume":"9","author":"Thouvenin","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0135","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.tig.2017.06.004","article-title":"Left-right patterning: breaking symmetry to asymmetric morphogenesis","volume":"33","author":"Grimes","year":"2017","journal-title":"Trends Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0140","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81705-5","article-title":"Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein","volume":"95","author":"Nonaka","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0145","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1242\/dev.01772","article-title":"Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer\u2019s vesicle is required for normal organogenesis","volume":"132","author":"Kramer-Zucker","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/cm.21157","article-title":"The awesome power of dikaryons for studying flagella and basal bodies in Chlamydomonas reinhardtii","volume":"71","author":"Dutcher","year":"2014","journal-title":"Cytoskeleton (Hoboken)"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0155","doi-asserted-by":"crossref","first-page":"R973","DOI":"10.1016\/j.cub.2014.08.047","article-title":"Multiciliated cells","volume":"24","author":"Brooks","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0160","doi-asserted-by":"crossref","first-page":"9510","DOI":"10.1073\/pnas.1706926114","article-title":"Motile cilia create fluid-mechanical microhabitats for the active recruitment of the host microbiome","volume":"114","author":"Nawroth","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2142\/biophysico.16.0_89","article-title":"Biophysics in oviduct: planar cell polarity, cilia, epithelial fold and tube morphogenesis, egg dynamics","volume":"16","author":"Koyama","year":"2019","journal-title":"Biophys. Physicobiol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0170","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1242\/dev.01663","article-title":"Kupffer\u2019s vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut","volume":"132","author":"Essner","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0175","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cub.2006.10.067","article-title":"Cilia-driven leftward flow determines laterality in Xenopus","volume":"17","author":"Schweickert","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0180","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature00849","article-title":"Determination of left-right patterning of the mouse embryo by artificial nodal flow","volume":"418","author":"Nonaka","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0185","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.2008011","article-title":"Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia","volume":"25","author":"Wallingford","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0190","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1523\/JNEUROSCI.3744-09.2010","article-title":"Cilia organize ependymal planar polarity","volume":"30","author":"Mirzadeh","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0195","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1371\/journal.pbio.0030268","article-title":"De novo formation of left-right asymmetry by posterior tilt of nodal cilia","volume":"3","author":"Nonaka","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0200","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature05771","article-title":"A positive feedback mechanism governs the polarity and motion of motile cilia","volume":"447","author":"Mitchell","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0205","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/ncb2040","article-title":"Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia","volume":"12","author":"Guirao","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ncb2042","article-title":"Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia","volume":"12","author":"Borovina","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0215","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.devcel.2017.02.010","article-title":"A Wnt5 activity asymmetry and intercellular signaling via PCP proteins polarize node cells for left-right symmetry breaking","volume":"40","author":"Minegishi","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0220","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/ng.104","article-title":"Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells","volume":"40","author":"Park","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0225","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrm.2017.60","article-title":"Genes and molecular pathways underpinning ciliopathies","volume":"18","author":"Reiter","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0230","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4843","article-title":"Motile and non-motile cilia in human pathology: from function to phenotypes","volume":"241","author":"Mitchison","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0235","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1242\/dmm.009340","article-title":"Mouse models of ciliopathies: the state of the art","volume":"5","author":"Norris","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0240","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jgg.2016.02.001","article-title":"Zebrafish as a model for human ciliopathies","volume":"43","author":"Song","year":"2016","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0245","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S2213-2600(19)30374-1","article-title":"Primary ciliary dyskinesia in the genomics age","volume":"8","author":"Lucas","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0250","doi-asserted-by":"crossref","DOI":"10.1242\/dev.170985","article-title":"Making and breaking symmetry in development, growth and disease","volume":"146","author":"Grimes","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0255","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1161\/CIRCULATIONAHA.106.649038","article-title":"Congenital heart disease and other heterotaxic defects in a large cohort of patients with primary ciliary dyskinesia","volume":"115","author":"Kennedy","year":"2007","journal-title":"Circulation"},{"issue":"Mar. (1)","key":"10.1016\/j.semcdb.2020.07.005_bib0260","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ajmg.c.31768","article-title":"Left-right patterning in congenital heart disease beyond heterotaxy","volume":"184","author":"Gabriel","year":"2020","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0265","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1038\/ncomms5418","article-title":"MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia","volume":"5","author":"Boon","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0270","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/ng.2961","article-title":"Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia","volume":"46","author":"Wallmeier","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0275","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/BC20100104","article-title":"1001 model organisms to study cilia and flagella","volume":"103","author":"Vincensini","year":"2011","journal-title":"Biol. Cell"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0280","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1242\/dev.052985","article-title":"The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer\u2019s vesicle in zebrafish","volume":"138","author":"Wang","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0285","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1440-169X.2007.00937.x","article-title":"Right-elevated expression of charon is regulated by fluid flow in medaka Kupffer\u2019s vesicle","volume":"49","author":"Hojo","year":"2007","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0290","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cub.2014.12.051","article-title":"Intraciliary calcium oscillations initiate vertebrate left-right asymmetry","volume":"25","author":"Yuan","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0295","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1126\/science.1230401","article-title":"Developmental biology. Cilia discern left from right","volume":"338","author":"Norris","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0300","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cub.2016.11.036","article-title":"Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations","volume":"27","author":"Reiten","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0305","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ng.727","article-title":"The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation","volume":"43","author":"Becker-Heck","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0310","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ajhg.2014.08.005","article-title":"CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation","volume":"95","author":"Hjeij","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0315","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.celrep.2016.01.069","article-title":"c21orf59\/kurly controls both cilia motility and polarization","volume":"14","author":"Jaffe","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0320","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/ng.2277","article-title":"CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms","volume":"44","author":"Panizzi","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0325","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.aaf6419","article-title":"Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature","volume":"352","author":"Grimes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0330","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/s41588-018-0260-3","article-title":"Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis","volume":"50","author":"Zhang","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0335","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.ajhg.2013.08.015","article-title":"Zebrafish ciliopathy screen plus human mutational analysis identifies C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia","volume":"93","author":"Austin-Tse","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0340","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ng.2707","article-title":"DYX1C1 is required for axonemal dynein assembly and ciliary motility","volume":"45","author":"Tarkar","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0345","article-title":"Imhotep and the discovery of cerebrospinal fluid","volume":"2014","author":"Blomstedt","year":"2014","journal-title":"Anat. Res. Int."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0350","first-page":"334","article-title":"A note from history: discovery of the cerebrospinal fluid","volume":"33","author":"Hajdu","year":"2003","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0355","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12987-016-0036-z","article-title":"Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish","volume":"13","author":"Fame","year":"2016","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0360","doi-asserted-by":"crossref","first-page":"e3090","DOI":"10.1371\/journal.pone.0003090","article-title":"In vivo analysis of choroid plexus morphogenesis in zebrafish","volume":"3","author":"Garc\u00eda-Lecea","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0365","first-page":"e4243","article-title":"Manual drainage of the zebrafish embryonic brain ventricles","author":"Chang","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0370","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/dneu.22300","article-title":"Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway","volume":"76","author":"Chang","year":"2016","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0375","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/glia.10238","article-title":"Precursors of neurons, neuroglia, and ependymal cells in the CNS: what are they? Where are they from? How do they get where they are going?","volume":"43","author":"Morest","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0380","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0156","article-title":"The role of motile cilia in the development and physiology of the nervous system","volume":"375","author":"Ringers","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0385","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.170139","article-title":"Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish","volume":"7","author":"Ribeiro","year":"2017","journal-title":"Open Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0390","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1038\/s41467-018-06225-x","article-title":"Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature","volume":"9","author":"Sternberg","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0395","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1016\/j.cub.2018.12.011","article-title":"Developmental biology: go with the flow to keep the body straight","volume":"29","author":"Grimes","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0400","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1242\/dev.123.1.129","article-title":"Mutations affecting development of the midline and general body shape during zebrafish embryogenesis","volume":"123","author":"Brand","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0405","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0306-4522(98)00252-8","article-title":"SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum","volume":"88","author":"Gobron","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0410","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V","article-title":"Subcommissural organ\/Reissner\u2019s fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth","volume":"32","author":"Gobron","year":"2000","journal-title":"Glia"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0415","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.brainresrev.2006.09.007","article-title":"The complex multidomain organization of SCO-spondin protein is highly conserved in mammals","volume":"53","author":"Meiniel","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0420","first-page":"117","article-title":"SCO-ping out the mechanisms underlying the etiology of hydrocephalus","volume":"24","author":"Huh","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0425","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.cub.2020.04.015","article-title":"The reissner fiber is highly dynamic in vivo and controls morphogenesis of the spine","volume":"30","author":"Troutwine","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0430","doi-asserted-by":"crossref","first-page":"R1198","DOI":"10.1016\/j.cub.2017.09.017","article-title":"Cerebrospinal-fluid-contacting neurons","volume":"27","author":"Orts-Del\u2019Immagine","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0435","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nature05084","article-title":"The cells and logic for mammalian sour taste detection","volume":"442","author":"Huang","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0440","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1113\/jphysiol.2012.227959","article-title":"Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem","volume":"590","author":"Orts-Del\u2019immagine","year":"2012","journal-title":"J Physiol"},{"issue":"Mar. (5)","key":"10.1016\/j.semcdb.2020.07.005_bib0445","article-title":"Sensory neurons contacting the cerebrospinal fluid require the reissner Fiber to detect spinal curvature in vivo","volume":"30","author":"Orts-Del\u2019Immagine","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0450","doi-asserted-by":"crossref","first-page":"R833","DOI":"10.1016\/j.cub.2018.05.080","article-title":"Developmental biology: Reissner\u2019s fiber and straightening of the body axis","volume":"28","author":"Driever","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119290","article-title":"Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons","volume":"10","author":"Quan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0460","doi-asserted-by":"crossref","DOI":"10.1242\/bio.052027","article-title":"Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine","volume":"9","author":"Lu","year":"2020","journal-title":"Biol. Open"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0465","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0169-328X(02)00565-X","article-title":"Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid","volume":"110","author":"Caprile","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0470","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1038\/ncomms5777","article-title":"ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease","volume":"5","author":"Hayes","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007817","article-title":"Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development","volume":"14","author":"Konjikusic","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0480","article-title":"Loss of the Reissner fiber and increased URP neuropeptide signaling underlie scoliosis in a zebrafish ciliopathy mutant","volume":"2019","author":"Vesque","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0485","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.cub.2020.04.020","article-title":"SCO-spondin defects and neuroinflammation are conserved mechanisms driving spinal deformity across genetic models of idiopathic scoliosis","volume":"30","author":"Rose","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0490","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11832-012-0457-4","article-title":"Epidemiology of adolescent idiopathic scoliosis","volume":"7","author":"Konieczny","year":"2013","journal-title":"J. Child. Orthop."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0495","doi-asserted-by":"crossref","first-page":"34","DOI":"10.21037\/atm.2019.10.67","article-title":"Scoliosis surgery in adulthood: what challenges for what outcome?","volume":"8","author":"Charles","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0500","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21037\/atm.2019.09.69","article-title":"Adolescent idiopathic scoliosis: indications for bracing and conservative treatments","volume":"8","author":"Kaelin","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0505","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2012.02.054","article-title":"A mechanism for gene-environment interaction in the etiology of congenital scoliosis","volume":"149","author":"Sparrow","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0510","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ydbio.2019.06.024","article-title":"What are you synching about? Emerging complexity of Notch signaling in the segmentation clock","volume":"460","author":"Venzin","year":"2020","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0515","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2011.05.011","article-title":"Vertebrate segmentation: from cyclic gene networks to scoliosis","volume":"145","author":"Pourqui\u00e9","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0520","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/bdrc.20093","article-title":"Disruption of the somitic molecular clock causes abnormal vertebral segmentation","volume":"81","author":"Sparrow","year":"2007","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0525","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00335-011-9335-5","article-title":"The mouse notches up another success: understanding the causes of human vertebral malformation","volume":"22","author":"Sparrow","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0530","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/74307","article-title":"Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis","volume":"24","author":"Bulman","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0535","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1002\/dvdy.21296","article-title":"Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects","volume":"236","author":"Loomes","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0540","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51221","article-title":"Notochord vacuoles absorb compressive bone growth during zebrafish spine formation","volume":"9","author":"Bagwell","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0545","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2013.11.028","article-title":"Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations","volume":"386","author":"Gray","year":"2014","journal-title":"Dev Biol"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0550","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1083\/jcb.201212095","article-title":"Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis","volume":"200","author":"Ellis","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0555","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41467-019-14169-z","article-title":"Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1\/TFEB pathway","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0560","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tig.2017.01.001","article-title":"Understanding idiopathic scoliosis: a new zebrafish school of thought","volume":"33","author":"Boswell","year":"2017","journal-title":"Trends Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0565","first-page":"31","article-title":"Role of high central leptin activity in a scoliosis model created in bipedal amputated mice","volume":"176","author":"Wu","year":"2012","journal-title":"Stud. Health Technol. Inform."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0570","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cbpc.2006.10.004","article-title":"Teleosts as models for human vertebral stability and deformity","volume":"145","author":"Gorman","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0575","first-page":"1700","article-title":"[Scoliosis in patients with intramedullary tumors]","volume":"26","author":"Sch\u00f6che","year":"1971","journal-title":"Gesundheitsw."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0580","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3171\/2013.1.SPINE12366","article-title":"Changes in CSF flow after one-stage posterior vertebral column resection in scoliosis patients with syringomyelia and Chiari malformation type I","volume":"18","author":"Wang","year":"2013","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0585","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11916-015-0491-2","article-title":"Neuroimaging and the clinical manifestations of Chiari Malformation Type I (CMI)","volume":"19","author":"McVige","year":"2015","journal-title":"Curr. Pain Headache Rep."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0590","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/00007632-199703150-00002","article-title":"Structural scoliosis model in dogs with experimentally induced syringomyelia","volume":"22","author":"Chuma","year":"1997","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0595","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10143-005-0391-8","volume":"28","author":"Turgut","year":"2005","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0600","doi-asserted-by":"crossref","first-page":"6821","DOI":"10.1038\/s41598-020-63822-x","article-title":"Continuous hypodynamic change of cerebrospinal fluid flow as a potential factor working for experimental scoliotic formation","volume":"10","author":"Zhao","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0605","doi-asserted-by":"crossref","first-page":"eaav1781","DOI":"10.1126\/sciadv.aav1781","article-title":"Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis","volume":"4","author":"Van Gennip","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0610","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s00244-012-9851-7","article-title":"Teratogenic effects of 4-nonylphenol on early embryonic and larval development of the catfish Heteropneustes fossilis","volume":"64","author":"Chaube","year":"2013","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0615","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.scitotenv.2018.06.213","article-title":"Developmental toxicity of synthetic phenolic antioxidants to the early life stage of zebrafish","volume":"643","author":"Yang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0620","doi-asserted-by":"crossref","first-page":"9067","DOI":"10.1007\/s11356-016-6282-4","article-title":"Comparative developmental toxicity of eight typical organic pollutants to red sea bream (Pagrosomus major) embryos and larvae","volume":"24","author":"Zhao","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0625","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032963","article-title":"Inflammation aggravates disease severity in Marfan syndrome patients","volume":"7","author":"Radonic","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0630","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00586-015-4108-6","article-title":"Comparison of the scoliosis curve patterns and MRI syrinx cord characteristics of idiopathic syringomyelia versus Chiari I malformation","volume":"25","author":"Zhu","year":"2016","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0635","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.devcel.2017.07.022","article-title":"The proprioceptive system masterminds spinal alignment: insight into the mechanism of scoliosis","volume":"42","author":"Blecher","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0640","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1038\/s41467-020-16971-6","article-title":"Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity","volume":"11","author":"Assaraf","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0645","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2017.0327","article-title":"New functions for the proprioceptive system in skeletal biology","volume":"373","author":"Blecher","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0650","article-title":"A genetic variant in GPR126 causing a decreased inclusion of exon 6 is associated with cartilage development in adolescent idiopathic scoliosis population","volume":"2019","author":"Xu","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0655","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1111\/jcmm.13486","article-title":"Genetic polymorphisms of GPR126 are functionally associated with PUMC classifications of adolescent idiopathic scoliosis in a Northern Han population","volume":"22","author":"Liu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0660","doi-asserted-by":"crossref","first-page":"E1098","DOI":"10.1097\/BRS.0000000000002123","article-title":"Genetic variant of GPR126 gene is functionally associated with adolescent idiopathic scoliosis in chinese population","volume":"42","author":"Qin","year":"2017","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0665","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1093\/hmg\/ddv170","article-title":"Gpr126\/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice","volume":"24","author":"Karner","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0670","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng.2639","article-title":"Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis","volume":"45","author":"Kou","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0675","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ygeno.2014.11.009","article-title":"Association of GPR126 gene polymorphism with adolescent idiopathic scoliosis in Chinese populations","volume":"105","author":"Xu","year":"2015","journal-title":"Genomics"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0680","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008096","article-title":"Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice","volume":"15","author":"Liu","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0685","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.1173474","article-title":"A G protein-coupled receptor is essential for Schwann cells to initiate myelination","volume":"325","author":"Monk","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0690","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1093\/hmg\/ddr332","article-title":"The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking","volume":"20","author":"Bachmann-Gagescu","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0695","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1172\/JCI77262","article-title":"Functional variants of POC5 identified in patients with idiopathic scoliosis","volume":"125","author":"Patten","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213269","article-title":"Adolescent idiopathic scoliosis associated POC5 mutation impairs cell cycle, cilia length and centrosome protein interactions","volume":"14","author":"Hassan","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.07.005_bib0705","doi-asserted-by":"crossref","first-page":"44260","DOI":"10.1038\/srep44260","article-title":"Identification of elongated primary cilia with impaired mechanotransduction in idiopathic scoliosis patients","volume":"7","author":"Oliazadeh","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2020.07.005_bib0710","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/dvdy.24208","article-title":"Kinesin family member 6 (kif6) is necessary for spine development in zebrafish","volume":"243","author":"Buchan","year":"2014","journal-title":"Dev. Dyn."}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119301739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119301739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:03:16Z","timestamp":1761066196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952119301739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":142,"alternative-id":["S1084952119301739"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2020.07.005","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On being the right shape: Roles for motile cilia and cerebrospinal fluid flow in body and spine morphology","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2020.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}