{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:11:23Z","timestamp":1790511083108,"version":"4.1.0"},"reference-count":230,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NWO","award":["#2019\/19435-3"],"award-info":[{"award-number":["#2019\/19435-3"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["#308868\/2018-8"],"award-info":[{"award-number":["#308868\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal do Ensino Superior"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.semcdb.2020.10.009","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T01:43:24Z","timestamp":1605923004000},"page":"20-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Transcription blockage by DNA damage in nucleotide excision repair-related neurological dysfunctions"],"prefix":"10.1016","volume":"114","author":[{"given":"Gustavo Satoru","family":"Kajitani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Luz de Souza","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira Rodrigues de Camargo","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana da Silva","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Carri\u00e3o Machado","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Frederico Martins","family":"Menck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2020.10.009_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102669","article-title":"DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms","volume":"81","author":"Abugable","year":"2019","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib4","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/S0140-6736(76)92652-0","article-title":"Relation of DNA repair processes to pathological ageing of the nervous system in Xeroderma Pigmentosum","volume":"307","author":"Andrews","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.semcdb.2020.10.009_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0027-5107(82)90047-1","article-title":"Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne syndrome and xeroderma pigmentosum","volume":"96","author":"Mayne","year":"1982","journal-title":"Mutat. Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib6","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/218652a0","article-title":"Defective repair replication of DNA in xeroderma pigmentosum","volume":"218","author":"Cleaver","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1590\/S1415-47572014000200008","article-title":"DNA repair diseases: what do they tell us about cancer and aging?","volume":"37","author":"Menck","year":"2014","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.freeradbiomed.2016.11.043","article-title":"Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes","volume":"107","author":"Tudek","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2017.01.029","article-title":"Sunlight damage to cellular DNA: Focus on oxidatively generated lesions","volume":"107","author":"Schuch","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.biochi.2003.10.017","article-title":"The eukaryotic nucleotide excision repair pathway","volume":"85","author":"Costa","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.semcdb.2020.10.009_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.dnarep.2015.09.003","article-title":"Nucleotide excision repair in humans","volume":"36","author":"Spivak","year":"2015","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/jid.2011.426","article-title":"Shining a light on xeroderma pigmentosum","volume":"132","author":"Digiovanna","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1600-0625.2012.01446.x","article-title":"Xeroderma pigmentosum complementation group G patient with a novel homozygous missense mutation and no neurological abnormalities","volume":"21","author":"Moriwaki","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/humu.22259","article-title":"Novel XPG (ERCC5) mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress","volume":"34","author":"Soltys","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.semcdb.2020.10.009_bib15","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.4161\/cc.10.12.15878","article-title":"The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome","volume":"10","author":"Trego","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcdb.2020.10.009_bib16","first-page":"535","article-title":"Non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous recombination and genome stability article non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous recombination and genome stability","volume":"61","author":"Trego","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib17","doi-asserted-by":"crossref","first-page":"14127","DOI":"10.1073\/pnas.1921311117","article-title":"Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations","volume":"117","author":"Tsutakawa","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(00)80177-X","article-title":"Strasbourg, reconstitution of the transcription factor TFIIH\u00a0: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7","volume":"3","author":"Tirode","year":"1999","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.dnarep.2011.04.028","article-title":"XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase","volume":"10","author":"Fuss","year":"2011","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib20","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1128\/MCB.00293-08","article-title":"Facilitates DNA double-strand break repair","volume":"28","author":"Ahmad","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molcel.2014.03.015","article-title":"XPF-ERCC1 acts in unhooking DNA interstrand crosslinks in cooperation","volume":"54","author":"Douwel","year":"2014","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/carcin\/bgv078","article-title":"Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex","volume":"36","author":"Takahata","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.semcdb.2020.10.009_bib23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.mad.2008.04.010","article-title":"Tissue-specific accelerated aging in nucleotide excision repair deficiency","volume":"129","author":"Niedernhofer","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.dnarep.2016.05.018","article-title":"XPA\u00a0: a key scaffold for human nucleotide excision repair","volume":"44","author":"Sugitani","year":"2016","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib25","doi-asserted-by":"crossref","first-page":"10151","DOI":"10.1073\/pnas.1610020113","article-title":"Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency","volume":"113","author":"Reid-Bayliss","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib26","doi-asserted-by":"crossref","DOI":"10.1590\/1678-4685-gmb-2019-0085","article-title":"Cockayne syndrome\u00a0: the many challenges and approaches to understand a multifaceted disease","volume":"43","author":"Vessoni","year":"2020","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.mad.2009.07.006","article-title":"Neuropathology of Cockayne syndrome: evidence for impaired development, premature aging, and neurodegeneration","volume":"130","author":"Weidenheim","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ajmg.1320420115","article-title":"Cockayne syndrome: review of 140 cases, Cockayne syndrome: review of 140 cases","volume":"42","author":"Nance","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2016.08.002","article-title":"Cockayne syndrome: Clinical features, model systems and pathways","volume":"33","author":"Karikkineth","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib30","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.celrep.2018.04.041","article-title":"Loss of proteostasis is a pathomechanism in Cockayne syndrome","volume":"23","author":"Alupei","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.10.009_bib31","doi-asserted-by":"crossref","first-page":"15410","DOI":"10.1073\/pnas.0404587101","article-title":"Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome","volume":"101","author":"Horibata","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib32","doi-asserted-by":"crossref","first-page":"15273","DOI":"10.1073\/pnas.0406894101","article-title":"The many faces of Cockayne syndrome","volume":"101","author":"Spivak","year":"2004","journal-title":"Proc. Natl. Acad. Sci. 101"},{"key":"10.1016\/j.semcdb.2020.10.009_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.mrfmmm.2005.03.017","article-title":"UV-sensitive syndrome","volume":"577","author":"Spivak","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib34","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/jmg.2007.057141","article-title":"Cerebro-oculo-facio-skeletal syndrome: Three additional cases with CSB mutations, new diagnostic criteria and an approach to investigation","volume":"45","author":"Laugel","year":"2008","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.dnarep.2009.10.005","article-title":"Trichothiodystrophy: from basic mechanisms to clinical implications","volume":"9","author":"Stefanini","year":"2010","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib36","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nature05456","article-title":"A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis","volume":"444","author":"Niedernhofer","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/1523-1747.ep12541383","article-title":"Cockayne\u2019s syndrome fibroblasts have increased sensitivity to ultraviolet light but normal rates of unscheduled dna synthesis","volume":"70","author":"Andrews","year":"1978","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib38","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1073\/pnas.75.4.1984","article-title":"Xeroderma pigmentosum neurological abnormalities correlate with colony forming ability after ultraviolet radiation","volume":"75","author":"Andrews","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0027-5107(82)90115-4","article-title":"Three complementation groups in Cockayne syndrome","volume":"106","author":"Lehmann","year":"1982","journal-title":"Mutat. Res. - Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.semcdb.2020.10.009_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0092-8674(85)90150-3","article-title":"DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall","volume":"40","author":"Bohr","year":"1985","journal-title":"Cell 40"},{"key":"10.1016\/j.semcdb.2020.10.009_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(87)90151-6","article-title":"Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene","volume":"51","author":"Mellon","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib42","doi-asserted-by":"crossref","first-page":"25409","DOI":"10.1074\/jbc.272.41.25409","article-title":"Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells","volume":"272","author":"Croteau","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib43","series-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","author":"Clark","year":"1999"},{"key":"10.1016\/j.semcdb.2020.10.009_bib44","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/dvdy.24522","article-title":"Neurodegeneration in Ataxia-Telangiectasia\u00a0: multiple roles of ATM kinase in cellular homeostasis","volume":"247","author":"Choy","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.semcdb.2020.10.009_bib46","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1590\/1678-4685-gmb-2016-0213","article-title":"A never-ending story: the steadily growing family of the FA and FA-like genes","volume":"40","author":"Gueiderikh","year":"2017","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.42988","article-title":"Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription","volume":"8","author":"Gao","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2020.10.009_bib48","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-biochem-062917-012239","article-title":"Nuclear genomic instability and aging","volume":"87","author":"Niedernhofer","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib49","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neulet.2016.04.065","article-title":"Oxidative stress and mitochondrial damage in the pathogenesis of ALS: new perspectives","volume":"636","author":"Bozzo","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.semcdb.2020.10.009_bib51","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/ijms20102407","article-title":"Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases","volume":"20","author":"Collin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib52","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: a key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.semcdb.2020.10.009_bib53","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.4161\/cc.6.18.4751","article-title":"The transcription stress response","volume":"6","author":"Ljungman","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcdb.2020.10.009_bib54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2012.02.001","article-title":"Pathways for repairing and tolerating the spectrum of oxidative DNA lesions","volume":"327","author":"Berquist","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.semcdb.2020.10.009_bib55","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2016.12.049","article-title":"Formation and repair of oxidatively generated damage in cellular DNA","volume":"107","author":"Cadet","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib56","first-page":"3242","article-title":"A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine","volume":"45","author":"Chaim","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib57","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1074\/jbc.M002259200","article-title":"The oxidative DNA lesion 8,5\u2019-(S)-cyclo-2\u2019-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells","volume":"275","author":"Brooks","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib58","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1073\/pnas.0402252101","article-title":"Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II","volume":"101","author":"Cline","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.10.009_bib59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mrfmmm.2005.03.014","article-title":"Transcription arrest at DNA damage sites","volume":"577","author":"Tornaletti","year":"2005","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.semcdb.2020.10.009_bib60","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1093\/nar\/gks357","article-title":"Endogenous formation and repair of oxidatively induced G[8\u20135m]T intrastrand cross-link lesion","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib61","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1474-9726.2012.00815.x","article-title":"An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress","volume":"11","author":"Pascucci","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib62","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/sj.onc.1210232","article-title":"The role of CSA in the response to oxidative DNA damage in human cells","volume":"26","author":"D\u2019Errico","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2020.10.009_bib63","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.freeradbiomed.2013.03.026","article-title":"Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue","volume":"61","author":"Maria Berra","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mutage\/gez020","article-title":"XPD\/ERCC2 mutations interfere in cellular responses to oxidative stress","volume":"34","author":"Lerner","year":"2019","journal-title":"Mutagenesis"},{"key":"10.1016\/j.semcdb.2020.10.009_bib65","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mad.2013.03.006","article-title":"The role of CSA and CSB protein in the oxidative stress response","volume":"134","author":"D\u2019Errico","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib66","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mad.2013.03.006","article-title":"The role of CSA and CSB protein in the oxidative stress response","volume":"134","author":"D\u2019Errico","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib67","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/nar\/27.5.1365","article-title":"Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells","volume":"27","author":"Dianov","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2020.10.009_bib68","doi-asserted-by":"crossref","first-page":"45772","DOI":"10.1074\/jbc.M107888200","article-title":"The Cockayne syndrome Group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA","volume":"276","author":"Tuo","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib69","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jid.2018.06.181","article-title":"Cockayne syndrome type A protein protects primary human keratinocytes from senescence","volume":"139","author":"Cordisco","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib70","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.dnarep.2008.09.009","article-title":"Accumulation of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice","volume":"8","author":"Kirkali","year":"2009","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib71","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.dnarep.2019.04.004","article-title":"High levels of oxidatively generated DNA damage 8,5\u2032-cyclo-2\u2032-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A gene-knockout mice","volume":"80","author":"Mori","year":"2019","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib72","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/cells8111377","article-title":"Purine DNA lesions at different oxygen concentration in DNA repair-impaired human cells (EUE-siXPA)","volume":"8","author":"Krokidis","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.semcdb.2020.10.009_bib73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0034-5687(01)00306-1","article-title":"Tissue oxygen tension and brain sensitivity to hypoxia","volume":"128","author":"Ereci\u0144ska","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib74","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1073\/pnas.070471597","article-title":"Removal of oxygen free-radical-induced 5\u2032,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells","volume":"97","author":"Kuraoka","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.10.009_bib75","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.dnarep.2008.01.017","article-title":"Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?","volume":"7","author":"Brooks","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib76","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.dnarep.2013.04.018","article-title":"Blinded by the UV light: how the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease","volume":"12","author":"Brooks","year":"2013","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib77","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/tx800367d","article-title":"Exocyclic DNA adducts as biomarkers of lipid oxidation and predictors of disease. Challenges in developing sensitive and specific methods for clinical studies","volume":"22","author":"Medeiros","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib78","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1074\/jbc.R700051200","article-title":"DNA adducts with lipid peroxidation products","volume":"283","author":"Blair","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib79","first-page":"7514","article-title":"Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal","volume":"43","author":"Maddukuri","year":"2009","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.semcdb.2020.10.009_bib80","doi-asserted-by":"crossref","first-page":"30832","DOI":"10.1074\/jbc.M204814200","article-title":"The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA","volume":"277","author":"Tuo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.freeradbiomed.2018.05.088","article-title":"ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation","volume":"124","author":"Czerwi\u0144ska","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib82","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tibs.2018.02.010","article-title":"The cellular response to transcription-blocking DNA damage","volume":"43","author":"Gregersen","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib83","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41580-019-0169-4","article-title":"The DNA damage response to transcription stress","volume":"20","author":"Lans","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib84","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.3390\/biom5031600","article-title":"Transcription blockage leads to new beginnings","volume":"5","author":"Andrade-Lima","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.semcdb.2020.10.009_bib85","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.dnarep.2018.08.007","article-title":"What happens at the lesion does not stay at the lesion: transcription-coupled nucleotide excision repair and the effects of DNA damage on transcription in cis and trans","volume":"71","author":"Geijer","year":"2018","journal-title":"DNA Repair (Amst.)."},{"key":"10.1016\/j.semcdb.2020.10.009_bib86","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.emboj.7601071","article-title":"Cockayne syndrome B protein regulates the transcriptional program after UV irradiation","volume":"25","author":"Proietti-De-Santis","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2020.10.009_bib87","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2014.06.034","article-title":"DNA damage and its links to neurodegeneration","volume":"83","author":"Madabhushi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2020.10.009_bib88","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1073\/pnas.180169797","article-title":"UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II","volume":"97","author":"Rockx","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib89","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.molcel.2019.01.033","article-title":"P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress","volume":"74","author":"Bugai","year":"2019","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib90","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/s41467-017-02145-4","article-title":"Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate","volume":"8","author":"Lavigne","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.10.009_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004483","article-title":"UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells","volume":"10","author":"Gyenis","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib92","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2009.03.010","article-title":"DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation","volume":"137","author":"Mu\u00f1oz","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib93","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.celrep.2017.02.066","article-title":"Major roles for pyrimidine dimers, nucleotide excision repair, and ATR in the alternative splicing response to UV irradiation","volume":"18","author":"Mu\u00f1oz","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.10.009_bib94","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature14512","article-title":"The core spliceosome as target and effector of non-canonical ATM signalling","volume":"523","author":"Tresini","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib95","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cell.2017.01.019","article-title":"UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene","volume":"168","author":"Williamson","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib96","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","article-title":"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response","volume":"142","author":"Huarte","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib97","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/ng.848","article-title":"Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters","volume":"43","author":"Hung","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib98","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.molcel.2007.10.008","article-title":"Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1","volume":"28","author":"Anindya","year":"2007","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib99","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.dnarep.2015.09.005","article-title":"DNA damage mediated transcription arrest: step back to go forward","volume":"36","author":"Mullenders","year":"2015","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib100","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1074\/jbc.RA117.000971","article-title":"RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells","volume":"293","author":"Chiou","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib101","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.dnarep.2018.08.006","article-title":"Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair","volume":"71","author":"Xu","year":"2018","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib102","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrc3006","article-title":"Transcriptional mutagenesis: causes and involvement in tumor development","volume":"11","author":"Br\u00e9geon","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.semcdb.2020.10.009_bib103","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1073\/pnas.1721764115","article-title":"O6-methylguanine\u2013induced transcriptional mutagenesis reduces p53 tumor-suppressor function","volume":"115","author":"Ezerskyte","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib104","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1073\/pnas.94.21.11205","article-title":"Cockayne syndrome group B protein enhances elongation by RNA polymerase II","volume":"94","author":"Selby","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib105","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1126\/science.1135400","article-title":"CPD damage recognition by transcribing RNA polymerase II","volume":"315","author":"Brueckner","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.10.009_bib106","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1101\/gad.261271.115","article-title":"Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution","volume":"29","author":"Hu","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib107","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1093\/nar\/gkv148","article-title":"DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes","volume":"43","author":"Andrade-Lima","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2020.10.009_bib108","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1073\/pnas.0308181101","article-title":"Regulation of ultraviolet light-induced gene expression by gene size","volume":"101","author":"McKay","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib109","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.molcel.2017.11.009","article-title":"Cockayne\u2019s syndrome A and B proteins regulate transcription arrest after genotoxic stress by promoting ATF3 degradation","volume":"68","author":"Epanchintsev","year":"2017","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib110","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1073\/pnas.1220071110","article-title":"Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress","volume":"110","author":"Kristensen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.10.009_bib111","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.molcel.2010.02.026","article-title":"Evidence that transcript cleavage Is essential for RNA polymerase II transcription and cell viability","volume":"38","author":"Sigurdsson","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib112","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.mad.2008.04.009","article-title":"The role of Cockayne syndrome group B (CSB) protein in base excision repair and aging","volume":"129","author":"Stevnsner","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib113","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1093\/nar\/gky579","article-title":"The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage","volume":"46","author":"Menoni","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib114","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1074\/jbc.M110.198796","article-title":"Preferential repair of oxidized base damage in the transcribed genes of mammalian cells","volume":"286","author":"Banerjee","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib115","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/tx060103g","article-title":"Transcription arrest at an abasic site in the transcribed strand of template DNA","volume":"19","author":"Tornaletti","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib116","doi-asserted-by":"crossref","first-page":"7700","DOI":"10.1093\/nar\/gkt524","article-title":"Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells","volume":"41","author":"Guo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib117","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.15252\/embj.201490041","article-title":"Cockayne syndrome group B protein regulates DNA double\u2010strand break repair and checkpoint activation","volume":"34","author":"Batenburg","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2020.10.009_bib118","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1038\/s41467-018-06586-3","article-title":"ROS-induced R loops trigger a transcription-coupled but BRCA1\/2-independent homologous recombination pathway through CSB","volume":"9","author":"Teng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.10.009_bib119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13049","article-title":"Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes","volume":"7","author":"Chakraborty","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.10.009_bib120","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jmb.2017.03.024","article-title":"Transcription-coupled DNA double-strand break repair: active genes need special care","volume":"429","author":"Marnef","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102661","article-title":"Non-canonical DNA\/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?","volume":"81","author":"Puget","year":"2019","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib122","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.tibs.2011.01.006","article-title":"Tidying up loose ends\u00a0: the role of polynucleotide kinase\/phosphatase in DNA strand break repair","volume":"36","author":"Weinfeld","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib123","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060815-014908","article-title":"Transcription as a threat to genome integrity","volume":"85","author":"Gaillard","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib124","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gad.324517.119","article-title":"Transcription-mediated replication hindrance: a major driver of genome instability","volume":"33","author":"G\u00f3mez-Gonz\u00e1lez","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib125","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.1021\/cr400017y","article-title":"Transcription-associated genome instability","volume":"113","author":"Gaillard","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib126","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev-genet-120213-092015","article-title":"Transcription-associated mutagenesis","volume":"48","author":"Jinks-robertson","year":"2014","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib127","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/sj.emboj.7600602","article-title":"Impairment of replication fork progression mediates RNA polII transcription-associated recombination","volume":"24","author":"Prado","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2020.10.009_bib128","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/MCB.00816-07","article-title":"Transcription-associated recombination is dependent on replication in mammalian cells","volume":"28","author":"Gottipati","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib129","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature11989","article-title":"Accelerated gene evolution through replication-transcription conflicts","volume":"495","author":"Paul","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib130","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.cell.2016.09.053","article-title":"Conflict\u00a0resolution in the genome: how transcription and replication make it work","volume":"167","author":"Hamperl","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib131","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrm.2016.88","article-title":"Transcription-replication conflicts: How they occur and how they are resolved","volume":"17","author":"Garc\u00eda-Muse","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib132","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2017.07.043","article-title":"Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses","volume":"170","author":"Hamperl","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib133","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrg3961","article-title":"R loops: new modulators of genome dynamics and function","volume":"16","author":"Santos-Pereira","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib134","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.molcel.2003.08.010","article-title":"Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination","volume":"12","author":"Huertas","year":"2003","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib135","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1093\/hmg\/ddu190","article-title":"Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2","volume":"23","author":"Fogel","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib136","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08007.019","article-title":"Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi\u2013Gouti\u00e8res syndrome","author":"Lim","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2020.10.009_bib137","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nsmb.3395","article-title":"DNA-RNA hybrids: the risks of DNA breakage during transcription","volume":"24","author":"Aguilera","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib138","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2014.10.020","article-title":"Transcription-Coupled nucleotide excision repair factors promote R-loop-induced genome instability","volume":"56","author":"Sollier","year":"2014","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib139","first-page":"1","article-title":"An R-loop-initiated CSB\u2013RAD52\u2013POLD3 pathway suppresses ROS-induced telomeric DNA breaks","volume":"48","author":"Tan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib140","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nn.3356","article-title":"Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-\u03b2","volume":"16","author":"Suberbielle","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib141","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.cell.2015.05.032","article-title":"Activity-induced DNA breaks govern the expression of neuronal early-response genes","volume":"161","author":"Madabhushi","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib142","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature19329","article-title":"Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice","volume":"537","author":"Vermeij","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib143","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nsmb.3473","article-title":"U1 snRNP telescripting regulates a size\u2013function-stratified human genome","volume":"24","author":"Oh","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib144","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.celrep.2018.03.141","article-title":"Loss of Sfpq causes long-gene transcriptopathy in the brain","volume":"23","author":"Takeuchi","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.10.009_bib145","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2019.03.014","article-title":"Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions","volume":"102","author":"Nussbacher","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2020.10.009_bib146","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s11427-014-4647-9","article-title":"RNA-binding proteins in neurological diseases","volume":"57","author":"Zhou","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib147","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","article-title":"Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43","volume":"14","author":"Polymenidou","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib148","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature12504","article-title":"Topoisomerases facilitate transcription of long genes linked to autism","volume":"501","author":"King","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib149","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11011","article-title":"Patterns and rates of exonic de novo mutations in autism spectrum disorders","volume":"485","author":"Devlin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature14319","article-title":"Disruption of DNA-methylation-dependent long gene repression in Rett syndrome","volume":"522","author":"Gabel","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib151","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.celrep.2017.10.001","article-title":"Understanding tissue-specific gene regulation","volume":"21","author":"Sonawane","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.10.009_bib152","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.semcdb.2020.10.009_bib153","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2015.03.059","article-title":"Gene length matters in neurons","volume":"86","author":"Zylka","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2020.10.009_bib154","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1073\/pnas.1014418108","article-title":"Intronic delay is essential for oscillatory expression in the segmentation clock","volume":"108","author":"Takashima","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib155","first-page":"1","article-title":"An in silico analysis of robust but fragile gene regulation links enhancer length to robustness","author":"Barr","year":"2019","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2020.10.009_bib156","doi-asserted-by":"crossref","first-page":"10017","DOI":"10.1073\/pnas.0602436103","article-title":"Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development","volume":"103","author":"Orii","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2020.10.009_bib157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a012583","article-title":"Base excision repair","volume":"5","author":"Krokan","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib158","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.neuroscience.2006.09.032","article-title":"DNA repair in aging rat neurons","volume":"145","author":"Rao","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.semcdb.2020.10.009_bib159","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.neurobiolaging.2012.12.016","article-title":"Modulation of DNA base excision repair during neuronal differentiation","volume":"34","author":"Sykora","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.semcdb.2020.10.009_bib160","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1432-1033.1979.tb13122.x","article-title":"\u03b2 from brain neurons is a repair enzyme","volume":"97","author":"Waser","year":"1979","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/j.semcdb.2020.10.009_bib161","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mad.2013.04.005","article-title":"Base excision repair in the mammalian brain: implication for age related neurodegeneration","volume":"134","author":"Sykora","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib162","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/nar\/gku1356","article-title":"DNA polymerase \u03b2 deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes","volume":"43","author":"Sykora","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2020.10.009_bib163","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.mad.2012.01.001","article-title":"Age-dependent decline of DNA base excision repair activity in rat cortical neurons","volume":"133","author":"Swain","year":"2012","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib164","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2005.09.053","article-title":"DNA double strand break repair in brain: reduced NHEJ activity in aging rat neurons","volume":"393","author":"Vyjayanti","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.semcdb.2020.10.009_bib165","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1093\/nar\/gkm756","article-title":"Changes in DNA repair during aging","volume":"35","author":"Gorbunova","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2020.10.009_bib166","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nature02661","article-title":"Gene regulation and DNA damage in the ageing human brain","volume":"429","author":"Lu","year":"2004","journal-title":"Lett. Nat."},{"key":"10.1016\/j.semcdb.2020.10.009_bib167","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1568-7864(01)00005-2","article-title":"DNA repair in terminally differentiated cells","volume":"1","author":"Nouspikel","year":"2002","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib168","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.neuroscience.2006.07.006","article-title":"DNA repair in differentiated cells: Some new answers to old questions","volume":"145","author":"Nouspikel","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.semcdb.2020.10.009_bib169","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.dnarep.2008.03.015","article-title":"Nucleotide excision repair and neurological diseases","volume":"7","author":"Nouspikel","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0027-5107(02)00258-0","article-title":"Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesis","volume":"510","author":"Doetsch","year":"2002","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.semcdb.2020.10.009_bib171","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/cr040466q","article-title":"RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis?","volume":"106","author":"Saxowsky","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib172","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00401-009-0601-5","article-title":"Oligodendrocytes: biology and pathology","volume":"119","author":"Bradl","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib173","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mad.2016.05.006","article-title":"DNA damage in the oligodendrocyte lineage and its role in brain aging","volume":"191","author":"Tse","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib174","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1474-9726.2009.00462.x","article-title":"Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes","volume":"8","author":"Lasiene","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S1740925X09990354","article-title":"Cell cycle dynamics of NG2 cells in the postnatal and ageing brain","volume":"5","author":"Psachoulia","year":"2009","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib176","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069143","article-title":"Versatile and simple approach to determine astrocyte territories in mouse neocortex and hippocampus","volume":"8","author":"Grosche","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.10.009_bib177","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.celrep.2016.12.041","article-title":"Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain","volume":"18","author":"Askew","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.10.009_bib178","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0197-4580(97)00169-3","article-title":"Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation","volume":"19","author":"Rozovsky","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.semcdb.2020.10.009_bib179","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.cdd.4401041","article-title":"Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration","volume":"9","author":"Rogove","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.semcdb.2020.10.009_bib180","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1158\/0008-5472.CAN-09-4295","article-title":"PTEN loss compromises homologous recombination repair in astrocytes: implications for GBM therapy with temoolomide or PARP inhibitors","volume":"70","author":"McEllin","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib181","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jrr\/rry084","article-title":"Radiation resistance of normal human astrocytes: the role of non-homologous end joining DNA repair activity","volume":"60","author":"Bylicky","year":"2019","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib182","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.dnarep.2006.12.006","article-title":"Neurons and astrocytes exhibit lower activities of global genome nucleotide excision repair than do fibroblasts","volume":"6","author":"Yamamoto","year":"2007","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib183","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.dnarep.2004.02.005","article-title":"Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death","volume":"3","author":"Kisby","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib184","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0891-5849(00)00214-8","article-title":"Glial cell type-specific responses to menadione-induced oxidative stress","volume":"28","author":"Hollensworth","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox6030062","article-title":"Cysteine, glutathione, and thiol redox balance in astrocytes","volume":"6","author":"McBean","year":"2017","journal-title":"Antioxidants"},{"key":"10.1016\/j.semcdb.2020.10.009_bib186","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1046\/j.1471-4159.2000.0741434.x","article-title":"Astrocytes provide cysteine to neurons by releasing glutathione","volume":"74","author":"Wang","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib187","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/sj.cdd.4400741","article-title":"The role of p53 in neuronal cell death","volume":"7","author":"Morrison","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.semcdb.2020.10.009_bib188","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2014.08.049","article-title":"Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: implications for neurodegeneration","volume":"583","author":"Jebelli","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"80\u2013.","key":"10.1016\/j.semcdb.2020.10.009_bib189","first-page":"1","article-title":"The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4","volume":"349","author":"Kang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2020.10.009_bib190","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0387-7604(99)00033-9","article-title":"Neurodegeneration in hereditary nucleotide repair disorders","volume":"21","author":"Itoh","year":"1999","journal-title":"Brain Dev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib191","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00401-010-0715-9","article-title":"Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice","volume":"120","author":"De Waard","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib192","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002405","article-title":"Age-related neuronal degeneration: Complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology","volume":"7","author":"Jaarsma","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib193","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mrfmmm.2006.06.007","article-title":"DNA repair in neurons: so if they don\u2019t divide what\u2019s to repair?","volume":"614","author":"Fishel","year":"2007","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.semcdb.2020.10.009_bib194","doi-asserted-by":"crossref","first-page":"8774","DOI":"10.1523\/JNEUROSCI.2315-06.2006","article-title":"Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS","volume":"26","author":"Gould","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib195","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.dnarep.2008.03.010","article-title":"Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases","volume":"7","author":"Brasnjevic","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.semcdb.2020.10.009_bib196","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1111\/j.1471-4159.2010.06859.x","article-title":"Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition","volume":"114","author":"Hetman","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.semcdb.2020.10.009_bib197","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-9822(06)00190-4","article-title":"Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence","volume":"7","author":"Weeda","year":"1997","journal-title":"Curr. Biol. 7"},{"key":"10.1016\/j.semcdb.2020.10.009_bib198","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/CIRCULATIONAHA.112.104380","article-title":"Nucleotide excision DNA repair is associated with age-related vascular dysfunction","volume":"126","author":"Durik","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2020.10.009_bib199","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI95145","article-title":"Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcdb.2020.10.009_bib200","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","article-title":"Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response","volume":"11","author":"Jurk","year":"2012","journal-title":"Aging Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib201","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/STROKEAHA.115.010835","article-title":"Vascular cell senescence contributes To blood-brain barrier breakdown","volume":"47","author":"Yamazaki","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.semcdb.2020.10.009_bib202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.12937","article-title":"Astrocyte senescence: evidence and significance","volume":"18","author":"Cohen","year":"2019","journal-title":"Aging Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib203","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neurobiolaging.2018.10.007","article-title":"Phenotypic and functional differences between senescent and aged murine microglia","volume":"74","author":"Stojiljkovic","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.semcdb.2020.10.009_bib204","doi-asserted-by":"crossref","first-page":"R772","DOI":"10.1016\/j.cub.2016.06.066","article-title":"Microglia: senescence impairs clearance of myelin debris","volume":"26","author":"Th\u00e9riault","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib205","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12832","article-title":"Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice","volume":"17","author":"Elmore","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib206","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted\u00a0apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2020.10.009_bib207","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics","volume":"8","author":"Fuhrmann-Stroissnigg","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2020.10.009_bib208","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib209","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.STR.0000206281.77178.ac","article-title":"Microglia potentiate damage to blood-brain barrier constituents: Improvement by minocycline in vivo and in vitro","volume":"37","author":"Yenari","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.semcdb.2020.10.009_bib210","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jnr.20587","article-title":"Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis","volume":"81","author":"Bizzozero","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.semcdb.2020.10.009_bib211","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.semcdb.2020.10.009_bib212","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1007\/s00018-014-1666-4","article-title":"Functional interplay between ATM\/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress","volume":"71","author":"Yan","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.semcdb.2020.10.009_bib213","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2020.10.009_bib214","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni.1775","article-title":"Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE","volume":"10","author":"Farez","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.semcdb.2020.10.009_bib215","first-page":"1","article-title":"Frataxin deficiency promotes excess microglial DNA damage and inflammation that is rescued by PJ34","volume":"11","author":"Shen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2020.10.009_bib216","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.neurobiolaging.2014.03.025","article-title":"Priming of microglia in a DNA-repair deficient model of accelerated aging","volume":"35","author":"Raj","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.semcdb.2020.10.009_bib217","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.celrep.2017.02.066","article-title":"Major roles for pyrimidine dimers, nucleotide excision repair, and ATR in the alternative splicing response to UV irradiation","volume":"18","author":"Mu\u00f1oz","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2020.10.009_bib218","doi-asserted-by":"crossref","first-page":"14454","DOI":"10.1073\/pnas.1412569111","article-title":"Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.semcdb.2020.10.009_bib219","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.228","article-title":"The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis.","volume":"5","author":"Ciaffardini","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.semcdb.2020.10.009_bib220","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1093\/hmg\/dds211","article-title":"Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome","volume":"21","author":"de S. Andrade","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib221","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/hmg\/ddw008","article-title":"Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony","volume":"25","author":"Vessoni","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib222","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tig.2012.06.004","article-title":"Nucleotide excision repair: new tricks with old bricks","volume":"28","author":"Kamileri","year":"2012","journal-title":"Trends Genet."},{"key":"10.1016\/j.semcdb.2020.10.009_bib223","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.4161\/cc.29018","article-title":"Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth","volume":"13","author":"Koch","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semcdb.2020.10.009_bib224","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1097-2765(02)00678-0","article-title":"CSB is a component of RNA pol I transcription","volume":"10","author":"Bradsher","year":"2002","journal-title":"Mol. Cell."},{"key":"10.1016\/j.semcdb.2020.10.009_bib225","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopha.2015.07.025","article-title":"Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight","volume":"74","author":"Bhat","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.semcdb.2020.10.009_bib226","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1096\/fj.09-147991","article-title":"Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane","volume":"24","author":"Aamann","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.semcdb.2020.10.009_bib227","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1084\/jem.20091834","article-title":"Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging","volume":"207","author":"Kamenisch","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.semcdb.2020.10.009_bib228","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/cbin.10917","article-title":"Role of mitochondrial dysfunction in the pathophysiology of DNA repair disorders","volume":"42","author":"Prates Mori","year":"2018","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.semcdb.2020.10.009_bib229","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000329999","article-title":"Role of p53 in neurodegenerative diseases","volume":"9","author":"Chang","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.semcdb.2020.10.009_bib230","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1042\/CS20170026","article-title":"Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1\u0394\/- mice","volume":"131","author":"Wu","year":"2017","journal-title":"Clin. Sci."}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119302551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952119302551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:05:35Z","timestamp":1761066335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952119302551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":230,"alternative-id":["S1084952119302551"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2020.10.009","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcription blockage by DNA damage in nucleotide excision repair-related neurological dysfunctions","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2020.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}