{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:09:12Z","timestamp":1782727752003,"version":"3.54.5"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HD-087351"],"award-info":[{"award-number":["HD-087351"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL-130253"],"award-info":[{"award-number":["HL-130253"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL-138426"],"award-info":[{"award-number":["HL-138426"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["1-0025"],"award-info":[{"award-number":["1-0025"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["5T32HL125247-04"],"award-info":[{"award-number":["5T32HL125247-04"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.semcdb.2021.05.019","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T09:40:24Z","timestamp":1625737224000},"page":"3-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Direct reprogramming as a route to cardiac repair"],"prefix":"10.1016","volume":"122","author":[{"given":"Glynnis A.","family":"Garry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Bassel-Duby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.semcdb.2021.05.019_bib1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart Disease and Stroke Statistics-2021 Update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.semcdb.2021.05.019_bib2","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/eurjhf\/hfr170","article-title":"Ten-year prognosis of heart failure in the community: follow-up data from the Echocardiographic Heart of England Screening (ECHOES) study","volume":"14","author":"Taylor","year":"2012","journal-title":"Eur. J. Heart Fail."},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrd.2017.106","article-title":"Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics","volume":"16","author":"Cahill","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.semcdb.2021.05.019_bib5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/jamacardio.2020.2696","article-title":"Trends in US heart transplant waitlist activity and volume during the coronavirus disease 2019 (COVID-19) pandemic","volume":"5","author":"DeFilippis","year":"2020","journal-title":"JAMA Cardiol."},{"issue":"8","key":"10.1016\/j.semcdb.2021.05.019_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrm3619","article-title":"Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair","volume":"14","author":"Xin","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41569-018-0036-6","article-title":"Therapeutic approaches for cardiac regeneration and repair","volume":"15","author":"Hashimoto","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cell.2012.07.035","article-title":"Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage","volume":"151","author":"Wamstad","year":"2012","journal-title":"Cell"},{"issue":"4 Pt B","key":"10.1016\/j.semcdb.2021.05.019_bib10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.shpsc.2013.06.001","article-title":"The epigenetic landscape in the course of time: Conrad Hal Waddington\u2019s methodological impact on the life sciences","volume":"44","author":"Baedke","year":"2013","journal-title":"Stud. Hist. Philos. Biol. Biomed. Sci."},{"issue":"4","key":"10.1016\/j.semcdb.2021.05.019_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0092-8674(79)90317-9","article-title":"Multiple new phenotypes induced in 10T1\/2 and 3T3 cells treated with 5-azacytidine","volume":"17","author":"Taylor","year":"1979","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb0111-2","article-title":"Out of Africa and into epigenetics: discovering reprogramming drugs","volume":"13","author":"Jones","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(87)90585-X","article-title":"Expression of a single transfected cDNA converts fibroblasts to myoblasts","volume":"51","author":"Davis","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2021.05.019_bib14","article-title":"Direct cell reprogramming: approaches, mechanisms and progress","author":"Wang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib15","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.stem.2011.11.012","article-title":"Historical origins of transdifferentiation and reprogramming","volume":"9","author":"Graf","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib16","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.stem.2012.05.005","article-title":"Induced pluripotent stem cells: past, present, and future","volume":"10","author":"Yamanaka","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.semcdb.2021.05.019_bib17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"5244","key":"10.1016\/j.semcdb.2021.05.019_bib18","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1126\/science.270.5244.1995","article-title":"A subclass of bHLH proteins required for cardiac morphogenesis","volume":"270","author":"Srivastava","year":"1995","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng0697-154","article-title":"Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND","volume":"16","author":"Srivastava","year":"1997","journal-title":"Nat. Genet"},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/dbio.1998.8849","article-title":"The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness","volume":"196","author":"Thomas","year":"1998","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.01562","article-title":"The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner","volume":"132","author":"McFadden","year":"2005","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ng0398-266","article-title":"Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1","volume":"18","author":"Firulli","year":"1998","journal-title":"Nat. Genet"},{"issue":"13","key":"10.1016\/j.semcdb.2021.05.019_bib23","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1101\/gad.9.13.1654","article-title":"Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5","volume":"9","author":"Lyons","year":"1995","journal-title":"Genes Dev."},{"issue":"5317","key":"10.1016\/j.semcdb.2021.05.019_bib24","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.276.5317.1404","article-title":"Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C","volume":"276","author":"Lin","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ng0197-30","article-title":"Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome","volume":"15","author":"Basson","year":"1997","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng0197-21","article-title":"Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family","volume":"15","author":"Yi Li","year":"1997","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/dbio.1999.9298","article-title":"Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome","volume":"211","author":"Bruneau","year":"1999","journal-title":"Dev. Biol."},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib28","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1172\/JCI23769","article-title":"Morphogenesis of the right ventricle requires myocardial expression of Gata4","volume":"115","author":"Zeisberg","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib29","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S1097-2765(00)80225-7","article-title":"An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA","volume":"4","author":"Cirillo","year":"1999","journal-title":"Mol. Cell"},{"issue":"16","key":"10.1016\/j.semcdb.2021.05.019_bib30","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1073\/pnas.1233635100","article-title":"The serum response factor coactivator myocardin is required for vascular smooth muscle development","volume":"100","author":"Li","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib31","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1172\/JCI63635","article-title":"Myocardin regulates BMP10 expression and is required for heart development","volume":"122","author":"Huang","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.semcdb.2021.05.019_bib32","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1242\/dev.01849","article-title":"BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart","volume":"132","author":"Phan","year":"2005","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib33","article-title":"Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function","volume":"7","author":"Sun","year":"2018","journal-title":"Biol. Open"},{"issue":"7013","key":"10.1016\/j.semcdb.2021.05.019_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature03071","article-title":"Baf60c is essential for function of BAF chromatin remodelling complexes in heart development","volume":"432","author":"Lickert","year":"2004","journal-title":"Nature"},{"issue":"7247","key":"10.1016\/j.semcdb.2021.05.019_bib35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nature08039","article-title":"Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors","volume":"459","author":"Takeuchi","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib36","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1073\/pnas.0608118104","article-title":"Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry","volume":"104","author":"Takeuchi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib38","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.devcel.2008.12.007","article-title":"Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling","volume":"16","author":"Ieda","year":"2009","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib39","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/CIRCRESAHA.112.270264","article-title":"Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5","volume":"111","author":"Chen","year":"2012","journal-title":"Circ. Res."},{"issue":"7400","key":"10.1016\/j.semcdb.2021.05.019_bib40","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib41","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s13238-017-0402-x","article-title":"Molecular barriers to direct cardiac reprogramming","volume":"8","author":"Vaseghi","year":"2017","journal-title":"Protein Cell"},{"issue":"7","key":"10.1016\/j.semcdb.2021.05.019_bib42","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm.3225","article-title":"Induced regeneration--the progress and promise of direct reprogramming for heart repair","volume":"19","author":"Addis","year":"2013","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.scr.2016.02.037","article-title":"Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes","volume":"16","author":"Liu","year":"2016","journal-title":"Stem Cell Res."},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib44","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2016.12.016","article-title":"Cooperative binding of transcription factors orchestrates reprogramming","volume":"168","author":"Chronis","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.stemcr.2013.07.005","article-title":"Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state","volume":"1","author":"Fu","year":"2013","journal-title":"Stem Cell Rep."},{"issue":"14","key":"10.1016\/j.semcdb.2021.05.019_bib46","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1073\/pnas.1301019110","article-title":"Reprogramming of human fibroblasts toward a cardiac fate","volume":"110","author":"Nam","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7400","key":"10.1016\/j.semcdb.2021.05.019_bib47","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.semcdb.2021.05.019_bib48","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1242\/dev.114025","article-title":"Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors","volume":"141","author":"Nam","year":"2014","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.semcdb.2021.05.019_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081805","article-title":"Single-construct polycistronic doxycycline-inducible vectors improve direct cardiac reprogramming and can be used to identify the critical timing of transgene expression","volume":"18","author":"Umei","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2021.05.019_bib50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yjmcc.2013.04.004","article-title":"Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success","volume":"60","author":"Addis","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.semcdb.2021.05.019_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063577","article-title":"Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming","volume":"8","author":"Christoforou","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/cvr\/cvt167","article-title":"Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain","volume":"100","author":"Hirai","year":"2013","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCRESAHA.116.305547","article-title":"Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming","volume":"116","author":"Wang","year":"2015","journal-title":"Circ. Res."},{"issue":"11\u201312","key":"10.1016\/j.semcdb.2021.05.019_bib54","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1387\/ijdb.103194hh","article-title":"Structure and functions of powerful transactivators: VP16, MyoD and FoxA","volume":"54","author":"Hirai","year":"2010","journal-title":"Int. J. Dev. Biol."},{"issue":"9","key":"10.1016\/j.semcdb.2021.05.019_bib55","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/stem.684","article-title":"Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD","volume":"29","author":"Hirai","year":"2011","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034149","article-title":"Efficient iPS cell production with the MyoD transactivation domain in serum-free culture","volume":"7","author":"Hirai","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.stem.2019.06.012","article-title":"Context-specific transcription factor functions regulate epigenomic and transcriptional dynamics during cardiac reprogramming","volume":"25","author":"Stone","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089678","article-title":"Inhibition of TGF\u03b2 signaling increases direct conversion of fibroblasts to induced cardiomyocytes","volume":"9","author":"Ifkovits","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2021.05.019_bib59","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1038\/ncomms9243","article-title":"High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling","volume":"6","author":"Zhao","year":"2015","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib60","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/CIRCULATIONAHA.116.024692","article-title":"Chemical enhancement of in vitro and in vivo direct cardiac reprogramming","volume":"135","author":"Mohamed","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2021.05.019_bib61","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib62","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41467-019-08626-y","article-title":"Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming","volume":"10","author":"Muraoka","year":"2019","journal-title":"Nat. Commun."},{"issue":"38","key":"10.1016\/j.semcdb.2021.05.019_bib63","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1073\/pnas.1516237112","article-title":"Akt1\/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes","volume":"112","author":"Zhou","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib64","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.stem.2019.03.022","article-title":"Cardiac reprogramming factors synergistically activate genome-wide cardiogenic stage-specific enhancers","volume":"25","author":"Hashimoto","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib65","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.stemcr.2015.10.019","article-title":"Fibroblast growth factors and vascular endothelial growth factor promote cardiac reprogramming under defined conditions","volume":"5","author":"Yamakawa","year":"2015","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.stem.2019.03.022","article-title":"Cardiac reprogramming factors synergistically activate genome-wide cardiogenic stage-specific enhancers","volume":"25","author":"Hashimoto","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib67","article-title":"Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib68","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.stemcr.2017.01.025","article-title":"Notch inhibition enhances cardiac reprogramming by increasing MEF2C transcriptional activity","volume":"8","author":"Abad","year":"2017","journal-title":"Stem Cell Rep."},{"issue":"5","key":"10.1016\/j.semcdb.2021.05.019_bib69","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.stem.2013.10.005","article-title":"Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency","volume":"13","author":"Wang","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"11","key":"10.1016\/j.semcdb.2021.05.019_bib70","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/ncb3256","article-title":"Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming","volume":"17","author":"Ma","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2021.05.019_bib71","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1126\/scitranslmed.aay7856","article-title":"Down-regulation of Beclin1 promotes direct cardiac reprogramming","volume":"12","author":"Wang","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"6290","key":"10.1016\/j.semcdb.2021.05.019_bib72","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.aaf1502","article-title":"Conversion of human fibroblasts into functional cardiomyocytes by small molecules","volume":"352","author":"Cao","year":"2016","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.semcdb.2021.05.019_bib73","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/cr.2015.99","article-title":"Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails","volume":"25","author":"Fu","year":"2015","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.semcdb.2021.05.019_bib74","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41422-018-0036-4","article-title":"Chemical-induced cardiac reprogramming in vivo","volume":"28","author":"Huang","year":"2018","journal-title":"Cell Res."},{"issue":"7330","key":"10.1016\/j.semcdb.2021.05.019_bib75","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature09783","article-title":"Pervasive roles of microRNAs in cardiovascular biology","volume":"469","author":"Small","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2021.05.019_bib76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2019.10.007","article-title":"MicroRNA delivery through nanoparticles","volume":"313","author":"Lee","year":"2019","journal-title":"J. Controll. Release"},{"issue":"7048","key":"10.1016\/j.semcdb.2021.05.019_bib77","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature03817","article-title":"Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis","volume":"436","author":"Zhao","year":"2005","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcdb.2021.05.019_bib78","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2007.03.030","article-title":"Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2","volume":"129","author":"Zhao","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib79","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.stem.2008.01.016","article-title":"MicroRNA regulation of cell lineages in mouse and human embryonic stem cells","volume":"2","author":"Ivey","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"5824","key":"10.1016\/j.semcdb.2021.05.019_bib80","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"van Rooij","year":"2007","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.semcdb.2021.05.019_bib81","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.devcel.2009.10.013","article-title":"A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance","volume":"17","author":"van Rooij","year":"2009","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.semcdb.2021.05.019_bib82","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/CIRCRESAHA.112.269035","article-title":"MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes","volume":"110","author":"Jayawardena","year":"2012","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib83","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.116.304510","article-title":"MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function","volume":"116","author":"Jayawardena","year":"2015","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.semcdb.2021.05.019_bib84","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.15252\/embj.201387605","article-title":"MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures","volume":"33","author":"Muraoka","year":"2014","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib85","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/cvr\/cvu023","article-title":"Inhibitors of suppressive histone modification promote direct reprogramming of fibroblasts to cardiomyocyte-like cells","volume":"102","author":"Hirai","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.semcdb.2021.05.019_bib86","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/CIRCRESAHA.116.308741","article-title":"Demethylation of H3K27 is essential for the induction of direct cardiac reprogramming by miR combo","volume":"120","author":"Dal-Pra","year":"2017","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.semcdb.2021.05.019_bib87","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/stem.2833","article-title":"Cardiomyocyte maturation requires TLR3 activated nuclear factor kappa B","volume":"36","author":"Hodgkinson","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.semcdb.2021.05.019_bib88","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yjmcc.2020.12.005","article-title":"Suppression of canonical TGF-beta signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis","volume":"153","author":"Riching","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"10","key":"10.1016\/j.semcdb.2021.05.019_bib89","doi-asserted-by":"crossref","first-page":"16503","DOI":"10.1002\/jcb.28885","article-title":"Transcription factor Tbx5 promotes cardiomyogenic differentiation of cardiac fibroblasts treated with 5-azacytidine","volume":"120","author":"Jia","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.semcdb.2021.05.019_bib90","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.stem.2016.02.003","article-title":"Bmi1 is a key epigenetic barrier to direct cardiac reprogramming","volume":"18","author":"Zhou","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"17","key":"10.1016\/j.semcdb.2021.05.019_bib91","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1101\/gad.305482.117","article-title":"ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression","volume":"31","author":"Zhou","year":"2017","journal-title":"Genes Dev."},{"issue":"13","key":"10.1016\/j.semcdb.2021.05.019_bib92","article-title":"PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis","volume":"146","author":"Wang","year":"2019","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.semcdb.2021.05.019_bib93","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1534\/genetics.117.199935","article-title":"Control of a novel spermatocyte-promoting factor by the male germline sex determination factor PHF7 of Drosophila melanogaster","volume":"206","author":"Yang","year":"2017","journal-title":"Genetics"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib94","doi-asserted-by":"crossref","first-page":"11611","DOI":"10.1038\/s41598-017-11524-2","article-title":"PHF7, a novel male gene influences female fecundity and population growth in Nilaparvata lugens St\u00e5l (Hemiptera: Delphacidae)","volume":"7","author":"Ge","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.semcdb.2021.05.019_bib95","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.devcel.2012.04.013","article-title":"Phf7 controls male sex determination in the Drosophila germline.","volume":"22","author":"Yang","year":"2012","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.semcdb.2021.05.019_bib96","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.celrep.2014.01.038","article-title":"Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4","volume":"6","author":"Wang","year":"2014","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2019.05.020","article-title":"Single-cell transcriptomic analyses of cell fate transitions during human cardiac reprogramming","volume":"25","author":"Zhou","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.05.019_bib98","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1367","article-title":"Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease","volume":"9","author":"Hadas","year":"2017","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"issue":"160","key":"10.1016\/j.semcdb.2021.05.019_bib99","doi-asserted-by":"crossref","DOI":"10.3791\/60832","article-title":"Delivery of modified mRNA in a myocardial infarction mouse model","author":"Kaur","year":"2020","journal-title":"J. Vis. Exp."},{"issue":"7","key":"10.1016\/j.semcdb.2021.05.019_bib100","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0092-8674(01)00404-4","article-title":"Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor","volume":"105","author":"Wang","year":"2001","journal-title":"Cell"},{"issue":"7678","key":"10.1016\/j.semcdb.2021.05.019_bib101","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature24454","article-title":"Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte","volume":"551","author":"Liu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2021.05.019_bib102","doi-asserted-by":"crossref","first-page":"16036","DOI":"10.1038\/celldisc.2016.36","article-title":"Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts","volume":"2","author":"Liu","year":"2016","journal-title":"Cell Discov"},{"issue":"5","key":"10.1016\/j.semcdb.2021.05.019_bib103","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41556-021-00668-z","article-title":"The histone reader PHF7 cooperates with the SWI\/SNF complex at cardiac super enhancers to promote direct reprogramming","volume":"23","author":"Garry","year":"2021","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.semcdb.2021.05.019_bib104","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijcard.2017.03.099","article-title":"Making human cardiomyocytes up to date: Derivation, maturation state and perspectives","volume":"241","author":"Kolanowski","year":"2017","journal-title":"Int J Cardiol"},{"issue":"13","key":"10.1016\/j.semcdb.2021.05.019_bib105","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.celrep.2017.09.005","article-title":"Comparative Gene Expression Analyses Reveal Distinct Molecular Signatures between Differentially Reprogrammed Cardiomyocytes","volume":"20","author":"Zhou","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.semcdb.2021.05.019_bib106","doi-asserted-by":"crossref","unstructured":"Miyamoto, K., et al., Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction. Cell Stem Cell, 2018. 22(1): p. 91-103 e5.","DOI":"10.1016\/j.stem.2017.11.010"},{"key":"10.1016\/j.semcdb.2021.05.019_bib107","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbrc.2021.04.121","article-title":"Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage","volume":"560","author":"Isomi","year":"2021","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952121001282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952121001282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:28:30Z","timestamp":1778588910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952121001282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":107,"alternative-id":["S1084952121001282"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2021.05.019","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct reprogramming as a route to cardiac repair","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2021.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}