{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:59:36Z","timestamp":1786996776117,"version":"build-2736575974"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_U12266B"],"award-info":[{"award-number":["MC_U12266B"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"UCL","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.semcdb.2021.09.011","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T02:10:51Z","timestamp":1632363051000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The influence of tissue spatial geometry and functional organisation on liver regeneration"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-2730","authenticated-orcid":false,"given":"Luigi","family":"Aloia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.semcdb.2021.09.011_bib1","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"issue":"12","key":"10.1016\/j.semcdb.2021.09.011_bib2","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1242\/dev.114215","article-title":"Orchestrating liver development","volume":"142","author":"Gordillo","year":"2015","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jhep.2018.01.005","article-title":"Development of the liver: insights into organ and tissue morphogenesis","volume":"68","author":"Ober","year":"2018","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.semcdb.2021.09.011_bib4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver regeneration","volume":"213","author":"Michalopoulos","year":"2007","journal-title":"J. Cell Physiol."},{"issue":"17","key":"10.1016\/j.semcdb.2021.09.011_bib5","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1113\/JP271769","article-title":"Cellular plasticity in the adult liver and stomach","volume":"594","author":"Aloia","year":"2016","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.stem.2020.08.016","article-title":"Epithelial plasticity during liver injury and regeneration","volume":"27","author":"Gadd","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/hep4.1628","article-title":"Hepatic stellate cell regulation of liver regeneration and repair","volume":"5","author":"Kitto","year":"2021","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.semcdb.2021.09.011_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.643055","article-title":"Epigenetic regulation of cell-fate changes that determine adult liver regeneration after injury","volume":"9","author":"Aloia","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.stem.2021.04.005","article-title":"Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids","volume":"28","author":"Marsee","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib11","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: Liver regeneration and normal liver tissue maintenance","volume":"65","author":"Michalopoulos","year":"2017","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.celrep.2014.07.003","article-title":"Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury","volume":"8","author":"Schaub","year":"2014","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.stem.2014.06.003","article-title":"Adult hepatocytes are generated by self-duplication rather than stem cell differentiation","volume":"15","author":"Yanger","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/j.2040-4603.2013.tb00490.x","article-title":"Hepatocyte polarity","volume":"3","author":"Treyer","year":"2013","journal-title":"Compr. Physiol."},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib15","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jhep.2015.06.015","article-title":"Structural and functional hepatocyte polarity and liver disease","volume":"63","author":"Gissen","year":"2015","journal-title":"J. Hepatol."},{"issue":"23","key":"10.1016\/j.semcdb.2021.09.011_bib16","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1073\/pnas.0909374107","article-title":"Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration","volume":"107","author":"Hoehme","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s42003-021-01936-2","article-title":"Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration","volume":"4","author":"Ishikawa","year":"2021","journal-title":"Commun. Biol."},{"issue":"13","key":"10.1016\/j.semcdb.2021.09.011_bib18","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.cub.2012.05.016","article-title":"Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration","volume":"22","author":"Miyaoka","year":"2012","journal-title":"Curr. Biol."},{"issue":"22","key":"10.1016\/j.semcdb.2021.09.011_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.141024","article-title":"Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration","volume":"5","author":"Chen","year":"2020","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib20","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1101\/gr.267013.120","article-title":"Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver","volume":"31","author":"Chembazhi","year":"2021","journal-title":"Genome Res."},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.stemcr.2019.01.010","article-title":"Lineage tracing reveals the bipotency of SOX9(+) hepatocytes during liver regeneration","volume":"12","author":"Han","year":"2019","journal-title":"Stem Cell Rep."},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.stem.2014.09.008","article-title":"Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes","volume":"15","author":"Tarlow","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2021.09.011_bib23","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"issue":"5907","key":"10.1016\/j.semcdb.2021.09.011_bib24","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.1161431","article-title":"Generation and regeneration of cells of the liver and pancreas","volume":"322","author":"Zaret","year":"2008","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.stem.2019.11.001","article-title":"Broad distribution of hepatocyte proliferation in liver homeostasis and regeneration","volume":"26","author":"Chen","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.stem.2019.11.014","article-title":"In vivo lineage tracing of polyploid hepatocytes reveals extensive proliferation during liver regeneration","volume":"26","author":"Matsumoto","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.stem.2019.10.011","article-title":"AXIN2(+) pericentral hepatocytes have limited contributions to liver homeostasis and regeneration","volume":"26","author":"Sun","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib28","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cell.2015.07.026","article-title":"Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer","volume":"162","author":"Font-Burgada","year":"2015","journal-title":"Cell"},{"issue":"7564","key":"10.1016\/j.semcdb.2021.09.011_bib29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14863","article-title":"Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver","volume":"524","author":"Wang","year":"2015","journal-title":"Nature"},{"issue":"7700","key":"10.1016\/j.semcdb.2021.09.011_bib30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41586-018-0004-7","article-title":"Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury","volume":"556","author":"Lin","year":"2018","journal-title":"Nature"},{"issue":"6532","key":"10.1016\/j.semcdb.2021.09.011_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb1625","article-title":"Liver homeostasis is maintained by midlobular zone 2 hepatocytes","volume":"371","author":"Wei","year":"2021","journal-title":"Science"},{"issue":"6532","key":"10.1016\/j.semcdb.2021.09.011_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc4346","article-title":"Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair","volume":"371","author":"He","year":"2021","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.semcdb.2021.09.011_bib33","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","article-title":"Long-term expansion of functional mouse and human hepatocytes as 3D organoids","volume":"175","author":"Hu","year":"2018","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2021.09.011_bib34","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.cell.2018.11.012","article-title":"Inflammatory cytokine TNFalpha promotes the long-term expansion of primary hepatocytes in 3D culture","volume":"175","author":"Peng","year":"2018","journal-title":"Cell"},{"issue":"7459","key":"10.1016\/j.semcdb.2021.09.011_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.semcdb.2021.09.011_bib36","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1016\/j.celrep.2017.11.005","article-title":"Massive and reproducible production of liver buds entirely from human pluripotent stem cells","volume":"21","author":"Takebe","year":"2017","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib37","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1053\/j.gastro.2020.06.010","article-title":"Human pluripotent stem cell-derived organoids as models of liver disease","volume":"159","author":"Ramli","year":"2020","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.semcdb.2021.09.011_bib38","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cmet.2019.05.007","article-title":"Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids","volume":"30","author":"Ouchi","year":"2019","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib39","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/j.gastro.2020.10.002","article-title":"High-fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids","volume":"160","author":"Shinozawa","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/j.2040-4603.2013.tb00495.x","article-title":"Physiology of cholangiocytes","volume":"3","author":"Tabibian","year":"2013","journal-title":"Compr. Physiol."},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1177\/1535370213489926","article-title":"Recent advances in the morphological and functional heterogeneity of the biliary epithelium","volume":"238","author":"Han","year":"2013","journal-title":"Exp. Biol. Med."},{"issue":"2","key":"10.1016\/j.semcdb.2021.09.011_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3727\/105221616X692568","article-title":"Regulators of cholangiocyte proliferation","volume":"17","author":"Hall","year":"2017","journal-title":"Gene Expr."},{"key":"10.1016\/j.semcdb.2021.09.011_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.7554\/eLife.15034","article-title":"Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling","volume":"5","author":"Kamimoto","year":"2016","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib44","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41467-018-03299-5","article-title":"Paracrine cellular senescence exacerbates biliary injury and impairs regeneration","volume":"9","author":"Ferreira-Gonzalez","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.semcdb.2021.09.011_bib45","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/hep.20130","article-title":"Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers","volume":"39","author":"Roskams","year":"2004","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib46","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/hep.26753","article-title":"Liver regeneration by stem\/progenitor cells","volume":"59","author":"Itoh","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2004-823100","article-title":"Canals of Hering: recent insights and current knowledge","volume":"24","author":"Saxena","year":"2004","journal-title":"Semin Liver Dis."},{"issue":"7768","key":"10.1016\/j.semcdb.2021.09.011_bib48","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.stem.2018.05.022","article-title":"Chronic liver injury induces conversion of biliary epithelial cells into hepatocytes","volume":"23","author":"Deng","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2021.09.011_bib50","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.jhep.2019.02.003","article-title":"Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury","volume":"70","author":"Manco","year":"2019","journal-title":"J. Hepatol."},{"issue":"7663","key":"10.1016\/j.semcdb.2021.09.011_bib51","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"Raven","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2021.09.011_bib52","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/hep.30270","article-title":"Hepatocyte-specific \u03b2-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes","volume":"69","author":"Russell","year":"2019","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.semcdb.2021.09.011_bib53","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/s41556-019-0402-6","article-title":"Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration","volume":"21","author":"Aloia","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2019.04.004","article-title":"Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration","volume":"25","author":"Pepe-Mooney","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib55","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.stem.2019.04.005","article-title":"YAP, but not RSPO-LGR4\/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury","volume":"25","author":"Planas-Paz","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.semcdb.2021.09.011_bib56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-pathmechdis-012419-032824","article-title":"Liver progenitors and adult cell plasticity in hepatic injury and repair: knowns and unknowns","volume":"15","author":"Ko","year":"2020","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.semcdb.2021.09.011_bib57","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/nrdp.2016.18","article-title":"Hepatocellular carcinoma","volume":"2","author":"Llovet","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"7436","key":"10.1016\/j.semcdb.2021.09.011_bib58","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.semcdb.2021.09.011_bib59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.semcdb.2021.09.011_bib60","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.4360","article-title":"Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids","volume":"23","author":"Sampaziotis","year":"2017","journal-title":"Nat. Med"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib61","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.31252","article-title":"Regional differences in human biliary tissues and corresponding in vitro-derived organoids","volume":"73","author":"Rimland","year":"2021","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib62","doi-asserted-by":"crossref","first-page":"769","DOI":"10.15252\/embr.201642169","article-title":"R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders","volume":"17","author":"Lugli","year":"2016","journal-title":"EMBO Rep."},{"issue":"8","key":"10.1016\/j.semcdb.2021.09.011_bib63","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nbt.3294","article-title":"Directed differentiation of cholangiocytes from human pluripotent stem cells","volume":"33","author":"Ogawa","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.semcdb.2021.09.011_bib64","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt.3275","article-title":"Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation","volume":"33","author":"Sampaziotis","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"6531","key":"10.1016\/j.semcdb.2021.09.011_bib65","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.aaz6964","article-title":"Cholangiocyte organoids can repair bile ducts after transplantation in the human liver","volume":"371","author":"Sampaziotis","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006972","article-title":"Insulin resistance disrupts epithelial repair and niche-progenitor Fgf signaling during chronic liver injury","volume":"17","author":"Manzano-N\u00fa\u00f1ez","year":"2019","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2021.09.011_bib67","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1101\/gad.204776.112","article-title":"FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration","volume":"27","author":"Takase","year":"2013","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib68","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nm.2667","article-title":"Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease","volume":"18","author":"Boulter","year":"2012","journal-title":"Nat. Med"},{"key":"10.1016\/j.semcdb.2021.09.011_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2021.07.002","article-title":"Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation","author":"Cordero-Espinoza","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"7","key":"10.1016\/j.semcdb.2021.09.011_bib70","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.celrep.2019.10.024","article-title":"Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis","volume":"29","author":"Dobie","year":"2019","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib71","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib72","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI66369","article-title":"Hepatic stellate cells in liver development, regeneration, and cancer","volume":"123","author":"Yin","year":"2013","journal-title":"J. Clin. Investig."},{"issue":"7783","key":"10.1016\/j.semcdb.2021.09.011_bib73","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib74","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.semcdb.2021.09.011_bib75","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nbt.4231","article-title":"Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells","volume":"36","author":"Halpern","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2021.09.011_bib76","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2021.09.011_bib77","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.matbio.2017.12.012","article-title":"Matrix metalloproteinases and liver fibrosis (translational aspects)","volume":"68\u201369","author":"Roeb","year":"2018","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib78","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI93562","article-title":"The balancing act of the liver: tissue regeneration versus fibrosis","volume":"128","author":"Cordero-Espinoza","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib79","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.cell.2019.03.026","article-title":"Somatic mutations increase hepatic clonal fitness and regeneration in chronic liver disease","volume":"177","author":"Zhu","year":"2019","journal-title":"Cell"},{"issue":"7779","key":"10.1016\/j.semcdb.2021.09.011_bib80","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41586-019-1670-9","article-title":"Somatic mutations and clonal dynamics in healthy and cirrhotic human liver","volume":"574","author":"Brunner","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib81","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2007.05.012","article-title":"Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction","volume":"133","author":"Richardson","year":"2007","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib82","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9440(10)63489-X","article-title":"Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease","volume":"163","author":"Roskams","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib83","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/hep.27706","article-title":"Hepatocyte buds derived from progenitor cells repopulate regions of parenchymal extinction in human cirrhosis","volume":"61","author":"Stueck","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib84","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1038\/s41467-020-17161-0","article-title":"Mechano-modulatory synthetic niches for liver organoid derivation","volume":"11","author":"Sorrentino","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib85","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41467-020-14283-3","article-title":"Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors","volume":"11","author":"Wilson","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib86","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/hep.30928","article-title":"Hepatocyte stress increases expression of yes-associated protein and transcriptional coactivator with PDZ-binding motif in hepatocytes to promote parenchymal inflammation and fibrosis","volume":"71","author":"Mooring","year":"2020","journal-title":"Hepatology"},{"issue":"7350","key":"10.1016\/j.semcdb.2021.09.011_bib87","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib88","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","article-title":"The Hippo pathway effector YAP controls mouse hepatic stellate cell activation","volume":"63","author":"Mannaerts","year":"2015","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.semcdb.2021.09.011_bib89","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ncb2936","article-title":"Metabolic control of YAP and TAZ by the mevalonate pathway","volume":"16","author":"Sorrentino","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib90","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1053\/j.gastro.2016.10.047","article-title":"Hippo signaling in the liver regulates organ size, cell fate, and carcinogenesis","volume":"152","author":"Patel","year":"2017","journal-title":"Gastroenterology"},{"issue":"23","key":"10.1016\/j.semcdb.2021.09.011_bib91","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.semcdb.2021.09.011_bib92","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.semcdb.2021.09.011_bib93","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jhep.2014.06.033","article-title":"YAP activation is an early event and a potential therapeutic target in liver cancer development","volume":"61","author":"Perra","year":"2014","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.semcdb.2021.09.011_bib94","doi-asserted-by":"crossref","first-page":"8985","DOI":"10.15252\/msb.20198985","article-title":"Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration","volume":"16","author":"Meyer","year":"2020","journal-title":"Mol. Syst. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib95","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2019.06.008","article-title":"A homeostatic arid1a-dependent permissive chromatin state licenses hepatocyte responsiveness to liver-injury-associated YAP signaling","volume":"25","author":"Li","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib96","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.celrep.2017.03.059","article-title":"Hepatocellular carcinomas originate predominantly from hepatocytes and benign lesions from hepatic progenitor cells","volume":"19","author":"Tummala","year":"2017","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.semcdb.2021.09.011_bib97","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.semcdb.2021.09.011_bib98","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ncb3389","article-title":"Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth","volume":"18","author":"Cox","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2021.09.011_bib99","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13046-018-0892-2","article-title":"Yes-associated protein (YAP) binds to HIF-1\u03b1 and sustains HIF-1\u03b1 protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress","volume":"37","author":"Zhang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.semcdb.2021.09.011_bib100","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.15252\/embj.201490379","article-title":"Aerobic glycolysis tunes YAP\/TAZ transcriptional activity","volume":"34","author":"Enzo","year":"2015","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.semcdb.2021.09.011_bib101","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jhep.2015.11.024","article-title":"Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape","volume":"64","author":"Page","year":"2016","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.semcdb.2021.09.011_bib102","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1136\/gutjnl-2015-311292","article-title":"Epigenetics in liver disease: from biology to therapeutics","volume":"65","author":"Hardy","year":"2016","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.semcdb.2021.09.011_bib103","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4438","article-title":"Human primary liver cancer-derived organoid cultures for disease modeling and drug screening","volume":"23","author":"Broutier","year":"2017","journal-title":"Nat. Med."},{"issue":"48","key":"10.1016\/j.semcdb.2021.09.011_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202000893","article-title":"A chemically defined hydrogel for human liver organoid culture","volume":"30","author":"Ye","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"10","key":"10.1016\/j.semcdb.2021.09.011_bib105","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/s41591-019-0599-8","article-title":"Safety profile of autologous macrophage therapy for liver cirrhosis","volume":"25","author":"Moroni","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcdb.2021.09.011_bib106","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-021-00373-7","article-title":"Liver regeneration and inflammation: from fundamental science to clinical applications","volume":"22","author":"Campana","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.semcdb.2021.09.011_bib107","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1242\/dev.031369","article-title":"Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver","volume":"136","author":"Okabe","year":"2009","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.semcdb.2021.09.011_bib108","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb3203","article-title":"Hepatic progenitor cells of biliary origin with liver repopulation capacity","volume":"17","author":"Lu","year":"2015","journal-title":"Nat. Cell Biol."}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952121002469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952121002469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:12:27Z","timestamp":1761066747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952121002469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":108,"alternative-id":["S1084952121002469"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2021.09.011","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of tissue spatial geometry and functional organisation on liver regeneration","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2021.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}