{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:46:24Z","timestamp":1793450784018,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR42309"],"award-info":[{"award-number":["AR42309"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.semcdb.2022.03.019","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T01:13:05Z","timestamp":1649380385000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Tenascin-C in fibrosis in multiple organs: Translational implications"],"prefix":"10.1016","volume":"128","author":[{"given":"Swati","family":"Bhattacharyya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim S.","family":"Midwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2022.03.019_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nrrheum.2014.222","article-title":"Systemic sclerosis in 2014: Advances in cohort enrichment shape future of trial design","volume":"11","author":"Allanore","year":"2015","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.semcdb.2022.03.019_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.613438","article-title":"Latent TGF-beta activation is a hallmark of the tenascin family","volume":"12","author":"Aubert","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/annrheumdis-2018-214294","article-title":"Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?","volume":"78","author":"Aungier","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.semcdb.2022.03.019_bib4","doi-asserted-by":"crossref","first-page":"232ra250","DOI":"10.1126\/scitranslmed.3008264","article-title":"FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling","volume":"6","author":"Bhattacharyya","year":"2014","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.semcdb.2022.03.019_bib5","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1038\/ncomms11703","article-title":"Tenascin-C drives persistence of organ fibrosis","volume":"7","author":"Bhattacharyya","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2022.03.019_bib6","doi-asserted-by":"crossref","unstructured":"S. Bhattacharyya et al., TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung. JCI Insight 3, 2018.","DOI":"10.1172\/jci.insight.98850"},{"key":"10.1016\/j.semcdb.2022.03.019_bib7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s11926-014-0474-z","article-title":"Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis","volume":"17","author":"Bhattacharyya","year":"2015","journal-title":"Curr. Rheuma Rep."},{"key":"10.1016\/j.semcdb.2022.03.019_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2017.09.011","article-title":"Endogenous ligands of TLR4 promote unresolving tissue fibrosis: Implications for systemic sclerosis and its targeted therapy","volume":"195","author":"Bhattacharyya","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.semcdb.2022.03.019_bib9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1089\/wound.2017.0732","article-title":"Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma","volume":"6","author":"Bhattacharyya","year":"2017","journal-title":"Adv. Wound Care (N. Rochelle)"},{"key":"10.1016\/j.semcdb.2022.03.019_bib10","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1158\/1078-0432.CCR-05-2804","article-title":"Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C","volume":"12","author":"Brack","year":"2006","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.semcdb.2022.03.019_bib11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/art.30647","article-title":"Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3","volume":"64","author":"Brissett","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.semcdb.2022.03.019_bib12","doi-asserted-by":"crossref","first-page":"L785","DOI":"10.1152\/ajplung.00385.2009","article-title":"Tenascin-C deficiency attenuates TGF-ss-mediated fibrosis following murine lung injury","volume":"299","author":"Carey","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib13","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.15252\/embr.201540337","article-title":"EGFR kinase activity is required for TLR4 signaling and the septic shock response","volume":"16","author":"Chattopadhyay","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.semcdb.2022.03.019_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/19336918.2015.1008333","article-title":"Transcriptional regulation of tenascin genes","volume":"9","author":"Chiovaro","year":"2015","journal-title":"Cell Adh Migr."},{"key":"10.1016\/j.semcdb.2022.03.019_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228693","article-title":"Effects of tenascin C on the integrity of extracellular matrix and skin aging","volume":"21","author":"Choi","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2022.03.019_bib16","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1073\/pnas.1511794112","article-title":"Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal","volume":"112","author":"De","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.semcdb.2022.03.019_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062076","article-title":"Tenascin C promiscuously binds growth factors via its fifth fibronectin type III-like domain","volume":"8","author":"De Laporte","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2022.03.019_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.635166","article-title":"Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies","volume":"12","author":"Dhaouadi","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41584-019-0322-7","article-title":"Shared and distinct mechanisms of fibrosis","volume":"15","author":"Distler","year":"2019","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.semcdb.2022.03.019_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/path.2099","article-title":"Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice","volume":"211","author":"El-Karef","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2466-14-120","article-title":"Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFbeta1","volume":"14","author":"Estany","year":"2014","journal-title":"BMC Pulm. Med"},{"key":"10.1016\/j.semcdb.2022.03.019_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10735-014-9573-4","article-title":"De novo expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection","volume":"45","author":"Franz","year":"2014","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.7754\/Clin.Lab.2013.130702","article-title":"Serum levels of tenascin-C variants in congestive heart failure patients: comparative analysis of ischemic, dilated, and hypertensive cardiomyopathy","volume":"60","author":"Franz","year":"2014","journal-title":"Clin. Lab"},{"key":"10.1016\/j.semcdb.2022.03.019_bib24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1681\/ASN.2016020165","article-title":"Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis","volume":"28","author":"Fu","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.brainres.2016.04.034","article-title":"Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats","volume":"1642","author":"Fujimoto","year":"2016","journal-title":"Brain Res"},{"key":"10.1016\/j.semcdb.2022.03.019_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00125-020-05108-5","article-title":"Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: a French prospective cohort","volume":"63","author":"Gellen","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.semcdb.2022.03.019_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbagrm.2007.11.012","article-title":"GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts","volume":"1779","author":"Ghatnekar","year":"2008","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.semcdb.2022.03.019_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4161\/19336918.2014.987587","article-title":"Tenascin-C: Form versus function","volume":"9","author":"Giblin","year":"2015","journal-title":"Cell Adh Migr."},{"key":"10.1016\/j.semcdb.2022.03.019_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.matbio.2020.06.003","article-title":"Alternative splicing controls cell lineage-specific responses to endogenous innate immune triggers within the extracellular matrix","volume":"93","author":"Giblin","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib30","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2169\/internalmedicine.48.2233","article-title":"Elevated levels of tenascin-C in patients with cryptogenic organizing pneumonia","volume":"48","author":"Hisatomi","year":"2009","journal-title":"Intern Med"},{"key":"10.1016\/j.semcdb.2022.03.019_bib31","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/ndt\/17.6.1005","article-title":"Elevation of serum and urine levels of TIMP-1 and tenascin in patients with renal disease","volume":"17","author":"Horstrup","year":"2002","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.semcdb.2022.03.019_bib32","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/labinvest.2010.100","article-title":"Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury","volume":"90","author":"Hsu","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.semcdb.2022.03.019_bib33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/labinvest.3780313","article-title":"Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction","volume":"81","author":"Imanaka-Yoshida","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.semcdb.2022.03.019_bib34","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1253\/circj.CJ-12-1033","article-title":"Tenascin-C in cardiovascular tissue remodeling: from development to inflammation and repair","volume":"76","author":"Imanaka-Yoshida","year":"2012","journal-title":"Circ. J."},{"key":"10.1016\/j.semcdb.2022.03.019_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115828","article-title":"Tenascin-C in Heart Diseases-The Role of Inflammation","volume":"22","author":"Imanaka-Yoshida","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2022.03.019_bib36","doi-asserted-by":"crossref","first-page":"C781","DOI":"10.1152\/ajpcell.00353.2020","article-title":"Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis","volume":"319","author":"Imanaka-Yoshida","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib37","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/1346-8138.12218","article-title":"Serum levels of tenascin-C in collagen diseases","volume":"40","author":"Inoue","year":"2013","journal-title":"J. Dermatol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nsmb.2756","article-title":"Splicing factor SRSF6 promotes hyperplasia of sensitized skin","volume":"21","author":"Jensen","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib39","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/sj.onc.1207064","article-title":"Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1","volume":"23","author":"Jinnin","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2022.03.019_bib40","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.jid.5700090","article-title":"Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase\/Akt and the protein kinase C signaling pathways","volume":"126","author":"Jinnin","year":"2006","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib41","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jcp.20527","article-title":"Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase\/Akt-dependent and mediated by Ets family transcription factors","volume":"206","author":"Jinnin","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib42","article-title":"Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts","volume":"10","author":"Johnson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2022.03.019_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/hh1401.093582","article-title":"Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease","volume":"89","author":"Jones","year":"2001","journal-title":"Circ. Res"},{"key":"10.1016\/j.semcdb.2022.03.019_bib44","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1164\/ajrccm.154.2.8756830","article-title":"Tenascin immunoreactivity as a prognostic marker in usual interstitial pneumonia","volume":"154","author":"Kaarteenaho-Wiik","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.semcdb.2022.03.019_bib45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/PL00007619","article-title":"Tenascin is increased in epithelial lining fluid in fibrotic lung disorders","volume":"176","author":"Kaarteenaho-Wiik","year":"1998","journal-title":"Lung"},{"key":"10.1016\/j.semcdb.2022.03.019_bib46","first-page":"350","article-title":"The role of tenascin-C and oxidative stress in rheumatic and congenital heart valve diseases: an observational study","volume":"13","author":"Karatas","year":"2013","journal-title":"Anadolu Kardiyol. Derg."},{"key":"10.1016\/j.semcdb.2022.03.019_bib47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4161\/19336918.2014.994901","article-title":"Tenascins in fibrotic disorders-from bench to bedside","volume":"9","author":"Kasprzycka","year":"2015","journal-title":"Cell Adh Migr."},{"key":"10.1016\/j.semcdb.2022.03.019_bib48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jjcc.2011.11.008","article-title":"Serum tenascin-C levels as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy","volume":"59","author":"Kitaoka","year":"2012","journal-title":"J. Cardiol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib49","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1002\/hep.24639","article-title":"Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury","volume":"54","author":"Kuriyama","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.semcdb.2022.03.019_bib50","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89073","article-title":"Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity","volume":"1","author":"Lofgren","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.semcdb.2022.03.019_bib51","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1080\/09168451.2016.1165600","article-title":"Tenascin-C promotes migration of hepatic stellate cells and production of type I collagen","volume":"80","author":"Ma","year":"2016","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1016\/j.semcdb.2022.03.019_bib52","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001052","article-title":"Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation","volume":"3","author":"Machino-Ohtsuka","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.semcdb.2022.03.019_bib53","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4330\/wjc.v8.i5.340","article-title":"Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4","volume":"8","author":"Maqbool","year":"2016","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.jcb.200302126","article-title":"FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration","volume":"161","author":"McKean","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib55","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1128\/MCB.17.6.3202","article-title":"The c-Jun-induced transformation process involves complex regulation of tenascin-C expression","volume":"17","author":"Mettouchi","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib56","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm.1987","article-title":"Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease","volume":"15","author":"Midwood","year":"2009","journal-title":"Nat. Med"},{"key":"10.1016\/j.semcdb.2022.03.019_bib57","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1007\/s00018-011-0783-6","article-title":"Advances in tenascin-C biology","volume":"68","author":"Midwood","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.semcdb.2022.03.019_bib58","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1242\/jcs.190546","article-title":"Tenascin-C at a glance","volume":"129","author":"Midwood","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.semcdb.2022.03.019_bib59","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/path.1730","article-title":"Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis","volume":"205","author":"Morimoto","year":"2005","journal-title":"J. Pathol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib60","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2020.1836713","article-title":"Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo","volume":"12","author":"Nadal","year":"2020","journal-title":"MAbs"},{"key":"10.1016\/j.semcdb.2022.03.019_bib61","first-page":"1237","article-title":"Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture","volume":"152","author":"Nakao","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib62","doi-asserted-by":"crossref","first-page":"26829","DOI":"10.1074\/jbc.M100239200","article-title":"The identification of Prx1 transcription regulatory domains provides a mechanism for unequal compensation by the Prx1 and Prx2 loci","volume":"276","author":"Norris","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.03.019_bib63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/104454901750070292","article-title":"Identification of domains mediating transcription activation, repression, and inhibition in the paired-related homeobox protein, Prx2 (S8)","volume":"20","author":"Norris","year":"2001","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib64","doi-asserted-by":"crossref","first-page":"ra86","DOI":"10.1126\/scisignal.aaf3596","article-title":"Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages","volume":"9","author":"Piccinini","year":"2016","journal-title":"Sci. Signal"},{"key":"10.1016\/j.semcdb.2022.03.019_bib65","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/HJH.0000000000001628","article-title":"Tenascin-C promotes chronic pressure overload-induced cardiac dysfunction, hypertrophy and myocardial fibrosis","volume":"36","author":"Podesser","year":"2018","journal-title":"J. Hypertens."},{"key":"10.1016\/j.semcdb.2022.03.019_bib66","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1215\/15228517-2007-053","article-title":"A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost","volume":"10","author":"Reardon","year":"2008","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112371","article-title":"Increased Serum Levels of Fetal Tenascin-C Variants in Patients with Pulmonary Hypertension: Novel Biomarkers Reflecting Vascular Remodeling and Right Ventricular Dysfunction?","volume":"18","author":"Rohm","year":"2017","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2022.03.019_bib68","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/HYPERTENSIONAHA.115.06004","article-title":"Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin alphaVbeta3\/nuclear factor-kappaB\/interleukin-6 axis","volume":"66","author":"Shimojo","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.semcdb.2022.03.019_bib69","first-page":"401","article-title":"Serum tenascin-C levels in atrium predict atrial structural remodeling processes in patients with atrial fibrillation","volume":"59","author":"Shiomi","year":"2020","journal-title":"J. Inter. Card. Electro"},{"key":"10.1016\/j.semcdb.2022.03.019_bib70","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.jacc.2017.07.789","article-title":"Bone Marrow-Derived Tenascin-C Attenuates Cardiac Hypertrophy by Controlling Inflammation","volume":"70","author":"Song","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib71","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9440(10)62954-9","article-title":"Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury","volume":"167","author":"Tamaoki","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib72","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/hrt.75.3.291","article-title":"Tenascin expression in endomyocardial biopsy specimens in patients with dilated cardiomyopathy: distribution along margin of fibrotic lesions","volume":"75","author":"Tamura","year":"1996","journal-title":"Heart"},{"key":"10.1016\/j.semcdb.2022.03.019_bib73","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","article-title":"Innate immunity in diabetic kidney disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib74","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1253\/circj.71.327","article-title":"Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy","volume":"71","author":"Terasaki","year":"2007","journal-title":"Circ. J."},{"key":"10.1016\/j.semcdb.2022.03.019_bib75","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/CIRCRESAHA.107.158220","article-title":"Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction","volume":"102","author":"Timmers","year":"2008","journal-title":"Circ. Res"},{"key":"10.1016\/j.semcdb.2022.03.019_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125793","article-title":"Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR)","volume":"10","author":"Trussoni","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2022.03.019_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237889","article-title":"Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment","volume":"15","author":"Wawrzyniak","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2022.03.019_bib78","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2015.09.024","article-title":"The function of miR-199a-5p\/Klotho regulating TLR4\/NF-kappaB p65\/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism","volume":"417","author":"Wu","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib79","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ejhf.464","article-title":"Significance of myocardial tenascin-C expression in left ventricular remodelling and long-term outcome in patients with dilated cardiomyopathy","volume":"18","author":"Yokokawa","year":"2016","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.semcdb.2022.03.019_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.620541","article-title":"Generation of transgenic mice that conditionally overexpress tenascin-C","volume":"12","author":"Yonebayashi","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.semcdb.2022.03.019_bib81","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.21037\/atm-2020-116","article-title":"Tenascin-C: an emerging prognostic biomarker in diabetes","volume":"8","author":"Yonebayashi","year":"2020","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.semcdb.2022.03.019_bib82","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12969-021-00562-w","article-title":"Serum tenascin-C predicts resistance to steroid combination therapy in high-risk Kawasaki disease: a multicenter prospective cohort study","volume":"19","author":"Yoshikane","year":"2021","journal-title":"Pedia Rheuma Online J."},{"key":"10.1016\/j.semcdb.2022.03.019_bib83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4239\/wjd.v12.i1.19","article-title":"Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC\/TLR4\/NF-kappaB\/miR-155-5p inflammatory loop","volume":"12","author":"Zhou","year":"2021","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.semcdb.2022.03.019_bib84","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.kint.2020.01.026","article-title":"Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via alphavbeta6 integrin signaling","volume":"97","author":"Zhu","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.semcdb.2022.03.019_bib85","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-017-01718-7","article-title":"Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers","volume":"8","author":"Zuliani-Alvarez","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2022.03.019_bib86","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/wound.2014.0599","article-title":"Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing","volume":"4","author":"Zuliani-Alvarez","year":"2015","journal-title":"Adv. Wound Care (N. Rochelle)"}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952122000878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952122000878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:08:57Z","timestamp":1761066537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952122000878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":86,"alternative-id":["S1084952122000878"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2022.03.019","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tenascin-C in fibrosis in multiple organs: Translational implications","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2022.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}