{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:44:21Z","timestamp":1791333861937,"version":"4.3.1"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"am","delay-in-days":125,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM138199"],"award-info":[{"award-number":["R35GM138199"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.semcdb.2022.12.004","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T21:09:22Z","timestamp":1672780162000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Good cop, bad cop: Polyamines play both sides in host immunity and viral replication"],"prefix":"10.1016","volume":"146","author":[{"given":"Yazmin E.","family":"Cruz-Pulido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan C.","family":"Mounce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2022.12.004_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/360597a0","article-title":"Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination","volume":"360","author":"Murakami","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2022.12.004_bib2","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1093\/emboj\/cdg158","article-title":"Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate","volume":"22","author":"Zhang","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2022.12.004_bib3","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1073\/pnas.91.9.3959","article-title":"Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting","volume":"91","author":"Rom","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2022.12.004_bib4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1042\/bj2040647","article-title":"A macromolecular inhibitor of the antizyme to ornithine decarboxylase","volume":"204","author":"Fujita","year":"1982","journal-title":"Biochem. J."},{"key":"10.1016\/j.semcdb.2022.12.004_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1042\/bj3460699","article-title":"Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression","volume":"346","author":"Nilsson","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.semcdb.2022.12.004_bib6","doi-asserted-by":"crossref","first-page":"23917","DOI":"10.18632\/oncotarget.4469","article-title":"Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.semcdb.2022.12.004_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00726-013-1598-6","article-title":"Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines","volume":"46","author":"Murakami","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.semcdb.2022.12.004_bib8","doi-asserted-by":"crossref","first-page":"9495","DOI":"10.1021\/bi010736o","article-title":"Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant","volume":"40","author":"Ekstrom","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.semcdb.2022.12.004_bib9","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1021\/bi0603975","article-title":"Mechanisms of allosteric regulation of trypanosoma cruzi S-adenosylmethionine decarboxylase","volume":"45","author":"Beswick","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.semcdb.2022.12.004_bib10","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1074\/jbc.M108375200","article-title":"Regulated translation termination at the upstream open reading frame in S-adenosylmethionine decarboxylase mRNA","volume":"277","author":"Lynn","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib11","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1261\/rna.39806","article-title":"Polyamine-regulated unproductive splicing and translation of spermidine\/spermine N1-acetyltransferase","volume":"12","author":"Hyv\u00f6nen","year":"2006","journal-title":"RNA"},{"key":"10.1016\/j.semcdb.2022.12.004_bib12","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1016\/S0021-9258(18)96507-5","article-title":"Multiple pathways of putrescine biosynthesis in Escherichia coli","volume":"241","author":"Morris","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1099\/mic.0.26009-0","article-title":"Identification of the putrescine biosynthetic genes in Pseudomonas aeruginosa and characterization of agmatine deiminase and N-carbamoylputrescine amidohydrolase of the arginine decarboxylase pathway","volume":"149","author":"Nakada","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1046\/j.1365-313X.2001.01100.x","article-title":"Arabidopsis polyamine biosynthesis: absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity","volume":"27","author":"Hanfrey","year":"2001","journal-title":"Plant J."},{"key":"10.1016\/j.semcdb.2022.12.004_bib15","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/BJ20041260","article-title":"Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine","volume":"388","author":"Horyn","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.semcdb.2022.12.004_bib16","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1471-4159.2005.03544.x","article-title":"Expression of arginine decarboxylase in brain regions and neuronal cells","volume":"96","author":"Iyo","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib17","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1046\/j.1471-4159.2000.0742201.x","article-title":"Characterization of arginine decarboxylase in rat brain and liver: distinction from ornithine decarboxylase","volume":"74","author":"Regunathan","year":"2000","journal-title":"J. Neurochem"},{"key":"10.1016\/j.semcdb.2022.12.004_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.114637","article-title":"Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses","volume":"90","author":"Wang","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2022.12.004_bib19","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1042\/bst0040610","article-title":"A new pathway for the biosynthesis of spermidine","volume":"4","author":"Tait","year":"1976","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.semcdb.2022.12.004_bib20","doi-asserted-by":"crossref","first-page":"9899","DOI":"10.1074\/jbc.M900110200","article-title":"An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in vibrio cholerae","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib21","doi-asserted-by":"crossref","first-page":"43301","DOI":"10.1074\/jbc.M111.307835","article-title":"Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota","volume":"286","author":"Hanfrey","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib22","first-page":"130","article-title":"Unusual polyamines in aquatic plants: the occurrence of homospermidine, norspermidine, thermospermine, norspermine, aminopropylhomospermidine, bis(aminopropyl)ethanediamine, and methylspermidine","volume":"76","author":"Hamana","year":"1998","journal-title":"Can. J. Bot."},{"key":"10.1016\/j.semcdb.2022.12.004_bib23","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1016\/j.febslet.2007.05.074","article-title":"Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine","volume":"581","author":"Knott","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.semcdb.2022.12.004_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0076-6879(83)94070-3","article-title":"Polyamines in thermus thermophilus: isolation, identification, and chemical synthesis","volume":"94","author":"Oshima","year":"1983","journal-title":"Methods Enzym."},{"issue":"1","key":"10.1016\/j.semcdb.2022.12.004_bib25","first-page":"21","article-title":"Temperature and salt dependent long linear and branched polyamine syntheses in the thermophiles belonging to the domain Archaea","volume":"7","author":"Hamana","year":"2008","journal-title":"J. Jpn. Soc. Extrem"},{"key":"10.1016\/j.semcdb.2022.12.004_bib26","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1128\/JB.00279-10","article-title":"Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis","volume":"192","author":"Morimoto","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib27","doi-asserted-by":"crossref","first-page":"20803","DOI":"10.1016\/S0021-9258(18)54780-3","article-title":"Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver","volume":"266","author":"Watanabe","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/07391102.1988.10507710","article-title":"Different binding modes of spermine to a-t and g-c base pairs modulate the bendingand stiffening of the dna double helix","volume":"6","author":"Marquet","year":"1988","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.semcdb.2022.12.004_bib29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/07391102.1986.10506340","article-title":"The condensation of chromatin and histone hi-depleted chromatin by spermine","volume":"4","author":"Marquet","year":"1986","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.semcdb.2022.12.004_bib30","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1021\/bi00386a058","article-title":"Polyamines and acetylpolyamines increase the stability and alter the conformation of nucleosome core particles","volume":"26","author":"Morgan","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.semcdb.2022.12.004_bib31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/bip.360240411","article-title":"Differential effects on the B\u2010to\u2010Z transition of Poly(dG\u2010me5dC)\u00b7Poly(dG\u2010me5dC) Produced by N1\u2013and N8\u2013Acetyle Spermidine","volume":"24","author":"Thomas","year":"1985","journal-title":"Biopolymers"},{"key":"10.1016\/j.semcdb.2022.12.004_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/(SICI)1097-4644(20000601)77:3<345::AID-JCB1>3.0.CO;2-P","article-title":"High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation","volume":"77","author":"Hobbs","year":"2000","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib33","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1261\/rna.1994310","article-title":"Probing tRNA interaction with biogenic polyamines","volume":"16","author":"Ouameur","year":"2010","journal-title":"RNA"},{"key":"10.1016\/j.semcdb.2022.12.004_bib34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0006-291X(84)80068-6","article-title":"Polyamine binding to phospholipid vesicles and inhibition of lipid peroxidation","volume":"122","author":"Tadolini","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2022.12.004_bib35","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1016\/0006-2952(86)90024-9","article-title":"The binding of polyamines to phospholipid bilayers","volume":"35","author":"Yung","year":"1986","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.semcdb.2022.12.004_bib36","doi-asserted-by":"crossref","first-page":"22517","DOI":"10.1016\/S0021-9258(17)31677-0","article-title":"Polyamine inhibition of transbilayer movement of plasma membrane phospholipids in the erythrocyte ghost*","volume":"269","author":"Bratton","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib37","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1016\/S0021-9258(18)34559-9","article-title":"The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine)","volume":"257","author":"Park","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00806584","article-title":"The polyamine-derived amino acid hypusine: Its post-translational formation in eIF-5A and its role in cell proliferation","volume":"10","author":"Park","year":"1996","journal-title":"Amino Acids"},{"key":"10.1016\/j.semcdb.2022.12.004_bib39","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1073\/pnas.78.5.2869","article-title":"Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor","volume":"78","author":"Park","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2022.12.004_bib40","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1073\/pnas.80.7.1854","article-title":"Identification of the hypusine-containing protein Hy+ as translation initiation factor eIF-4D","volume":"80","author":"Cooper","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2022.12.004_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molcel.2013.04.021","article-title":"eif5A promotes translation of polyproline motifs","volume":"51","author":"Gutierrez","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcdb.2022.12.004_bib42","doi-asserted-by":"crossref","first-page":"27827","DOI":"10.1016\/S0021-9258(18)46861-5","article-title":"Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines","volume":"269","author":"Park","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib43","first-page":"115","article-title":"Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation","volume":"1221","author":"Hanauske-Abel","year":"1994","journal-title":"BBA\u00a0Mol. Cell Res"},{"key":"10.1016\/j.semcdb.2022.12.004_bib44","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0006-291X(87)80279-6","article-title":"Additive growth-inhibitory effects of DL-\u03b1-difluoromethylornithine and antiestrogens on MCF-7 breast cancer cell line","volume":"148","author":"Thomas","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"219","key":"10.1016\/j.semcdb.2022.12.004_bib45","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.6823570","article-title":"Spermidine requirement for cell proliferation in eukaroytic cells: structural specificity and quantitation","volume":"80","author":"Porter","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2022.12.004_bib46","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.1999.276.3.C684","article-title":"Polyamine depletion arrests cell cycle and induces inhibitors p21(Waf1)\/(Cip1), p27(Kip1), and p53 in IEC-6 cells","volume":"276","author":"Ray","year":"1999","journal-title":"Am. J. Physiol. - Cell Physiol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib47","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1006\/bbrc.1994.1990","article-title":"Activation of the proto-oncogene c-myc and c-fos by c-ras: Involvement of polyamines","volume":"202","author":"Tabib","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2022.12.004_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aax0715","article-title":"Hypusine biosynthesis in \u03b2 cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis","volume":"12","author":"Levasseur","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.semcdb.2022.12.004_bib49","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1016\/S0021-9258(18)68954-9","article-title":"The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells","volume":"263","author":"Holtta","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-3835(95)03763-M","article-title":"Involvement of the polyamine pathway in breast cancer progression","volume":"92","author":"Manni","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.semcdb.2022.12.004_bib51","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1038\/sj.onc.1201748","article-title":"Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA","volume":"16","author":"Pyronnet","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2022.12.004_bib52","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1016\/S0021-9258(19)41234-9","article-title":"Enhanced differential synthesis of proteins in a mammalian cell free system by addition of polyamines","volume":"250","author":"Atkins","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib53","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0006-291X(75)90798-6","article-title":"Defective 30S ribosomal particles in a polyamine auxotroph of Escherichia coli","volume":"67","author":"Echandi","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2022.12.004_bib54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1432-1033.1985.tb09188.x","article-title":"Polyamine depletion results in impairment of polyribosome formation and protein synthesis before onset of DNA synthesis in mitogen\u2010activated human lymphocytes","volume":"152","author":"H\u00d6LTT\u00c4","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib55","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0006-291X(79)91541-9","article-title":"Comparative studies on the increase by polyamines of fidelity of protein synthesis in Escherichia coli and wheat germ cell-free systems","volume":"91","author":"Igarashi","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2022.12.004_bib56","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.127.3302.814.b","article-title":"Presence of polyamines in certain bacterial viruses","volume":"127","author":"Ames","year":"1958","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2022.12.004_bib57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0042-6822(57)90061-2","article-title":"Some minor components of bacteriophage T2 particles","volume":"4","author":"Hershey","year":"1957","journal-title":"Virology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib58","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1016\/S0021-9258(17)43142-5","article-title":"Radiochemical determination of polyamines in poliovirus and human rhinovirus 14","volume":"259","author":"Fout","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0042-6822(62)90117-4","article-title":"Nature of the polyamine in plant viruses","volume":"17","author":"Johnson","year":"1962","journal-title":"Virology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib60","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0042-6822(83)90090-9","article-title":"Carbon-13 and proton nuclear magnetic resonance spectroscopy of plant viruses: evidence for protein-nucleic acid interactions in Belladonna mottle virus and detection of polyamines in turnip yellow mosaic virus","volume":"130","author":"Virudachalam","year":"1983","journal-title":"Virology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib61","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/acs.biochem.6b01166","article-title":"Packaged and free satellite tobacco mosaic virus (STMV) RNA genomes adopt distinct conformational states","volume":"56","author":"Larman","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.semcdb.2022.12.004_bib62","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1073\/pnas.68.11.2818","article-title":"Compartmentalization of spermine and spermidine in the herpes simplex virion","volume":"68","author":"Gibson","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2022.12.004_bib63","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0042-6822(85)90316-2","article-title":"The incorporation of radiolabeled polyamines and methionine into turnip yellow mosaic virus in protoplasts from infected plants","volume":"144","author":"Balint","year":"1985","journal-title":"Virology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib64","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1021\/acsinfecdis.0c00402","article-title":"Virion-associated polyamines transmit with bunyaviruses to maintain infectivity and promote entry","volume":"6","author":"Mastrodomenico","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.semcdb.2022.12.004_bib65","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00530-19","article-title":"Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions","volume":"93","author":"Mastrodomenico","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib66","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0022-2836(78)90044-X","article-title":"Studies of DNA packaging into the heads of bacteriophage lambda","volume":"126","author":"Syvanen","year":"1978","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib67","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0042-6822(77)90100-3","article-title":"Early events in the in Vitro packaging of bacteriophage \u03bb DNA","volume":"78","author":"Becker","year":"1977","journal-title":"Virology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(75)90158-8","article-title":"DNA packaging steps in bacteriophage lambda head assembly","volume":"91","author":"Kaiser","year":"1975","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01249861","article-title":"Spermidine stimulation of foot-and-mouth disease virus RNA-dependent RNA polymerase activity","volume":"36","author":"Lazarus","year":"1972","journal-title":"Arch. Gesamt Virusforsch."},{"key":"10.1016\/j.semcdb.2022.12.004_bib70","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0003-9861(75)90194-0","article-title":"Stimulation of in vitro transcription of T4 DNA by the polyamine spermidine","volume":"169","author":"Nuss","year":"1975","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.semcdb.2022.12.004_bib71","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/jvi.9.3.419-422.1972","article-title":"Polyamines in the synthesis of bacteriophage deoxyribonucleic acid. I. Lack of dependence of polyamine synthesis on bacteriophage deoxyribonucleic acid synthesis","volume":"9","author":"Dion","year":"1972","journal-title":"J. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib72","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/jvi.1.3.559-568.1967","article-title":"Differential effect of polyamines on T4 morphogenesis","volume":"1","author":"Shalitin","year":"1967","journal-title":"J. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib73","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1749-6632.1970.tb39399.x","article-title":"Effects of spermidine on the rna polymerase reaction","volume":"171","author":"Gumport","year":"1970","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.semcdb.2022.12.004_bib74","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1093\/nar\/22.14.2784","article-title":"Synthetic polyamines stimulate in vitro transcription by T7 RNA polymerase","volume":"22","author":"Frugier","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semcdb.2022.12.004_bib75","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1099\/0022-1317-49-2-397","article-title":"The effect of polyamines on herpes simplex virus type 1 DNA polymerase purified from infected baby hamster kidney cells (BHK-21\/C13)","volume":"49","author":"Wallace","year":"1980","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib76","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/S0021-9258(19)69631-6","article-title":"Polyamines stimulate DNA-directed DNA synthesis catalyzed by mammalian type C retroviral DNA polymerases","volume":"256","author":"Marcus","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib77","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0167-4781(85)90116-2","article-title":"Polyamines stimulate DNA-dependent RNA synthesis catalyzed by vaccinia virus","volume":"826","author":"Moussatch\u00e9","year":"1985","journal-title":"BBA Gene Struct. Expr."},{"key":"10.1016\/j.semcdb.2022.12.004_bib78","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0020-711X(85)90081-3","article-title":"Activation of mammalian RNA polymerases by polyamines","volume":"17","author":"Blair","year":"1985","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib79","first-page":"535","article-title":"Effect of spermidine on the activity of DNA polymerases","volume":"281","author":"Chiu","year":"1972","journal-title":"BBA Sect. Nucleic Acids Protein Synth."},{"key":"10.1016\/j.semcdb.2022.12.004_bib80","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chom.2016.06.011","article-title":"Interferon-induced spermidine-spermine acetyltransferase and polyamine depletion restrict zika and chikungunya viruses","volume":"20","author":"Mounce","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.semcdb.2022.12.004_bib81","first-page":"1172","article-title":"Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus","volume":"77","author":"Korovina","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.semcdb.2022.12.004_bib82","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01260-18","article-title":"Differential mechanisms for the involvement of polyamines and hypusinated eIF5A in ebola virus gene expression","volume":"92","author":"Olsen","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib83","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0006-291X(83)91563-2","article-title":"Spermidine and spermine stimulate the activity of T4-DNA ligase","volume":"117","author":"P\u00f6s\u00f6","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2022.12.004_bib84","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1432-1033.1975.tb21021.x","article-title":"Kinetics and effect of salts and polyamines on T4 polynucleotide ligase","volume":"60","author":"Raae","year":"1975","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib85","first-page":"638","article-title":"Activation of mammalian DNA ligase by polyamines","volume":"95","author":"Teraoka","year":"1980","journal-title":"Top. Catal."},{"key":"10.1016\/j.semcdb.2022.12.004_bib86","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0167-4838(83)90129-2","article-title":"Kinetic studies on the reaction catalyzed by DNA ligase from calf thymus","volume":"747","author":"Teraoka","year":"1983","journal-title":"Biochim. Biophys. Acta BBA Protein Struct. Mol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/v11050403","article-title":"Coxsackievirus B3 responds to polyamine depletion via enhancement of 2A and 3C protease activity","volume":"11","author":"Dial","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.semcdb.2022.12.004_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/v13020310","article-title":"Polyamine analog diethylnorspermidine restricts coxsackievirus B3 and is overcome by 2A protease mutation in vitro","volume":"13","author":"Hulsebosch","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.semcdb.2022.12.004_bib89","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1104\/pp.70.6.1592","article-title":"Effects of exogenous 1,3-diaminopropane and spermidine on senescence of oat leaves: I. Inhibition of protease activity, ethylene production, and chlorophyll loss as related to polyamine content","volume":"70","author":"Shih","year":"1982","journal-title":"Plant Physiol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib90","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.febslet.2005.01.043","article-title":"The fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase increases in the presence of polyamines","volume":"579","author":"Bakhanashvili","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.semcdb.2022.12.004_bib91","doi-asserted-by":"crossref","unstructured":"Ruhl, M. et al. Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans- activation. J. Cell Biol. 123, 1309\u20131320 (1993).","DOI":"10.1083\/jcb.123.6.1309"},{"key":"10.1016\/j.semcdb.2022.12.004_bib92","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1126\/science.271.5257.1858","article-title":"Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor elF-5A","volume":"271","author":"Bevec","year":"1996","journal-title":"Sci. (80-. )"},{"key":"10.1016\/j.semcdb.2022.12.004_bib93","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000109118","article-title":"Eukaryotic initiation factor 5A activity and HIV-1 rev function","volume":"6","author":"Bevec","year":"1997","journal-title":"NeuroSignals"},{"key":"10.1016\/j.semcdb.2022.12.004_bib94","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1742-4690-6-90","article-title":"Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A","volume":"6","author":"Hoque","year":"2009","journal-title":"Retrovirology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib95","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00882-16","article-title":"Polyamines and hypusination are required for ebolavirus gene expression and replication","volume":"7","author":"Olsen","year":"2016","journal-title":"MBio"},{"issue":"194\u2013205","key":"10.1016\/j.semcdb.2022.12.004_bib96","article-title":"eIF5A functions globally in translation elongation and termination","volume":"66","author":"Schuller","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcdb.2022.12.004_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010503","article-title":"Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection","volume":"18","author":"Fiches","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.semcdb.2022.12.004_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111234","article-title":"Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance","volume":"40","author":"Choi","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.semcdb.2022.12.004_bib99","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1021\/acsinfecdis.0c00491","article-title":"Targeting polyamines inhibits coronavirus infection by reducing cellular attachment and entry","volume":"7","author":"Firpo","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.semcdb.2022.12.004_bib100","article-title":"Polyamines and eIF5A hypusination facilitate SREBP2 translation and cholesterol synthesis to enhance enterovirus attachment and infection","volume":"2021","author":"Firpo","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.semcdb.2022.12.004_bib101","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1021\/acsinfecdis.2c00071","article-title":"Polyamine-linked cholesterol incorporation in rift valley fever virus particles promotes infectivity","volume":"8","author":"Mastrodomenico","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.semcdb.2022.12.004_bib102","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1099\/0022-1317-42-2-265","article-title":"Stimulation of ornithine decarboxylase by human cytomegalovirus","volume":"42","author":"Isom","year":"1979","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib103","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virusres.2013.07.004","article-title":"Downregulation of the polyamine regulator spermidine\/spermine N1-acetyltransferase by Epstein-Barr virus in a Burkitt\u2019s lymphoma cell line","volume":"177","author":"Shi","year":"2013","journal-title":"Virus Res"},{"key":"10.1016\/j.semcdb.2022.12.004_bib104","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbrc.2017.01.032","article-title":"Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism","volume":"483","author":"Smirnova","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2022.12.004_bib105","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/v14071418","article-title":"Transcriptional and translational dynamics of zika and dengue virus infection","volume":"14","author":"Singh","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.semcdb.2022.12.004_bib106","doi-asserted-by":"crossref","first-page":"9547","DOI":"10.1074\/jbc.C111.337816","article-title":"Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase","volume":"287","author":"Charlop-Powers","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2022.12.004_bib107","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1099\/vir.0.066951-0","article-title":"Novel gammaherpesvirus functions encoded by bovine herpesvirus 6 (bovine lymphotropic virus)","volume":"95","author":"Jia","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib108","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-020-01619-4","article-title":"Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome","volume":"4","author":"Kim","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib109","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12964-021-00717-y","article-title":"Systemic and topical administration of spermidine accelerates skin wound healing","volume":"19","author":"Ito","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.semcdb.2022.12.004_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1832857","article-title":"Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice","volume":"12","author":"Ma","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.semcdb.2022.12.004_bib111","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.immuni.2017.01.005","article-title":"A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells","volume":"46","author":"Mondanelli","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.semcdb.2022.12.004_bib112","article-title":"Spermidine suppresses inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity","volume":"23","author":"Li","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.semcdb.2022.12.004_bib113","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1182\/blood.V99.9.3263","article-title":"Type I interferons produced by dendritic cells promote their phenotypic and functional activation","volume":"99","author":"Montoya","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semcdb.2022.12.004_bib114","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1073\/pnas.1614958114","article-title":"Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications","volume":"114","author":"Hardbower","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"352\u2013363","key":"10.1016\/j.semcdb.2022.12.004_bib115","article-title":"Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation","volume":"30","author":"Puleston","year":"2019","journal-title":"Cell Metab."},{"issue":"110\u2013125","key":"10.1016\/j.semcdb.2022.12.004_bib116","article-title":"Polyamines control eIF5A hypusination, tfeb translation, and autophagy to reverse B cell senescence","volume":"76","author":"Zhang","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.semcdb.2022.12.004_bib117","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/7422","article-title":"Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients","volume":"5","author":"Baize","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.semcdb.2022.12.004_bib118","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.4049\/jimmunol.1300304","article-title":"An essential role of antibodies in the control of chikungunya virus infection","volume":"190","author":"Lum","year":"2013","journal-title":"J. Immunol."},{"issue":"4186\u20134202","key":"10.1016\/j.semcdb.2022.12.004_bib119","article-title":"Polyamine metabolism is a central determinant of helper T cell lineage fidelity","volume":"184","author":"Puleston","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2022.12.004_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108587","article-title":"Polyamines polarized Th2\/Th9 cell-fate decision by regulating GATA3 expression","volume":"693","author":"Nakamura","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.semcdb.2022.12.004_bib121","first-page":"2798","article-title":"Selective modulation by \u0251-difluoromethylornithine of T-lymphocyte and antilbody-mediated cytotoxic responses to mouse tumor allografts","volume":"46","author":"Ehrke","year":"1986","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcdb.2022.12.004_bib122","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0008-8749(87)90184-5","article-title":"Intracellular polyamine biosynthesis is required for interleukin 2 responsiveness during lymphocyte mitogenesis","volume":"106","author":"Bowlin","year":"1987","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib123","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2011.09.021","article-title":"The transcription factor myc controls metabolic reprogramming upon T lymphocyte activation","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.semcdb.2022.12.004_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.03706","article-title":"Autophagy is a critical regulator of memory CD8+ T cell formation","volume":"3","author":"Puleston","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2022.12.004_bib125","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1172\/JCI118842","article-title":"Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response","volume":"98","author":"Missale","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.semcdb.2022.12.004_bib126","first-page":"449","article-title":"Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity","volume":"25","author":"Tsai","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.semcdb.2022.12.004_bib127","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1084\/jem.175.5.1337","article-title":"Anti-cd8 impairs clearance of herpes simplex virus from the nervous system: implications for the fate of virally infected Neurons","volume":"175","author":"Simmons","year":"1992","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.semcdb.2022.12.004_bib128","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1084\/jem.191.9.1459","article-title":"CD8+ T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons","volume":"191","author":"Liu","year":"2000","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.semcdb.2022.12.004_bib129","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/0035-9203(85)90195-6","article-title":"Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial","volume":"79","author":"Van Nieuwenhove","year":"1985","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.semcdb.2022.12.004_bib130","unstructured":"Loprinzi, C.L. et al. Toxicity Evaluation of Difluoromethylornithine: Doses for Chemoprevention ri1. 5, 371\u2013374."},{"key":"10.1016\/j.semcdb.2022.12.004_bib131","article-title":"A phase I trial of DFMO targeting polyamine addiction in patients with relapsed\/refractory neuroblastoma","volume":"10","author":"Sholler","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2022.12.004_bib132","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.tiv.2007.09.017","article-title":"Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells","volume":"22","author":"qiang","year":"2008","journal-title":"Toxicol. Vitr"},{"key":"10.1016\/j.semcdb.2022.12.004_bib133","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820947489","article-title":"Thymoquinone and difluoromethylornithine (DFMO) synergistically induce apoptosis of human acute T lymphoblastic leukemia jurkat cells through the modulation of epigenetic pathways","volume":"19","author":"Alhosin","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.semcdb.2022.12.004_bib134","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/jvi.50.1.145-154.1984","article-title":"D,L-alpha-difluoromethylornithine inhibits human cytomegalovirus replication","volume":"50","author":"Gibson","year":"1984","journal-title":"J. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib135","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1128\/JVI.01347-16","article-title":"Inhibition of polyamine biosynthesis is a broad-spectrum strategy against RNA viruses","volume":"90","author":"Mounce","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.semcdb.2022.12.004_bib136","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3892\/or.2011.1592","article-title":"Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma","volume":"27","author":"Tian","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.semcdb.2022.12.004_bib137","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.biopha.2016.11.016","article-title":"DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery","volume":"84","author":"Akyol","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.semcdb.2022.12.004_bib138","first-page":"1","article-title":"Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation","volume":"1112","author":"Coni","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952122003640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952122003640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:18:05Z","timestamp":1761067085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952122003640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":138,"alternative-id":["S1084952122003640"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2022.12.004","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Good cop, bad cop: Polyamines play both sides in host immunity and viral replication","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2022.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}