{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:52:36Z","timestamp":1789570356919,"version":"build-2803163510"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009400","name":"Heinrich Heine University D\u00fcsseldorf Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.semcdb.2023.01.008","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T08:35:01Z","timestamp":1673512501000},"page":"250-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"PC","title":["Epigenetics in T-cell driven inflammation and cancer"],"prefix":"10.1016","volume":"154","author":[{"given":"Lea","family":"Falkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Buddenkotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Datsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7766","key":"10.1016\/j.semcdb.2023.01.008_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/ije\/dyr184","article-title":"The epigenotype. 1942","volume":"41","author":"Waddington","year":"2012","journal-title":"Int J. Epidemiol."},{"issue":"8","key":"10.1016\/j.semcdb.2023.01.008_bib3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet"},{"issue":"11","key":"10.1016\/j.semcdb.2023.01.008_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrg.2016.98","article-title":"Transition states and cell fate decisions in epigenetic landscapes","volume":"17","author":"Moris","year":"2016","journal-title":"Nat. Rev. Genet"},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/aam.aam_56_18","article-title":"Inflammation and cancer","volume":"18","author":"Singh","year":"2019","journal-title":"Ann. Afr. Med"},{"issue":"12","key":"10.1016\/j.semcdb.2023.01.008_bib6","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s41590-020-0802-6","article-title":"Environmental pollutants and the immune response","volume":"21","author":"Suzuki","year":"2020","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1571","article-title":"Stress-induced immune dysfunction: implications for health","volume":"5","author":"Glaser","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.semcdb.2023.01.008_bib8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41576-020-0270-8","article-title":"The evolving metabolic landscape of chromatin biology and epigenetics","volume":"21","author":"Dai","year":"2020","journal-title":"Nat. Rev. Genet"},{"issue":"11","key":"10.1016\/j.semcdb.2023.01.008_bib9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2017.07.010","article-title":"The mechanisms of T cell selection in the thymus","volume":"38","author":"Takaba","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1749-6632.1992.tb38673.x","article-title":"Apoptosis and T-cell repertoire selection in the thymus","volume":"663","author":"Owen","year":"1992","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.semcdb.2023.01.008_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"21","key":"10.1016\/j.semcdb.2023.01.008_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218011","article-title":"CD4 T helper cell subsets and related human immunological disorders","volume":"21","author":"Zhu","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2023.01.008_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.715234","article-title":"CD8(+) T Cell Exhaustion in Cancer","volume":"12","author":"Dolina","year":"2021","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.semcdb.2023.01.008_bib14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T cell exhaustion during chronic viral infection and cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu. Rev. Immunol."},{"issue":"6316","key":"10.1016\/j.semcdb.2023.01.008_bib16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1126\/science.aae0491","article-title":"The epigenetic landscape of T cell exhaustion","volume":"354","author":"Sen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2023.01.008_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/imr.13079","article-title":"Exploring epigenetic reprogramming during central nervous system infection","author":"Van Roy","year":"2022","journal-title":"Immunol. Rev."},{"issue":"6648","key":"10.1016\/j.semcdb.2023.01.008_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 A resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.semcdb.2023.01.008_bib19","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0022-2836(02)00386-8","article-title":"Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution","volume":"319","author":"Davey","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib20","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2015.14191","article-title":"Epigenetics of T lymphocytes in health and disease","volume":"145","author":"Leoni","year":"2015","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.semcdb.2023.01.008_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.669992","article-title":"Epigenetic reprogramming of CD4(+) Helper T cells as a strategy to improve anticancer immunotherapy","volume":"12","author":"Renaude","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fnmol.2018.00169","article-title":"The role of activity-dependent DNA demethylation in the adult brain and in neurological disorders","volume":"11","author":"Bayraktar","year":"2018","journal-title":"Front Mol. Neurosci."},{"issue":"12","key":"10.1016\/j.semcdb.2023.01.008_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12123657","article-title":"Non-coding RNAs as mediators of epigenetic changes in malignancies","volume":"12","author":"Kumar","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.semcdb.2023.01.008_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.canlet.2020.06.024","article-title":"Non-coding RNAs, metabolic stress and adaptive mechanisms in cancer","volume":"491","author":"Liu","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.semcdb.2023.01.008_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.644718","article-title":"Insight Into the prospects for RNAi therapy of cancer","volume":"12","author":"Tian","year":"2021","journal-title":"Front Pharm."},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2023.01.008_bib27","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.bjc.6603023","article-title":"MicroRNAs in cell proliferation, cell death, and tumorigenesis","volume":"94","author":"Hwang","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.semcdb.2023.01.008_bib28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","article-title":"MicroRNAs: synthesis, mechanism, function, and recent clinical trials","volume":"1803","author":"Wahid","year":"2010","journal-title":"Biochim Biophys. Acta"},{"issue":"10","key":"10.1016\/j.semcdb.2023.01.008_bib29","first-page":"17110","article-title":"Competing endogenous RNA in cancer: a new pattern of gene expression regulation","volume":"8","author":"Qu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12033","article-title":"NF-kappaB: roles and regulation in different CD4(+) T-cell subsets","volume":"252","author":"Oh","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.semcdb.2023.01.008_bib31","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target Ther."},{"issue":"5596","key":"10.1016\/j.semcdb.2023.01.008_bib32","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.1071914","article-title":"The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation","volume":"298","author":"Hoffmann","year":"2002","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.semcdb.2023.01.008_bib33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1158\/2326-6066.CIR-14-0112","article-title":"NF-kappaB, an active player in human cancers","volume":"2","author":"Xia","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.semcdb.2023.01.008_bib34","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3389\/fimmu.2020.01387","article-title":"The NF-kappaB Signaling pathway, the microbiota, and gastrointestinal tumorigenesis: recent advances","volume":"11","author":"Peng","year":"2020","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12272-021-01307-9","article-title":"Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases","volume":"44","author":"Seok","year":"2021","journal-title":"Arch. Pharm. Res"},{"key":"10.1016\/j.semcdb.2023.01.008_bib36","article-title":"Dopamine activates NF-kappaB and primes the NLRP3 inflammasome in primary human macrophages","volume":"2","author":"Nolan","year":"2020","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.semcdb.2023.01.008_bib37","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3389\/fimmu.2019.01412","article-title":"Structural Basis of IL-1 family cytokine signaling","volume":"10","author":"Fields","year":"2019","journal-title":"Front Immunol."},{"issue":"24","key":"10.1016\/j.semcdb.2023.01.008_bib38","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1111\/bph.12876","article-title":"IL-1beta and IL-18: inflammatory markers or mediators of hypertension?","volume":"171","author":"Krishnan","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"22","key":"10.1016\/j.semcdb.2023.01.008_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223642","article-title":"Role of long noncoding RNAs in the regulation of cellular immune response and inflammatory diseases","volume":"11","author":"Feng","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.semcdb.2023.01.008_bib40","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3389\/fimmu.2018.02061","article-title":"The dual nature of type I and type II interferons","volume":"9","author":"Lee","year":"2018","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.semcdb.2023.01.008_bib41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.semcdb.2023.01.008_bib42","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.immuni.2013.05.007","article-title":"Cytosolic sensing of viruses","volume":"38","author":"Goubau","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.semcdb.2023.01.008_bib43","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3389\/fimmu.2019.00778","article-title":"Sources of type I interferons in infectious immunity: plasmacytoid dendritic cells not always in the Driver's seat","volume":"10","author":"Ali","year":"2019","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4049\/jimmunol.164.1.64","article-title":"Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells","volume":"164","author":"Fukao","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib46","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3389\/fimmu.2019.01425","article-title":"An NFkappaB activity calculator to delineate signaling crosstalk: type I and II interferons enhance nfkappab via distinct mechanisms","volume":"10","author":"Mitchell","year":"2019","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ni887","article-title":"Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process","volume":"4","author":"Bruniquel","year":"2003","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib48","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.4049\/jimmunol.176.7.4083","article-title":"Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells","volume":"176","author":"Kersh","year":"2006","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.semcdb.2023.01.008_bib49","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2014.07.031","article-title":"Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus","volume":"158","author":"Feng","year":"2014","journal-title":"Cell"},{"issue":"7310","key":"10.1016\/j.semcdb.2023.01.008_bib50","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nature09303","article-title":"Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification","volume":"466","author":"Ito","year":"2010","journal-title":"Nature"},{"issue":"5929","key":"10.1016\/j.semcdb.2023.01.008_bib51","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.semcdb.2023.01.008_bib52","doi-asserted-by":"crossref","first-page":"627","DOI":"10.18632\/oncotarget.316","article-title":"Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem\/progenitor cell compartments and in human cancers","volume":"2","author":"Haffner","year":"2011","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.immuni.2018.01.013","article-title":"Transformation of accessible chromatin and 3D nucleome underlies lineage commitment of early T cells","volume":"48","author":"Hu","year":"2018","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.immuni.2018.01.012","article-title":"Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells","volume":"48","author":"Johnson","year":"2018","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib55","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jaci.2018.07.014","article-title":"Epigenetic mechanisms regulating T-cell responses","volume":"142","author":"Schmidl","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.semcdb.2023.01.008_bib56","doi-asserted-by":"crossref","first-page":"515","DOI":"10.15252\/embj.201592534","article-title":"Inducible chromatin priming is associated with the establishment of immunological memory in T cells, The","volume":"35","author":"Bevington","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2023.01.008_bib57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10134","article-title":"Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells","volume":"5","author":"Allison","year":"2016","journal-title":"Elife"},{"issue":"6","key":"10.1016\/j.semcdb.2023.01.008_bib58","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1084\/jem.20060066","article-title":"T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent","volume":"203","author":"Zhang","year":"2006","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib59","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1093\/jimmunol\/194.7.2961","article-title":"Pillars article: a novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000. 100: 655-669","volume":"194","author":"Szabo","year":"2015","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.semcdb.2023.01.008_bib60","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1172\/JCI72477","article-title":"Regulatory T cells use \"Itch\" to control asthma","volume":"123","author":"Chen","year":"2013","journal-title":"J. Clin. Invest"},{"issue":"39","key":"10.1016\/j.semcdb.2023.01.008_bib61","doi-asserted-by":"crossref","first-page":"40640","DOI":"10.1074\/jbc.M407576200","article-title":"Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression","volume":"279","author":"Morinobu","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"31","key":"10.1016\/j.semcdb.2023.01.008_bib62","doi-asserted-by":"crossref","first-page":"11410","DOI":"10.1073\/pnas.0403334101","article-title":"Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development","volume":"101","author":"Baguet","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.semcdb.2023.01.008_bib63","doi-asserted-by":"crossref","first-page":"8372","DOI":"10.4049\/jimmunol.181.12.8372","article-title":"T-Bet Dependent Removal of Sin3A-Histone Deacetylase Complexes at the Ifng Locus Drives Th1 Differentiation","volume":"181","author":"Chang","year":"2008","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.semcdb.2023.01.008_bib64","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.immuni.2013.09.012","article-title":"The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells","volume":"39","author":"Tumes","year":"2013","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib65","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/eji.201545550","article-title":"Generating long-lived CD8(+) T-cell memory: insights from epigenetic programs","volume":"46","author":"Dogra","year":"2016","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.semcdb.2023.01.008_bib66","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.4049\/jimmunol.1301395","article-title":"Global DNA methylation remodeling accompanies CD8 T cell effector function","volume":"191","author":"Scharer","year":"2013","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.semcdb.2023.01.008_bib67","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri3173","article-title":"The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation","volume":"12","author":"Weng","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.semcdb.2023.01.008_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123459","article-title":"New insights into epigenetic regulation of T cell differentiation","volume":"10","author":"Dutta","year":"2021","journal-title":"Cells"},{"issue":"25","key":"10.1016\/j.semcdb.2023.01.008_bib69","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1182\/blood-2008-07-170589","article-title":"MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1","volume":"113","author":"Garzon","year":"2009","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib70","doi-asserted-by":"crossref","first-page":"14647","DOI":"10.3390\/ijms140714647","article-title":"miR-29 represses the activities of DNA methyltransferases and DNA demethylases","volume":"14","author":"Morita","year":"2013","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib71","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cell.2013.06.026","article-title":"MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling","volume":"154","author":"Song","year":"2013","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.semcdb.2023.01.008_bib72","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/ni.1797","article-title":"An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a","volume":"10","author":"Ebert","year":"2009","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.semcdb.2023.01.008_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077983","article-title":"MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase zeta","volume":"8","author":"Shin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2023.01.008_bib74","doi-asserted-by":"crossref","first-page":"16399","DOI":"10.1038\/srep16399","article-title":"miR-150 regulates differentiation and cytolytic effector function in CD8+ T cells","volume":"5","author":"Smith","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib75","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1534\/genetics.115.179176","article-title":"MicroRNAs and their targets are differentially regulated in adult and neonatal mouse CD8+ T cells","volume":"201","author":"Wissink","year":"2015","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib76","first-page":"131","article-title":"Mechanism of T cell regulation by microRNAs","volume":"10","author":"Liu","year":"2013","journal-title":"Cancer Biol. Med"},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib77","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/imr.13029","article-title":"Cell-intrinsic and -extrinsic roles of miRNAs in regulating T cell immunity","volume":"304","author":"Cho","year":"2021","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.semcdb.2023.01.008_bib78","first-page":"967","article-title":"Genome wide DNA methylation landscape reveals glioblastoma's influence on epigenetic changes in tumor infiltrating CD4+ T cells. Oncotarget","volume":"12","author":"Bam","year":"2021"},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib79","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1393596","article-title":"Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype","volume":"7","author":"Borgoni","year":"2018","journal-title":"Oncoimmunology"},{"issue":"4","key":"10.1016\/j.semcdb.2023.01.008_bib80","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1158\/0008-5472.CAN-09-2755","article-title":"Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells","volume":"70","author":"Niwa","year":"2010","journal-title":"Cancer Res."},{"issue":"Suppl 5","key":"10.1016\/j.semcdb.2023.01.008_bib81","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2164-15-S5-S7","article-title":"Transcriptome assembly and quantification from Ion Torrent RNA-Seq data","volume":"15","author":"Mangul","year":"2014","journal-title":"BMC Genom."},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib82","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2011.06.015","article-title":"Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells","volume":"35","author":"Youngblood","year":"2011","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib83","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41590-021-00949-7","article-title":"Not-so-opposite ends of the spectrum: CD8(+) T cell dysfunction across chronic infection, cancer and autoimmunity","volume":"22","author":"Collier","year":"2021","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.semcdb.2023.01.008_bib84","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s41590-022-01224-z","article-title":"Epigenetic regulation of T cell exhaustion","volume":"23","author":"Belk","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib85","article-title":"Role of the orphan nuclear receptor NR4A family in T-cell biology","volume":"11","author":"Odagiu","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"8","key":"10.1016\/j.semcdb.2023.01.008_bib86","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41590-021-00979-1","article-title":"Epigenetic scars of CD8(+) T cell exhaustion persist after cure of chronic infection in humans","volume":"22","author":"Yates","year":"2021","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib87","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(02)01080-2","article-title":"Cellular memory and the histone code","volume":"111","author":"Turner","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2023.01.008_bib88","article-title":"The interplay between epigenetic regulation and CD8(+) T cell differentiation\/exhaustion for T cell immunotherapy","volume":"9","author":"Wong","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib89","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13059-019-1921-y","article-title":"Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis","volume":"21","author":"Yang","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.semcdb.2023.01.008_bib90","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3389\/fimmu.2019.00856","article-title":"The emerging epigenetic role of CD8+T cells in autoimmune diseases: a systematic review","volume":"10","author":"Deng","year":"2019","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib91","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.immuni.2016.12.015","article-title":"SATB1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells","volume":"46","author":"Stephen","year":"2017","journal-title":"Immunity"},{"issue":"21","key":"10.1016\/j.semcdb.2023.01.008_bib92","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.2217\/epi-2020-0267","article-title":"Epigenetic regulation of immune checkpoints and T cell exhaustion markers in tumor-infiltrating T cells of colorectal cancer patients","volume":"12","author":"Sasidharan Nair","year":"2020","journal-title":"Epigenomics"},{"issue":"7764","key":"10.1016\/j.semcdb.2023.01.008_bib93","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","article-title":"TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion","volume":"571","author":"Khan","year":"2019","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.semcdb.2023.01.008_bib94","doi-asserted-by":"crossref","first-page":"12410","DOI":"10.1073\/pnas.1905675116","article-title":"TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion","volume":"116","author":"Seo","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.semcdb.2023.01.008_bib95","article-title":"Non-coding RNAs: Key players in T cell exhaustion","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol."},{"issue":"10","key":"10.1016\/j.semcdb.2023.01.008_bib96","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/ijc.30912","article-title":"MiR-15a\/16 deficiency enhances anti-tumor immunity of glioma-infiltrating CD8+ T cells through targeting mTOR","volume":"141","author":"Yang","year":"2017","journal-title":"Int J. Cancer"},{"issue":"12","key":"10.1016\/j.semcdb.2023.01.008_bib97","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1158\/2326-6066.CIR-17-0479","article-title":"Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg\/Th17 cell imbalance in epithelial ovarian cancer","volume":"6","author":"Zhou","year":"2018","journal-title":"Cancer Immunol. Res."},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib98","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1448330","article-title":"Leukemia cell-derived microvesicles induce T cell exhaustion via miRNA delivery","volume":"7","author":"Cui","year":"2018","journal-title":"Oncoimmunology"},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib99","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1158\/2326-6066.CIR-19-0522","article-title":"MicroRNAs in tumor exosomes drive immune escape in melanoma","volume":"8","author":"Vignard","year":"2020","journal-title":"Cancer Immunol. Res."},{"issue":"10","key":"10.1016\/j.semcdb.2023.01.008_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046874","article-title":"Identifying mRNA, microRNA and protein profiles of melanoma exosomes","volume":"7","author":"Xiao","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.semcdb.2023.01.008_bib101","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1016\/j.celrep.2017.08.065","article-title":"miR-150-Mediated Foxo1 Regulation Programs CD8(+) T Cell Differentiation","volume":"20","author":"Ban","year":"2017","journal-title":"Cell Rep."},{"issue":"33","key":"10.1016\/j.semcdb.2023.01.008_bib102","doi-asserted-by":"crossref","first-page":"53735","DOI":"10.18632\/oncotarget.10731","article-title":"miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"issue":"21","key":"10.1016\/j.semcdb.2023.01.008_bib103","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1073\/pnas.0914127107","article-title":"Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory","volume":"107","author":"Jeannet","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.semcdb.2023.01.008_bib104","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.immuni.2010.08.002","article-title":"Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1","volume":"33","author":"Zhou","year":"2010","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069677","article-title":"4-1BB signaling activates the t cell factor 1 effector\/beta-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K\/AKT activation to promote the proliferation of CD8+ T Cells","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.semcdb.2023.01.008_bib106","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1158\/0008-5472.CAN-13-2690","article-title":"LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses","volume":"74","author":"Xu","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.semcdb.2023.01.008_bib107","doi-asserted-by":"crossref","first-page":"30923","DOI":"10.1038\/srep30923","article-title":"MicroRNA-491 regulates the proliferation and apoptosis of CD8(+) T cells","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."},{"issue":"35","key":"10.1016\/j.semcdb.2023.01.008_bib108","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1038\/sj.onc.1205699","article-title":"5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy","volume":"21","author":"Christman","year":"2002","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.semcdb.2023.01.008_bib109","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13148-021-01154-x","article-title":"DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application","volume":"13","author":"Hu","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.semcdb.2023.01.008_bib110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/1476-4598-9-305","article-title":"Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation","volume":"9","author":"Gravina","year":"2010","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.semcdb.2023.01.008_bib111","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.molcel.2021.01.038","article-title":"DNA hypomethylating agents increase activation and cytolytic activity of CD8(+) T cells","volume":"81","author":"Loo Yau","year":"2021","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib112","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1158\/1078-0432.CCR-19-0727","article-title":"Cooperative immune-mediated mechanisms of the HDAC inhibitor entinostat, an IL15 superagonist, and a cancer vaccine effectively synergize as a novel cancer therapy","volume":"26","author":"Hicks","year":"2020","journal-title":"Clin. Cancer Res"},{"issue":"49","key":"10.1016\/j.semcdb.2023.01.008_bib113","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1038\/onc.2015.46","article-title":"Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity","volume":"34","author":"Cao","year":"2015","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.semcdb.2023.01.008_bib114","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00262-018-2283-0","article-title":"Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model","volume":"68","author":"Llopiz","year":"2019","journal-title":"Cancer Immunol. Immunother."}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952123000083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952123000083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:19:10Z","timestamp":1761067150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952123000083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":114,"alternative-id":["S1084952123000083"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2023.01.008","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetics in T-cell driven inflammation and cancer","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2023.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}