{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:51:35Z","timestamp":1792003895440,"version":"4.4.0"},"reference-count":154,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell & Developmental Biology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.semcdb.2023.07.010","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:20:20Z","timestamp":1690334420000},"page":"244-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Vagal pathways for systemic regulation of glucose metabolism"],"prefix":"10.1016","volume":"156","author":[{"given":"Diba","family":"Borgmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Fenselau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.6","article-title":"Pancreatic regulation of glucose homeostasis","volume":"48","author":"R\u00f6der","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.semcdb.2023.07.010_bib2","article-title":"Le\u00e7ons de physiologie exp\u00e9rimentale appliqu\u00e9e \u00e0 la m\u00e9decine: faites au Coll\u00e8ge de France","author":"Bernard","year":"1855","journal-title":"JB Bailli\u00e8re Et. fils"},{"key":"10.1016\/j.semcdb.2023.07.010_bib3","doi-asserted-by":"crossref","first-page":"15259","DOI":"10.1038\/ncomms15259","article-title":"Neuronal control of peripheral insulin sensitivity and glucose metabolism","volume":"8","author":"Ruud","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib4","first-page":"125","article-title":"AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose","volume":"165","author":"Steculorum","year":"2016","journal-title":"Tissue, Cell"},{"issue":"7","key":"10.1016\/j.semcdb.2023.07.010_bib5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.cmet.2022.06.001","article-title":"The cephalic phase of insulin release is modulated by IL-1\u03b2","volume":"34","author":"Wiedemann","year":"2022","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib6","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s42255-021-00408-5","article-title":"Central nervous system regulation of organismal energy and glucose homeostasis","volume":"3","author":"Myers","year":"2021","journal-title":"Nat. Metab."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.beem.2014.05.002","article-title":"Neural control of the endocrine pancreas","volume":"28","author":"Rodriguez-Diaz","year":"2014","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib8","doi-asserted-by":"crossref","first-page":"G651","DOI":"10.1152\/ajpgi.00195.2018","article-title":"Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome","volume":"315","author":"Metz","year":"2018","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0165-1838(83)90044-9","article-title":"Central connections of the hepatic branch of the vagus nerve: a horseradish peroxidase histochemical study","volume":"7","author":"Rogers","year":"1983","journal-title":"J. Auton. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib10","doi-asserted-by":"crossref","first-page":"R523","DOI":"10.1152\/ajpregu.1990.258.2.R523","article-title":"Identification of vagal preganglionics that mediate cephalic phase insulin response","volume":"258","author":"Berthoud","year":"1990","journal-title":"Am. J. Physiol. -Regul., Integr. Comp. Physiol."},{"key":"10.1016\/j.semcdb.2023.07.010_bib11","article-title":"Gut-brain circuits for fat preference","author":"Li","year":"2022","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","article-title":"Sensory neurons that detect stretch and nutrients in the digestive system","volume":"166","author":"Williams","year":"2016","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib13","doi-asserted-by":"crossref","first-page":"R657","DOI":"10.1152\/ajpregu.00345.2011","article-title":"Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus","volume":"302","author":"Lee","year":"2012","journal-title":"Am. J. Physiol. -Regul., Integr. Comp. Physiol."},{"key":"10.1016\/j.semcdb.2023.07.010_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1463-1326.2011.01453.x","article-title":"Brain glucose sensing and neural regulation of insulin and glucagon secretion","volume":"13","author":"Thorens","year":"2011","journal-title":"Diabetes, Obes. Metab."},{"key":"10.1016\/j.semcdb.2023.07.010_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101175","article-title":"The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders","volume":"46","author":"Richards","year":"2021","journal-title":"Mol. Metab."},{"issue":"10","key":"10.1016\/j.semcdb.2023.07.010_bib16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-018-0062-1","article-title":"The metabolic role of vagal afferent innervation","volume":"15","author":"Waise","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7190","key":"10.1016\/j.semcdb.2023.07.010_bib17","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/nature06852","article-title":"Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production","volume":"452","author":"Wang","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib18","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cmet.2017.04.032","article-title":"Gut-Brain Glucose Signaling in Energy Homeostasis","volume":"25","author":"Soty","year":"2017","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrn.2018.8","article-title":"Signalling from the periphery to the brain that regulates energy homeostasis","volume":"19","author":"Kim","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Auton. Neurosci.: Basic Clin."},{"issue":"6778","key":"10.1016\/j.semcdb.2023.07.010_bib21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"issue":"5487","key":"10.1016\/j.semcdb.2023.07.010_bib22","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Br\u00fcning","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cmet.2007.05.004","article-title":"Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production","volume":"5","author":"K\u00f6nner","year":"2007","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib24","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1172\/JCI59816","article-title":"Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice","volume":"122","author":"Berglund","year":"2012","journal-title":"J. Clin. Invest"},{"issue":"13","key":"10.1016\/j.semcdb.2023.07.010_bib25","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.neuron.2021.05.004","article-title":"Highly selective brain-to-gut communication via genetically defined vagus neurons","volume":"109","author":"Tao","year":"2021","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib26","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2019.10.031","article-title":"Genetic Identification of Vagal Sensory Neurons That Control Feeding","volume":"179","author":"Bai","year":"2019","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.semcdb.2023.07.010_bib27","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An Atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s42255-021-00363-1","article-title":"A genetic map of the mouse dorsal vagal complex and its role in obesity","volume":"3","author":"Ludwig","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.semcdb.2023.07.010_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101240","article-title":"A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing","volume":"53","author":"Dowsett","year":"2021","journal-title":"Mol. Metab."},{"issue":"7","key":"10.1016\/j.semcdb.2023.07.010_bib30","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cmet.2021.05.002","article-title":"Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism","volume":"33","author":"Borgmann","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.semcdb.2023.07.010_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/B978-0-444-64032-1.00027-8","article-title":"Basics of autonomic nervous system function","volume":"160","author":"Gibbons","year":"2019","journal-title":"Handb. Clin. Neurol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1113\/jphysiol.1969.sp008974","article-title":"Secretomotor function of the dorsal motor nucleus of the vagus","volume":"205","author":"Kerr","year":"1969","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00125-017-4409-x","article-title":"Human pancreatic neuro-insular network in health and fatty infiltration","volume":"61","author":"Tang","year":"2018","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1748-1716.1982.tb07158.x","article-title":"Effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats","volume":"116","author":"Andersson","year":"1982","journal-title":"Acta Physiol. Scand."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib35","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12718","article-title":"Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation","volume":"4","author":"Meyers","year":"2016","journal-title":"Physiol. Rep."},{"issue":"52","key":"10.1016\/j.semcdb.2023.07.010_bib36","doi-asserted-by":"crossref","first-page":"21456","DOI":"10.1073\/pnas.1211659110","article-title":"Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function","volume":"109","author":"Rodriguez-Diaz","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.semcdb.2023.07.010_bib37","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0026-0495(96)90268-1","article-title":"Effect of parasympathetic denervation of liver and pancreas on glucose kinetics in man","volume":"45","author":"Fabris","year":"1996","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib38","first-page":"E958","article-title":"Functional vagal input to chemically identified neurons in pancreatic ganglia as revealed by Fos expression","volume":"277","author":"Wang","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib39","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0006-8993(91)90846-N","article-title":"Morphology and distribution of efferent vagal innervation of rat pancreas as revealed with anterograde transport of Dil","volume":"553","author":"Berthoud","year":"1991","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00254508","article-title":"Cephalic phase, reflex insulin secretion neuroanatomical and physiological characterization","volume":"20","author":"Berthoud","year":"1981","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s001250051322","article-title":"Autonomic regulation of islet hormone secretion \u2013 Implications for health and disease","volume":"43","author":"Ahr\u00e9n","year":"2000","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.semcdb.2023.07.010_bib42","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1007\/s00125-020-05204-6","article-title":"CNS control of the endocrine pancreas","volume":"63","author":"Faber","year":"2020","journal-title":"Diabetologia"},{"issue":"Suppl 1","key":"10.1016\/j.semcdb.2023.07.010_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/dom.12346","article-title":"Neural regulation of pancreatic islet cell mass and function","volume":"16","author":"Thorens","year":"2014","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.semcdb.2023.07.010_bib44","unstructured":"P. Langerhans, Beitrage zur mikroskopischen Anatomie der Bauchspeicheldruse, Inaugural Disseration, Gustav Lange, 1869."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2337\/diab.17.1.33","article-title":"Nature of islet-cell innervation in the cat pancreas","volume":"17","author":"Esterhuizen","year":"1968","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-1838(84)90065-1","article-title":"Preganglionic innervation of the pancreas islet cells in the rat","volume":"10","author":"Luiten","year":"1984","journal-title":"J. Auton. Nerv. Syst."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib47","doi-asserted-by":"crossref","first-page":"G694","DOI":"10.1152\/ajpgi.00116.2019","article-title":"Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation","volume":"317","author":"Chien","year":"2019","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib48","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0031-9384(89)90024-3","article-title":"Cephalic postprandial thermogenesis in human subjects","volume":"46","author":"LeBlanc","year":"1989","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib49","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0016-5085(86)90943-1","article-title":"Role of thought, sight, smell, and taste of food in the cephalic phase of gastric acid secretion in humans","volume":"90","author":"Feldman","year":"1986","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib50","doi-asserted-by":"crossref","first-page":"E336","DOI":"10.1152\/ajpendo.1980.238.4.E336","article-title":"Cephalic-phase insulin secretion in normal and pancreatic islet-transplanted rats","volume":"238","author":"Berthoud","year":"1980","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1152\/ajplegacy.1976.230.1.56","article-title":"Preabsorptive insulin release and hypoglycemia in rats","volume":"230","author":"Louis-Sylvestre","year":"1976","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01235635","article-title":"The mechanism of insulin secretion after oral glucose administration. II. Reflex insulin secretion in conscious dogs bearing fistulas of the digestive tract by sham-feeding of glucose or tap water","volume":"8","author":"Hommel","year":"1972","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib53","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/ajplegacy.1975.229.4.1019","article-title":"Rapid insulin release after ingestion of a meal in the unanesthetized rat","volume":"229","author":"Strubbe","year":"1975","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib54","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1146\/annurev.bi.64.070195.003353","article-title":"Metabolic coupling factors in pancreatic \u03b2-cell signal transduction","volume":"64","author":"Newgard","year":"1995","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib55","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.2337\/diabetes.50.5.1030","article-title":"The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia","volume":"50","author":"Ahr\u00e9n","year":"2001","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib56","doi-asserted-by":"crossref","first-page":"E95","DOI":"10.1152\/ajpendo.1984.246.1.E95","article-title":"Reduced postprandial heat production with gavage as compared with meal feeding in human subjects","volume":"246","author":"LeBlanc","year":"1984","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2023.07.010_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/j.1469-445X.1999.01872.x","article-title":"Vagotomy Suppresses Cephalic Phase Insulin Release in Sheep","volume":"84","author":"Herath","year":"1999","journal-title":"Exp. Physiol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib58","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0031-9384(80)90241-3","article-title":"Cephalic insulin response as a test for completeness of vagotomy to the pancreas","volume":"24","author":"Woods","year":"1980","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib59","doi-asserted-by":"crossref","first-page":"R615","DOI":"10.1152\/ajpregu.1992.263.3.R615","article-title":"Parasympathetic involvement in rapid meal-associated conditioned insulin secretion in the rat","volume":"263","author":"Strubbe","year":"1992","journal-title":"Am. J. Physiol. -Regul., Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib60","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.physbeh.2011.01.012","article-title":"How neural mediation of anticipatory and compensatory insulin release helps us tolerate food","volume":"103","author":"Teff","year":"2011","journal-title":"Physiol. Behav."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib61","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s11517-019-01950-x","article-title":"Modeling the effect of the cephalic phase of insulin secretion on glucose metabolism","volume":"57","author":"G\u00fcemes","year":"2019","journal-title":"Med. Biol. Eng. Comput."},{"issue":"37","key":"10.1016\/j.semcdb.2023.07.010_bib62","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"33","key":"10.1016\/j.semcdb.2023.07.010_bib63","doi-asserted-by":"crossref","first-page":"13998","DOI":"10.1073\/pnas.0810087106","article-title":"IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat","volume":"106","author":"Ehses","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"15","key":"10.1016\/j.semcdb.2023.07.010_bib64","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N. Engl. J. Med"},{"issue":"9","key":"10.1016\/j.semcdb.2023.07.010_bib65","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1210\/jc.2010-2724","article-title":"Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity","volume":"96","author":"Dandona","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib66","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.diabet.2013.07.003","article-title":"Impact of interleukin-1\u03b2 antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial","volume":"39","author":"Hensen","year":"2013","journal-title":"Diabetes Metab."},{"issue":"8","key":"10.1016\/j.semcdb.2023.07.010_bib67","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.2337\/dc12-1835","article-title":"Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1\u03b2 antibody, in patients with type 2 diabetes","volume":"36","author":"Sloan-Lancaster","year":"2013","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib68","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/dc08-1161","article-title":"Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study","volume":"32","author":"Herder","year":"2009","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib69","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2337\/diabetes.52.3.812","article-title":"Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"52","author":"Spranger","year":"2003","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib70","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41593-018-0286-y","article-title":"Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism","volume":"22","author":"Garc\u00eda-C\u00e1ceres","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib71","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1037\/0735-7044.97.6.1025","article-title":"Influence of external and covert food stimuli on insulin secretion in obese and normal persons","volume":"97","author":"Johnson","year":"1983","journal-title":"Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib72","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0031-9384(86)90316-1","article-title":"Cephalic phase insulin secretion in relation to food presentation in normal and overweight subjects","volume":"36","author":"Simon","year":"1986","journal-title":"Physiol. Behav."},{"issue":"07","key":"10.1016\/j.semcdb.2023.07.010_bib73","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1055\/s-2007-1012349","article-title":"Cephalic phase of insulin secretion in obese women","volume":"18","author":"Osuna","year":"1986","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.semcdb.2023.07.010_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-022-00909-y","article-title":"Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism","author":"Jimenez-Gonzalez","year":"2022","journal-title":"Nat. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib75","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1172\/JCI117150","article-title":"Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia, The","volume":"93","author":"Borg","year":"1994","journal-title":"J. Clin. Investig."},{"issue":"15","key":"10.1016\/j.semcdb.2023.07.010_bib76","article-title":"Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal","volume":"118","author":"Sutton","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.semcdb.2023.07.010_bib77","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fnins.2013.00071","article-title":"Revisiting the ventral medial nucleus of the hypothalamus: the roles of SF-1 neurons in energy homeostasis","volume":"7","author":"Choi","year":"2013","journal-title":"Front. Neurosci."},{"issue":"1319","key":"10.1016\/j.semcdb.2023.07.010_bib78","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1098\/rspb.1992.0017","article-title":"Extracellular cations modulate the ATP sensitivity of ATP-K+ channels in rat ventromedial hypothalamic neurons","volume":"247","author":"Treherne","year":"1992","journal-title":"Proc. Biol. Sci."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib79","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.cmet.2014.11.006","article-title":"A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia","volume":"20","author":"Garfield","year":"2014","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib80","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib81","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2017.06.014","article-title":"Toward a wiring diagram understanding of appetite control","volume":"95","author":"Andermann","year":"2017","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib82","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.physbeh.2007.01.011","article-title":"Central opioids and consumption of sweet tastants: When reward outweighs homeostasis","volume":"91","author":"Olszewski","year":"2007","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib83","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.febslet.2007.11.063","article-title":"Neuronal control of energy homeostasis","volume":"582","author":"Gao","year":"2008","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib84","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nn.2739","article-title":"AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training","volume":"14","author":"Aponte","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"7491","key":"10.1016\/j.semcdb.2023.07.010_bib85","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature12956","article-title":"An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger","volume":"507","author":"Krashes","year":"2014","journal-title":"Nature"},{"issue":"5748","key":"10.1016\/j.semcdb.2023.07.010_bib86","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1115524","article-title":"NPY\/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates","volume":"310","author":"Luquet","year":"2005","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.semcdb.2023.07.010_bib87","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1523\/JNEUROSCI.2742-12.2013","article-title":"Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, Respectively","volume":"33","author":"Zhan","year":"2013","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.semcdb.2023.07.010_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030415","article-title":"Effects of hypothalamic neurodegeneration on energy balance","volume":"3","author":"Xu","year":"2005","journal-title":"PLoS Biol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib89","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cell.2005.08.035","article-title":"Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure","volume":"123","author":"Balthasar","year":"2005","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib90","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice","volume":"88","author":"Huszar","year":"1997","journal-title":"Cell"},{"issue":"6612","key":"10.1016\/j.semcdb.2023.07.010_bib91","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/385165a0","article-title":"Role of melanocortinergic neurons in feeding and the agouti obesity syndrome","volume":"385","author":"Fan","year":"1997","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.semcdb.2023.07.010_bib92","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1172\/JCI200112954","article-title":"Central melanocortin receptors regulate insulin action","volume":"108","author":"Obici","year":"2001","journal-title":"J. Clin. Invest"},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib93","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.2337\/db14-1257","article-title":"Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus","volume":"64","author":"Morgan","year":"2015","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.semcdb.2023.07.010_bib94","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJMoa022050","article-title":"Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene","volume":"348","author":"Farooqi","year":"2003","journal-title":"N. Engl. J. Med"},{"issue":"7702","key":"10.1016\/j.semcdb.2023.07.010_bib95","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41586-018-0049-7","article-title":"Genetic identification of leptin neural circuits in energy and glucose homeostases","volume":"556","author":"Xu","year":"2018","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.semcdb.2023.07.010_bib96","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nn.3737","article-title":"Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia","volume":"17","author":"Berglund","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib97","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cmet.2011.01.010","article-title":"Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis","volume":"13","author":"Rossi","year":"2011","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib98","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cell.2012.12.022","article-title":"Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons","volume":"152","author":"Sohn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2023.07.010_bib99","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainres.2013.09.002","article-title":"Intrapancreatic ganglia neurons receive projection fibers from melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve of the mouse","volume":"1537","author":"Tsumori","year":"2013","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib100","first-page":"6295","article-title":"Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production, Nature","volume":"11","author":"Kwon","year":"2020","journal-title":"Communications"},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib101","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s12276-021-00705-9","article-title":"Autonomic control of energy balance and glucose homeostasis","volume":"54","author":"Hyun","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib102","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bbadis.2010.01.006","article-title":"The role of the autonomic nervous liver innervation in the control of energy metabolism","volume":"1802","author":"Yi","year":"2010","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib103","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cmet.2009.07.005","article-title":"Intestinal cholecystokinin controls glucose production through a neuronal network","volume":"10","author":"Cheung","year":"2009","journal-title":"Cell Metab."},{"issue":"7036","key":"10.1016\/j.semcdb.2023.07.010_bib104","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nature03439","article-title":"Hypothalamic KATP channels control hepatic glucose production","volume":"434","author":"Pocai","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib105","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00185458","article-title":"An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system","volume":"186","author":"Berthoud","year":"1992","journal-title":"Anat. Embryol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib106","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cmet.2021.01.012","article-title":"Metabolic stress drives sympathetic neuropathy within the liver","volume":"33","author":"Liu","year":"2021","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib107","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ar.1091910106","article-title":"Intrahepatic distribution of nerves in the rat","volume":"191","author":"Reilly","year":"1978","journal-title":"Anat. Rec."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib108","first-page":"65","article-title":"The activity and cytochemical localization of acetylcholinesterase and butyrylcholinesterase in the rat liver","volume":"39","author":"Satler","year":"1974","journal-title":"Histochemistry"},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib109","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/j.gastro.2020.10.034","article-title":"Pancreatic \u03b2-Cells Communicate With Vagal Sensory Neurons","volume":"160","author":"Makhmutova","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2011.05.008","article-title":"Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas","volume":"14","author":"Rodriguez-Diaz","year":"2011","journal-title":"Cell Metab."},{"issue":"9","key":"10.1016\/j.semcdb.2023.07.010_bib111","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.2337\/dbi21-0003","article-title":"Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex","volume":"70","author":"Ludwig","year":"2021","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.semcdb.2023.07.010_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110962","article-title":"Genetic encoding of an esophageal motor circuit","volume":"39","author":"Coverdell","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib113","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-1838(80)90007-7","article-title":"Localization of parasympathetic preganglionic cell bodies innervating the pancreas within the vagal nucleus and nucleus ambiguus of the rat brain stem: evidence of dual innervation based on the retrograde axonal transport of horseradish peroxidase","volume":"2","author":"Weaver","year":"1980","journal-title":"J. Auton. Nerv. Syst."},{"issue":"14","key":"10.1016\/j.semcdb.2023.07.010_bib114","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1523\/JNEUROSCI.4177-04.2005","article-title":"Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids","volume":"25","author":"Appleyard","year":"2005","journal-title":"J. Neurosci."},{"issue":"37","key":"10.1016\/j.semcdb.2023.07.010_bib115","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1523\/JNEUROSCI.1865-19.2020","article-title":"Leptin Sensitizes NTS Neurons to Vagal Input by Increasing Postsynaptic NMDA Receptor Currents","volume":"40","author":"Neyens","year":"2020","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib116","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1152\/jn.2001.85.5.2213","article-title":"Reliability of monosynaptic sensory transmission in brain stem neurons in vitro","volume":"85","author":"Doyle","year":"2001","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib117","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuron.2017.09.014","article-title":"Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling","volume":"96","author":"Resch","year":"2017","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib118","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00187819","article-title":"Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing","volume":"191","author":"Berthoud","year":"1995","journal-title":"Anat. Embryol. (Berl. )"},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib119","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s004290050037","article-title":"Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract","volume":"195","author":"Berthoud","year":"1997","journal-title":"Anat. Embryol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cne.903190206","article-title":"Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor","volume":"319","author":"Berthoud","year":"1992","journal-title":"J. Comp. Neurol."},{"issue":"1\u20133","key":"10.1016\/j.semcdb.2023.07.010_bib121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Auton. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.semcdb.2023.07.010_bib122","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0006-8993(96)01222-X","article-title":"Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract: anatomical identification and functional integrity","volume":"746","author":"Berthoud","year":"1997","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib123","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-1838(89)90015-5","article-title":"Vagal afferent fibers almost exclusively innervate islets in the rat pancreas as demonstrated by anterograde tracing","volume":"29","author":"Neuhuber","year":"1989","journal-title":"J. Auton. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib124","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0304-3940(83)90395-6","article-title":"Extrinsic innervation of the rat pancreas: Demonstration of vagal sensory neurones in the rat by retrograde tracing","volume":"42","author":"Sharkey","year":"1983","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib125","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/cne.23892","article-title":"Vagal intramuscular arrays: the specialized mechanoreceptor arbors that innervate the smooth muscle layers of the stomach examined in the rat","volume":"524","author":"Powley","year":"2016","journal-title":"J. Comp. Neurol."},{"issue":"5","key":"10.1016\/j.semcdb.2023.07.010_bib126","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cell.2017.01.025","article-title":"Gut-brain cross-talk in metabolic control","volume":"168","author":"Clemmensen","year":"2017","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.semcdb.2023.07.010_bib127","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1038\/s41366-021-00894-3","article-title":"Learning of food preferences: mechanisms and implications for obesity & metabolic diseases","volume":"45","author":"Berthoud","year":"2021","journal-title":"Int J. Obes. (Lond. )"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib128","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.physbeh.2004.04.037","article-title":"Gastric satiation is volumetric, intestinal satiation is nutritive","volume":"82","author":"Powley","year":"2004","journal-title":"Physiol. Behav."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib129","doi-asserted-by":"crossref","first-page":"G1217","DOI":"10.1152\/ajpgi.00249.2002","article-title":"I. Morphology and topography of vagal afferents innervating the GI tract","volume":"283","author":"Powley","year":"2002","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"key":"10.1016\/j.semcdb.2023.07.010_bib130","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.676869","article-title":"Gastrointestinal Distension by Pectin-Containing Carbonated Solution Suppresses Food Intake and Enhances Glucose Tolerance via GLP-1 Secretion and Vagal Afferent Activation","volume":"12","author":"Ohbayashi","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"7835","key":"10.1016\/j.semcdb.2023.07.010_bib131","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2933-1","article-title":"Discoveries in structure and physiology of mechanically activated ion channels","volume":"587","author":"Kefauver","year":"2020","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib132","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/cne.22541","article-title":"Vagal afferent innervation of the proximal gastrointestinal tract mucosa: chemoreceptor and mechanoreceptor architecture","volume":"519","author":"Powley","year":"2011","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib133","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00187819","article-title":"Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing","volume":"191","author":"Berthoud","year":"1995","journal-title":"Anat. Embryol."},{"issue":"1\u20132","key":"10.1016\/j.semcdb.2023.07.010_bib134","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.autneu.2009.07.007","article-title":"Gut chemosensing: interactions between gut endocrine cells and visceral afferents","volume":"153","author":"Raybould","year":"2010","journal-title":"Auton. Neurosci."},{"issue":"6408","key":"10.1016\/j.semcdb.2023.07.010_bib135","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib136","first-page":"903","article-title":"The metabolic impact of small intestinal nutrient sensing, Nature","volume":"12","author":"Duca","year":"2021","journal-title":"Communications"},{"issue":"7804","key":"10.1016\/j.semcdb.2023.07.010_bib137","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41586-020-2199-7","article-title":"The gut\u2013brain axis mediates sugar preference","volume":"580","author":"Tan","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib138","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41593-021-00982-7","article-title":"The preference for sugar over sweetener depends on a gut sensor cell","volume":"25","author":"Buchanan","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib139","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cmet.2017.09.019","article-title":"Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway","volume":"27","author":"Bauer","year":"2018","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2337\/db11-1029","article-title":"Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion","volume":"61","author":"Gorboulev","year":"2012","journal-title":"Diabetes"},{"issue":"14","key":"10.1016\/j.semcdb.2023.07.010_bib141","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1097\/00001756-200110080-00024","article-title":"Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity","volume":"12","author":"Randich","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.semcdb.2023.07.010_bib142","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1982.sp014415","article-title":"Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig","volume":"332","author":"Niijima","year":"1982","journal-title":"J. Physiol."},{"issue":"Suppl 1","key":"10.1016\/j.semcdb.2023.07.010_bib143","doi-asserted-by":"crossref","first-page":"i178","DOI":"10.1093\/chemse\/bjh172","article-title":"Role played by vagal chemical sensors in the hepato-portal region and duodeno-intestinal canal: an electrophysiological study","volume":"30","author":"Niijima","year":"2005","journal-title":"Chem. Senses"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib144","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2337\/db08-1437","article-title":"Hypoglycemic detection at the portal vein: absent in humans or yet to be elucidated?","volume":"58","author":"Donovan","year":"2009","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.semcdb.2023.07.010_bib145","doi-asserted-by":"crossref","first-page":"E857","DOI":"10.1152\/ajpendo.00283.2007","article-title":"Portal vein hypoglycemia is essential for full induction of hypoglycemia-associated autonomic failure with slow-onset hypoglycemia","volume":"293","author":"Matveyenko","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib146","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1210\/en.2013-1794","article-title":"Essentiality of Portal Vein Receptors in Hypoglycemic Counterregulation: Direct Proof Via Denervation in Male Canines","volume":"155","author":"Ionut","year":"2014","journal-title":"Endocrinology"},{"issue":"7897","key":"10.1016\/j.semcdb.2023.07.010_bib147","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41586-021-04359-5","article-title":"Sensory representation and detection mechanisms of gut osmolality change","volume":"602","author":"Ichiki","year":"2022","journal-title":"Nature"},{"issue":"7903","key":"10.1016\/j.semcdb.2023.07.010_bib148","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41586-022-04515-5","article-title":"A multidimensional coding architecture of the vagal interoceptive system","volume":"603","author":"Zhao","year":"2022","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.semcdb.2023.07.010_bib149","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.cell.2022.05.007","article-title":"An inter-organ neural circuit for appetite suppression","volume":"185","author":"Zhang","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3940(87)90597-0","article-title":"Capsaicin-sensitive vagal afferent neurons innervating the rat pancreas","volume":"77","author":"Carobi","year":"1987","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.semcdb.2023.07.010_bib151","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cell.2006.10.038","article-title":"TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes","volume":"127","author":"Razavi","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2023.07.010_bib152","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1460-9568.2006.05261.x","article-title":"Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type2 diabetes","volume":"25","author":"Gram","year":"2007","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.semcdb.2023.07.010_bib153","doi-asserted-by":"crossref","first-page":"R1071","DOI":"10.1152\/ajpregu.1994.267.4.R1071","article-title":"Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice","volume":"267","author":"Karlsson","year":"1994","journal-title":"Am. J. Physiol. -Regul., Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.semcdb.2023.07.010_bib154","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02787472","article-title":"The role of CGRP and afferent nerves in the modulation of pancreatic enzyme secretion in the rat","volume":"22","author":"Jaworek","year":"1997","journal-title":"Int. J. Pancreatol."}],"container-title":["Seminars in Cell & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952123001465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952123001465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:24:34Z","timestamp":1761067474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952123001465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":154,"alternative-id":["S1084952123001465"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2023.07.010","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vagal pathways for systemic regulation of glucose metabolism","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2023.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}