{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:49:20Z","timestamp":1793688560466,"version":"4.5.1"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210102134"],"award-info":[{"award-number":["DP210102134"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2021155"],"award-info":[{"award-number":["2021155"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2038886"],"award-info":[{"award-number":["2038886"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["102036"],"award-info":[{"award-number":["102036"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.semcdb.2025.103622","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T16:46:38Z","timestamp":1749141998000},"page":"103622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Cardiac trabeculation in vertebrates: Convergent evolution or evolutionary adaptations associated with heart complexity?"],"prefix":"10.1016","volume":"172","author":[{"given":"Yen T.H.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diptarka","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-2226","authenticated-orcid":false,"given":"Gonzalo","family":"del Monte-Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00006.2003","article-title":"Cardiac chamber formation: development, genes, and evolution","volume":"83","author":"Moorman","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.semcdb.2025.103622_bib2","series-title":"Embryology of the Heart","first-page":"11","author":"del Monte-Nieto","year":"2021"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/CIRCGENETICS.111.961086","article-title":"The impact of mechanical forces in heart morphogenesis","volume":"5","author":"Granados-Riveron","year":"2012","journal-title":"Circ. Cardiovasc Genet"},{"key":"10.1016\/j.semcdb.2025.103622_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fphys.2014.00318","article-title":"Mechanical regulation of cardiac development","volume":"5","author":"Lindsey","year":"2014","journal-title":"Front. Physiol."},{"issue":"7 Pt B","key":"10.1016\/j.semcdb.2025.103622_bib5","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2016.03.004","article-title":"Interplay between cardiac function and heart development","volume":"1863","author":"Andres-Delgado","year":"2016","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.semcdb.2025.103622_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/bs.ctdb.2018.12.009","article-title":"Fluid forces shape the embryonic heart: Insights from zebrafish","volume":"132","author":"Sidhwani","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103622_bib7","article-title":"Rhythmic forces shaping the zebrafish cardiac system","author":"Fukui","year":"2024","journal-title":"Trends Cell Biol."},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ajmg.c.31366","article-title":"Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation","volume":"163C","author":"Samsa","year":"2013","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"issue":"11","key":"10.1016\/j.semcdb.2025.103622_bib9","first-page":"1325","article-title":"Formation and malformation of cardiac trabeculae: biological basis, clinical significance, and special yield of magnetic resonance imaging in assessment","volume":"31","author":"Captur","year":"2015","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.semcdb.2025.103622_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ceb.2021.04.009","article-title":"Sculpting the heart: cellular mechanisms shaping valves and trabeculae","volume":"73","author":"Gunawan","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103622_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.857581","article-title":"Endocardial-myocardial interactions during early cardiac differentiation and trabeculation","volume":"9","author":"Qu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"6","key":"10.1016\/j.semcdb.2025.103622_bib12","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4161\/cc.3.6.949","article-title":"Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw","volume":"3","author":"Grego-Bessa","year":"2004","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.semcdb.2025.103622_bib13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/CIRCRESAHA.110.218693","article-title":"Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium","volume":"107","author":"Lai","year":"2010","journal-title":"Circ. Res."},{"issue":"7705","key":"10.1016\/j.semcdb.2025.103622_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41586-018-0110-6","article-title":"Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation","volume":"557","author":"Del Monte-Nieto","year":"2018","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000146455","article-title":"Morphologic study of ventricular trabeculation in the embryonic chick heart","volume":"130","author":"Icardo","year":"1987","journal-title":"Acta Anat."},{"issue":"5","key":"10.1016\/j.semcdb.2025.103622_bib16","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.RES.57.5.759","article-title":"Ventricular trabeculations in the chick embryo heart and their contribution to ventricular and muscular septal development","volume":"57","author":"Ben-Shachar","year":"1985","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/(SICI)1097-0185(199707)248:3<421::AID-AR15>3.0.CO;2-R","article-title":"Developmental changes in the myocardial architecture of the chick","volume":"248","author":"Sedmera","year":"1997","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/1097-0185(20001001)260:2<148::AID-AR50>3.0.CO;2-X","article-title":"Structure and function of the developing zebrafish heart","volume":"260","author":"Hu","year":"2000","journal-title":"Anat. Rec."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib19","first-page":"9","article-title":"The zebrafish model system in cardiovascular research: a tiny fish with mighty prospects","volume":"2013","author":"Poon","year":"2013","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"10.1016\/j.semcdb.2025.103622_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/bs.ctdb.2024.02.005","article-title":"Cardiac construction-Recent advances in morphological and transcriptional modeling of early heart development","volume":"156","author":"Noel","year":"2024","journal-title":"Curr. Top. Dev. Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib21","article-title":"A matter of the heart: the african clawed frog xenopus as a model for studying vertebrate cardiogenesis and congenital heart defects","volume":"3","author":"Hempel","year":"2016","journal-title":"J. Cardiovasc Dev. Dis."},{"issue":"7","key":"10.1016\/j.semcdb.2025.103622_bib22","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ymthe.2018.05.022","article-title":"Development, proliferation, and growth of the mammalian heart","volume":"26","author":"Gunthel","year":"2018","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib23","article-title":"Functional morphology of the cardiac jelly in the tubular heart of vertebrate embryos","volume":"6","author":"Manner","year":"2019","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"22","key":"10.1016\/j.semcdb.2025.103622_bib24","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/dev.053736","article-title":"A dual role for ErbB2 signaling in cardiac trabeculation","volume":"137","author":"Liu","year":"2010","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/dev.098632","article-title":"High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation","volume":"141","author":"Staudt","year":"2014","journal-title":"Development"},{"issue":"27","key":"10.1016\/j.semcdb.2025.103622_bib26","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1073\/pnas.1606385113","article-title":"N-cadherin relocalization during cardiac trabeculation","volume":"113","author":"Cherian","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib27","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1016\/j.celrep.2016.11.023","article-title":"In vivo visualization of cardiomyocyte apicobasal polarity reveals epithelial to mesenchymal-like transition during cardiac trabeculation","volume":"17","author":"Jimenez-Amilburu","year":"2016","journal-title":"Cell Rep."},{"issue":"7836","key":"10.1016\/j.semcdb.2025.103622_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-020-2946-9","article-title":"Tension heterogeneity directs form and fate to pattern the myocardial wall","volume":"588","author":"Priya","year":"2020","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.semcdb.2025.103622_bib29","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1242\/dev.125724","article-title":"Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish","volume":"142","author":"Samsa","year":"2015","journal-title":"Development"},{"issue":"7609","key":"10.1016\/j.semcdb.2025.103622_bib30","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature18310","article-title":"Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis","volume":"534","author":"Han","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103622_bib31","doi-asserted-by":"crossref","first-page":"15281","DOI":"10.1038\/ncomms15281","article-title":"Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling","volume":"8","author":"Rasouli","year":"2017","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/dvdy.22526","article-title":"Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish","volume":"240","author":"Peshkovsky","year":"2011","journal-title":"Dev. Dyn."},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jmor.1051250306","article-title":"Embryonic development of the heart. I. A light and electron microscopic study of myocardial development in the early chick embryo","volume":"125","author":"Manasek","year":"1968","journal-title":"J. Morphol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ydbio.2009.09.019","article-title":"Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6","volume":"336","author":"Abu-Daya","year":"2009","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/dbio.1999.9559","article-title":"The morphology of heart development in Xenopus laevis","volume":"218","author":"Mohun","year":"2000","journal-title":"Dev. Biol."},{"issue":"24","key":"10.1016\/j.semcdb.2025.103622_bib36","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1002\/1873-3468.13930","article-title":"Dynamic transcriptome profiling toward understanding the development of the human embryonic heart during different Carnegie stages","volume":"594","author":"Meng","year":"2020","journal-title":"FEBS Lett."},{"issue":"11-12","key":"10.1016\/j.semcdb.2025.103622_bib37","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1387\/ijdb.130302bk","article-title":"Remodeling of the myocardium in early trabeculation and cardiac valve formation; a role for TGFbeta2","volume":"57","author":"Kruithof","year":"2013","journal-title":"Int J. Dev. Biol."},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib38","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/dev.121.10.3141","article-title":"Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages","volume":"121","author":"Stainier","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2025.103622_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73231","article-title":"Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish","volume":"11","author":"Qi","year":"2022","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.devcel.2007.11.018","article-title":"Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis","volume":"14","author":"Stankunas","year":"2008","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.devcel.2014.12.009","article-title":"The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression","volume":"32","author":"Zhou","year":"2015","journal-title":"Dev. Cell"},{"issue":"14","key":"10.1016\/j.semcdb.2025.103622_bib42","doi-asserted-by":"crossref","DOI":"10.1242\/dev.164194","article-title":"In vivo analysis of cardiomyocyte proliferation during trabeculation","volume":"145","author":"Uribe","year":"2018","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ydbio.2012.05.001","article-title":"Growth of the developing mouse heart: an interactive qualitative and quantitative 3D atlas","volume":"368","author":"de Boer","year":"2012","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.celrep.2016.03.012","article-title":"Single-cell lineage tracing reveals that oriented cell division contributes to trabecular morphogenesis and regional specification","volume":"15","author":"Li","year":"2016","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.semcdb.2025.103622_bib45","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.celrep.2016.01.030","article-title":"Atypical protein kinase C-dependent polarized cell division is required for myocardial trabeculation","volume":"14","author":"Passer","year":"2016","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib46","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41556-020-0475-2","article-title":"Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution","volume":"22","author":"Yue","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103622_bib47","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.123.323321","article-title":"Nrg1 regulates cardiomyocyte migration and cell cycle in ventricular development","author":"Grego-Bessa","year":"2023","journal-title":"Circ. Res"},{"issue":"7","key":"10.1016\/j.semcdb.2025.103622_bib48","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00246-019-02161-9","article-title":"Defects in trabecular development contribute to left ventricular noncompaction","volume":"40","author":"Choquet","year":"2019","journal-title":"Pedia Cardiol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41467-017-00118-1","article-title":"Identification of a hybrid myocardial zone in the mammalian heart after birth","volume":"8","author":"Tian","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ajmg.c.31369","article-title":"Molecular mechanism of ventricular trabeculation\/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC)","volume":"163C","author":"Zhang","year":"2013","journal-title":"Am. J. Med Genet C. Semin Med Genet"},{"issue":"7395","key":"10.1016\/j.semcdb.2025.103622_bib51","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature11045","article-title":"Clonally dominant cardiomyocytes direct heart morphogenesis","volume":"484","author":"Gupta","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib52","article-title":"Modeling human cardiac arrhythmias: insights from zebrafish","volume":"9","author":"Gauvrit","year":"2022","journal-title":"J. Cardiovasc Dev. Dis."},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib53","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.devcel.2006.12.011","article-title":"Notch signaling is essential for ventricular chamber development","volume":"12","author":"Grego-Bessa","year":"2007","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0014-4827(02)00102-7","article-title":"Neuregulins: functions, forms, and signaling strategies","volume":"284","author":"Falls","year":"2003","journal-title":"Exp. Cell Res"},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib55","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/CIRCRESAHA.112.267286","article-title":"Neuregulin in cardiovascular development and disease","volume":"111","author":"Odiete","year":"2012","journal-title":"Circ. Res"},{"issue":"11","key":"10.1016\/j.semcdb.2025.103622_bib56","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-018-0100-2","article-title":"Notch and interacting signalling pathways in cardiac development, disease, and regeneration","volume":"15","author":"MacGrogan","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib57","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/cvr\/cvs250","article-title":"Inhibition of Notch2 by Numb\/Numblike controls myocardial compaction in the heart","volume":"96","author":"Yang","year":"2012","journal-title":"Cardiovasc Res"},{"issue":"12","key":"10.1016\/j.semcdb.2025.103622_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203100","article-title":"Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function","volume":"13","author":"Salguero-Jimenez","year":"2018","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.semcdb.2025.103622_bib60","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gad.12.12.1825","article-title":"The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system","volume":"12","author":"Britsch","year":"1998","journal-title":"Genes Dev."},{"issue":"6555","key":"10.1016\/j.semcdb.2025.103622_bib61","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/378390a0","article-title":"Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor","volume":"378","author":"Gassmann","year":"1995","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.semcdb.2025.103622_bib62","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96002","article-title":"Tie2 regulates endocardial sprouting and myocardial trabeculation","volume":"5","author":"Qu","year":"2019","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.semcdb.2025.103622_bib63","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1002\/dvdy.21246","article-title":"Monitoring Notch1 activity in development: evidence for a feedback regulatory loop","volume":"236","author":"Del Monte","year":"2007","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib64","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ncb3280","article-title":"Sequential Notch activation regulates ventricular chamber development","volume":"18","author":"D'Amato","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib65","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00018-020-03664-y","article-title":"Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology","volume":"78","author":"Muhleder","year":"2021","journal-title":"Cell Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.semcdb.2025.103622_bib66","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.celrep.2018.04.080","article-title":"Myocardial angiopoietin-1 controls atrial chamber morphogenesis by spatiotemporal degradation of cardiac jelly","volume":"23","author":"Kim","year":"2018","journal-title":"Cell Rep."},{"issue":"5322","key":"10.1016\/j.semcdb.2025.103622_bib67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.semcdb.2025.103622_bib68","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0092-8674(00)81813-9","article-title":"Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis","volume":"87","author":"Suri","year":"1996","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.semcdb.2025.103622_bib69","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1242\/dev.01094","article-title":"BMP10 is essential for maintaining cardiac growth during murine cardiogenesis","volume":"131","author":"Chen","year":"2004","journal-title":"Development"},{"issue":"16","key":"10.1016\/j.semcdb.2025.103622_bib70","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125908","article-title":"Semaphorin 3E\/PlexinD1 signaling is required for cardiac ventricular compaction","volume":"4","author":"Sandireddy","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib71","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1038\/s41467-024-48362-6","article-title":"Endocardial HDAC3 is required for myocardial trabeculation","volume":"15","author":"Jang","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.semcdb.2025.103622_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110556","article-title":"Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies","volume":"27","author":"Zhu","year":"2024","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib73","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cmet.2014.12.015","article-title":"Semaphorin signaling in cardiovascular development","volume":"21","author":"Epstein","year":"2015","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib74","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1172\/JCI63635","article-title":"Myocardin regulates BMP10 expression and is required for heart development","volume":"122","author":"Huang","year":"2012","journal-title":"J. Clin. Invest"},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nm.3046","article-title":"Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy","volume":"19","author":"Luxan","year":"2013","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.semcdb.2025.103622_bib76","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1242\/dev.089920","article-title":"Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity","volume":"140","author":"Chen","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2025.103622_bib77","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yjmcc.2021.03.008","article-title":"Creld1 regulates myocardial development and function","volume":"156","author":"Beckert","year":"2021","journal-title":"J. Mol. Cell Cardiol."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib78","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1101\/gad.1167304","article-title":"Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2","volume":"18","author":"Toyofuku","year":"2004","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.semcdb.2025.103622_bib79","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/ncb1193","article-title":"Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling","volume":"6","author":"Toyofuku","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.devcel.2004.06.002","article-title":"PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development","volume":"7","author":"Gitler","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2025.103622_bib81","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.diff.2016.11.004","article-title":"Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse","volume":"94","author":"Bourke","year":"2016","journal-title":"Differentiation"},{"issue":"12","key":"10.1016\/j.semcdb.2025.103622_bib82","doi-asserted-by":"crossref","DOI":"10.1242\/dev.173476","article-title":"Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development","volume":"146","author":"Li","year":"2019","journal-title":"Development"},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib83","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255043","article-title":"Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction","volume":"24","author":"Chiang","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.semcdb.2025.103622_bib84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.matbio.2015.06.003","article-title":"The extracellular matrix: Tools and insights for the \"omics\" era","volume":"49","author":"Naba","year":"2016","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib85","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/14789450.2018.1421947","article-title":"Proteomic analysis of the cardiac extracellular matrix: clinical research applications","volume":"15","author":"Lindsey","year":"2018","journal-title":"Expert Rev. Proteom."},{"issue":"17","key":"10.1016\/j.semcdb.2025.103622_bib86","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.jacc.2020.03.024","article-title":"Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1\/4: JACC Focus Seminar","volume":"75","author":"Del Monte-Nieto","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7356","key":"10.1016\/j.semcdb.2025.103622_bib87","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature10316","article-title":"Dynamic molecular processes mediate cellular mechanotransduction","volume":"475","author":"Hoffman","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib88","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ydbio.2014.12.022","article-title":"Recent advances in the study of zebrafish extracellular matrix proteins","volume":"401","author":"Jessen","year":"2015","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib89","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/cvr\/cvab004","article-title":"Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development","volume":"118","author":"Derrick","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib90","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI10272","article-title":"Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme","volume":"106","author":"Camenisch","year":"2000","journal-title":"J. Clin. Invest"},{"issue":"9","key":"10.1016\/j.semcdb.2025.103622_bib91","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/glycob\/cws095","article-title":"Versican\/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development","volume":"22","author":"Hatano","year":"2012","journal-title":"Glycobiology"},{"issue":"24","key":"10.1016\/j.semcdb.2025.103622_bib92","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.cub.2003.11.055","article-title":"heart of glass regulates the concentric growth of the heart in zebrafish","volume":"13","author":"Mably","year":"2003","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib93","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.devcel.2008.12.007","article-title":"Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling","volume":"16","author":"Ieda","year":"2009","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.semcdb.2025.103622_bib94","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/cvr\/cvae111","article-title":"beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation","volume":"120","author":"Miao","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib95","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/dvdy.23716","article-title":"Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1\/2 activation, and to attenuate trabecular cardiomyocyte proliferation","volume":"241","author":"Cooley","year":"2012","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib96","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1172\/JCI96993","article-title":"Zinc transporter Slc39a8 is essential for cardiac ventricular compaction","volume":"128","author":"Lin","year":"2018","journal-title":"J. Clin. Invest"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib97","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng875","article-title":"Cardiac troponin T is essential in sarcomere assembly and cardiac contractility","volume":"31","author":"Sehnert","year":"2002","journal-title":"Nat. Genet"},{"issue":"3","key":"10.1016\/j.semcdb.2025.103622_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050053","article-title":"Functional modulation of cardiac form through regionally confined cell shape changes","volume":"5","author":"Auman","year":"2007","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib99","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2011.12.005","article-title":"Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart","volume":"362","author":"Lin","year":"2012","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.devcel.2014.06.020","article-title":"Blood flow and Bmp signaling control endocardial chamber morphogenesis","volume":"30","author":"Dietrich","year":"2014","journal-title":"Dev. Cell"},{"issue":"13","key":"10.1016\/j.semcdb.2025.103622_bib101","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96672","article-title":"Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation","volume":"3","author":"Lee","year":"2018","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.semcdb.2025.103622_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010142","article-title":"Fluid mechanics of the zebrafish embryonic heart trabeculation","volume":"18","author":"Cairelli","year":"2022","journal-title":"PLoS Comput. Biol."},{"issue":"8","key":"10.1016\/j.semcdb.2025.103622_bib103","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1172\/JCI89549","article-title":"4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation","volume":"126","author":"Lee","year":"2016","journal-title":"J. Clin. Invest"},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005828","article-title":"A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling","volume":"13","author":"Vedula","year":"2017","journal-title":"PLoS Comput. Biol."},{"issue":"10","key":"10.1016\/j.semcdb.2025.103622_bib105","doi-asserted-by":"crossref","DOI":"10.1242\/dev.159210","article-title":"The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish","volume":"145","author":"Lai","year":"2018","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.semcdb.2025.103622_bib106","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.devcel.2006.09.006","article-title":"Klf2 is an essential regulator of vascular hemodynamic forces in vivo","volume":"11","author":"Lee","year":"2006","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.semcdb.2025.103622_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000246","article-title":"Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart","volume":"7","author":"Vermot","year":"2009","journal-title":"PLoS Biol."},{"issue":"13","key":"10.1016\/j.semcdb.2025.103622_bib108","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202310","article-title":"Mechanical forces remodel the cardiac extracellular matrix during zebrafish development","volume":"151","author":"Gentile","year":"2024","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.semcdb.2025.103622_bib109","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11517-008-0304-4","article-title":"The development of the heart and microcirculation: role of shear stress","volume":"46","author":"Poelmann","year":"2008","journal-title":"Med Biol. Eng. Comput."},{"issue":"24","key":"10.1016\/j.semcdb.2025.103622_bib110","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1242\/dev.00831","article-title":"Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis","volume":"130","author":"Huang","year":"2003","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib111","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ydbio.2008.07.007","article-title":"Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo","volume":"322","author":"Nishii","year":"2008","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib112","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ydbio.2018.07.007","article-title":"The effects of reduced hemodynamic loading on morphogenesis of the mouse embryonic heart","volume":"442","author":"Hoog","year":"2018","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib113","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1097-0185(20000401)258:4<319::AID-AR1>3.0.CO;2-O","article-title":"Developmental patterning of the myocardium","volume":"258","author":"Sedmera","year":"2000","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.semcdb.2025.103622_bib114","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ar.10098","article-title":"Cellular changes in experimental left heart hypoplasia","volume":"267","author":"Sedmera","year":"2002","journal-title":"Anat. Rec."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib115","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1152\/physrev.00040.2011","article-title":"Evolution of placental function in mammals: the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses","volume":"92","author":"Carter","year":"2012","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.semcdb.2025.103622_bib116","doi-asserted-by":"crossref","DOI":"10.1242\/dev.172957","article-title":"Gene-environment interaction impacts on heart development and embryo survival","volume":"146","author":"Moreau","year":"2019","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.semcdb.2025.103622_bib117","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1038\/s41467-021-23660-5","article-title":"Maternal iron deficiency perturbs embryonic cardiovascular development in mice","volume":"12","author":"Kalisch-Smith","year":"2021","journal-title":"Nat. Commun."},{"issue":"16-18","key":"10.1016\/j.semcdb.2025.103622_bib118","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1089\/ars.2023.0349","article-title":"Nicotinamide adenine dinucleotide deficiency and its impact on mammalian development","volume":"39","author":"Dunwoodie","year":"2023","journal-title":"Antioxid. Redox Signal"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952125000321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952125000321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:36:24Z","timestamp":1762364184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952125000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":118,"alternative-id":["S1084952125000321"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2025.103622","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac trabeculation in vertebrates: Convergent evolution or evolutionary adaptations associated with heart complexity?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2025.103622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103622"}}