{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:08:40Z","timestamp":1791616120558,"version":"4.3.4"},"reference-count":232,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031369","name":"Evelyn F. and William L. McKnight Brain Institute, University of Florida Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031369","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007672","name":"Mechanobiology Institute, Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023839","name":"Department of Biological Sciences, Western Michigan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["T2EP30222\\u20130026"],"award-info":[{"award-number":["T2EP30222\\u20130026"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.semcdb.2025.103642","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T17:53:56Z","timestamp":1754934836000},"page":"103642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Capturing ovarian dynamics through spatial profiling of the mechano-microenvironment"],"prefix":"10.1016","volume":"175","author":[{"given":"Kosei","family":"Tomida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan Ting","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-3949","authenticated-orcid":false,"given":"Chii Jou","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2025.103642_bib1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s10815-018-1180-y","article-title":"Biomechanics and mechanical signaling in the ovary: a systematic review","volume":"35","author":"Shah","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.semcdb.2025.103642_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/rmb2.12404","article-title":"Mechanobiology of the female reproductive system","volume":"20","author":"Matsuzaki","year":"2021","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10815-010-9478-4","article-title":"A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health","volume":"28","author":"Woodruff","year":"2011","journal-title":"J. Assist. Reprod. Genet"},{"key":"10.1016\/j.semcdb.2025.103642_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1095\/biolreprod.114.121368","article-title":"Dynamic reciprocity between cells and their microenvironment in reproduction","volume":"92","author":"Thorne","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1038107","article-title":"Squeezing the eggs to grow: the mechanobiology of mammalian folliculogenesis","volume":"10","author":"Biswas","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav9960","article-title":"Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes","volume":"5","author":"Nagamatsu","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.semcdb.2025.103642_bib7","doi-asserted-by":"crossref","first-page":"17474","DOI":"10.1073\/pnas.1312830110","article-title":"Hippo signaling disruption and akt stimulation of ovarian follicles for infertility treatment","volume":"110","author":"Kawamura","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2025.103642_bib8","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/humrep\/dey250","article-title":"Dynamics of PI3K and hippo signaling pathways during in vitro human follicle activation","volume":"33","author":"Grosbois","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/biolre\/ioz215","article-title":"Interaction between PI3K\/AKT and hippo pathways during in vitro follicular activation and response to fragmentation and chemotherapy exposure using a mouse immature ovary model","volume":"102","author":"Devos","year":"2020","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib10","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10439-017-1816-6","article-title":"Alginate: a versatile biomaterial to encapsulate isolated ovarian follicles","volume":"45","author":"Vanacker","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.semcdb.2025.103642_bib11","article-title":"Age-associated increased stiffness of the ovarian microenvironment impairs follicle development and oocyte quality and rapidly alters follicle gene expression","author":"Pietroforte","year":"2024","journal-title":"BioRxivorg"},{"key":"10.1016\/j.semcdb.2025.103642_bib12","series-title":"Current Topics in Developmental Biology","article-title":"Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles","author":"Owen","year":"2024"},{"key":"10.1016\/j.semcdb.2025.103642_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/rep.1.00960","article-title":"Formation of ovarian follicular fluid May be due to the osmotic potential of large glycosaminoglycans and proteoglycans","volume":"132","author":"Clarke","year":"2006","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib14","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1095\/biolreprod.109.082941","article-title":"Formation of the ovarian follicular antrum and follicular fluid","volume":"82","author":"Rodgers","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/rep.0.1210307","article-title":"M. Br\u00e4nnstr\u00f6m, Novel method for intrafollicular pressure measurements in the rat ovary: increased intrafollicular pressure after hCG stimulation","volume":"121","author":"Matousek","year":"2001","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1530\/jrf.0.0850593","article-title":"Relaxation-induced contraction of smooth muscle surrounding hamster ovarian follicles","volume":"85","author":"Self","year":"1989","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib17","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1210\/en.2005-1228","article-title":"Endothelin-2 in ovarian follicle rupture","volume":"147","author":"Ko","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.semcdb.2025.103642_bib18","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/s42003-024-07074-9","article-title":"Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation","volume":"7","author":"Zaniker","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib19","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/s41556-024-01524-6","article-title":"Ex vivo imaging reveals the spatiotemporal control of ovulation","volume":"26","author":"Thomas","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jez.1402160316","article-title":"The role of follicular smooth muscle cells in hamster ovulation","volume":"216","author":"Martin","year":"1981","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.semcdb.2025.103642_bib21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0090-6980(74)80031-6","article-title":"Effects of indomethacin and prostaglandin F-2-alpha on ovulation and ovarian contractility in the rabbit","volume":"5","author":"Diaz-Infante","year":"1974","journal-title":"Prostaglandins"},{"key":"10.1016\/j.semcdb.2025.103642_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1530\/jrf.0.0680017","article-title":"Blockage of ovulation in the explanted hamster ovary by a collagenase inhibitor","volume":"68","author":"Ichikawa","year":"1983","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1530\/REP-16-0129","article-title":"Reproductive age-associated fibrosis in the stroma of the mammalian ovary","volume":"152","author":"Briley","year":"2016","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13259","article-title":"Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices","volume":"19","author":"Amargant","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib25","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/humrep\/deaa100","article-title":"Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause","volume":"35","author":"Ouni","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib26","doi-asserted-by":"crossref","first-page":"9686","DOI":"10.18632\/aging.103237","article-title":"Ovulation and ovarian wound healing are impaired with advanced reproductive age","volume":"12","author":"Mara","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.semcdb.2025.103642_bib27","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/s41467-021-25934-4","article-title":"A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis","volume":"12","author":"Ouni","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib28","article-title":"Ovarian biomechanics: from health to disease","volume":"11","author":"Sun","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.semcdb.2025.103642_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41598-024-84338-8","article-title":"Evaluation of ovarian stiffness and its biological mechanism using shear wave elastography in polycystic ovary syndrome","volume":"15","author":"He","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn4564","article-title":"Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary","volume":"8","author":"Umehara","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.semcdb.2025.103642_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq1475","article-title":"Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice","volume":"8","author":"Landry","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.semcdb.2025.103642_bib32","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/REP-19-0501","article-title":"The ovarian stroma as a new frontier","volume":"160","author":"Kinnear","year":"2020","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13048-023-01300-4","article-title":"The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities","volume":"16","author":"Shen","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.semcdb.2025.103642_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56454-3","article-title":"Proteomic analyses of decellularized porcine ovaries identified new matrisome proteins and spatial differences across and within ovarian compartments","volume":"9","author":"Henning","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib35","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1074\/mcp.RA117.000469","article-title":"A draft map of the human ovarian proteome for tissue engineering and clinical applications","volume":"18","author":"Ouni","year":"2019","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.semcdb.2025.103642_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1933719107309818","article-title":"The role of the extracellular matrix in ovarian follicle development","volume":"14","author":"Woodruff","year":"2007","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.semcdb.2025.103642_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121099","article-title":"Micromechanical mapping of the intact ovary interior reveals contrasting mechanical roles for follicles and stroma","volume":"277","author":"Hopkins","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.semcdb.2025.103642_bib38","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.actbio.2023.07.010","article-title":"Micromechanical characterizations and viscoelastic modeling reveal elastic and viscoelastic heterogeneities in ovarian tissue and the significant viscoelastic contribution to the apparent elastic modulus determined by AFM indentation","volume":"168","author":"Stewart","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.semcdb.2025.103642_bib39","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/humrep\/dead008","article-title":"Spatio-temporal remodelling of the composition and architecture of the human ovarian cortical extracellular matrix during in vitro culture","volume":"38","author":"Grosbois","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/GME.0000000000000755","article-title":"Aging ovary and the role for advanced glycation end products","volume":"24","author":"Pertynska-Marczewska","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.semcdb.2025.103642_bib41","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1038\/s41467-023-42382-4","article-title":"Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction","volume":"14","author":"Barbazan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib42","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2322762122","article-title":"Cell-matrix feedback controls stretch-induced cellular memory and fibroblast activation","volume":"122","author":"Hong","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2025.103642_bib43","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1530\/REP-10-0483","article-title":"A macrophage and theca cell-enriched stromal cell population influences growth and survival of immature murine follicles in vitro","volume":"141","author":"Tingen","year":"2011","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib44","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1530\/REP-19-0330","article-title":"Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary","volume":"159","author":"Zhang","year":"2020","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib45","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.semcdb.2025.103642_bib46","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2021.04.021","article-title":"Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer","volume":"54","author":"Buechler","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.semcdb.2025.103642_bib47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/molehr\/gal060","article-title":"Extracellular matrix of the human cyclic corpus luteum","volume":"12","author":"Irving-Rodgers","year":"2006","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib48","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1530\/rep.1.01062","article-title":"Vascular composition, apoptosis, and expression of angiogenic factors in the corpus luteum during prostaglandin F2alpha-induced regression in sheep","volume":"131","author":"Vonnahme","year":"2006","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1254943","article-title":"Mechanisms of angioregression of the corpus luteum","volume":"14","author":"Monaco","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib50","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/biolre\/iox052","article-title":"Changes in immune cell distribution and their cytokine\/chemokine production during regression of the rhesus macaque corpus luteum","volume":"96","author":"Bishop","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib51","article-title":"Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures","author":"Converse","year":"2024","journal-title":"BioRxivorg"},{"key":"10.1016\/j.semcdb.2025.103642_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003204","article-title":"Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures","volume":"23","author":"Converse","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib53","article-title":"Theca cell mechanics and tissue pressure regulate mammalian ovarian folliculogenesis","author":"Biswas","year":"2024","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib54","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00418-006-0194-1","article-title":"Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis","volume":"126","author":"Berkholtz","year":"2006","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib55","doi-asserted-by":"crossref","first-page":"C34","DOI":"10.1152\/ajpcell.2002.282.1.C34","article-title":"Basal lamina of ovarian follicle regulates an inward Cl(-) current in differentiated granulosa cells","volume":"282","author":"Qin","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib56","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00441-009-0905-8","article-title":"Dynamics of extracellular matrix in ovarian follicles and corpora lutea of mice","volume":"339","author":"Irving-Rodgers","year":"2010","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.semcdb.2025.103642_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.111.096156","article-title":"Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles","volume":"86","author":"Mora","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib58","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1530\/REP-17-0503","article-title":"The role of tight junction proteins in ovarian follicular development and ovarian cancer","volume":"155","author":"Zhang","year":"2018","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib59","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1016\/j.bpj.2016.04.049","article-title":"The mechanics of ovulation depend on an incredibly soft and sugar-rich extracellular matrix","volume":"110","author":"Curtis","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.semcdb.2025.103642_bib60","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/j.bpj.2016.03.023","article-title":"Micromechanical analysis of the hyaluronan-rich matrix surrounding the oocyte reveals a uniquely soft and elastic composition","volume":"110","author":"Chen","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.semcdb.2025.103642_bib61","first-page":"78","article-title":"Molecular organization and mechanical properties of the hyaluronan matrix surrounding the mammalian oocyte","author":"Salustri","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib62","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1530\/jrf.0.0520174","article-title":"K. Unsicker, fluorescence histochemical demonstration of a relationship between adrenergic nerves and cells containing actin and myosin in the rat ovary, with special reference to the follicle wall","volume":"52","author":"Walles","year":"1978","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib63","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/humrep\/der066","article-title":"Expression pattern of endothelin system components and localization of smooth muscle cells in the human pre-ovulatory follicle","volume":"26","author":"Choi","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib64","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14004","article-title":"Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan","volume":"22","author":"Babayev","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib65","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21074","article-title":"Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes","volume":"6","author":"Rocio Servin-Vences","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2025.103642_bib66","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41467-018-03502-7","article-title":"Voltage gating of mechanosensitive PIEZO channels","volume":"9","author":"Moroni","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2023.103128","article-title":"Mechanosensitive channels in the mechanical component of the exercise pressor reflex","volume":"250","author":"Hori","year":"2023","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.semcdb.2025.103642_bib68","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103642_bib69","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1089\/ars.2010.3647","article-title":"Go with the flow: how Kr\u00fcppel-like factor 2 regulates the vasoprotective effects of shear stress","volume":"15","author":"Nayak","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.semcdb.2025.103642_bib70","doi-asserted-by":"crossref","first-page":"17693","DOI":"10.1074\/jbc.REV119.007963","article-title":"Control of cellular responses to mechanical cues through YAP\/TAZ regulation","volume":"294","author":"Dasgupta","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.semcdb.2025.103642_bib71","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib72","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev-biophys-070816-033547","article-title":"Mechanotransduction by the actin cytoskeleton: converting mechanical stimuli into biochemical signals","volume":"47","author":"Harris","year":"2018","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.semcdb.2025.103642_bib73","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/19396368.2017.1411990","article-title":"Regulation of follicle growth through hormonal factors and mechanical cues mediated by hippo signaling pathway","volume":"64","author":"Kawashima","year":"2018","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.semcdb.2025.103642_bib74","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.fertnstert.2020.07.031","article-title":"Hippo signaling disruption and ovarian follicle activation in infertile patients","volume":"114","author":"Hsueh","year":"2020","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.semcdb.2025.103642_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2014-1020","article-title":"Intraovarian control of early folliculogenesis","volume":"36","author":"Hsueh","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.semcdb.2025.103642_bib76","doi-asserted-by":"crossref","first-page":"10049","DOI":"10.1096\/fj.201900179RR","article-title":"Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development","volume":"33","author":"Lv","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.semcdb.2025.103642_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1198873","article-title":"The role of hippo pathway in ovarian development","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib78","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1096\/fj.201900609R","article-title":"Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance","volume":"33","author":"Tsoi","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.semcdb.2025.103642_bib79","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1210\/endrev\/bnac013","article-title":"Hippo signaling in the ovary: emerging roles in development, fertility, and disease","volume":"43","author":"Clark","year":"2022","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.semcdb.2025.103642_bib80","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1159\/000369752","article-title":"Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice","volume":"35","author":"Xiang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.semcdb.2025.103642_bib81","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1096\/fj.14-267856","article-title":"Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the hippo signaling effector YAP","volume":"29","author":"Cheng","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.semcdb.2025.103642_bib82","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/jcp.27024","article-title":"Hippo pathway functions as a downstream effector of AKT signaling to regulate the activation of primordial follicles in mice","volume":"234","author":"Hu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111524","article-title":"YAP signaling in preovulatory granulosa cells is critical for the functioning of the EGF network during ovulation","volume":"541","author":"Dos Santos","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.semcdb.2025.103642_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-41954-0","article-title":"Regulation of follicular activation signaling pathways by in vitro inhibition of YAP\/TAZ activity in mouse ovaries","volume":"13","author":"Devos","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib85","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.tibs.2021.05.005","article-title":"PI3K functions as a hub in mechanotransduction","volume":"46","author":"Di-Luoffo","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.semcdb.2025.103642_bib86","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjac048","article-title":"Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K\/AKT signaling","volume":"14","author":"Wei","year":"2022","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib87","article-title":"Comparative analysis of PI3K-AKT and MEK-ERK1\/2 signaling-driven molecular changes in granulosa cells","volume":"169","author":"Baddela","year":"2025","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.semcdb.2025.103642_bib88","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10815-007-9156-3","article-title":"PTEN and akt expression during growth of human ovarian follicles","volume":"24","author":"Goto","year":"2007","journal-title":"J. Assist. Reprod. Genet"},{"key":"10.1016\/j.semcdb.2025.103642_bib89","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1210\/jc.2008-1948","article-title":"Insulin attenuates the insulin-like growth factor-I (IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in luteinized granulosa cells with an increase in PTEN","volume":"94","author":"Iwase","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2025.103642_bib90","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2023.2227280","article-title":"Downregulated lncRNA HOTAIR ameliorates polycystic ovaries syndrome via IGF-1 mediated PI3K\/Akt pathway","volume":"39","author":"Chen","year":"2023","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.semcdb.2025.103642_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053810","article-title":"Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling","volume":"8","author":"Adhikari","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2025.103642_bib92","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1073\/pnas.1617233114","article-title":"mTORC1\/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy","volume":"114","author":"Goldman","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2025.103642_bib93","doi-asserted-by":"crossref","first-page":"9838","DOI":"10.3390\/ijms22189838","article-title":"PI3K\/PTEN\/AKT signaling pathways in germ cell development and their involvement in germ cell tumors and ovarian dysfunctions","volume":"22","author":"De Felici","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2025.103642_bib94","first-page":"722","article-title":"An update on physiopathological roles of akt in the ReprodAKTive mammalian ovary","volume":"14","author":"Giaccari","year":"2024","journal-title":"Life (Basel)"},{"key":"10.1016\/j.semcdb.2025.103642_bib95","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1262\/jrd.09-094H","article-title":"Formation of primordial follicles and immunolocalization of PTEN, PKB and FOXO3A proteins in the ovaries of fetal and neonatal pigs","volume":"56","author":"Ding","year":"2010","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.semcdb.2025.103642_bib96","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/humupd\/dmv037","article-title":"Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood","volume":"21","author":"Zhang","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.semcdb.2025.103642_bib97","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10815-019-01628-1","article-title":"Role of the PI3K and hippo pathways in follicle activation after grafting of human ovarian tissue","volume":"37","author":"Masciangelo","year":"2020","journal-title":"J. Assist. Reprod. Genet"},{"key":"10.1016\/j.semcdb.2025.103642_bib98","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s10815-020-01790-x","article-title":"PTEN and FOXO3 expression in the prenatal and postnatal human ovary","volume":"37","author":"Albamonte","year":"2020","journal-title":"J. Assist. Reprod. Genet"},{"key":"10.1016\/j.semcdb.2025.103642_bib99","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/GCO.0000000000000268","article-title":"Activation of dormant follicles: a new treatment for premature ovarian failure?","volume":"28","author":"Kawamura","year":"2016","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.semcdb.2025.103642_bib100","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1210\/jc.2016-1589","article-title":"In vitro activation of follicles and fresh tissue auto-transplantation in primary ovarian insufficiency patients","volume":"101","author":"Zhai","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.semcdb.2025.103642_bib101","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.rbmo.2019.09.007","article-title":"Drug-free in-vitro activation of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve","volume":"40","author":"Kawamura","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.semcdb.2025.103642_bib102","doi-asserted-by":"crossref","first-page":"R445","DOI":"10.1016\/j.cub.2018.02.003","article-title":"Tensile forces and mechanotransduction at cell-cell junctions","volume":"28","author":"Charras","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib103","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3389\/fphys.2018.00824","article-title":"Cellular mechanotransduction: from tension to function","volume":"9","author":"Martino","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183316","article-title":"Cell-cell junctions as sensors and transducers of mechanical forces","volume":"1862","author":"Angulo-Urarte","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.semcdb.2025.103642_bib105","article-title":"Granulosa cell-layer stiffening prevents escape of mural granulosa cells from the post-ovulatory follicle","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.semcdb.2025.103642_bib106","doi-asserted-by":"crossref","unstructured":"A. Emery, O.W. Blaschuk, T.D. Dinh, T. McPhee, R. Becker, A.D. Abell, K.M. Mrozik, A.C.W. Zannettino, R.L. Robker, D.L. Russell, N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation, 2024. https:\/\/doi.org\/10.7554\/elife.92068.","DOI":"10.7554\/eLife.92068.1"},{"key":"10.1016\/j.semcdb.2025.103642_bib107","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1152\/ajplegacy.1963.205.6.1067","article-title":"Measurements of intrafollicular pressures in the rabbit ovary","volume":"205","author":"Espey","year":"1963","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib108","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1152\/ajplegacy.1964.207.3.590","article-title":"Follicular pressure and distensibility in ovulation","volume":"207","author":"Rondell","year":"1964","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib109","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0015-0282(16)43824-0","article-title":"Intrafollicular pressure within preovulatory follicles of the pig","volume":"31","author":"Bronson","year":"1979","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.semcdb.2025.103642_bib110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.actbio.2014.11.022","article-title":"Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo","volume":"13","author":"Wood","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.semcdb.2025.103642_bib111","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1089\/ten.tea.2020.0037","article-title":"Ultrasound shear wave velocity varies across anatomical region in ex vivo bovine ovaries","volume":"26","author":"Gargus","year":"2020","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.semcdb.2025.103642_bib112","doi-asserted-by":"crossref","first-page":"7347","DOI":"10.1038\/s41598-024-57867-5","article-title":"Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies","volume":"14","author":"Franko","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib113","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/s42003-021-02662-5","article-title":"Mechanical mapping of mammalian follicle development using brillouin microscopy","volume":"4","author":"Chan","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib114","article-title":"Three-dimensional quantitative micro-elastography reveals alterations in spatial elasticity patterns of follicles and corpora lutea in murine ovaries during ageing","author":"Jaeschke","year":"2024","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib115","doi-asserted-by":"crossref","DOI":"10.1088\/2515-7647\/adb360","article-title":"Microrheology of the cumulus-oocyte matrix using optical tweezers","volume":"7","author":"Campugan","year":"2025","journal-title":"J. Phys. Photonics"},{"key":"10.1016\/j.semcdb.2025.103642_bib116","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1158\/0008-5472.CAN-10-1242","article-title":"Hippo pathway effector yap is an ovarian cancer oncogene","volume":"70","author":"Hall","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcdb.2025.103642_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152712","article-title":"Correction: YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients","volume":"11","author":"Xia","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2025.103642_bib118","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/biolre\/ioae050","article-title":"Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease","volume":"110","author":"Zaniker","year":"2024","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib119","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12551-024-01231-4","article-title":"Novel imaging and biophysical approaches to study tissue hydraulics in mammalian folliculogenesis","volume":"16","author":"Turley","year":"2024","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.semcdb.2025.103642_bib120","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1364\/AO.54.006111","article-title":"Optical coherence tomography imaging for analysis of follicular development in ovarian tissue","volume":"54","author":"Watanabe","year":"2015","journal-title":"Appl. Opt."},{"key":"10.1016\/j.semcdb.2025.103642_bib121","first-page":"2621","article-title":"The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway","volume":"127","author":"McGrail","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.semcdb.2025.103642_bib122","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ydbio.2014.11.002","article-title":"Quantitative methods for analyzing cell-cell adhesion in development","volume":"401","author":"Kashef","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib123","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bpj.2015.06.015","article-title":"Characterizing cell adhesion by using micropipette aspiration","volume":"109","author":"Hogan","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.semcdb.2025.103642_bib124","doi-asserted-by":"crossref","DOI":"10.1038\/srep28535","article-title":"Wide and high resolution tension measurement using FRET in embryo","volume":"6","author":"Yamashita","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib125","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-50142-z","article-title":"In situ FRET measurement of cellular tension using conventional confocal laser microscopy in newly established reporter mice expressing actinin tension sensor","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib126","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41557-018-0127-3","article-title":"A fluorescent membrane tension probe","volume":"10","author":"Colom","year":"2018","journal-title":"Nat. Chem."},{"key":"10.1016\/j.semcdb.2025.103642_bib127","doi-asserted-by":"crossref","DOI":"10.1242\/dev.192773","article-title":"Inferring cell junction tension and pressure from cell geometry","volume":"148","author":"Roffay","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2025.103642_bib128","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/s41592-023-02084-7","article-title":"Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy","volume":"20","author":"Ichbiah","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103642_bib129","article-title":"Fully three-dimensional force inference in intestinal organoids reveals ratchet-like bud stabilization","author":"Drozdowski","year":"2025","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib130","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/s41551-023-01015-3","article-title":"Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies","volume":"7","author":"Soteriou","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.semcdb.2025.103642_bib131","article-title":"High-throughput mechanomic screening reveals novel regulators of single-cell mechanics","author":"Strampe","year":"2025","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib132","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s12276-024-01186-2","article-title":"Advances in single-cell omics and multiomics for high-resolution molecular profiling","volume":"56","author":"Lim","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.semcdb.2025.103642_bib133","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1038\/s41467-019-11036-9","article-title":"Single-cell reconstruction of follicular remodeling in the human adult ovary","volume":"10","author":"Fan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib134","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77239","article-title":"A single-cell Atlas of the cycling murine ovary","volume":"11","author":"Morris","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2025.103642_bib135","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/OGX.0000000000000805","article-title":"Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells","volume":"75","author":"Wagner","year":"2020","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.semcdb.2025.103642_bib136","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100920118","article-title":"Single-cell sequencing reveals suppressive transcriptional programs regulated by MIS\/AMH in neonatal ovaries","volume":"118","author":"Meinsohn","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2025.103642_bib137","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74915","article-title":"Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function","volume":"12","author":"Ben Yaakov","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2025.103642_bib138","article-title":"Single-cell Atlas of human ovaries reveals the role of the pyroptotic macrophage in ovarian aging","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.semcdb.2025.103642_bib139","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s43587-023-00552-5","article-title":"A single-cell Atlas of the aging mouse ovary","volume":"4","author":"Isola","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.semcdb.2025.103642_bib140","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","article-title":"Single-cell transcriptomic Atlas of primate ovarian aging","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib141","article-title":"The regulatory landscapes of human ovarian ageing","author":"Jin","year":"2022","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib142","article-title":"Transcriptomic signatures of mouse ovarian aging and estropausal transition at single cell resolution","author":"Wang","year":"2024","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib143","doi-asserted-by":"crossref","first-page":"39638","DOI":"10.1038\/srep39638","article-title":"Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib144","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13062-024-00496-9","article-title":"Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice","volume":"19","author":"Xiao","year":"2024","journal-title":"Biol. Direct"},{"key":"10.1016\/j.semcdb.2025.103642_bib145","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adm7506","article-title":"Cellular Atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing","volume":"10","author":"Jones","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.semcdb.2025.103642_bib146","article-title":"Single-cell and spatiotemporal profile of ovulation in the mouse ovary","author":"Huang","year":"2024","journal-title":"BioRxivorg"},{"key":"10.1016\/j.semcdb.2025.103642_bib147","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13516","article-title":"A spatiotemporal gene expression and cell atlases of the developing rat ovary","volume":"56","author":"Shi","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.semcdb.2025.103642_bib148","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s43587-024-00607-1","article-title":"Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1","volume":"4","author":"Wu","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.semcdb.2025.103642_bib149","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cell.2024.01.021","article-title":"The cycling and aging mouse female reproductive tract at single-cell resolution","volume":"187","author":"Winkler","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11427-023-2360-3","article-title":"Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity","volume":"67","author":"Jiang","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.semcdb.2025.103642_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104819","article-title":"Spatially resolved transcriptomic profiling of ovarian aging in mice","volume":"25","author":"Russ","year":"2022","journal-title":"IScience"},{"key":"10.1016\/j.semcdb.2025.103642_bib152","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/procel\/pwad063","article-title":"Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics","volume":"15","author":"Lu","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib153","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1038\/s41467-024-51185-0","article-title":"In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity","volume":"15","author":"Rooda","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib154","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3390\/nano12030345","article-title":"Impact of aging on the ovarian extracellular matrix and derived 3D scaffolds","volume":"12","author":"Pennarossa","year":"2022","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.semcdb.2025.103642_bib155","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaae023","article-title":"Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes","volume":"30","author":"Galatidou","year":"2024","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib156","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/dead093.577","article-title":"P-219 Single-follicle spatial proteomics of the whole ovary by MALDI mass spectrometry imaging: towards the identification of protein-markers of the follicle\u2019s quality","volume":"38","author":"Zuccotti","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib157","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/acs.jproteome.3c00545","article-title":"Transcriptomics and spatial proteomics for discovery and validation of missing proteins in the human ovary","volume":"23","author":"M\u00e9ar","year":"2024","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.semcdb.2025.103642_bib158","doi-asserted-by":"crossref","first-page":"7946","DOI":"10.1038\/s41467-023-43898-5","article-title":"Author correction: automated imaging and identification of proteoforms directly from ovarian cancer tissue","volume":"14","author":"McGee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib159","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/1471-2164-12-417","article-title":"Transcriptome profiling of sheep granulosa cells and oocytes during early follicular development obtained by laser capture microdissection","volume":"12","author":"Bonnet","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.semcdb.2025.103642_bib160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbrc.2021.07.083","article-title":"A time-resolved transcriptome landscape of the developing mouse ovary","volume":"572","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib161","first-page":"10821","article-title":"Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature","volume":"15","author":"Dipali","year":"2023","journal-title":"Aging (Albany NY) 15"},{"key":"10.1016\/j.semcdb.2025.103642_bib162","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2024.1480153","article-title":"Comparative study of the three-dimensional genomes of granulosa cells in germinal vesicle and metaphase II follicles","volume":"15","author":"Mao","year":"2024","journal-title":"Front. Genet"},{"key":"10.1016\/j.semcdb.2025.103642_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100895","article-title":"Isolation of high-quality total RNA and RNA sequencing of single bovine oocytes","volume":"2","author":"Biase","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.semcdb.2025.103642_bib164","article-title":"The use of laser microdissection in the identification of suitable reference genes for normalization of quantitative real-time PCR in human FFPE epithelial ovarian tissue samples","volume":"9","author":"Cai","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2025.103642_bib165","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1101\/gr.190595.115","article-title":"Defining cell types and states with single-cell genomics","volume":"25","author":"Trapnell","year":"2015","journal-title":"Genome Res"},{"key":"10.1016\/j.semcdb.2025.103642_bib166","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41592-023-01791-5","article-title":"Single-cell proteomics enabled by next-generation sequencing or mass spectrometry","volume":"20","author":"Bennett","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103642_bib167","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/CIRCULATIONAHA.120.045536","article-title":"Transcatheter aortic valve implantation represents an anti-inflammatory therapy via reduction of shear stress-induced, Piezo-1-mediated monocyte activation","volume":"142","author":"Baratchi","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2025.103642_bib168","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/JLB.3A0520-100RR","article-title":"Tensile force transmitted through LFA-1 bonds mechanoregulate neutrophil inflammatory response","volume":"108","author":"Morikis","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib169","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/aor.13874","article-title":"Neutrophil injury and function alterations induced by high mechanical shear stress with short exposure time","volume":"45","author":"Sun","year":"2021","journal-title":"Artif. Organs"},{"key":"10.1016\/j.semcdb.2025.103642_bib170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12915-022-01266-7","article-title":"Fluid shear stress enhances t cell activation through Piezo1","volume":"20","author":"Hope","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib171","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/s41467-020-15821-9","article-title":"Consistent RNA sequencing contamination in GTEx and other data sets","volume":"11","author":"Nieuwenhuis","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib172","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1158\/1078-0432.CCR-21-4383","article-title":"Spatial metabolomics identifies distinct tumor-specific subtypes in gastric cancer patients","volume":"28","author":"Wang","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.semcdb.2025.103642_bib173","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1038\/s41467-024-49403-w","article-title":"Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues","volume":"15","author":"Kamp","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib174","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/acs.analchem.4c05665","article-title":"Comprehensive approach for sequential MALDI-MSI analysis of lipids, N-glycans, and peptides in fresh-frozen rodent brain tissues","volume":"97","author":"Lee","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.semcdb.2025.103642_bib175","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301929","article-title":"High-quality single-cell transcriptomics from ovarian histological sections during folliculogenesis","volume":"6","author":"Ikeda","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.semcdb.2025.103642_bib176","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2317418121","article-title":"A spatiotemporal molecular Atlas of the ovulating mouse ovary","volume":"121","author":"Mantri","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2025.103642_bib177","article-title":"Aging disrupts spatiotemporal coordination in the cycling ovary","author":"Lan","year":"2024","journal-title":"BioRxiv"},{"key":"10.1016\/j.semcdb.2025.103642_bib178","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/cancers14092262","article-title":"Space- and time-resolved metabolomics of a high-grade serous ovarian cancer mouse model","volume":"14","author":"Sah","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.semcdb.2025.103642_bib179","article-title":"Ultrahigh resolution lipid mass spectrometry imaging of high-grade serous ovarian cancer mouse models","author":"Ma","year":"2023","journal-title":"BioRxivorg"},{"key":"10.1016\/j.semcdb.2025.103642_bib180","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaad006","article-title":"MALDI mass spectrometry imaging shows a gradual change in the proteome landscape during mouse ovarian folliculogenesis","volume":"29","author":"Fiorentino","year":"2023","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.semcdb.2025.103642_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109174","article-title":"Delineating lipidomic landscapes in human and mouse ovaries: spatial signatures and chemically-induced alterations via MALDI mass spectrometry imaging: spatial ovarian lipidomics","volume":"194","author":"Pascuali","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.semcdb.2025.103642_bib182","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jgg.2023.03.011","article-title":"Spatially resolved transcriptomics: a comprehensive review of their technological advances, applications, and challenges","volume":"50","author":"Cheng","year":"2023","journal-title":"J. Genet. Genom."},{"key":"10.1016\/j.semcdb.2025.103642_bib183","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41580-024-00768-2","article-title":"Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics","volume":"26","author":"Gulati","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib184","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.chembiol.2024.08.008","article-title":"Advances in spatial proteomics: mapping proteome architecture from protein complexes to subcellular localizations","volume":"31","author":"Breckels","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib185","article-title":"The evolving landscape of spatial proteomics technologies in the AI age","author":"Hu","year":"2024","journal-title":"Fundam. Res."},{"key":"10.1016\/j.semcdb.2025.103642_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102245","article-title":"Multiomics insights into the female reproductive aging","volume":"95","author":"Wei","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.semcdb.2025.103642_bib187","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics","volume":"353","author":"St\u00e5hl","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103642_bib188","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41592-019-0548-y","article-title":"High-definition spatial transcriptomics for in situ tissue profiling","volume":"16","author":"Vickovic","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103642_bib189","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41587-020-0472-9","article-title":"Multiplex digital spatial profiling of proteins and RNA in fixed tissue","volume":"38","author":"Merritt","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103642_bib190","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.aaw1219","article-title":"Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution","volume":"363","author":"Rodriques","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103642_bib191","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.cell.2022.04.003","article-title":"Spatiotemporal transcriptomic Atlas of mouse organogenesis using DNA nanoball-patterned arrays","volume":"185","author":"Chen","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib192","doi-asserted-by":"crossref","first-page":"8353","DOI":"10.1038\/s41467-023-43458-x","article-title":"10x development teams, S.E.B. Taylor, high resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis","volume":"14","author":"Janesick","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib193","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/s41587-022-01483-z","article-title":"High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging","volume":"40","author":"He","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103642_bib194","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa6090","article-title":"RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells","volume":"348","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103642_bib195","doi-asserted-by":"crossref","first-page":"19490","DOI":"10.1073\/pnas.1912459116","article-title":"Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression","volume":"116","author":"Xia","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.semcdb.2025.103642_bib196","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.2869","article-title":"Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry","volume":"11","author":"Giesen","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103642_bib197","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.cell.2018.07.010","article-title":"Deep profiling of mouse splenic architecture with CODEX multiplexed imaging","volume":"174","author":"Goltsev","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103642_bib198","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1038\/s41596-021-00556-8","article-title":"CODEX multiplexed tissue imaging with DNA-conjugated antibodies","volume":"16","author":"Black","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.semcdb.2025.103642_bib199","article-title":"Abstract P1-04-05: multiplexed immunofluorescence staining of intra-tumoral immune cell populations and associations with immunohistochemical, clinical, and pathologic variables in breast cancer","volume":"82","author":"O\u2019Meara","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.semcdb.2025.103642_bib200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.semcdb.2025.103642_bib201","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adp8496","article-title":"Spatial transcriptomics in bone mechanomics: exploring the mechanoregulation of fracture healing in the era of spatial omics","volume":"11","author":"Mathavan","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.semcdb.2025.103642_bib202","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41592-025-02618-1","article-title":"A computational pipeline for spatial mechano-transcriptomics","volume":"22","author":"Hallou","year":"2025","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103642_bib203","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1152\/jappl.2000.89.6.2498","article-title":"Selected contribution: regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells","volume":"89","author":"Peake","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.semcdb.2025.103642_bib204","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166237","article-title":"EGR1 regulates transcription downstream of mechanical signals during tendon formation and healing","volume":"11","author":"Gaut","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2025.103642_bib205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trsl.2016.05.003","article-title":"Atheroprotective laminar flow inhibits hippo pathway effector YAP in endothelial cells","volume":"176","author":"Xu","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.semcdb.2025.103642_bib206","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrm3416","article-title":"Transduction of mechanical and cytoskeletal cues by YAP and TAZ","volume":"13","author":"Halder","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib207","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112431","article-title":"Dysregulated collagen homeostasis by matrix stiffening and TGF-\u03b21 in fibroblasts from idiopathic pulmonary fibrosis patients: role of FAK\/Akt","volume":"18","author":"Gim\u00e9nez","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2025.103642_bib208","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.semcdb.2023.03.006","article-title":"Imaging spatiotemporal translation regulation in vivo","volume":"154","author":"Blake","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib209","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.matbio.2022.03.005","article-title":"Proteome-wide and matrisome-specific Atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility","volume":"109","author":"Ouni","year":"2022","journal-title":"Matrix Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103917","article-title":"Single cell analysis of mechanical properties and EMT-related gene expression profiles in cancer fingers","volume":"25","author":"Zou","year":"2022","journal-title":"IScience"},{"key":"10.1016\/j.semcdb.2025.103642_bib211","doi-asserted-by":"crossref","first-page":"50049","DOI":"10.1021\/acsomega.4c00591","article-title":"Unveiling the molecular secrets: a comprehensive review of Raman spectroscopy in biological research","volume":"9","author":"Chandra","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.semcdb.2025.103642_bib212","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.actbio.2023.03.016","article-title":"Raman microspectroscopy identifies fibrotic tissues in collagen-related disorders via deconvoluted collagen type I spectra","volume":"162","author":"Becker","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.semcdb.2025.103642_bib213","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.actbio.2025.04.009","article-title":"Contact-free characterization of nuclear mechanics using correlative Brillouin-Raman Micro-Spectroscopy in living cells","volume":"198","author":"Kerdegari","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.semcdb.2025.103642_bib214","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2021.0642","article-title":"Brillouin-Raman microspectroscopy for the morpho-mechanical imaging of human lamellar bone","volume":"19","author":"Alunni Cardinali","year":"2022","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.semcdb.2025.103642_bib215","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/s41598-023-28735-5","article-title":"Brillouin-Raman micro-spectroscopy and machine learning techniques to classify osteoarthritic lesions in the human articular cartilage","volume":"13","author":"Alunni Cardinali","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103642_bib216","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s42003-024-06496-9","article-title":"Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography","volume":"7","author":"Bresci","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib217","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s42003-024-05788-4","article-title":"High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy","volume":"7","author":"Lee","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib218","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s43018-022-00388-9","article-title":"Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer","volume":"3","author":"Boehm","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.semcdb.2025.103642_bib219","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1038\/s41388-023-02857-6","article-title":"Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption","volume":"42","author":"Geaney","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.semcdb.2025.103642_bib220","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1038\/s41467-024-48667-6","article-title":"Histopathologic image-based deep learning classifier for predicting platinum-based treatment responses in high-grade serous ovarian cancer","volume":"15","author":"Ahn","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib221","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40364-024-00632-7","article-title":"Integrated analysis of spatial transcriptomics and CT phenotypes for unveiling the novel molecular characteristics of recurrent and non-recurrent high-grade serous ovarian cancer","volume":"12","author":"Ju","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.semcdb.2025.103642_bib222","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cels.2018.05.015","article-title":"Linear regression links transcriptomic data and cellular Raman spectra","volume":"7","author":"Kobayashi-Kirschvink","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.semcdb.2025.103642_bib223","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001699","article-title":"Histologically resolved multiomics enables precise molecular profiling of human intratumor heterogeneity","volume":"20","author":"Chen","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.semcdb.2025.103642_bib224","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1038\/s41467-023-41417-0","article-title":"Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution","volume":"14","author":"Sigle","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103642_bib225","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/s41587-023-02082-2","article-title":"Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA","volume":"42","author":"Kobayashi-Kirschvink","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103642_bib226","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1089\/ten.tea.2022.0128","article-title":"Machine learning in tissue engineering","volume":"29","author":"Guo","year":"2023","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.semcdb.2025.103642_bib227","doi-asserted-by":"crossref","DOI":"10.1007\/s11831-024-10100-y","article-title":"Machine learning in biomaterials, biomechanics\/mechanobiology, and biofabrication: state of the art and perspective","author":"Wu","year":"2024","journal-title":"Arch. Comput. Methods Eng."},{"key":"10.1016\/j.semcdb.2025.103642_bib228","article-title":"Recent advances in artificial intelligent strategies for tissue engineering and regenerative Medicine","volume":"30","author":"Gharibshahian","year":"2024","journal-title":"Ski. Res. Technol."},{"key":"10.1016\/j.semcdb.2025.103642_bib229","unstructured":"C. Almagro-P\u00e9rez, A.H. Song, L. Weishaupt, A. Kim, G. Jaume, D.F.K. Williamson, K. Hemker, M.Y. Lu, K. Singh, B. Chen, L.P. Le, A.S. Baras, S. Jiang, A. Bashashati, J.T.C. Liu, F. Mahmood, AI-driven 3D Spatial Transcriptomics, ArXiv [Cs.CV] (2025). https:\/\/doi.org\/10.48550\/ARXIV.2502.17761.."},{"key":"10.1016\/j.semcdb.2025.103642_bib230","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq2084","article-title":"Deep-tissue transcriptomics and subcellular imaging at high spatial resolution","volume":"388","author":"Gandin","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103642_bib231","series-title":"Organ Tissue Engineering","first-page":"285","article-title":"Tissue-engineered ovary","author":"Laronda","year":"2021"},{"key":"10.1016\/j.semcdb.2025.103642_bib232","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-37086-0","article-title":"Dynamic in vitro culture of bovine and human ovarian tissue enhances follicle progression and health","volume":"13","author":"Barbato","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952125000527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952125000527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:18:47Z","timestamp":1772882327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952125000527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":232,"alternative-id":["S1084952125000527"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2025.103642","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Capturing ovarian dynamics through spatial profiling of the mechano-microenvironment","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2025.103642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103642"}}