{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:44:17Z","timestamp":1792061057877,"version":"4.4.0"},"reference-count":134,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL007444"],"award-info":[{"award-number":["T32HL007444"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R15HD108782"],"award-info":[{"award-number":["R15HD108782"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P20GM103460"],"award-info":[{"award-number":["P20GM103460"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.semcdb.2025.103648","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T22:36:33Z","timestamp":1756420593000},"page":"103648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Charting the cardiac landscape: Advances in spatial transcriptomics for heart biology"],"prefix":"10.1016","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0950","authenticated-orcid":false,"given":"Elie N.","family":"Farah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessyka T.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Bloomekatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C.","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semcdb.2025.103648_bib1","series-title":"Bruneau University of Oxford, heart development and disease","author":"G.I","year":"2020"},{"key":"10.1016\/j.semcdb.2025.103648_bib2","series-title":"Heart Development and Disease","author":"Dubois","year":"2024"},{"key":"10.1016\/j.semcdb.2025.103648_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.gde.2016.05.029","article-title":"Myocardial plasticity: cardiac development, regeneration and disease","volume":"40","author":"Bloomekatz","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.semcdb.2025.103648_bib4","series-title":"in: Curr. Top. Dev. Biol","first-page":"157","article-title":"The Cardiac Conduction System: History, Development, and Disease","author":"Lee","year":"2024"},{"key":"10.1016\/j.semcdb.2025.103648_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ceb.2021.04.009","article-title":"Sculpting the heart: cellular mechanisms shaping valves and trabeculae","volume":"73","author":"Gunawan","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.devcel.2007.05.012","article-title":"Vessel and blood specification override cardiac potential in anterior mesoderm","volume":"13","author":"Schoenebeck","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib7","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/CIRCRESAHA.110.227405","article-title":"Myocardial lineage development","volume":"107","author":"Evans","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib8","series-title":"in: Adv. Exp. Med. Biol","first-page":"189","article-title":"Using zebrafish to analyze the genetic and environmental etiologies of congenital heart defects","author":"Shrestha","year":"2020"},{"key":"10.1016\/j.semcdb.2025.103648_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.gde.2016.05.029","article-title":"Myocardial plasticity: cardiac development, regeneration and disease","volume":"40","author":"Bloomekatz","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.semcdb.2025.103648_bib10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/378386a0","article-title":"Multiple essential functions of neuregulin in development","volume":"378","author":"Meyer","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/378394a0","article-title":"Requirement for neuregulin receptor erbB2 in neural and cardiac development","volume":"378","author":"Lee","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib12","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/dev.053736","article-title":"A dual role for ErbB2 signaling in cardiac trabeculation","volume":"137","author":"Liu","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.semcdb.2025.103648_bib13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/dvdy.22526","article-title":"Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish","volume":"240","author":"Peshkovsky","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.semcdb.2025.103648_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/CIRCRESAHA.110.218693","article-title":"Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium","volume":"107","author":"Lai","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15281","article-title":"Regulation of cardiomyocyte behavior in zebrafish trabeculation by neuregulin 2a signaling","volume":"8","author":"Rasouli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib16","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1242\/dev.125724","article-title":"Cardiac contraction activates endocardial notch signaling to modulate chamber maturation in zebrafish","volume":"142","author":"Samsa","year":"2015","journal-title":"Dev"},{"key":"10.1016\/j.semcdb.2025.103648_bib17","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/CIRCRESAHA.124.323658","article-title":"Repair of the infarcted heart: cellular effectors, molecular mechanisms and therapeutic opportunities","volume":"134","author":"Hilgendorf","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib18","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCRESAHA.117.312586","article-title":"Mechanisms of cardiac repair and regeneration","volume":"122","author":"Broughton","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.semcdb.2021.04.023","article-title":"Single cell RNA sequencing approaches to cardiac development and congenital heart disease","volume":"118","author":"Samad","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib21","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1172\/JCI98215","article-title":"Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart","volume":"128","author":"Fu","year":"2018","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.semcdb.2025.103648_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics","volume":"353","author":"St\u00e5hl","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.aaw1219","article-title":"Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution","volume":"363","author":"Rodriques","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib24","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2020.10.026","article-title":"High-Spatial-Resolution Multi-Omics sequencing via deterministic barcoding in tissue","volume":"183","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nmeth.2892","article-title":"Single-cell in situ RNA profiling by sequential hybridization","volume":"11","author":"Lubeck","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib26","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.1250212","article-title":"Highly multiplexed subcellular RNA sequencing in situ","volume":"343","author":"Lee","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib27","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1126\/science.aag1039","article-title":"PROTEIN TRANSLATION. Seeing translation","volume":"352","author":"Iwasaki","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa6090","article-title":"Spatially resolved, highly multiplexed RNA profiling in single cells","volume":"348","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib29","series-title":"Methods Enzymol.","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.mie.2016.03.020","article-title":"RNA imaging with multiplexed Error-Robust fluorescence in situ hybridization (MERFISH)","author":"Moffitt","year":"2016"},{"key":"10.1016\/j.semcdb.2025.103648_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax2656","article-title":"Expansion sequencing: spatially precise in situ transcriptomics in intact biological systems","volume":"371","author":"Alon","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","article-title":"Exploring tissue architecture using spatial transcriptomics","volume":"596","author":"Rao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5483\/BMBRep.2022.55.3.014","article-title":"Recent advances in spatially resolved transcriptomics: challenges and opportunities","volume":"55","author":"Lee","year":"2022","journal-title":"BMB Rep."},{"key":"10.1016\/j.semcdb.2025.103648_bib33","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41592-022-01409-2","article-title":"Museum of spatial transcriptomics","volume":"19","author":"Moses","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib34","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-022-01448-2","article-title":"The expanding vistas of spatial transcriptomics","volume":"41","author":"Tian","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103648_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm1741","article-title":"Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH","volume":"377","author":"Fang","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib36","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.neuron.2016.10.001","article-title":"In situ transcription profiling of single cells reveals spatial organization of cells in the mouse hippocampus","volume":"92","author":"Shah","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.semcdb.2025.103648_bib37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41586-019-1049-y","article-title":"Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+","volume":"568","author":"Eng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5691","article-title":"Three-dimensional intact-tissue sequencing of single-cell transcriptional states","volume":"361","author":"Wang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-46437-y","article-title":"Mapping human tissues with highly multiplexed RNA in situ hybridization","volume":"15","author":"Kalhor","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib40","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nprot.2014.191","article-title":"Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues","volume":"10","author":"Lee","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.semcdb.2025.103648_bib41","unstructured":"10x Genomics, Xenium In Situ, (n.d.) \u3008https:\/\/www.10xgenomics.com\/platforms\/xenium\u3009."},{"key":"10.1016\/j.semcdb.2025.103648_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071820","article-title":"Sequencing mRNA from Cryo-Sliced drosophila embryos to determine Genome-Wide spatial patterns of gene expression","volume":"8","author":"Combs","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semcdb.2025.103648_bib43","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cell.2014.09.038","article-title":"Genome-wide RNA tomography in the zebrafish embryo","volume":"159","author":"Junker","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12139","article-title":"Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling","volume":"7","author":"Nichterwitz","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib45","series-title":"In: Methods Mol. Biol","first-page":"95","article-title":"LCM-seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-based Rna Sequencing","author":"Nichterwitz","year":"2018"},{"key":"10.1016\/j.semcdb.2025.103648_bib46","unstructured":"Spatial transcriptomics, 10x Genomics (n.d.) \u3008https:\/\/www.10xgenomics.com\/spatial-transcriptomic\u3009."},{"key":"10.1016\/j.semcdb.2025.103648_bib47","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41592-019-0548-y","article-title":"High-definition spatial transcriptomics for in situ tissue profiling","volume":"16","author":"Vickovic","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib48","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.cell.2022.04.003","article-title":"Spatiotemporal transcriptomic Atlas of mouse organogenesis using DNA nanoball-patterned arrays","volume":"185","author":"Chen","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib49","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.cell.2020.07.005","article-title":"Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front","volume":"182","author":"Sch\u00fcrch","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib50","unstructured":"PhenoCycler System | Akoya Biosciences, (n.d.). \u3008https:\/\/www.akoyabio.com\/phenocycler\/\u3009 (accessed May 6, 2025)."},{"key":"10.1016\/j.semcdb.2025.103648_bib51","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41592-021-01203-6","article-title":"Spatial omics and multiplexed imaging to explore cancer biology","volume":"18","author":"Lewis","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s43556-023-00144-0","article-title":"Spatial transcriptomics in development and disease","volume":"4","author":"Zhou","year":"2023","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.semcdb.2025.103648_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202206939","article-title":"Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research","volume":"10","author":"Park","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.semcdb.2025.103648_bib54","unstructured":"Space Ranger, 10x Genomics (n.d.) \u3008https:\/\/www.10xgenomics.com\/support\/software\/space\u3009."},{"key":"10.1016\/j.semcdb.2025.103648_bib55","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-021-03705-x","article-title":"Spatially resolved cell Atlas of the mouse primary motor cortex by MERFISH","volume":"598","author":"Zhang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib56","doi-asserted-by":"crossref","DOI":"10.1101\/2023.02.17.529010","article-title":"A unified pipeline for FISH spatial transcriptomics","volume":"3","author":"Cisar","year":"2023","journal-title":"Cell Genom."},{"key":"10.1016\/j.semcdb.2025.103648_bib57","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib58","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41587-021-01044-w","article-title":"Cell segmentation in imaging-based spatial transcriptomics","volume":"40","author":"Petukhov","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103648_bib59","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.cels.2024.04.006","article-title":"Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning","volume":"15","author":"Laubscher","year":"2024","journal-title":"Cell Syst."},{"key":"10.1016\/j.semcdb.2025.103648_bib60","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1016\/j.cell.2024.05.055","article-title":"Open-ST: high-resolution spatial transcriptomics in 3D","volume":"187","author":"Schott","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib61","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103648_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: Large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41592-021-01358-2","article-title":"Squidpy: a scalable framework for spatial omics analysis","volume":"19","author":"Palla","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib64","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41588-024-01664-3","article-title":"BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis","volume":"56","author":"Singhal","year":"2024","journal-title":"Nat. Genet"},{"key":"10.1016\/j.semcdb.2025.103648_bib65","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jgg.2024.11.009","article-title":"KanCell: dissecting cellular heterogeneity in biological tissues through integrated single-cell and spatial transcriptomics","volume":"52","author":"Wang","year":"2025","journal-title":"J. Genet. Genom."},{"key":"10.1016\/j.semcdb.2025.103648_bib67","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s41592-021-01264-7","article-title":"Deep learning and alignment of spatially resolved single-cell transcriptomes with tangram","volume":"18","author":"Biancalani","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib68","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41587-021-01139-4","article-title":"Cell2location maps fine-grained cell types in spatial transcriptomics","volume":"40","author":"Kleshchevnikov","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103648_bib69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41592-019-0701-7","article-title":"Statistical analysis of spatial expression patterns for spatially resolved transcriptomic studies","volume":"17","author":"Sun","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib70","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.4636","article-title":"SpatialDE: identification of spatially variable genes","volume":"15","author":"Svensson","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17900-3","article-title":"A clustering-independent method for finding differentially expressed genes in single-cell transcriptome data","volume":"11","author":"Vandenbon","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1012991","article-title":"Transfer learning of multicellular organization via single-cell and spatial transcriptomics","volume":"21","author":"Tan","year":"2025","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib74","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","article-title":"CellPhoneDB: inferring cell\u2013cell communication from combined expression of multi-subunit ligand\u2013receptor complexes","volume":"15","author":"Efremova","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.semcdb.2025.103648_bib75","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s42003-025-07625-8","article-title":"Deconvolution and inference of spatial communication through optimization algorithm for spatial transcriptomics","volume":"8","author":"Wang","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib76","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/s41592-023-01938-4","article-title":"SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks","volume":"20","author":"Bravo Gonz\u00e1lez-Blas","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib77","doi-asserted-by":"crossref","unstructured":"X. Qiu, D.Y. Zhu, J. Yao, Z. Jing, L. Zuo, M. Wang, K.H. (Joseph) Min, H. Pan, S. Wang, S. Liao, Y. Lai, S. Hao, Y.R. Lu, M. Hill, J.D. Martin-Rufino, C. Weng, A.M. Riera-Escandell, M. Chen, L. Wu, Y. Zhang, X. Wei, M. Li, X. Huang, R. Xiang, Z. Yang, C. Liu, T. Xia, Y. Liang, J. Xu, Q. Hu, Y. Hu, H. Zhu, Y. Li, A. Chen, M.A. Esteban, Y. Gu, D.A. Lauffenburger, X. Xu, L. Liu, J.S. Weissman, S. Liu, Y. Bai, Spateo: multidimensional spatiotemporal modeling of single-cell spatial transcriptomics, BioRxiv (2022) 2022.12.07.519417. https:\/\/doi.org\/10.1101\/2022.12.07.519417.","DOI":"10.1101\/2022.12.07.519417"},{"key":"10.1016\/j.semcdb.2025.103648_bib78","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13059-021-02286-2","article-title":"Giotto: a toolbox for integrative analysis and visualization of spatial expression data","volume":"22","author":"Dries","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2025.01.002","article-title":"Decoding the blueprints of embryo development with single-cell and spatial omics","volume":"167","author":"Liu","year":"2025","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib80","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/ijms26030995","article-title":"Spatial transcriptomics in human cardiac tissue","volume":"26","author":"Nguyen","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2025.103648_bib81","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.devcel.2015.12.010","article-title":"Spatially resolved Genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration","volume":"36","author":"Wu","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib82","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31515","article-title":"Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt\/\u03b2-catenin signaling in autonomic control of heart rate","volume":"7","author":"Burkhard","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.semcdb.2025.103648_bib83","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.devcel.2007.06.006","article-title":"Wnt\/\u03b2-Catenin signaling and cardiogenesis: timing does matter","volume":"13","author":"Tzahor","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib84","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.devcel.2019.07.014","article-title":"Canonical Wnt5b signaling directs outlying Nkx2.5+ mesoderm into pacemaker cardiomyocytes","volume":"50","author":"Ren","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib85","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/stem.3106","article-title":"Canonical wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells","volume":"38","author":"Liang","year":"2020","journal-title":"Stem Cells"},{"key":"10.1016\/j.semcdb.2025.103648_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-21892-z","article-title":"Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis","volume":"12","author":"Mantri","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib87","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037192","article-title":"Epicardium in heart development","volume":"12","author":"Cao","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib88","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature03000","article-title":"Thymosin \u03b24 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair","volume":"432","author":"Bock-Marquette","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib89","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.121.056666","article-title":"PRDM16 is a compact Myocardium-Enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle","volume":"145","author":"Wu","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2025.103648_bib90","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.cell.2019.11.025","article-title":"A spatiotemporal Organ-Wide gene expression and cell Atlas of the developing human heart","volume":"179","author":"Asp","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.semcdb.2025.103648_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-024-07171-z","article-title":"Spatially organized cellular communities form the developing human heart","author":"Farah","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib92","article-title":"Multi-modal refinement of the human heart Atlas during the first gestational trimester","volume":"152","author":"De Bono","year":"2025","journal-title":"Dev"},{"key":"10.1016\/j.semcdb.2025.103648_bib93","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/01.RES.0000263008.66799.aa","article-title":"Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy","volume":"100","author":"Osio","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib94","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature18310","article-title":"Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis","volume":"534","author":"Han","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib95","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvi\u0148ukov\u00e1","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib96","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/s41586-023-06311-1","article-title":"Spatially resolved multiomics of human cardiac niches","volume":"619","author":"Kanemaru","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib97","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41586-022-05060-x","article-title":"Spatial multi-omic map of human myocardial infarction","volume":"608","author":"Kuppe","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib98","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s44161-022-00160-3","article-title":"Single-cell and spatial transcriptomics of the infarcted heart define the dynamic onset of the border zone in response to mechanical destabilization","volume":"1","author":"Calcagno","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071362","article-title":"Ankyrin repeat domain 1 protein: a functionally pleiotropic protein with cardiac biomarker potential","volume":"18","author":"Ling","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.semcdb.2025.103648_bib100","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s44161-022-00140-7","article-title":"Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction","volume":"1","author":"Yamada","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30630-y","article-title":"Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-\u03b2-IGFBP7 axis","volume":"13","author":"Ko","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib102","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13462-5","article-title":"Spatial detection of fetal marker genes expressed at low level in adult human heart tissue","volume":"7","author":"Asp","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.semcdb.2025.103648_bib103","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/cvr\/cvac072","article-title":"Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy","volume":"119","author":"Boogerd","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.111895","article-title":"EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy","volume":"28","author":"Kyriakopoulou","year":"2025","journal-title":"IScience"},{"key":"10.1016\/j.semcdb.2025.103648_bib105","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170246","article-title":"ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts","volume":"134","author":"Hoeft","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.semcdb.2025.103648_bib106","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib107","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib108","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/CIRCULATIONAHA.121.058655","article-title":"Direct reprogramming improves cardiac function and reverses fibrosis in chronic myocardial infarction","volume":"147","author":"Tani","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2025.103648_bib109","article-title":"Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction","volume":"151","author":"Yamada","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.semcdb.2025.103648_bib110","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1172\/JCI85782","article-title":"Alternatively activated macrophages determine repair of the infarcted adult murine heart","volume":"126","author":"Shiraishi","year":"2016","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.semcdb.2025.103648_bib111","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-024-08008-5","article-title":"Targeting immune-fibroblast cell communication in heart failure","volume":"635","author":"Amrute","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib112","doi-asserted-by":"crossref","DOI":"10.1038\/s44161-025-00617-1","article-title":"Dynamic molecular Atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells","volume":"4","author":"Li","year":"2025","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib113","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-024-07806-1","article-title":"Spatially clustered type I interferon responses at injury borderzones","volume":"633","author":"Ninh","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib114","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s44161-022-00138-1","article-title":"Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis","volume":"1","author":"Mantri","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-025-02143-9","article-title":"Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.semcdb.2025.103648_bib116","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib117","doi-asserted-by":"crossref","DOI":"10.1186\/1471-213X-11-21","article-title":"The zebrafish heart regenerates after cryoinjury-induced myocardial infarction","volume":"11","author":"Chablais","year":"2011","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib118","article-title":"An organ-wide spatiotemporal transcriptomic and cellular Atlas of the regenerating zebrafish heart","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.semcdb.2025.103648_bib119","article-title":"Characterizing neonatal heart maturation, regeneration, and scar resolution using spatial transcriptomics","volume":"9","author":"Misra","year":"2022","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.semcdb.2025.103648_bib120","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1038\/sj.emboj.7600454","article-title":"Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein","volume":"23","author":"Pradervand","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.semcdb.2025.103648_bib121","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s44161-024-00428-w","article-title":"YAP induces a neonatal-like pro-renewal niche in the adult heart","volume":"3","author":"Li","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.semcdb.2025.103648_bib122","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","article-title":"The hippo pathway in the heart: pivotal roles in development, disease, and regeneration","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.semcdb.2025.103648_bib123","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41586-022-05094-1","article-title":"Spatial profiling of chromatin accessibility in mouse and human tissues","volume":"609","author":"Deng","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib124","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41594-023-01060-1","article-title":"Droplet-based single-cell joint profiling of histone modifications and transcriptomes","volume":"30","author":"Xie","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib125","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41588-021-00863-6","article-title":"CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains","volume":"53","author":"Huang","year":"2021","journal-title":"Nat. Genet"},{"key":"10.1016\/j.semcdb.2025.103648_bib126","first-page":"1","article-title":"Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues","author":"Chang","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.semcdb.2025.103648_bib127","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-023-05795-1","article-title":"Spatial epigenome\u2013transcriptome co-profiling of mammalian tissues","volume":"616","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.semcdb.2025.103648_bib128","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/tra.12730","article-title":"Mechanisms and consequences of subcellular RNA localization across diverse cell types","volume":"21","author":"Engel","year":"2020","journal-title":"Traffic"},{"key":"10.1016\/j.semcdb.2025.103648_bib129","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41556-024-01444-5","article-title":"Mechanistic insights into the basis of widespread RNA localization","volume":"26","author":"Chekulaeva","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib130","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-025-03507-8","article-title":"Decoding subcellular RNA localization one molecule at a time","volume":"26","author":"Biayna","year":"2025","journal-title":"Genome Biol."},{"key":"10.1016\/j.semcdb.2025.103648_bib131","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"Ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib132","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/s41592-021-01255-8","article-title":"SpaGCN: integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network","volume":"18","author":"Hu","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.semcdb.2025.103648_bib133","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb2986","article-title":"Characterization of a common progenitor pool of the epicardium and myocardium","volume":"371","author":"Tyser","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.semcdb.2025.103648_bib134","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/CIRCRESAHA.121.318943","article-title":"Unveiling complexity and multipotentiality of early heart fields","volume":"129","author":"Zhang","year":"2021","journal-title":"Circ. Res."}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952125000588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952125000588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:49:23Z","timestamp":1779943763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952125000588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":134,"alternative-id":["S1084952125000588"],"URL":"https:\/\/doi.org\/10.1016\/j.semcdb.2025.103648","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Charting the cardiac landscape: Advances in spatial transcriptomics for heart biology","name":"articletitle","label":"Article Title"},{"value":"Seminars in Cell & Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semcdb.2025.103648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103648"}}