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Lett."},{"issue":"16","key":"10.1016\/j.semcdb.2026.103690_bib75","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1093\/nar\/gkaa661","article-title":"The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2","volume":"48","author":"Geng","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.semcdb.2026.103690_bib76","article-title":"SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions","volume":"12","author":"Kumari","year":"2021","journal-title":"GENES-BASEL"},{"issue":"4","key":"10.1016\/j.semcdb.2026.103690_bib77","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.3390\/ijms24043665","article-title":"Autophagy and the Insulin-like Growth Factor (IGF) System in Colonic Cells: Implications for Colorectal Neoplasia","volume":"24","author":"Kasprzak","year":"2023","journal-title":"Int. J. Mol. 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