{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:41:12Z","timestamp":1790476872187,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Diagnostic Pathology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.semdp.2025.150917","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:05:56Z","timestamp":1747753556000},"page":"150917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory rhabdomyoblastic tumor: A review and update"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-7351","authenticated-orcid":false,"given":"Andrew L.","family":"Folpe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semdp.2025.150917_bib0001","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41379-020-00703-8","article-title":"Inflammatory leiomyosarcoma\" and \"histiocyte-rich rhabdomyoblastic tumor\": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as \"Inflammatory Rhabdomyoblastic tumor","volume":"34","author":"Cloutier","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0002","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2559.1995.tb00323.x","article-title":"Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma","volume":"27","author":"Merchant","year":"1995","journal-title":"Histopathology"},{"key":"10.1016\/j.semdp.2025.150917_bib0003","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41379-018-0145-0","article-title":"Histiocyte-rich rhabdomyoblastic tumor: rhabdomyosarcoma, rhabdomyoma, or rhabdomyoblastic tumor of uncertain malignant potential? A histologically distinctive rhabdomyoblastic tumor in search of a place in the classification of skeletal muscle neoplasms","volume":"32","author":"Martinez","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0004","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00428-020-02774-z","article-title":"Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor","volume":"477","author":"Michal","year":"2020","journal-title":"Virchows Arch"},{"key":"10.1016\/j.semdp.2025.150917_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100131","article-title":"Rhabdomyosarcoma arising in inflammatory rhabdomyoblastic tumor: a genetically distinctive subtype of Rhabdomyosarcoma","volume":"36","author":"Dehner","year":"2023","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0006","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.anndiagpath.2018.07.002","article-title":"Clinicopathologic features of 300 rhabdomyosarcomas with emphasis upon differential expression of skeletal muscle specific markers in the various subtypes: a single institutional experience","volume":"36","author":"Rekhi","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0007","first-page":"515","article-title":"Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas","volume":"130","author":"Skalli","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0008","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cm.10022","article-title":"Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation","volume":"51","author":"Springer","year":"2002","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.semdp.2025.150917_bib0009","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/(SICI)1096-9896(199805)185:1<112::AID-PATH54>3.0.CO;2-U","article-title":"Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes","volume":"185","author":"Dal Cin","year":"1998","journal-title":"J Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/106689690501300210","article-title":"So-called \"inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity","volume":"13","author":"Chang","year":"2005","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/modpathol.2017.113","article-title":"Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature","volume":"31","author":"Arbajian","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1078\/0344-0338-00351","article-title":"Inflammatory leiomyosarcoma of the retroperitoneum","volume":"199","author":"Morovic","year":"2003","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.semdp.2025.150917_bib0013","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1053\/j.jfas.2005.12.010","article-title":"Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature","volume":"45","author":"Efstathopoulos","year":"2006","journal-title":"J Foot Ankle Surg"},{"key":"10.1016\/j.semdp.2025.150917_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100359","article-title":"Inflammatory rhabdomyoblastic tumor: clinicopathologic and molecular analysis of 13 cases","volume":"37","author":"Odate","year":"2024","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0015","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/gcc.23072","article-title":"Inflammatory leiomyosarcoma\/rhabdomyoblastic tumor: a report of two cases with novel genetic findings","volume":"61","author":"Sukhanova","year":"2022","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.semdp.2025.150917_bib0016","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41379-021-00791-0","article-title":"Inflammatory rhabdomyoblastic tumor with progression to high-grade rhabdomyosarcoma","volume":"34","author":"Geiersbach","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0017","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/s41379-021-00797-8","article-title":"Toward a unifying entity that encompasses most, but perhaps not all, inflammatory leiomyosarcomas and histiocyte-rich rhabdomyoblastic tumors","volume":"34","author":"Lee","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0018","first-page":"154","article-title":"A rare case of A low-grade inflammatory leiomyosarcoma\/histiocyte-rich rhabdomyoblastic tumor in the neck of an adolescent male","volume":"39","author":"Rekhi","year":"2023","journal-title":"Turk Patoloji Derg"},{"key":"10.1016\/j.semdp.2025.150917_bib0019","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026105","article-title":"Clinicopathological analysis and genomic profiling of a rare histiocyte-rich rhabdomyoblastic tumor: a case report","volume":"100","author":"Xia","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.semdp.2025.150917_bib0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.path.2023.06.008","article-title":"Inflammatory rhabdomyoblastic tumor: from a nebulous smooth muscle neoplasm to a novel skeletal muscle tumor subtype","volume":"17","author":"Michal","year":"2024","journal-title":"Surg Pathol Clin"},{"key":"10.1016\/j.semdp.2025.150917_bib0021","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1593\/neo.12930","article-title":"Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma","volume":"14","author":"Nord","year":"2012","journal-title":"Neoplasia"},{"key":"10.1016\/j.semdp.2025.150917_bib0022","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1158\/2159-8290.CD-22-0786","article-title":"Genomic patterns of malignant peripheral nerve sheath tumor (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA","volume":"13","author":"Cortes-Ciriano","year":"2023","journal-title":"Cancer Discov"},{"key":"10.1016\/j.semdp.2025.150917_bib0023","first-page":"vdaa155","article-title":"Near haploidization is a genomic hallmark which defines a molecular subgroup of giant cell glioblastoma","volume":"2","author":"Baker","year":"2020","journal-title":"Neurooncol Adv"},{"key":"10.1016\/j.semdp.2025.150917_bib0024","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0165-4608(85)90064-0","article-title":"A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line","volume":"18","author":"Bigner","year":"1985","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.semdp.2025.150917_bib0025","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ccell.2018.06.013","article-title":"Widespread chromosomal losses and mitochondrial DNA alterations as genetic drivers in hurthle cell carcinoma","volume":"34","author":"Gopal","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semdp.2025.150917_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038287","article-title":"Genome haploidisation with chromosome 7 retention in oncocytic follicular thyroid carcinoma","volume":"7","author":"Corver","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.semdp.2025.150917_bib0027","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ccell.2018.07.002","article-title":"Integrated genomic analysis of hurthle cell cancer reveals oncogenic drivers, recurrent mitochondrial mutations, and unique chromosomal landscapes","volume":"34","author":"Ganly","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semdp.2025.150917_bib0028","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/2159-8290.CD-18-0804","article-title":"Integrative molecular characterization of malignant pleural mesothelioma","volume":"8","author":"Hmeljak","year":"2018","journal-title":"Cancer Discov"},{"key":"10.1016\/j.semdp.2025.150917_bib0029","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0002-9440(10)64796-7","article-title":"Near-haploidy and subsequent polyploidization characterize the progression of peripheral chondrosarcoma","volume":"157","author":"Bovee","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0030","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ccell.2016.07.013","article-title":"Comprehensive pan-genomic characterization of adrenocortical carcinoma","volume":"30","author":"Zheng","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.semdp.2025.150917_bib0031","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41379-022-01107-6","article-title":"Myxoid pleomorphic liposarcoma is distinguished from other liposarcomas by widespread loss of heterozygosity and significantly worse overall survival: a genomic and clinicopathologic study","volume":"35","author":"Dermawan","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0032","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1097\/PAS.0000000000001927","article-title":"Superficial CD34-positive fibroblastic tumor: a clinicopathologic, immunohistochemical, and molecular study of 59 cases","volume":"46","author":"Anderson","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0033","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/PAP.0000000000000151","article-title":"Hemosiderotic fibrolipomatous tumor, pleomorphic hyalinizing angiectatic tumor, and myxoinflammatory fibroblastic sarcoma: related or not?","volume":"24","author":"Boland","year":"2017","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0034","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/jcp.2007.049387","article-title":"Inflammatory myofibroblastic tumours: where are we now?","volume":"61","author":"Gleason","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/PAP.0b013e31828625bf","article-title":"Cutaneous neoplasms showing EWSR1 rearrangement","volume":"20","author":"Boland","year":"2013","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.semdp.2025.150917_bib0036","series-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Goldblum","year":"2019"},{"key":"10.1016\/j.semdp.2025.150917_bib0037","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00428-019-02676-9","article-title":"The current landscape of rhabdomyosarcomas: an update","volume":"476","author":"Leiner","year":"2020","journal-title":"Virchows Arch"}],"container-title":["Seminars in Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074025702500053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074025702500053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T02:04:45Z","timestamp":1749261885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074025702500053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S074025702500053X"],"URL":"https:\/\/doi.org\/10.1016\/j.semdp.2025.150917","relation":{},"ISSN":["0740-2570"],"issn-type":[{"value":"0740-2570","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory rhabdomyoblastic tumor: A review and update","name":"articletitle","label":"Article Title"},{"value":"Seminars in Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semdp.2025.150917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150917"}}