{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:15:17Z","timestamp":1761488117433},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.semnephrol.2008.05.004","type":"journal-article","created":{"date-parts":[[2008,9,21]],"date-time":"2008-09-21T09:31:23Z","timestamp":1221989483000},"page":"447-456","source":"Crossref","is-referenced-by-count":6,"title":["Pediatric Critical Care Management of Septic Shock Prior to Acute Kidney Injury and Renal Replacement Therapy"],"prefix":"10.1016","volume":"28","author":[{"given":"James D.","family":"Fortenberry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2008.05.004_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.semnephrol.2008.05.002","article-title":"Acute kidney injury and dialysis in children: illustrative cases","volume":"28","author":"Symons","year":"2008","journal-title":"Sem Neph"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.PCC.0000161289.22464.C3","article-title":"Scope and epidemiology of pediatric sepsis","author":"Watson","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib3","series-title":"Fighting disease, fostering development","year":"1996"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib4","series-title":"Changing history","year":"1996"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib5","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","article-title":"Rapid increase in hospitalization and mortality rates from severe sepsis in the United States: a trend analysis from 1993 to 2003","volume":"35","author":"Dobrovsky","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1164\/rccm.200207-682OC","article-title":"The epidemiology of severe sepsis in children in the United States","volume":"167","author":"Watson","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1164\/rccm.200405-630OC","article-title":"Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children","volume":"171","author":"Leclerc","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00130478-200107000-00001","article-title":"Microvascular thrombosis in pediatric multiple organ failure: is it a therapeutic target?","volume":"2","author":"Nguyen","year":"2001","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib9","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1097\/00003246-199606000-00031","article-title":"Sepsis\/septic shock: participation of the microcirculation: an abbreviated review","volume":"24","author":"Hinshaw","year":"1996","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib10","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-200107001-00020","article-title":"Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis","volume":"29","author":"Grinnell","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib11","first-page":"36","article-title":"Coagulation\/fibrinolysis balance in septic shock related to cytokines and clinical state","volume":"24","author":"Massignon","year":"1994","journal-title":"Haemostasis"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib12","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1055\/s-0037-1615923","article-title":"Hemostatic factor and inflammatory disease","volume":"82","author":"Degan","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1055\/s-2000-13214","article-title":"LPS and cytokine-activated endothelium","volume":"26","author":"Bierhaus","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1072-7515(98)00177-X","article-title":"The role of endothelium in changes in procoagulant activity in sepsis","volume":"187","author":"Iba","year":"1998","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1172\/JCI115592","article-title":"Characterization of a functional thrombin receptor","volume":"89","author":"Coughlin","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jac\/41.suppl_1.17","article-title":"The haemotological manifestations of sepsis","author":"Mammen","year":"1998","journal-title":"J Anitimicrob Chemother"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"34","author":"Levi","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib18","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/S0140-6736(07)61016-2","article-title":"Epidemic meningitis, meningococcaemia, and Neisseria meningitides","volume":"369","author":"Stephens","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib19","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00006454-199611000-00009","article-title":"Pathophysiology, treatment and outcome of meningococcemia: a review and recent outcome","volume":"15","author":"Kirsch","year":"1996","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib20","series-title":"Pediatric critical care medicine","first-page":"1374","article-title":"Infectious syndromes in the pediatric intensive care unit","author":"Dhanani","year":"2006"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1574-6976.2006.00051.x","article-title":"Conquering the meningococcus","volume":"31","author":"Stephens","year":"2007","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib22","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/00003246-200206000-00040","article-title":"ACCM Task Force Committee. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock","volume":"30","author":"Carcillo","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib23","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/jama.266.9.1242","article-title":"Role of early fluid resuscitation in pediatric septic shock","volume":"266","author":"Carcillo","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib24","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/adc.85.5.386","article-title":"Reduction in case fatality rate from meningococcal disease associated with improved healthcare delivery","volume":"85","author":"Booy","year":"2001","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1542\/peds.112.4.793","article-title":"Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome","volume":"112","author":"Han","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib26","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1542\/peds.107.6.1309","article-title":"Outcome in children receiving continuous venovenous hemofiltration","volume":"107","author":"Goldstein","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib28","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1097\/01.CCM.0000132897.52737.49","article-title":"Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis","volume":"32","author":"Foland","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib29","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1542\/peds.102.2.e19","article-title":"Hemodynamic support in fluid-refractory pediatric septic shock","volume":"102","author":"Ceneviva","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib31","first-page":"184","article-title":"Ceftriaxone drug alert: no longer for first line use in meningococcal sepsis (letter)","volume":"93","author":"Faust","year":"2008","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib32","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/01.PCC.0000288710.11834.E6","article-title":"A history of adjunctive glucocorticoid treatment for pediatric sepsis: moving beyond steroid pulp fiction toward evidence-based medicine","volume":"8","author":"Zimmerman","year":"2007","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib33","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1097\/00003246-199910000-00032","article-title":"Admission cortisol and ACTH levels in children with meningococcal disease: evidence of adrenal insufficiency?","volume":"27","author":"Riordan","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/adc.80.1.51","article-title":"Adrenal insufficiency in septic shock","volume":"80","author":"Hatherill","year":"1999","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00006454-200204000-00013","article-title":"Low serum cortisol in combination with high ACTH concentrations are associated with poor outcome in children with severe meningococcal disease","volume":"21","author":"De Kleijn","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib36","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.CCM.0000117317.18092.E4","article-title":"Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock","volume":"32","author":"Dellinger","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib37","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jama.288.7.862","article-title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock","volume":"288","author":"Annane","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/CMR.13.1.144-166.2000","article-title":"Update on meningococcal disease with emphasis on pathogenesis and clinical management","volume":"13","author":"van Deuren","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00130478-200301000-00002","article-title":"The use of extracorporeal techniques to remove humoral factors in sepsis","volume":"4","author":"McMaster","year":"2003","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib41","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1097\/01.CCM.0000072121.61120.D8","article-title":"Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans","volume":"31","author":"deKleijn","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib42","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0140-6736(07)60411-5","article-title":"Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomized clinical trial","volume":"369","author":"Nadel","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib43","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1097\/01.CCM.0000133667.86429.5D","article-title":"Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: a retrospective study","volume":"32","author":"Zenz","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/bja\/78.1.97","article-title":"Effect of low-dose dopamine on serum concentrations of prolactin in critically ill patients","volume":"78","author":"Bailey","year":"1997","journal-title":"Br J Anaesthesia"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/01.PCC.0000128607.68261.7C","article-title":"Association of timing, duration and intensity of hyperglycemia with ICU mortality in critically ill children","volume":"5","author":"Srinivasan","year":"2004","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib46","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1097\/01.CCM.0000282072.56245.91","article-title":"Mechanisms of sepsis-induced organ dysfunction","volume":"35","author":"Abraham","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib47","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3109\/08860229709037221","article-title":"Outcome of acute renal failure in meningococcemia","volume":"19","author":"Marotto","year":"1997","journal-title":"Ren Fail"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib48","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1097\/01.CCM.0000284508.05247.B3","article-title":"Decreased ADAMTS-13 is associated with a poor prognosis in sepsis-induced organ failure","volume":"35","author":"Martin","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/01.PCC.0000163285.74452.23","article-title":"Long-term outcome of meningococcal sepsis-associated acute renal failure","volume":"6","author":"Slack","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib50","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1001\/jama.283.7.904","article-title":"Extracorporeal life support: the University of Michigan experience","volume":"283","author":"Bartlett","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1053\/j.spid.2006.04.005","article-title":"Extracorporeal therapies in sepsis: experience and promise","volume":"17","author":"Fortenberry","year":"2006","journal-title":"Semin Pediatr Infect Dis"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/01.PCC.0000282155.25974.8F","article-title":"Extracorporeal membrane oxygenation for refractory septic shock in children: one institution's experience","volume":"8","author":"MacLaren","year":"2007","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib53","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(96)12106-1","article-title":"Extracorporeal support for intractable cardiorespiratory failure due to meningococcal disease","volume":"349","author":"Goldman","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2008.05.004_bib54","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/j.1651-2227.2004.tb00851.x","article-title":"Extracorporeal life support for children with meningococcal septicemia","volume":"93","author":"Luyt","year":"2004","journal-title":"Acta Pediatr"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929508001125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929508001125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:07:50Z","timestamp":1557792470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929508001125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0270929508001125"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2008.05.004","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}