{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:01:05Z","timestamp":1790737265627,"version":"4.1.0"},"reference-count":115,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.semnephrol.2009.03.009","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T20:43:19Z","timestamp":1247863399000},"page":"321-337","source":"Crossref","is-referenced-by-count":158,"title":["Cell and Molecular Biology of Kidney Development"],"prefix":"10.1016","volume":"29","author":[{"given":"Kimberly J.","family":"Reidy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman D.","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2009.03.009_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00849241","article-title":"Early organogenesis of the kidney","volume":"1","author":"Saxen","year":"1987","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib2","first-page":"3","article-title":"Pediatric nephrology","author":"Holliday","year":"1994"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib3","first-page":"43","article-title":"Interspecies chimeras: an experimental approach for studies on embryonic angiogenesis","volume":"63","author":"Sariola","year":"1985","journal-title":"Med Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000101798","article-title":"Role of the VEGF\u2014a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier","volume":"106","author":"Eremina","year":"2007","journal-title":"Nephron Physiol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/382073a0","article-title":"Defects in enteric innervation and kidney development in mice lacking GDNF","volume":"382","author":"Pichel","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ar.10174","article-title":"Qualitative and quantitative morphology of renal nerves in C57BL\/6J mice","volume":"268","author":"Fazan","year":"2002","journal-title":"Anat Rec"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib7","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/dev.006155","article-title":"Wnt\/beta-catenin signaling regulates nephron induction during mouse kidney development","volume":"134","author":"Park","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ydbio.2008.02.010","article-title":"Canonical WNT\/beta-catenin signaling is required for ureteric branching","volume":"317","author":"Bridgewater","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1242\/dev.119.3.711","article-title":"Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development","volume":"119","author":"Rothenpieler","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib10","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1681\/ASN.2006070739","article-title":"Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney","volume":"18","author":"Narlis","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib11","doi-asserted-by":"crossref","first-page":"F494","DOI":"10.1152\/ajprenal.00416.2006","article-title":"Canonical WNT signaling during kidney development","volume":"293","author":"Iglesias","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib12","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1242\/dev.02442","article-title":"Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells","volume":"133","author":"James","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.modgep.2006.02.003","article-title":"Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development","volume":"6","author":"Stricker","year":"2006","journal-title":"Gene Expr Patterns"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ydbio.2008.09.010","article-title":"Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney","volume":"324","author":"Mugford","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s004670050788","article-title":"The zebrafish pronephros: a genetic system for studies of kidney development","volume":"14","author":"Drummond","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib16","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ydbio.2006.08.063","article-title":"Odd-skipped genes encode repressors that control kidney development","volume":"301","author":"Tena","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib17","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1242\/dev.022830","article-title":"Odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate","volume":"135","author":"Mudumana","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/dbio.1997.8629","article-title":"Model systems for the study of kidney development: use of the pronephros in the analysis of organ induction and patterning","volume":"188","author":"Vize","year":"1997","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature02083","article-title":"Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib20","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1242\/dev.00536","article-title":"Six1 is required for the early organogenesis of mammalian kidney","volume":"130","author":"Xu","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib21","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1128\/MCB.00465-07","article-title":"A Hox-Eya-Pax complex regulates early kidney developmental gene expression","volume":"27","author":"Gong","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib22","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1073\/pnas.0308475101","article-title":"SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes","volume":"101","author":"Ruf","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.mod.2007.01.002","article-title":"Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects","volume":"124","author":"Kobayashi","year":"2007","journal-title":"Mech Dev"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib24","doi-asserted-by":"crossref","first-page":"18918","DOI":"10.1074\/jbc.M600180200","article-title":"Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development","volume":"281","author":"Chai","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib25","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1242\/dev.128.16.3105","article-title":"Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development","volume":"128","author":"Nishinakamura","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib26","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/sj.emboj.7601381","article-title":"Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney","volume":"25","author":"Self","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.stem.2008.05.020","article-title":"Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development","volume":"3","author":"Kobayashi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib28","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1242\/dev.01858","article-title":"Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development","volume":"132","author":"Kobayashi","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/dvg.20309","article-title":"Laser capture-microarray analysis of Lim1 mutant kidney development","volume":"45","author":"Potter","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(93)90515-R","article-title":"WT-1 is required for early kidney development","volume":"74","author":"Kreidberg","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib31","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1002\/j.1460-2075.1996.tb00804.x","article-title":"PAX8-mediated activation of the wt1 tumor suppressor gene","volume":"15","author":"Dehbi","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib32","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1242\/dev.02095","article-title":"Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa","volume":"132","author":"Gao","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<252::AID-DVG8>3.0.CO;2-K","article-title":"Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud","volume":"24","author":"Donovan","year":"1999","journal-title":"Dev Genet"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib34","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1681\/ASN.2006030277","article-title":"Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study","volume":"17","author":"Weber","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib35","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1242\/dev.02457","article-title":"The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development","volume":"133","author":"Sakaki-Yumoto","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1242\/dev.01604","article-title":"Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development","volume":"132","author":"Levinson","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib37","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1681\/ASN.V10102125","article-title":"Vascular endothelial growth factor induces nephrogenesis and vasculogenesis","volume":"10","author":"Tufro","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib38","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1006\/dbio.2000.9845","article-title":"VEGF spatially directs angiogenesis during metanephric development in vitro","volume":"227","author":"Tufro","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ydbio.2006.07.026","article-title":"c-kit delineates a distinct domain of progenitors in the developing kidney","volume":"299","author":"Schmidt-Ott","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib40","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1101\/gad.993302","article-title":"Hox11 paralogous genes are essential for metanephric kidney induction","volume":"16","author":"Wellik","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib41","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2008.03.044","article-title":"Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo","volume":"319","author":"Mugford","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ydbio.2004.03.025","article-title":"Real-time analysis of ureteric bud branching morphogenesis in vitro","volume":"271","author":"Watanabe","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ydbio.2008.02.010","article-title":"Canonical WNT\/beta-catenin signaling is required for ureteric branching","volume":"317","author":"Bridgewater","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/382076a0","article-title":"Renal and neuronal abnormalities in mice lacking GDNF","volume":"382","author":"Moore","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1101\/SQB.1996.061.01.047","article-title":"GDNF is required for kidney development and enteric innervation","volume":"61","author":"Pichel","year":"1996","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib46","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/382070a0","article-title":"Renal agenesis and the absence of enteric neurons in mice lacking GDNF","volume":"382","author":"Sanchez","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib47","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1073\/pnas.93.20.10657","article-title":"Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis","volume":"93","author":"Vega","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib48","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/381789a0","article-title":"GDNF signalling through the Ret receptor tyrosine kinase","volume":"381","author":"Durbec","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib49","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret","volume":"367","author":"Schuchardt","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib50","first-page":"F938","article-title":"Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control","volume":"275","author":"Moreau","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/dbio.2001.0557","article-title":"Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase","volume":"243","author":"Tang","year":"2002","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib52","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ydbio.2007.04.051","article-title":"PTEN modulates GDNF\/RET mediated chemotaxis and branching morphogenesis in the developing kidney","volume":"307","author":"Kim","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib53","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1083\/jcb.142.5.1337","article-title":"The RET-glial cell-derived neurotrophic factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells","volume":"142","author":"Tang","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib54","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ajhg.2007.10.008","article-title":"Renal aplasia in humans is associated with RET mutations","volume":"82","author":"Skinner","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib55","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1038\/sj.onc.1205741","article-title":"RET receptor tyrosine kinase isoforms in kidney function and disease","volume":"21","author":"Lee","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib56","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.devcel.2004.12.004","article-title":"Sprouty1 is a critical regulator of GDNF\/RET-mediated kidney induction","volume":"8","author":"Basson","year":"2005","journal-title":"Dev Cell"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib57","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1242\/dev.127.7.1387","article-title":"Murine forkhead\/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract","volume":"127","author":"Kume","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib58","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1534-5807(04)00108-X","article-title":"SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site","volume":"6","author":"Grieshammer","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib59","first-page":"121","article-title":"Screening for mutations in BMP4 and FOXC1 genes in congenital anomalies of the kidney and urinary tract in humans","volume":"28","author":"Nakano","year":"2003","journal-title":"Tokai J Exp Clin Med"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib60","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1681\/ASN.2007060692","article-title":"ROBO2 gene variants are associated with familial vesicoureteral reflux","volume":"19","author":"Bertoli-Avella","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/bies.20357","article-title":"GDNF\/Ret signaling and the development of the kidney","volume":"28","author":"Costantini","year":"2006","journal-title":"Bioessays"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib62","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.devcel.2004.11.008","article-title":"The role of GDNF\/Ret signaling in ureteric bud cell fate and branching morphogenesis","volume":"8","author":"Shakya","year":"2005","journal-title":"Dev Cell"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib63","doi-asserted-by":"crossref","first-page":"F1123","DOI":"10.1152\/ajprenal.00444.2003","article-title":"Overexpression of RET leads to vesicoureteric reflux in mice","volume":"287","author":"Yu","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib64","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.mod.2007.12.003","article-title":"Semaphorin3a inhibits ureteric bud branching morphogenesis","volume":"125","author":"Tufro","year":"2008","journal-title":"Mech Dev"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib65","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/ng1623","article-title":"Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis","volume":"37","author":"Gribouval","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib66","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.mop.0000193288.56528.40","article-title":"The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract","volume":"18","author":"Niimura","year":"2006","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib67","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1083\/jcb.146.1.255","article-title":"Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome","volume":"146","author":"Cano-Gauci","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/dbio.2000.0127","article-title":"Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis","volume":"231","author":"Grisaru","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib69","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/372679a0","article-title":"Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4","volume":"372","author":"Stark","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib70","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1006\/dbio.1994.1360","article-title":"Induction of kidney epithelial morphogenesis by cells expressing Wnt-1","volume":"166","author":"Herzlinger","year":"1994","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib71","doi-asserted-by":"crossref","first-page":"12705","DOI":"10.1074\/jbc.M513181200","article-title":"PAX2 activates WNT4 expression during mammalian kidney development","volume":"281","author":"Torban","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000147846","article-title":"Mesenchyme to epithelium transition during development of the mammalian kidney tubule","volume":"156","author":"Davies","year":"1996","journal-title":"Acta Anat (Basel)"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib73","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1101\/gad.12.12.1894","article-title":"Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase","volume":"12","author":"Bullock","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib74","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s00467-007-0504-4","article-title":"Molecular regulation of kidney development: is the answer blowing in the Wnt?","volume":"22","author":"Merkel","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib75","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ydbio.2007.11.016","article-title":"Beta-catenin is necessary to keep cells of ureteric bud\/Wolffian duct epithelium in a precursor state","volume":"314","author":"Marose","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib76","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0925-4773(01)00282-9","article-title":"Secreted Frizzled-related proteins can regulate metanephric development","volume":"102","author":"Yoshino","year":"2001","journal-title":"Mech Dev"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib77","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.4161\/cc.5.13.2928","article-title":"Control of murine kidney development by sonic hedgehog and its GLI effectors","volume":"5","author":"Gill","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib78","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1242\/dev.02220","article-title":"GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis","volume":"133","author":"Hu","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib79","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/hmg\/11.9.1129","article-title":"Pallister-Hall syndrome phenotype in mice mutant for Gli3","volume":"11","author":"Bose","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib80","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/jpsu.2001.20722","article-title":"Murine models of VACTERL syndrome: role of sonic hedgehog signaling pathway","volume":"36","author":"Kim","year":"2001","journal-title":"J Pediatr Surg"},{"issue":"22","key":"10.1016\/j.semnephrol.2009.03.009_bib81","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1242\/dev.129.22.5301","article-title":"Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney","volume":"129","author":"Yu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib82","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1242\/dev.01324","article-title":"TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population","volume":"131","author":"Oxburgh","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib83","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1242\/dev.01251","article-title":"Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis","volume":"131","author":"Michos","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib84","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1152\/ajprenal.2001.280.1.F19","article-title":"BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways","volume":"280","author":"Piscione","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib85","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1681\/ASN.2007010080","article-title":"BMP receptor ALK3 controls collecting system development","volume":"19","author":"Hartwig","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib86","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.mod.2005.03.007","article-title":"Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo","volume":"122","author":"Hartwig","year":"2005","journal-title":"Mech Dev"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib87","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ydbio.2005.08.024","article-title":"BMP4 substitutes for loss of BMP7 during kidney development","volume":"286","author":"Oxburgh","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib88","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1681\/ASN.2007111212","article-title":"Podocyte-derived BMP7 is critical for nephron development","volume":"19","author":"Kazama","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib89","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1681\/ASN.2006090983","article-title":"Bmp in podocytes is essential for normal glomerular capillary formation","volume":"19","author":"Ueda","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib90","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0012-1606(03)00100-3","article-title":"Regulation of metanephric kidney development by growth\/differentiation factor 11","volume":"257","author":"Esquela","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib91","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ydbio.2006.03.011","article-title":"Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct","volume":"295","author":"Maeshima","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib92","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.02861","article-title":"Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF\/WNT11 feedback signalling during kidney branching morphogenesis","volume":"134","author":"Michos","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib93","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1083\/jcb.200106075","article-title":"Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition","volume":"155","author":"Allen","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib94","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/dev.128.7.1045","article-title":"TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis","volume":"128","author":"Plisov","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib95","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ydbio.2006.04.469","article-title":"FGF is essential for both condensation and mesenchymal-epithelial transition stages of pronephric kidney tubule development","volume":"297","author":"Urban","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib96","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00467-006-0239-7","article-title":"Role of fibroblast growth factor receptor signaling in kidney development","volume":"22","author":"Bates","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib97","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1242\/dev.01944","article-title":"FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons","volume":"132","author":"Grieshammer","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib98","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ydbio.2005.12.034","article-title":"Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme","volume":"291","author":"Poladia","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib99","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1203\/PDR.0b013e318187cc12","article-title":"Role of fibroblast growth factor receptor 2 in kidney mesenchyme","volume":"64","author":"Hains","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib100","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1242\/dev.01200","article-title":"Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development","volume":"131","author":"Chi","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib101","doi-asserted-by":"crossref","first-page":"F1404","DOI":"10.1152\/ajprenal.90378.2008","article-title":"Bradykinin B2 receptor null mice harboring a Ser23-to-Ala substitution in the p53 gene are protected from renal dysgenesis","volume":"295","author":"El-Dahr","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"10.1016\/j.semnephrol.2009.03.009_bib102","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1158\/0008-5472.CAN-05-3241","article-title":"Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor","volume":"66","author":"Rankin","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib103","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ki.1996.336","article-title":"Expression of a cut-related homeobox gene in developing and polycystic mouse kidney","volume":"50","author":"Vanden Heuvel","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib104","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0070-2153(08)00606-6","article-title":"Mouse models of polycystic kidney disease","volume":"84","author":"Wilson","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib105","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1111\/j.1523-1755.2005.00625.x","article-title":"Roles of HNF-1beta in kidney development and congenital cystic diseases","volume":"68","author":"Igarashi","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib106","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1038\/sj.ki.5000314","article-title":"VEGF receptor 2 blockade leads to renal cyst formation in mice","volume":"69","author":"McGrath-Morrow","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib107","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1242\/dev.02773","article-title":"Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron","volume":"134","author":"Cheng","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib108","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/dev.121.3.867","article-title":"Repression of Pax-2 by WT1 during normal kidney development","volume":"121","author":"Ryan","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib109","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1097\/01.ASN.0000146687.99058.25","article-title":"The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1","volume":"15","author":"Wagner","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib110","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ydbio.2007.10.047","article-title":"Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus","volume":"313","author":"Kanasaki","year":"2008","journal-title":"Dev Biol"},{"issue":"3","key":"10.1016\/j.semnephrol.2009.03.009_bib111","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1172\/JCI26027","article-title":"Tbx18 regulates the development of the ureteral mesenchyme","volume":"116","author":"Airik","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib112","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1242\/dev.022442","article-title":"Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4","volume":"135","author":"Caubit","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib113","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1242\/dev.023697","article-title":"A dual requirement for Iroquois genes during Xenopus kidney development","volume":"135","author":"Alarcon","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib114","doi-asserted-by":"crossref","first-page":"18473","DOI":"10.1073\/pnas.0509457102","article-title":"The zebrafish kohtalo\/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney","volume":"102","author":"Hong","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2009.03.009_bib115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1387\/ijdb.052005dl","article-title":"The role of XTRAP-gamma in Xenopus pronephros development","volume":"49","author":"Li","year":"2005","journal-title":"Int J Dev Biol"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929509000461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929509000461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T20:00:33Z","timestamp":1633723233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929509000461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":115,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0270929509000461"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2009.03.009","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}