{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:05:48Z","timestamp":1788671148191,"version":"build-2803163510"},"reference-count":97,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","seminarsinnephrology.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.semnephrol.2018.05.009","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T19:38:09Z","timestamp":1533325089000},"page":"397-409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Personalized Management of Bone and Mineral Disorders and Precision Medicine in End-Stage Kidney Disease"],"prefix":"10.1016","volume":"38","author":[{"given":"Anna","family":"Jovanovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kendrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2018.05.009_bib0001","volume":"2017","year":"2017"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0002","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0003","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.2174\/1381612820666140212194926","article-title":"Vascular calcification in chronic kidney disease: role of disordered mineral metabolism","volume":"20","author":"Palit","year":"2014","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0004","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0005","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/j.ajkd.2008.03.020","article-title":"Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"52","author":"Tentori","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0006","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0007","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1172\/JCI111995","article-title":"Evidence for alteration of the vitamin D-endocrine system in blacks","volume":"76","author":"Bell","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0008","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ki.2008.4","article-title":"Prevalence and severity of disordered mineral metabolism in blacks with chronic kidney disease","volume":"73","author":"Gutierrez","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0009","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1053\/j.ajkd.2008.07.036","article-title":"Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III)","volume":"53","author":"de Boer","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0010","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1093\/ndt\/gfq316","article-title":"Racial differences in postprandial mineral ion handling in health and in chronic kidney disease","volume":"25","author":"Gutierrez","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0011","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/ndt\/gfs080","article-title":"Contribution of calcium, phosphorus and 25-hydroxyvitamin D to the excessive severity of secondary hyperparathyroidism in African-Americans with CKD","volume":"27","author":"Ennis","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0012","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ki.2013.443","article-title":"Ethnic differences in bone and mineral metabolism in healthy people and patients with CKD","volume":"85","author":"Jorgetti","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0013","first-page":"92","article-title":"Female hemodialysis patients have an increased risk of nodular hyperplasia of parathyroid glands","volume":"18","author":"Lomonte","year":"2005","journal-title":"J Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0014","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/ndt\/gfi311","article-title":"A high body mass index and female gender are associated with an increased risk of nodular hyperplasia of parathyroid glands in chronic uraemia","volume":"21","author":"Basile","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0015","first-page":"3860","article-title":"Predictors of short-term changes in serum intact parathyroid hormone levels in hemodialysis patients: role of phosphorus, calcium and gender","volume":"83","author":"Indridason","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1440-1797.2006.00531.x","article-title":"Race and sex: predictors of the severity of hyperparathyroidism in peritoneal dialysis patients","volume":"11","author":"Fan","year":"2006","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0017","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1681\/ASN.2004020138","article-title":"The fall and rise of parathyroidectomy in US hemodialysis patients, 1992 to 2002","volume":"16","author":"Foley","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0018","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jss.2009.07.034","article-title":"Gender differences among patients with secondary hyperparathyroidism undergoing parathyroidectomy","volume":"168","author":"Cheng","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0019","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1046\/j.1523-1755.2003.00331.x","article-title":"Proliferation in hyperplastic human and normal rat parathyroid glands: role of phosphate, calcitriol, and gender","volume":"64","author":"Almaden","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0020","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ki.2008.33","article-title":"Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia","volume":"73","author":"Faroqui","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0021","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1053\/j.ajkd.2011.06.011","article-title":"Relation of sex and estrogen therapy to serum fibroblast growth factor 23, serum phosphorus and urine phosphorus: the Heart and Soul Study","volume":"58","author":"Ix","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0022","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1681\/ASN.2008121258","article-title":"Indirect regulation of PTH by estrogens may require FGF23","volume":"20","author":"Carrillo-Lopez","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0023","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/sdi.12439","article-title":"Removal of phosphorus by hemodialysis","volume":"28","author":"Daugirdas","year":"2015","journal-title":"Semin Dial"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0024","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/j.jrn.2005.10.008","article-title":"Impact of convective flow on phosphorus removal in maintenance hemodialysis patients","volume":"16","author":"Lornoy","year":"2006","journal-title":"J Ren Nutr"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0025","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.2215\/CJN.03860411","article-title":"Kinetic model of phosphorus mobilization during and after short and conventional hemodialysis","volume":"6","author":"Agar","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0026","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ki.1986.252","article-title":"The absorption of dietary phosphorus and calcium in hemodialysis patients","volume":"30","author":"Ramirez","year":"1986","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0027","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/ndt\/12.8.1640","article-title":"RenaGel, a novel calcium- and aluminum-free phosphate binder, inhibits phosphate absorption in normal volunteers","volume":"12","author":"Burke","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0028","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1681\/ASN.2009111104","article-title":"Common genetic variants associate with serum phosphorus concentration","volume":"21","author":"Kestenbaum","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0029","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1681\/ASN.2016010069","article-title":"Genetic variants associated with circulating parathyroid hormone","volume":"28","author":"Robinson-Cohen","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.semnephrol.2018.05.009_bib0030","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1210\/jc.2017-01802","article-title":"Trans-ethnic evaluation identifies novel low frequency loci associated with 25-hydroxyvitamin D concentrations","volume":"103","author":"Hong","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0031","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1172\/JCI113886","article-title":"Reduction of dietary phosphorus absorption by phosphorus binders. A theoretical, in vitro, and in vivo study","volume":"83","author":"Sheikh","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0032","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1210\/jc.2008-1861","article-title":"Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans","volume":"94","author":"Jung","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0033","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1093\/hmg\/ddq342","article-title":"Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels","volume":"19","author":"O'Seaghdha","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001035","article-title":"Genome-side meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene","volume":"6","author":"Kapur","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/jhg.2015.46","article-title":"Association of common variants in the calcium-sensing receptor gene with serum calcium levels in East Asians","volume":"60","author":"Vinayagamoorthy","year":"2015","journal-title":"J Hum Genet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0036","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000204960","article-title":"Associations of vitamin D receptor, calcium-sensing receptor and parathyroid hormone gene polymorphisms with calcium homeostasis and peripheral bone density in adult Finns","volume":"2","author":"Laaksonen","year":"2009","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0037","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.gene.2011.10.017","article-title":"Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in health individuals: a meta-analysis","volume":"491","author":"He","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0038","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(98)06434-4","article-title":"A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations","volume":"353","author":"Cole","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0039","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1210\/jc.2004-0129","article-title":"Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor","volume":"89","author":"Scillitani","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0040","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/eje.0.1440257","article-title":"Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls","volume":"144","author":"Lorentzon","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0041","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2265.2006.02634.x","article-title":"Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density","volume":"65","author":"Harding","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0042","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000045681","article-title":"Association of polymorphic alleles of the calcium-sensing receptor gene with parathyroid hormone secretion in hemodialysis patients","volume":"85","author":"Yano","year":"2000","journal-title":"Nephron"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0043","first-page":"114","article-title":"The clinical significance of parathyroid tissue calcium sensing receptor gene polymorphisms and expression levels in end-stage renal disease patients","volume":"72","author":"Eren","year":"2009","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0044","doi-asserted-by":"crossref","first-page":"35188","DOI":"10.1038\/srep35188","article-title":"Associations of the calcium-sensing receptor gene CASR rs7652589 SNP with nephrolithiasis and secondary hyperparathyroidism in haemodialysis patients","volume":"6","author":"Grzegorzewska","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119459","article-title":"Association studies of calcium-sensing receptor (CaSR) polymorphisms with serum concentrations of glucose and phosphate and vascular calcification in renal transplant recipients","volume":"10","author":"Babinsky","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2383216","article-title":"Polymorphisms of vitamin d signaling pathway genes and calcium-sensing receptor gene in respect to survival of hemodialysis patients: a prospective observational study","volume":"2016","author":"Grzegorzewska","year":"2016","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0047","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5414\/CNP57131","article-title":"Calcium-sensing receptor gene polymorphism affects the parathyroid response to moderate hypercalcemic suppression in patients with end-stage renal disease","volume":"57","author":"Yokoyama","year":"2002","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0048","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.2215\/CJN.11141016","article-title":"Calcium-sensing receptor genotype and response to cinacalcet in patients undergoing hemodialysis","volume":"12","author":"Moe","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003796","article-title":"Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations","volume":"9","author":"O'Seaghdha","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0050","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1681\/ASN.V8101546","article-title":"Association between vitamin D receptor gene polymorphism and relative hypoparathyroidism in patients with chronic renal failure","volume":"8","author":"Fernandez","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0051","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/ajkd.1998.v32.pm9740163","article-title":"Vitamin D receptor gene polymorphisms affect secondary hyperparathyroidism in hemodialyzed patients","volume":"32","author":"Nagaba","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0052","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/ajcp\/112.3.366","article-title":"Bsml polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients","volume":"112","author":"Tagliabue","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0053","first-page":"111","article-title":"Influence of Bsml vitamin D receptor gene polymorphism on the response to a single bolus of calcitriol in hemodialysis patients","volume":"56","author":"Marco","year":"2001","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0054","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1046\/j.1523-1755.1999.00678.x","article-title":"Vitamin D receptor genotype influences parathyroid hormone and calcitriol levels in predialysis patients","volume":"56","author":"Marco","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0055","first-page":"116","article-title":"BB genotype of the vitamin D receptor gene polymorphism postpones parathyroidectomy in hemodialysis patients","volume":"16","author":"Borras","year":"2003","journal-title":"J Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0056","doi-asserted-by":"crossref","first-page":"e51171","DOI":"10.1371\/journal.pone.0051171","article-title":"Interactions between serum vitamin D levels and vitamin D receptor gene Fokl polymorphisms for renal function in patients with type 2 diabetes","volume":"7","author":"Yokoyama","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0057","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1359\/jbmr.090717","article-title":"Vitamin D receptor (VDR) gene polymorphism is associated with left ventricular (LV) mass and predicts left ventricular hypertrophy (LVH) progression in end-stage renal disease (ESRD) patients","volume":"25","author":"Testa","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0058","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/00365513.2012.743163","article-title":"Relationship of Bsml polymorphism of vitamin D receptor gene with left ventricular hypertrophy and atherosclerosis in hemodialysis patients","volume":"73","author":"El-Shehaby","year":"2013","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0059","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3390\/nu6031029","article-title":"Vitamin D receptor gene polymorphism and left ventricular hypertrophy in chronic kidney disease","volume":"6","author":"Santoro","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0060","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patient with chronic kidney disease: the PRIMO randomized controlled trial","volume":"307","author":"Thadani","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0061","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1681\/ASN.2013010103","article-title":"Effect of paricalcitol on left ventricular mass and function in CKD\u2014the OPERA trial","volume":"25","author":"Wang","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0062","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1681\/ASN.2005111194","article-title":"Relationship between moderate to severe kidney disease and hip fracture in the United States","volume":"17","author":"Nickolas","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0063","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"Alem","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0064","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0272-6386(04)00958-8","article-title":"Increased risk of mortality associated with hip fracture in the dialysis population","volume":"44","author":"Mittalhenkle","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0065","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1053\/j.ajkd.2009.12.041","article-title":"Intact PTH combined with the PTH ratio for diagnosis of bone turnover in dialysis patients: a diagnostic test study","volume":"55","author":"Herberth","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0066","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/j.ajkd.2015.06.023","article-title":"Diagnostic accuracy of bone turnover markers and bone histology in patients with CKD treated by dialysis","volume":"67","author":"Sprague","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0067","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/ndt\/11.6.1065","article-title":"Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients","volume":"11","author":"Couttenye","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0068","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/hdi.12454","article-title":"Bone-specific alkaline phosphatase and bone turnover in African American hemodialysis patients","volume":"21","author":"Yessayan","year":"2017","journal-title":"Hemodial Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0069","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ndt\/gfr317","article-title":"Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients-a single-center cohort study","volume":"27","author":"Iimori","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0070","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jbmr.2406","article-title":"Bone mineral density predicts fractures in chronic kidney disease","volume":"30","author":"West","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0071","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2215\/CJN.06040614","article-title":"Comparison of fracture risk prediction among individuals with reduced and normal kidney function","volume":"10","author":"Naylor","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0072","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","article-title":"KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention and treatment of chronic kidney disease-mineral bone disorder (CKD-MBD)","volume":"7","year":"2017","journal-title":"Kidney Int Suppl."},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0073","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1210\/jc.2014-4346","article-title":"Bone material strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of bone mineral density","volume":"100","author":"Malgo","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0074","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/jbmr.2497","article-title":"Bone tissue properties measurement by reference point indentation in glucocorticoid-induced osteoporosis","volume":"30","author":"Mellibovsky","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0075","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/CIRCRESAHA.111.247965","article-title":"Genetics in arterial calcification","volume":"109","author":"Rutsch","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0076","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1111\/j.1523-1755.2005.00345.x","article-title":"Low fetuin-A levels are associated with cardiovascular death: impact of variations in the gene encoding fetuin","volume":"67","author":"Stenvinkel","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0077","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1159\/000309789","article-title":"Association of AHSG gene polymorphisms and aortic stiffness in peritoneal dialysis patients","volume":"31","author":"Jwang","year":"2010","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0078","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1159\/000088809","article-title":"Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients","volume":"25","author":"Brancaccio","year":"2005","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0079","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000302722","article-title":"Vascular calcification and cardiovascular outcome in dialysis patients: the role of gene polymorphisms","volume":"29","author":"Cozzolino","year":"2010","journal-title":"Blood Purif"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0080","series-title":"ERA-EDTA XLI Congress","article-title":"Association between the matrix GLA protein-7 polymorphism and carotid intima-media area and left ventricular hypertrophy in end-stage renal disease patients [abstract]","author":"Wang","year":"2004"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0081","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(03)12710-9","article-title":"Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study","volume":"361","author":"Ketteler","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0082","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1159\/000095782","article-title":"Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients","volume":"26","author":"Cozzolini","year":"2006","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0083","first-page":"699","article-title":"Genetic polymorphism of alpha 2HS-glycoprotein","volume":"38","author":"Cox","year":"1986","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0084","doi-asserted-by":"crossref","first-page":"8713","DOI":"10.1038\/s41598-017-09328-5","article-title":"Association of Matrix Gla protein gene (rs1800801, rs 1800802, rs4236) polymorphism with vascular calcification and atherosclerotic disease: a meta-analysis","volume":"18","author":"Sheng","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0085","first-page":"69","article-title":"T-138c polymorphism of matric gla promoter alters its expression but is not directly associated with atherosclerotic vascular calcification","volume":"50","author":"Kobayashi","year":"2004","journal-title":"Kobe J Med Sci"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0086","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1681\/ASN.2012030240","article-title":"Nanoparticle-based test measures overall propensity for calcification in serum","volume":"23","author":"Pasch","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0087","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/sj.ki.5002164","article-title":"Association of pulse wave velocity with vascular and valvular calcification in hemodialysis patients","volume":"71","author":"Raggi","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0088","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2215\/CJN.02190507","article-title":"Progressive vascular calcification over 2years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease","volume":"2","author":"Sigrist","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0089","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1681\/ASN.2013060635","article-title":"Serum calcification propensity predicts all-cause mortality in predialysis CKD","volume":"25","author":"Smith","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151508","article-title":"High-flux hemodialysis and high-volume hemodiafiltration improve serum calcification propensity","volume":"11","author":"Dekker","year":"2016","journal-title":"PLos One"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0091","first-page":"380","article-title":"Oral magnesium supplementation in chronic kidney disease stages 3 and 4: efficacy, safety and effect on serum calcification propensity-a prospective randomized double-blinded placebo-controlled clinical trial","volume":"30","author":"Bressendorff","year":"2016","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0092","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167929","article-title":"Phosphocalcic markers and calcification propensity for assessment of interstitial fibrosis and vascular lesions in kidney allograft recipients","volume":"11","author":"Berchtold","year":"2016","journal-title":"PLos One"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0093","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1681\/ASN.2012030223","article-title":"Effects of phosphate binders in moderate CKD","volume":"23","author":"Block","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0094","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2215\/CJN.03820411","article-title":"Mortality in kidney disease patients treated with phosphate binders: a randomized study","volume":"7","author":"Di Iorio","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0095","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1053\/j.ajkd.2013.03.023","article-title":"Sevelamer versus calcium carbonate in incident hemodialysis patients: results of an open-label 24-month randomized clinical trial","volume":"62","author":"Di Iorio","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0096","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ki.2015.67","article-title":"A dearth of data: the problem of phosphorus in prescription medications","volume":"87","author":"Sherman","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.009_bib0097","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1525-139X.2006.00160.x","article-title":"Gene polymorphism association studies in dialysis: bone and mineral metabolism","volume":"19","author":"Ertuk","year":"2006","journal-title":"Semin Dial"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929518300718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929518300718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T19:06:23Z","timestamp":1661713583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929518300718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":97,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0270929518300718"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2018.05.009","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Personalized Management of Bone and Mineral Disorders and Precision Medicine in End-Stage Kidney Disease","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nephrology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semnephrol.2018.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}