{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:34:30Z","timestamp":1781094870260,"version":"3.54.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","seminarsinnephrology.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.semnephrol.2018.05.022","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T18:13:51Z","timestamp":1535739231000},"page":"521-530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Biomarkers and Precision Medicine in IgA Nephropathy"],"prefix":"10.1016","volume":"38","author":[{"given":"Francesco Paolo","family":"Schena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Natasha","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2018.05.022_bib0001","unstructured":"Schena FP, Nistor I. The global burden of Immunoglobulin A nephropathy-a systematic review. Sem Nephrol. 2018"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0002","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0272-6386(99)70417-8","article-title":"Familial clustering of IgA nephropathy: further evidence in an Italian population","volume":"33","author":"Scolari","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0003","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1056\/NEJM198501243120403","article-title":"Familial IgA nephropathy. Evidence of an inherited mechanism of disease","volume":"312","author":"Julian","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0004","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1681\/ASN.V132453","article-title":"Increased risk of end-stage renal disease in familial IgA nephropathy","volume":"13","author":"Schena","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0005","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1681\/ASN.2011050464","article-title":"The pathophysiology of IgA nephropathy","volume":"22","author":"Suzuki","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0006","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.ki.5002185","article-title":"Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels","volume":"71","author":"Moldoveanu","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0007","doi-asserted-by":"crossref","first-page":"e98081","DOI":"10.1371\/journal.pone.0098081","article-title":"A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases","volume":"9","author":"Yanagawa","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0008","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1523-1755.2005.67107.x","article-title":"IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells","volume":"67","author":"Novak","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0009","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1074\/jbc.M211097200","article-title":"Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase2","volume":"278","author":"Iwasaki","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1074\/jbc.M109056200","article-title":"Purification, characterization, and subunit structure of rat core 1 beta1,3-galactosyltransferase","volume":"277","author":"Ju","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0011","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1681\/ASN.2007091052","article-title":"Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy","volume":"19","author":"Gharavi","year":"2008","journal-title":"Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0012","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1681\/ASN.2016020184","article-title":"IgA1 glycosylation is heritable in healthy twins","volume":"28","author":"Lomax-Browne","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0013","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/ndt\/gfm913","article-title":"Serum under-galactosylated IgA1 is increased in Japanese patients with IgA nephropathy","volume":"23","author":"Shimozato","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0014","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1093\/ndt\/gfp294","article-title":"Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy","volume":"24","author":"Lin","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ki.2011.16","article-title":"Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Sch\u00f6nlein purpura nephritis","volume":"80","author":"Kiryluk","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0016","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/ki.2012.197","article-title":"The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression","volume":"82","author":"Zhao","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0017","article-title":"Effect of immunosuppressive drugs on the changes of serum galactose-deficient IgA1 in patients with IgA nephropathy","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166700","article-title":"Aberrant IgA1 glycosylation in IgA nephropathy: a systematic review","volume":"11","author":"Sun","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0019","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1681\/ASN.2011060567","article-title":"Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy","volume":"23","author":"Serino","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0020","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/ndt\/gfv032","article-title":"Role of let-7b in the regulation of N-acetylgalactosaminyltransferase 2 in IgA nephropathy","volume":"3","author":"Serino","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0021","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ki.2015.333","article-title":"In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy","volume":"89","author":"Serino","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0022","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI5535","article-title":"Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies","volume":"104","author":"Tomana","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0023","first-page":"1668","article-title":"Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity","volume":"119","author":"Suzuki","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0024","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1681\/ASN.2012010053","article-title":"Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy","volume":"23","author":"Berthoux","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0025","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1681\/ASN.2016060670","article-title":"Prognostic value of serum biomarkers of autoimmunity for recurrence of IgA nephropathy after kidney transplantation","volume":"28","author":"Berthoux","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0026","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1172\/JCI112522","article-title":"Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies","volume":"77","author":"Czerkinsky","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0027","first-page":"583","article-title":"IgA1 and IgA2 immune complexes in primary IgA nephropathy and Henoch-Schonlein nephritis","volume":"57","author":"Coppo","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0028","first-page":"15","article-title":"Increased serum levels of IgA1-IgG immune complexes and anti-F(ab')2 antibodies in patients with primary IgA nephropathy","volume":"77","author":"Schena","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0029","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s10157-013-0921-6","article-title":"Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy","volume":"18","author":"Suzuki","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0030","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1471-4914(02)02405-X","article-title":"Pathogenic significance of IgA receptor interactions in IgA nephropathy","volume":"8","author":"Monteiro","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0031","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/ki.2010.314","article-title":"Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy","volume":"78","author":"Vuong","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0032","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1046\/j.1523-1755.2003.00756.x","article-title":"Complexes of IgA with FcalphaRI\/CD89 are not specific for primary IgA nephropathy","volume":"63","author":"van der Boog","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0033","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1515\/cclm-2017-0090","article-title":"Circulating CD89-IgA complex does not predict deterioration of kidney function in Korean patients with IgA nephropathy","volume":"56","author":"Jhee","year":"2017","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0034","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.autrev.2015.05.009","article-title":"Diagnosis and monitoring of IgA nephropathy: the role of biomarkers as an alternative to renal biopsy","volume":"14","author":"Moresco","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0035","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.clinbiochem.2013.01.017","article-title":"Soluble transferrin receptor in urine, a new biomarker for IgA nephropathy and Henoch-Sch\u00f6nlein purpura nephritis","volume":"46","author":"Delanghe","year":"2013","journal-title":"Clin Biochem"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0036","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbacli.2016.02.002","article-title":"Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and Henoch-Sch\u00f6nlein purpura nephritis","volume":"5","author":"Moresco","year":"2016","journal-title":"BBA Clin"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0037","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1681\/ASN.2005090923","article-title":"Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease","volume":"17","author":"Roos","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0038","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1093\/ndt\/13.8.1984","article-title":"Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy","volume":"13","author":"Endo","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0039","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2169\/internalmedicine.43.1023","article-title":"Relationship between serum IgA\/C3 ratio and progression of IgA nephropathy","volume":"43","author":"Komatsu","year":"2004","journal-title":"Intern Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12882-017-0658-7","article-title":"Increased C4 and decreased C3 levels are associated with a poor prognosis in patients with immunoglobulin A nephropathy: a retrospective study","volume":"18","author":"Pan","year":"2017","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0041","doi-asserted-by":"crossref","first-page":"e40495","DOI":"10.1371\/journal.pone.0040495","article-title":"Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0042","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/ki.1987.101","article-title":"Complement activation in IgA nephropathy","volume":"31","author":"Wyatt","year":"1987","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0043","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/ki.1997.171","article-title":"Activated complement C3: a potentially novel predictor of progressive IgA nephropathy","volume":"51","author":"Zwirner","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0044","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng.787","article-title":"Genome-wide association study identifies susceptibility loci for IgA nephropathy","volume":"43","author":"Gharavi","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002765","article-title":"Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis","volume":"8","author":"Kiryluk","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0046","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1681\/ASN.2015111210","article-title":"Fine mapping implicates a deletion of CFHR1 and CFHR3 in protection from IgA nephropathy in Han Chinese","volume":"27","author":"Xie","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0047","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.kint.2017.03.043","article-title":"Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy","volume":"92","author":"Medjeral-Thomas","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0048","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.kint.2017.03.041","article-title":"Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy","volume":"92","author":"Tortajada","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0049","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1053\/j.ajkd.2016.02.042","article-title":"Early change in urine protein as a surrogate end point in studies of IgA nephropathy: an individual-patient meta-analysis","volume":"68","author":"Inker","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0050","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.1038\/s41598-017-09393-w","article-title":"Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis","volume":"7","author":"Krochmal","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0051","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1159\/000065465","article-title":"Prognostic value of urinary interleukin 6 in patients with IgA nephropathy: an 8-year follow-up study","volume":"92","author":"Harada","year":"2002","journal-title":"Nephron"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0052","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1098-2825(2001)15:1<30::AID-JCLA6>3.0.CO;2-X","article-title":"Urinary levels of interleukin-8 (IL-8) and disease activity in patients with IgA nephropathy","volume":"15","author":"Huang","year":"2001","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0053","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1681\/ASN.V76906","article-title":"Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: a pathogenetic role in interstitial monocytes recruitment","volume":"7","author":"Grandaliano","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0054","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.nefro.2016.11.017","article-title":"Value of urinary levels of interleukin-6, epidermal growth factor, monocyte chemoattractant protein type 1 and transforming growth factor \u03b21 in predicting the extent of fibrosis lesions in kidney biopsies of patients with IgA nephropathy","volume":"37","author":"Segarra-Medrano","year":"2017","journal-title":"Nefrologia"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0055","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1038\/ki.1996.521","article-title":"Urinary IL-6\/EGF ratio: a useful prognostic marker for the progression of renal damage in IgA nephropathy","volume":"50","author":"Ranieri","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0056","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/sj.ki.5002621","article-title":"The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy","volume":"73","author":"Torres","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0057","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ndt\/gfv104","article-title":"Urine podocyte mRNAs mark disease activity in IgA nephropathy","volume":"30","author":"Fukuda","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0058","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1093\/ndt\/gfl240","article-title":"IgA-containing immune complexes in the urine of IgA nephropathy patients","volume":"21","author":"Matousovic","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0059","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1042\/CS20140733","article-title":"microRNAs in glomerular diseases from pathophysiology to potential treatment target","volume":"128","author":"Schena","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0060","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1159\/000343452","article-title":"Urinary miR-21, miR-29, and miR-93: novel biomarkers of fibrosis","volume":"36","author":"Wang","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0061","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1155\/2012\/842764","article-title":"Micro-RNA expression in the urinary sediment of patients with chronic kidney diseases","volume":"33","author":"Szeto","year":"2012","journal-title":"Dis Markers"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0062","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1155\/2010\/396328","article-title":"Expression of microRNAs in the urinary sediment of patients with IgA nephropathy","volume":"28","author":"Wang","year":"2010","journal-title":"Dis Markers"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0063","series-title":"ROC curves for continuous data","author":"Krzanowski","year":"2009"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0064","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1681\/ASN.2013121300","article-title":"Key concepts and limitations of statistical methods for evaluating biomarkers of kidney disease","volume":"25","author":"Parikh","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2043-9113-1-1","article-title":"Clinical bioinformatics: a new emerging science","volume":"1","author":"Wang","year":"2011","journal-title":"J Clin Bioinforma"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0066","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1161\/CIRCULATIONAHA.109.901413","article-title":"MORGAM project. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project","volume":"121","author":"Blankenberg","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0067","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1741-7015-11-220","article-title":"Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration","volume":"11","author":"McShane","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0068","unstructured":"Available from: CDER-Biomarker-QualificationProgram@fda.hhs.gov."},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0069","unstructured":"Bouri K. Regulatory considerations of the use of next generation sequencing and biomarkers to support the implementation of precision medicine. Presented at the Summit on Controversies in Precision Medicine; 2017 Nov 13-15; Berlin, Germany."},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2015.06.041","article-title":"Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families","volume":"571","author":"Liu","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0071","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/joim.12565","article-title":"Multiple rare genetic variants co-segregating with familial IgA nephropathy all act within a single immune-related network","volume":"281","author":"Cox","year":"2017","journal-title":"J Intern Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0072","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.2215\/CJN.13651215","article-title":"Defining glomerular disease in mechanistic terms: implementing an integrative biology approach in nephrology","volume":"11","author":"Mariani","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0073","doi-asserted-by":"crossref","first-page":"316ra193","DOI":"10.1126\/scitranslmed.aac7071","article-title":"Tissue transcriptome\u2013driven identification of epidermal growth factor as a chronic kidney disease biomarker","volume":"7","author":"Ju","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0074","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1523-1755.2004.00499.x","article-title":"Gene expression fingerprint in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression","volume":"65","author":"Henger","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0075","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2215\/CJN.01450214","article-title":"Glomerular disease: looking beyond pathology","volume":"9","author":"Wiggins","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.05.022_bib0076","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12882-017-0669-4","article-title":"The biobank for the molecular classification of kidney disease: research translation and precision medicine in nephrology","volume":"18","author":"Muruve","year":"2017","journal-title":"BMC Nephrol"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929518300846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929518300846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T02:07:12Z","timestamp":1661911632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929518300846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0270929518300846"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2018.05.022","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers and Precision Medicine in IgA Nephropathy","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nephrology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semnephrol.2018.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}